JPWO2020201773A5 - - Google Patents
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- Publication number
- JPWO2020201773A5 JPWO2020201773A5 JP2021560410A JP2021560410A JPWO2020201773A5 JP WO2020201773 A5 JPWO2020201773 A5 JP WO2020201773A5 JP 2021560410 A JP2021560410 A JP 2021560410A JP 2021560410 A JP2021560410 A JP 2021560410A JP WO2020201773 A5 JPWO2020201773 A5 JP WO2020201773A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyridin
- imidazo
- carboxamide
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1904848.7 | 2019-04-05 | ||
| GBGB1904848.7A GB201904848D0 (en) | 2019-04-05 | 2019-04-05 | Inhibitory compounds |
| GBGB1912603.6A GB201912603D0 (en) | 2019-09-02 | 2019-09-02 | Inhibitory compounds |
| GB1912603.6 | 2019-09-02 | ||
| GB1919095.8 | 2019-12-20 | ||
| GBGB1919095.8A GB201919095D0 (en) | 2019-12-20 | 2019-12-20 | Inhibitory compounds |
| PCT/GB2020/050898 WO2020201773A1 (en) | 2019-04-05 | 2020-04-03 | Mettl3 inhibitory compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022528562A JP2022528562A (ja) | 2022-06-14 |
| JPWO2020201773A5 true JPWO2020201773A5 (https=) | 2023-04-10 |
| JP2022528562A5 JP2022528562A5 (https=) | 2023-04-10 |
| JP7762957B2 JP7762957B2 (ja) | 2025-10-31 |
Family
ID=70285722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560410A Active JP7762957B2 (ja) | 2019-04-05 | 2020-04-03 | Ｍｅｔｔｌ３阻害化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US12358915B2 (https=) |
| EP (1) | EP3946618A1 (https=) |
| JP (1) | JP7762957B2 (https=) |
| CN (1) | CN113905787A (https=) |
| WO (1) | WO2020201773A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| JP7640458B2 (ja) | 2018-10-05 | 2025-03-05 | アンナプルナ バイオ インコーポレイテッド | Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物 |
| AU2020321955A1 (en) | 2019-07-30 | 2022-03-17 | Eikonizo Therapapeutics, Inc. | HDAC6 inhibitors and uses thereof |
| IL293340A (en) | 2019-12-02 | 2022-07-01 | Storm Therapeutics Ltd | Polyheterocyclic compounds as mettl3 inhibitors |
| US20230391770A1 (en) * | 2020-10-06 | 2023-12-07 | Storm Therapeutics Limited | Mettl3 inhibitory compounds |
| US11944608B2 (en) * | 2020-10-26 | 2024-04-02 | New York University | Targeting RNA viruses using inhibitors of METTL3 |
| WO2022243333A1 (en) * | 2021-05-17 | 2022-11-24 | Universität Zürich | N6-adenosine-methyltransferase inhibitors in cancer treatment |
| GB202107907D0 (en) * | 2021-06-02 | 2021-07-14 | Storm Therapeutics Ltd | Combination therapies |
| GB202107905D0 (en) * | 2021-06-02 | 2021-07-14 | Storm Therapeutics Ltd | Processes for the preparation of inhibitory compounds |
| CN116514805A (zh) * | 2021-12-10 | 2023-08-01 | 成都先导药物开发股份有限公司 | Mettl3抑制剂化合物 |
| US20250145627A1 (en) * | 2022-02-11 | 2025-05-08 | Xizang Haisco Pharmaceutical Co., Ltd. | METTL3 Inhibitor and Composition, and Application of Same in Medicine |
| IL316201A (en) | 2022-04-08 | 2024-12-01 | Eikonizo Therapeutics Inc | Oxadiazole HDAC6 inhibitors and their uses |
| CN114869891A (zh) * | 2022-04-28 | 2022-08-09 | 复旦大学附属中山医院 | Mettl3抑制剂在制备治疗肝癌药物中的应用 |
| CN117045801A (zh) * | 2022-05-13 | 2023-11-14 | 中国科学院广州生物医药与健康研究院 | m6A RNA甲基化酶抑制剂与免疫检查点抑制剂联合治疗肿瘤 |
| JP2025530847A (ja) * | 2022-09-16 | 2025-09-17 | 北京華益健康薬物研究中心 | Ｍｅｔｔｌ３阻害剤化合物、その医薬組成物及び用途 |
| WO2024107763A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | N6-adenosine-methyltransferase protacs and methods of use thereof |
| GB202218672D0 (en) | 2022-12-12 | 2023-01-25 | Storm Therapeutics Ltd | Inhibitory compounds |
| WO2024153775A1 (en) | 2023-01-20 | 2024-07-25 | Epics Therapeutics | Piperidine derivatives as mettl3 inhibitors |
| WO2024200835A1 (en) | 2023-03-30 | 2024-10-03 | Novalix | Novel mettl3 inhibitors and use thereof in therapy |
| GB202316683D0 (en) * | 2023-10-31 | 2023-12-13 | Storm Therapeutics Ltd | Inhibitory compounds |
| WO2025237957A1 (en) | 2024-05-14 | 2025-11-20 | Institut Curie | Composition for treatment of estrogen-dependent cancer comprising a mettl-3 inhibitor and a topoisomerase-1 inhibitor |
| CN121735955A (zh) * | 2024-09-25 | 2026-03-27 | 中国科学院上海药物研究所 | 稠合双环类化合物及其制备方法、组合物和应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3946031A (en) * | 1973-10-04 | 1976-03-23 | Syntex Inc. | 2-Substituted-1,2,4-thiadiazolo-[2,3-a]-benzimidazoles |
| US3880874A (en) * | 1973-10-04 | 1975-04-29 | Syntex Inc | 2-Substituted -1,2,4-thiadiazolo-(2,3-a)benzimidazoles and process for their preparation |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| SK288365B6 (sk) | 1999-02-10 | 2016-07-01 | Astrazeneca Ab | Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy |
| NZ516610A (en) | 1999-08-04 | 2004-05-28 | Icagen Inc | Benzanilides as potassium channel openers |
| DE19936780A1 (de) | 1999-08-09 | 2001-02-15 | Basf Ag | Neue Antagonisten von Integrinrezeptoren |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
| CN1255392C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管生成抑制剂的秋水仙醇衍生物 |
| AU2002232439A1 (en) | 2000-11-29 | 2002-06-11 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
| EA200400595A1 (ru) | 2001-11-09 | 2004-10-28 | Бёрингер Ингельхайм Фармасьютиклз, Инк. | Бензимидазолы, применяемые в качестве ингибиторов протеинкиназы |
| PE20070978A1 (es) | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
| US20100029619A1 (en) * | 2006-08-04 | 2010-02-04 | Takeda Pharmaceutical Company Limted | Fused heterocyclic compound |
| CL2008001626A1 (es) | 2007-06-05 | 2009-06-05 | Takeda Pharmaceuticals Co | Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer. |
| FR2925901B1 (fr) | 2008-01-02 | 2011-03-04 | Sanofi Aventis | DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| SG184073A1 (en) | 2010-03-18 | 2012-10-30 | Pasteur Institut Korea | Anti-infective compounds |
| US20200129596A1 (en) | 2017-03-13 | 2020-04-30 | City Of Hope | m6A mRNA MODIFICATION IN CANCER TREATMENT |
| IL293340A (en) * | 2019-12-02 | 2022-07-01 | Storm Therapeutics Ltd | Polyheterocyclic compounds as mettl3 inhibitors |
-
2020
- 2020-04-03 CN CN202080040641.3A patent/CN113905787A/zh active Pending
- 2020-04-03 US US17/601,292 patent/US12358915B2/en active Active
- 2020-04-03 JP JP2021560410A patent/JP7762957B2/ja active Active
- 2020-04-03 WO PCT/GB2020/050898 patent/WO2020201773A1/en not_active Ceased
- 2020-04-03 EP EP20718757.6A patent/EP3946618A1/en active Pending
-
2025
- 2025-06-04 US US19/228,039 patent/US20250388577A1/en active Pending
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