CN118702683A - 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法 - Google Patents

吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法 Download PDF

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Publication number
CN118702683A
CN118702683A CN202410574853.XA CN202410574853A CN118702683A CN 118702683 A CN118702683 A CN 118702683A CN 202410574853 A CN202410574853 A CN 202410574853A CN 118702683 A CN118702683 A CN 118702683A
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mmol
compound
mixture
amino
yield
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Chinese (zh)
Inventor
李晓东
迈克尔·劳伦斯·巴斯克斯
万昭奎
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Lingke Pharmaceutical Hangzhou Co ltd
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Lingke Pharmaceutical Hangzhou Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
CN202410574853.XA 2019-04-08 2020-04-08 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法 Pending CN118702683A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/CN2019/081742 WO2020206588A1 (en) 2019-04-08 2019-04-08 Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
CNPCT/CN2019/081742 2019-04-08
CN202080026011.0A CN113993861B (zh) 2019-04-08 2020-04-08 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法
PCT/CN2020/083779 WO2020207414A1 (en) 2019-04-08 2020-04-08 Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof

Related Parent Applications (1)

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CN202080026011.0A Division CN113993861B (zh) 2019-04-08 2020-04-08 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法

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CN118702683A true CN118702683A (zh) 2024-09-27

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CN202410574853.XA Pending CN118702683A (zh) 2019-04-08 2020-04-08 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法
CN202080026011.0A Active CN113993861B (zh) 2019-04-08 2020-04-08 吡唑基-氨基-嘧啶基衍生物的苯醚和苯胺及其组合物和方法

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US (2) US20220259182A1 (https=)
EP (1) EP3953347A4 (https=)
JP (1) JP2022529309A (https=)
KR (1) KR20210151105A (https=)
CN (2) CN118702683A (https=)
CA (1) CA3134902A1 (https=)
IL (1) IL287014A (https=)
TW (1) TWI839504B (https=)
WO (2) WO2020206588A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020118683A1 (en) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
WO2020206588A1 (en) * 2019-04-08 2020-10-15 Lynk Pharmaceuticals Co., Ltd. Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
AU2021352535B2 (en) * 2020-09-30 2026-02-12 Beone Medicines I Gmbh 3-[(1h-pyrazol-4-yl)oxy]pyrazin-2-amine compounds as hpk1 inhibitor and use thereof
CN116751191B (zh) * 2023-05-19 2025-09-16 凌科药业(杭州)有限公司 一种吡唑基-氨基-嘧啶基衍生物的晶型、制备方法及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1373257B9 (en) * 2001-03-29 2008-10-15 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
GB201012105D0 (en) * 2010-07-19 2010-09-01 Domainex Ltd Novel pyrimidine compounds
JP2012080515A (ja) * 2010-09-09 2012-04-19 Sony Corp 立体撮像装置
AU2011328237A1 (en) * 2010-11-09 2013-05-23 Cellzome Limited Pyridine compounds and aza analogues thereof as TYK2 inhibitors
WO2012142329A1 (en) * 2011-04-12 2012-10-18 Myrexis, Inc. Compositions and therapeutic uses of ikk-related kinase epsilon and tankbinding kinase 1 inhibitors
DE102011112978A1 (de) * 2011-09-09 2013-03-14 Merck Patent Gmbh Benzonitrilderivate
GB201303109D0 (en) * 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
WO2015100609A1 (en) * 2013-12-31 2015-07-09 Beaufour Ipsen Tianjin Pharmaceutical Co., Ltd New substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase
NO2721710T3 (https=) * 2014-08-21 2018-03-31
NZ729618A (en) * 2014-09-26 2018-07-27 Gilead Sciences Inc Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
KR101846475B1 (ko) * 2015-04-27 2018-04-09 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 화합물 및 이를 포함하는 약학적 조성물
WO2020206588A1 (en) * 2019-04-08 2020-10-15 Lynk Pharmaceuticals Co., Ltd. Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof

Also Published As

Publication number Publication date
CA3134902A1 (en) 2020-10-15
TW202104208A (zh) 2021-02-01
KR20210151105A (ko) 2021-12-13
IL287014A (en) 2021-12-01
WO2020206588A1 (en) 2020-10-15
CN113993861A (zh) 2022-01-28
JP2022529309A (ja) 2022-06-21
US20240083882A1 (en) 2024-03-14
CN113993861B (zh) 2024-05-14
US20220259182A1 (en) 2022-08-18
WO2020207414A1 (en) 2020-10-15
EP3953347A4 (en) 2023-01-18
TWI839504B (zh) 2024-04-21
EP3953347A1 (en) 2022-02-16
US12024503B2 (en) 2024-07-02

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Country or region after: China

Address after: 310018 No. 291 Fucheng Road, Xiaoshan Street, Qiantang District, Hangzhou City, Zhejiang Province Room 5-402

Applicant after: Lingke Pharmaceutical (Zhejiang) Co., Ltd.

Address before: 310018 Zhejiang Province, Hangzhou City, Hangzhou Economic and Technological Development Zone, No. 291 Fucheng Road, 5th floor, 4th floor

Applicant before: Lingke Pharmaceutical (Hangzhou) Co., Ltd.

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