JPWO2020207414A5 - - Google Patents
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- Publication number
- JPWO2020207414A5 JPWO2020207414A5 JP2021555343A JP2021555343A JPWO2020207414A5 JP WO2020207414 A5 JPWO2020207414 A5 JP WO2020207414A5 JP 2021555343 A JP2021555343 A JP 2021555343A JP 2021555343 A JP2021555343 A JP 2021555343A JP WO2020207414 A5 JPWO2020207414 A5 JP WO2020207414A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable form
- derivative
- isotopic derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 49
- 230000000155 isotopic effect Effects 0.000 claims 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 229910052698 phosphorus Inorganic materials 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000003053 piperidines Chemical class 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2019/081742 WO2020206588A1 (en) | 2019-04-08 | 2019-04-08 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| CNPCT/CN2019/081742 | 2019-04-08 | ||
| PCT/CN2020/083779 WO2020207414A1 (en) | 2019-04-08 | 2020-04-08 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022529309A JP2022529309A (ja) | 2022-06-21 |
| JP2022529309A5 JP2022529309A5 (https=) | 2023-04-12 |
| JPWO2020207414A5 true JPWO2020207414A5 (https=) | 2023-04-12 |
Family
ID=72751495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021555343A Pending JP2022529309A (ja) | 2019-04-08 | 2020-04-08 | ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20220259182A1 (https=) |
| EP (1) | EP3953347A4 (https=) |
| JP (1) | JP2022529309A (https=) |
| KR (1) | KR20210151105A (https=) |
| CN (2) | CN118702683A (https=) |
| CA (1) | CA3134902A1 (https=) |
| IL (1) | IL287014A (https=) |
| TW (1) | TWI839504B (https=) |
| WO (2) | WO2020206588A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020118683A1 (en) * | 2018-12-14 | 2020-06-18 | Lynk Pharmaceuticals Co. Ltd. | Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| WO2020206588A1 (en) * | 2019-04-08 | 2020-10-15 | Lynk Pharmaceuticals Co., Ltd. | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| AU2021352535B2 (en) * | 2020-09-30 | 2026-02-12 | Beone Medicines I Gmbh | 3-[(1h-pyrazol-4-yl)oxy]pyrazin-2-amine compounds as hpk1 inhibitor and use thereof |
| CN116751191B (zh) * | 2023-05-19 | 2025-09-16 | 凌科药业(杭州)有限公司 | 一种吡唑基-氨基-嘧啶基衍生物的晶型、制备方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1373257B9 (en) * | 2001-03-29 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| GB201012105D0 (en) * | 2010-07-19 | 2010-09-01 | Domainex Ltd | Novel pyrimidine compounds |
| JP2012080515A (ja) * | 2010-09-09 | 2012-04-19 | Sony Corp | 立体撮像装置 |
| AU2011328237A1 (en) * | 2010-11-09 | 2013-05-23 | Cellzome Limited | Pyridine compounds and aza analogues thereof as TYK2 inhibitors |
| WO2012142329A1 (en) * | 2011-04-12 | 2012-10-18 | Myrexis, Inc. | Compositions and therapeutic uses of ikk-related kinase epsilon and tankbinding kinase 1 inhibitors |
| DE102011112978A1 (de) * | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | Benzonitrilderivate |
| GB201303109D0 (en) * | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
| WO2015100609A1 (en) * | 2013-12-31 | 2015-07-09 | Beaufour Ipsen Tianjin Pharmaceutical Co., Ltd | New substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase |
| NO2721710T3 (https=) * | 2014-08-21 | 2018-03-31 | ||
| NZ729618A (en) * | 2014-09-26 | 2018-07-27 | Gilead Sciences Inc | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
| KR101846475B1 (ko) * | 2015-04-27 | 2018-04-09 | 주식회사 녹십자 | TNIK, IKKε 및 TBK1 억제제로서의 화합물 및 이를 포함하는 약학적 조성물 |
| WO2020206588A1 (en) * | 2019-04-08 | 2020-10-15 | Lynk Pharmaceuticals Co., Ltd. | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
-
2019
- 2019-04-08 WO PCT/CN2019/081742 patent/WO2020206588A1/en not_active Ceased
-
2020
- 2020-04-08 CN CN202410574853.XA patent/CN118702683A/zh active Pending
- 2020-04-08 WO PCT/CN2020/083779 patent/WO2020207414A1/en not_active Ceased
- 2020-04-08 CN CN202080026011.0A patent/CN113993861B/zh active Active
- 2020-04-08 JP JP2021555343A patent/JP2022529309A/ja active Pending
- 2020-04-08 KR KR1020217033750A patent/KR20210151105A/ko active Pending
- 2020-04-08 EP EP20787550.1A patent/EP3953347A4/en not_active Withdrawn
- 2020-04-08 US US17/437,989 patent/US20220259182A1/en not_active Abandoned
- 2020-04-08 TW TW109111716A patent/TWI839504B/zh not_active IP Right Cessation
- 2020-04-08 CA CA3134902A patent/CA3134902A1/en active Pending
-
2021
- 2021-10-05 IL IL287014A patent/IL287014A/en unknown
-
2023
- 2023-10-06 US US18/377,741 patent/US12024503B2/en active Active
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