JPWO2020184691A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020184691A5 JPWO2020184691A5 JP2021505150A JP2021505150A JPWO2020184691A5 JP WO2020184691 A5 JPWO2020184691 A5 JP WO2020184691A5 JP 2021505150 A JP2021505150 A JP 2021505150A JP 2021505150 A JP2021505150 A JP 2021505150A JP WO2020184691 A5 JPWO2020184691 A5 JP WO2020184691A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- smtp
- formula
- agent according
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 208000002249 Diabetes Complications Diseases 0.000 claims 5
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 5
- 206010012655 Diabetic complications Diseases 0.000 claims 5
- 208000033679 diabetic kidney disease Diseases 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 108060006698 EGF receptor Proteins 0.000 claims 3
- VXBACGOTEDOFMV-WCNSUVJQSA-N (2r)-2-[(2s,3s)-2-[(3e)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3h-pyrano[2,3-e]isoindol-8-yl]-2-(4-hydroxyphenyl)acetic acid Chemical compound C1([C@H](C(O)=O)N2CC3=C4O[C@@]([C@H](CC4=C(O)C=C3C2=O)O)(C)CC/C=C(C)/CCC=C(C)C)=CC=C(O)C=C1 VXBACGOTEDOFMV-WCNSUVJQSA-N 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- -1 amino compound Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 230000002485 urinary effect Effects 0.000 claims 2
- OKAJGJWZTRMUCU-PIQVELQNSA-N (2r)-2-[(2s,3s)-2-[(3e)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3h-pyrano[2,3-e]isoindol-8-yl]-2-phenylacetic acid Chemical compound C1([C@H](C(O)=O)N2CC3=C4O[C@@]([C@H](CC4=C(O)C=C3C2=O)O)(C)CC/C=C(C)/CCC=C(C)C)=CC=CC=C1 OKAJGJWZTRMUCU-PIQVELQNSA-N 0.000 claims 1
- CRNDCHORWGDFGR-PXTWCNKMSA-N (2s)-2,5-bis[(2s,3s)-2-[(3e)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3h-pyrano[2,3-e]isoindol-8-yl]pentanoic acid Chemical compound C1[C@H](O)[C@](C)(CC\C=C(/C)CCC=C(C)C)OC2=C1C(O)=CC(C1=O)=C2CN1[C@H](C(O)=O)CCCN1CC2=C3O[C@](CC/C=C(C)/CCC=C(C)C)(C)[C@@H](O)CC3=C(O)C=C2C1=O CRNDCHORWGDFGR-PXTWCNKMSA-N 0.000 claims 1
- VXBACGOTEDOFMV-UWIOTWEISA-N (2s)-2-[(2s,3s)-2-[(3e)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3h-pyrano[2,3-e]isoindol-8-yl]-2-(4-hydroxyphenyl)acetic acid Chemical compound C1([C@@H](C(O)=O)N2CC3=C4O[C@@]([C@H](CC4=C(O)C=C3C2=O)O)(C)CC/C=C(C)/CCC=C(C)C)=CC=C(O)C=C1 VXBACGOTEDOFMV-UWIOTWEISA-N 0.000 claims 1
- OKAJGJWZTRMUCU-ZDLNXABXSA-N (2s)-2-[(2s,3s)-2-[(3e)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3h-pyrano[2,3-e]isoindol-8-yl]-2-phenylacetic acid Chemical compound C1([C@@H](C(O)=O)N2CC3=C4O[C@@]([C@H](CC4=C(O)C=C3C2=O)O)(C)CC/C=C(C)/CCC=C(C)C)=CC=CC=C1 OKAJGJWZTRMUCU-ZDLNXABXSA-N 0.000 claims 1
- SJMBRLPDWBJVRZ-UHFFFAOYSA-N 2,6-bis[2-(4,8-dimethylnona-3,7-dienyl)-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyrano[2,3-e]isoindol-8-yl]hexanoic acid Chemical compound C1C(O)C(C)(CCC=C(C)CCC=C(C)C)OC2=C1C(O)=CC(C1=O)=C2CN1C(C(O)=O)CCCCN1CC2=C3OC(CCC=C(C)CCC=C(C)C)(C)C(O)CC3=C(O)C=C2C1=O SJMBRLPDWBJVRZ-UHFFFAOYSA-N 0.000 claims 1
- XHODRTXQJFAAJR-RQZCQDPDSA-N 2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-8-(2-hydroxyethyl)-2-methyl-4,9-dihydro-3H-pyrano[2,3-e]isoindol-7-one Chemical compound OC1=C2CC(O)C(CC/C=C(C)/CCC=C(C)C)(C)OC2=C2CN(CCO)C(=O)C2=C1 XHODRTXQJFAAJR-RQZCQDPDSA-N 0.000 claims 1
- XGUHYRYUXUVLOK-REWPJTCUSA-N SMTP-0 Natural products CC(C)=CCCC(C)=CCC[C@]1(C)Oc2c3CNC(=O)c3cc(O)c2C[C@@H]1O XGUHYRYUXUVLOK-REWPJTCUSA-N 0.000 claims 1
- CRNDCHORWGDFGR-CLUVFYJOSA-N SMTP-7 Natural products CC(=CCCC(=CCC[C@]1(C)Oc2c(C[C@H]1O)c(O)cc3C(=O)N(CCC[C@@H](N4Cc5c6O[C@@](C)(CCC=C(C)CCC=C(C)C)[C@H](O)Cc6c(O)cc5C4=O)C(=O)O)Cc23)C)C CRNDCHORWGDFGR-CLUVFYJOSA-N 0.000 claims 1
- SJMBRLPDWBJVRZ-JEMJXRSUSA-N SMTP-8 Natural products CC(=CCCC(=CCC[C@@]1(C)Oc2c(C[C@H]1O)c(O)cc3C(=O)N(CCCC[C@@H](N4Cc5c6O[C@@](C)(CCC=C(C)CCC=C(C)C)[C@H](O)Cc6c(O)cc5C4=O)C(=O)O)Cc23)C)C SJMBRLPDWBJVRZ-JEMJXRSUSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000005518 mononeuropathy Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- CRNDCHORWGDFGR-UHFFFAOYSA-N orniplabin Natural products C1C(O)C(C)(CCC=C(C)CCC=C(C)C)OC2=C1C(O)=CC(C1=O)=C2CN1C(C(O)=O)CCCN1CC2=C3OC(CCC=C(C)CCC=C(C)C)(C)C(O)CC3=C(O)C=C2C1=O CRNDCHORWGDFGR-UHFFFAOYSA-N 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019044670 | 2019-03-12 | ||
| PCT/JP2020/010967 WO2020184691A1 (ja) | 2019-03-12 | 2020-03-12 | 薬剤及び該薬剤を用いて糖尿病合併症を治療又は予防する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2020184691A1 JPWO2020184691A1 (https=) | 2020-09-17 |
| JPWO2020184691A5 true JPWO2020184691A5 (https=) | 2022-01-27 |
Family
ID=72426033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021505150A Withdrawn JPWO2020184691A1 (https=) | 2019-03-12 | 2020-03-12 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220218664A1 (https=) |
| EP (1) | EP3939659A4 (https=) |
| JP (1) | JPWO2020184691A1 (https=) |
| KR (1) | KR20220009371A (https=) |
| CN (1) | CN114126711A (https=) |
| AU (1) | AU2020238177A1 (https=) |
| BR (1) | BR112021018084A8 (https=) |
| CA (1) | CA3133204A1 (https=) |
| CL (1) | CL2021002373A1 (https=) |
| EA (1) | EA202192483A1 (https=) |
| IL (1) | IL286289A (https=) |
| MX (1) | MX2021011007A (https=) |
| PE (1) | PE20220333A1 (https=) |
| SG (1) | SG11202109982YA (https=) |
| WO (1) | WO2020184691A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220040294A (ko) * | 2020-09-23 | 2022-03-30 | 씨엔지바이오 주식회사 | 6-메톡시-2-펜에틸이소인돌린-1-온 유도체 및 이를 포함하는 신경질환의 치료용 조성물 |
| WO2022171151A1 (zh) * | 2021-02-10 | 2022-08-18 | 上海森辉医药有限公司 | 一种smtp-7衍生物及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05176782A (ja) * | 1992-01-08 | 1993-07-20 | Taisho Pharmaceut Co Ltd | Ｎｇｆ作用増強因子 |
| JP4313049B2 (ja) * | 2003-01-23 | 2009-08-12 | 株式会社ティーティーシー | 血管新生関連疾患の予防又は治療用医薬組成物 |
| JP2004224737A (ja) | 2003-01-23 | 2004-08-12 | Ttc:Kk | 新規トリプレニルフェノール化合物 |
| US20090270476A1 (en) | 2005-10-06 | 2009-10-29 | Keiji Hasumi | Pharmaceutical composition for treatment or prevention of nephritis and manufacturing method thereof |
| EP2000540B1 (en) | 2006-03-27 | 2014-05-14 | Tokyo University of Agriculture and Technology Tlo Co., Ltd. | Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer |
| WO2010110026A1 (ja) * | 2009-03-25 | 2010-09-30 | 国立大学法人東京農工大学 | メタボリックシンドローム、肥満、高血糖症、高脂血症および／又は脂肪肝のための医薬組成物 |
| WO2011004620A1 (ja) * | 2009-07-06 | 2011-01-13 | 国立大学法人東京農工大学 | 細胞保護剤 |
| WO2011125930A1 (ja) * | 2010-04-02 | 2011-10-13 | 日本製薬株式会社 | 炎症性腸疾患又は自己免疫性の末梢神経障害の予防又は治療剤 |
| JP5952257B2 (ja) * | 2011-02-24 | 2016-07-13 | 株式会社ティムス | 可溶性エポキシドハイドロラーゼ阻害剤 |
| JP2019044670A (ja) | 2017-08-31 | 2019-03-22 | スズキ株式会社 | 内燃機関の排出ガス浄化システム |
-
2020
- 2020-03-12 SG SG11202109982Y patent/SG11202109982YA/en unknown
- 2020-03-12 AU AU2020238177A patent/AU2020238177A1/en not_active Abandoned
- 2020-03-12 MX MX2021011007A patent/MX2021011007A/es unknown
- 2020-03-12 CN CN202080035808.7A patent/CN114126711A/zh active Pending
- 2020-03-12 PE PE2021001508A patent/PE20220333A1/es unknown
- 2020-03-12 CA CA3133204A patent/CA3133204A1/en active Pending
- 2020-03-12 JP JP2021505150A patent/JPWO2020184691A1/ja not_active Withdrawn
- 2020-03-12 EA EA202192483A patent/EA202192483A1/ru unknown
- 2020-03-12 EP EP20771088.0A patent/EP3939659A4/en not_active Withdrawn
- 2020-03-12 KR KR1020217032312A patent/KR20220009371A/ko not_active Withdrawn
- 2020-03-12 BR BR112021018084A patent/BR112021018084A8/pt not_active Application Discontinuation
- 2020-03-12 US US17/438,801 patent/US20220218664A1/en not_active Abandoned
- 2020-03-12 WO PCT/JP2020/010967 patent/WO2020184691A1/ja not_active Ceased
-
2021
- 2021-09-10 CL CL2021002373A patent/CL2021002373A1/es unknown
- 2021-09-12 IL IL286289A patent/IL286289A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2020184691A5 (https=) | ||
| JP4264137B2 (ja) | 抗血栓性有機硝酸塩 | |
| JP3190340B2 (ja) | 酸化窒素供与体プロドラッグとしての求核試薬−酸化窒素付加物の酸素置換誘導体 | |
| JP2002536329A5 (https=) | ||
| RU2017143609A (ru) | Соединения для применения для лечения нервно-мышечных расстройств | |
| JP2012504608A5 (https=) | ||
| JP2001514167A5 (https=) | ||
| JP2018524339A5 (https=) | ||
| KR950032182A (ko) | 벤즈이미다졸 유도체 | |
| JP2008525416A5 (https=) | ||
| JP2023538524A5 (https=) | ||
| CA2167673A1 (en) | Condensed benzazepine derivative and pharmaceutical composition thereof | |
| JP2009523841A5 (https=) | ||
| JP2005514420A5 (https=) | ||
| JPH05503519A (ja) | キレート化合物 | |
| JP2005532287A5 (https=) | ||
| JP2010517955A5 (https=) | ||
| JP2005532296A5 (https=) | ||
| EP1460077A1 (en) | Novel pyrazolopyrimidones and their use as PDE inhibitors | |
| JP2007510662A5 (https=) | ||
| JP2014514290A5 (https=) | ||
| EP1396266A1 (en) | Aqueous cilostazol preparation for injection | |
| FR2772025A1 (fr) | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique | |
| RU2374228C2 (ru) | Производные 4-фенилпиперидина в качестве ингибиторов ренина | |
| US5654484A (en) | Polyamine derivatives as antineoplastic agents |