CN114340646A - 诱导体内器官发育的微创细胞移植方法 - Google Patents

诱导体内器官发育的微创细胞移植方法 Download PDF

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CN114340646A
CN114340646A CN202080043054.XA CN202080043054A CN114340646A CN 114340646 A CN114340646 A CN 114340646A CN 202080043054 A CN202080043054 A CN 202080043054A CN 114340646 A CN114340646 A CN 114340646A
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days
cells
lymph nodes
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E·拉加西
P·A·C·方特斯
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University of Pittsburgh
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CN202080043054.XA 2019-04-11 2020-04-10 诱导体内器官发育的微创细胞移植方法 Pending CN114340646A (zh)

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US201962832492P 2019-04-11 2019-04-11
US62/832,492 2019-04-11
PCT/US2020/027783 WO2020210710A1 (en) 2019-04-11 2020-04-10 Minimally invasive cell transplant procedure to induce the development of in vivo organogenesis

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US (1) US12569276B2 (https=)
EP (2) EP4427813A3 (https=)
JP (2) JP7672704B2 (https=)
KR (1) KR20210155390A (https=)
CN (1) CN114340646A (https=)
AU (1) AU2020271121B2 (https=)
BR (1) BR112021020451A2 (https=)
CA (1) CA3136471A1 (https=)
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Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
WO2023023353A1 (en) * 2021-08-19 2023-02-23 Kassab Ghassan S Intranodal needle and method of using the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202761247U (zh) * 2012-07-25 2013-03-06 西安交通大学医学院第一附属医院 一种医用内窥镜注射器
WO2014138486A1 (en) * 2013-03-06 2014-09-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Lymph node as a site for transplantation, organogenesis and function for multiple tissues and organs
US20160002595A1 (en) * 2013-02-18 2016-01-07 University Health Network Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells
WO2018152488A1 (en) * 2017-02-17 2018-08-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fat-associated lymphoid clusters as sites for transplantation,tissue regeneration, organogenesis and function for multiple tissues
US20190099198A1 (en) * 2017-10-02 2019-04-04 URO-1, Inc. Anti-microbial medical injection assemblies for onabotulinumtoxina delivery and methods of use thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610288B1 (en) 1995-05-26 2003-08-26 Diacrin, Inc. Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function
US6154560A (en) 1996-08-30 2000-11-28 The Cleveland Clinic Foundation System and method for staging regional lymph nodes using quantitative analysis of endoscopic ultrasound images
JP2000107299A (ja) * 1998-10-06 2000-04-18 Machida Endscope Co Ltd 内視鏡用注射針装置
SG155053A1 (en) 2002-07-19 2009-09-30 Vesta Therapeutics Inc Method of obtaining viable human liver cells, including hepatic stem/progenitor cells
US7653427B2 (en) 2004-11-12 2010-01-26 Intra-Medical Imaging LLC Method and instrument for minimally invasive sentinel lymph node location and biopsy
US7824376B2 (en) * 2004-12-24 2010-11-02 Olympus Corporation Injection needle apparatus for making injection in tissue in body cavity
US7804990B2 (en) 2006-01-25 2010-09-28 Siemens Medical Solutions Usa, Inc. System and method for labeling and identifying lymph nodes in medical images
US11191785B2 (en) * 2008-03-07 2021-12-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Lymph node as a site for transplantation, organogenesis and function for multiple tissues and organs
WO2009111778A2 (en) 2008-03-07 2009-09-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Lymph nodes as a site for regeneration
US20120045764A1 (en) 2009-05-01 2012-02-23 Markus Grompe Method of expanding human hepatocytes in vivo
WO2013069143A1 (ja) * 2011-11-10 2013-05-16 株式会社高研 超音波気管支内視鏡用トレーニングモデル
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
EP4299721A3 (en) 2013-05-08 2024-04-24 ProKidney Organoids comprising isolated renal cells and uses thereof
JP6383938B2 (ja) 2014-02-04 2018-09-05 国立大学法人名古屋大学 高濃度脂肪組織由来間葉系幹細胞含有脂肪による声門閉鎖不全の治療
SG10202009095VA (en) * 2014-11-26 2020-10-29 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
JP6594133B2 (ja) * 2015-09-16 2019-10-23 富士フイルム株式会社 内視鏡位置特定装置、内視鏡位置特定装置の作動方法および内視鏡位置特定プログラム
WO2018134729A1 (en) 2017-01-18 2018-07-26 Technion Research & Development Foundation Ltd. Sparsity-based ultrasound super-resolution imaging
EP4349263B1 (en) 2017-05-31 2026-03-04 Mayo Foundation for Medical Education and Research Methods for super-resolution ultrasound imaging of microvessels
EP3634514A4 (en) 2017-06-09 2021-03-10 President and Fellows of Harvard College METHODS FOR IMPROVING THE DEVELOPMENT OF RENAL ORGANOIDS AND METHODS OF USING THEREOF
WO2019006127A1 (en) 2017-06-28 2019-01-03 Rutgers, The State University Of New Jersey ORGANOIDS DERIVED FROM A SINGLE RENAL CELL

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202761247U (zh) * 2012-07-25 2013-03-06 西安交通大学医学院第一附属医院 一种医用内窥镜注射器
US20160002595A1 (en) * 2013-02-18 2016-01-07 University Health Network Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells
WO2014138486A1 (en) * 2013-03-06 2014-09-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Lymph node as a site for transplantation, organogenesis and function for multiple tissues and organs
WO2018152488A1 (en) * 2017-02-17 2018-08-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fat-associated lymphoid clusters as sites for transplantation,tissue regeneration, organogenesis and function for multiple tissues
US20190099198A1 (en) * 2017-10-02 2019-04-04 URO-1, Inc. Anti-microbial medical injection assemblies for onabotulinumtoxina delivery and methods of use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOPPO T 等: "Rescue of lethal hepatic failure by hepatized lymph nodes in mice", 《GASTROENTEROLOGY》, vol. 140, no. 2, 28 February 2011 (2011-02-28), pages 656 - 666 *
KOMORI J 等: "The mouse lymph node as an ectopic transplantation site for multiple tissues", 《NAT BIOTECHNOL》, vol. 30, no. 10, 31 October 2012 (2012-10-31), pages 976 - 983, XP055791194, DOI: 10.1038/nbt.2379 *

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