JP2022529309A - ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法 - Google Patents

ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法 Download PDF

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JP2022529309A
JP2022529309A JP2021555343A JP2021555343A JP2022529309A JP 2022529309 A JP2022529309 A JP 2022529309A JP 2021555343 A JP2021555343 A JP 2021555343A JP 2021555343 A JP2021555343 A JP 2021555343A JP 2022529309 A JP2022529309 A JP 2022529309A
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pharmaceutically acceptable
compound
acceptable form
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isotope derivative
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JP2022529309A5 (https=
JPWO2020207414A5 (https=
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リー，シアオドン
ローレンス バスケス，マイケル
ワン，ジャオクイ
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リンク ファーマシューティカルズ シーオー．エルティーディー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P37/02—Immunomodulators
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
JP2021555343A 2019-04-08 2020-04-08 ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法 Pending JP2022529309A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2019/081742 WO2020206588A1 (en) 2019-04-08 2019-04-08 Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
CNPCT/CN2019/081742 2019-04-08
PCT/CN2020/083779 WO2020207414A1 (en) 2019-04-08 2020-04-08 Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof

Publications (3)

Publication Number Publication Date
JP2022529309A true JP2022529309A (ja) 2022-06-21
JP2022529309A5 JP2022529309A5 (https=) 2023-04-12
JPWO2020207414A5 JPWO2020207414A5 (https=) 2023-04-12

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JP2021555343A Pending JP2022529309A (ja) 2019-04-08 2020-04-08 ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法

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US (2) US20220259182A1 (https=)
EP (1) EP3953347A4 (https=)
JP (1) JP2022529309A (https=)
KR (1) KR20210151105A (https=)
CN (2) CN118702683A (https=)
CA (1) CA3134902A1 (https=)
IL (1) IL287014A (https=)
TW (1) TWI839504B (https=)
WO (2) WO2020206588A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023543212A (ja) * 2020-09-30 2023-10-13 ベイジーン リミテッド Ｈｐｋ１阻害剤としての３－［（１ｈ－ピラゾール－４－イル）オキシ］ピラジン－２－アミン化合物及びその使用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020118683A1 (en) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
WO2020206588A1 (en) * 2019-04-08 2020-10-15 Lynk Pharmaceuticals Co., Ltd. Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
CN116751191B (zh) * 2023-05-19 2025-09-16 凌科药业(杭州)有限公司 一种吡唑基-氨基-嘧啶基衍生物的晶型、制备方法及应用

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JP2004529140A (ja) * 2001-03-29 2004-09-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｃ−ｊｕｎｎ末端キナーゼ（ｊｎｋ）および他のタンパク質キナーゼのインヒビター
JP2013531055A (ja) * 2010-07-19 2013-08-01 ドメイネクス リミテッド プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物
JP2014500254A (ja) * 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
JP2014510794A (ja) * 2011-04-12 2014-05-01 アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド ＩＫＫ関連キナーゼεおよびＴＡＮＫ結合キナーゼ１の阻害剤の組成物および治療的使用
JP2014526447A (ja) * 2011-09-09 2014-10-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング キナーゼインヒビターとしてのベンゾニトリル誘導体
JP2016513120A (ja) * 2013-02-21 2016-05-12 ドメイネクス リミテッド 新規ピリミジン化合物
JP2017524022A (ja) * 2014-08-21 2017-08-24 ファイザー・インク Ｊａｋ阻害剤としてのアミノピリミジニル化合物
JP2017529373A (ja) * 2014-09-26 2017-10-05 ギリアード サイエンシーズ， インコーポレイテッド Ｔａｎｋ結合キナーゼ阻害剤化合物として有用なアミノトリアジン誘導体

Family Cites Families (4)

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JP2012080515A (ja) * 2010-09-09 2012-04-19 Sony Corp 立体撮像装置
WO2015100609A1 (en) * 2013-12-31 2015-07-09 Beaufour Ipsen Tianjin Pharmaceutical Co., Ltd New substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase
KR101846475B1 (ko) * 2015-04-27 2018-04-09 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 화합물 및 이를 포함하는 약학적 조성물
WO2020206588A1 (en) * 2019-04-08 2020-10-15 Lynk Pharmaceuticals Co., Ltd. Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004529140A (ja) * 2001-03-29 2004-09-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｃ−ｊｕｎｎ末端キナーゼ（ｊｎｋ）および他のタンパク質キナーゼのインヒビター
JP2013531055A (ja) * 2010-07-19 2013-08-01 ドメイネクス リミテッド プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物
JP2014500254A (ja) * 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
JP2014510794A (ja) * 2011-04-12 2014-05-01 アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド ＩＫＫ関連キナーゼεおよびＴＡＮＫ結合キナーゼ１の阻害剤の組成物および治療的使用
JP2014526447A (ja) * 2011-09-09 2014-10-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング キナーゼインヒビターとしてのベンゾニトリル誘導体
JP2016513120A (ja) * 2013-02-21 2016-05-12 ドメイネクス リミテッド 新規ピリミジン化合物
JP2017524022A (ja) * 2014-08-21 2017-08-24 ファイザー・インク Ｊａｋ阻害剤としてのアミノピリミジニル化合物
JP2017529373A (ja) * 2014-09-26 2017-10-05 ギリアード サイエンシーズ， インコーポレイテッド Ｔａｎｋ結合キナーゼ阻害剤化合物として有用なアミノトリアジン誘導体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023543212A (ja) * 2020-09-30 2023-10-13 ベイジーン リミテッド Ｈｐｋ１阻害剤としての３－［（１ｈ－ピラゾール－４－イル）オキシ］ピラジン－２－アミン化合物及びその使用
JP7840580B2 (ja) 2020-09-30 2026-04-06 ビーワン メディシンズ ワン ゲーエムベーハー Ｈｐｋ１阻害剤としての３－［（１ｈ－ピラゾール－４－イル）オキシ］ピラジン－２－アミン化合物及びその使用

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CN118702683A (zh) 2024-09-27
CA3134902A1 (en) 2020-10-15
TW202104208A (zh) 2021-02-01
KR20210151105A (ko) 2021-12-13
IL287014A (en) 2021-12-01
WO2020206588A1 (en) 2020-10-15
CN113993861A (zh) 2022-01-28
US20240083882A1 (en) 2024-03-14
CN113993861B (zh) 2024-05-14
US20220259182A1 (en) 2022-08-18
WO2020207414A1 (en) 2020-10-15
EP3953347A4 (en) 2023-01-18
TWI839504B (zh) 2024-04-21
EP3953347A1 (en) 2022-02-16
US12024503B2 (en) 2024-07-02

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