JPWO2020163268A5 - - Google Patents
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- Publication number
- JPWO2020163268A5 JPWO2020163268A5 JP2021546360A JP2021546360A JPWO2020163268A5 JP WO2020163268 A5 JPWO2020163268 A5 JP WO2020163268A5 JP 2021546360 A JP2021546360 A JP 2021546360A JP 2021546360 A JP2021546360 A JP 2021546360A JP WO2020163268 A5 JPWO2020163268 A5 JP WO2020163268A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- formula
- motor neuron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 41
- 150000001875 compounds Chemical class 0.000 claims description 29
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 206010001497 Agitation Diseases 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 210000002161 motor neuron Anatomy 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001550 time effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024033668A JP2024063191A (ja) | 2019-02-06 | 2024-03-06 | Ｋｃｎｑ増強剤としての１－（（２－（２，２，２－トリフルオロエトキシ）ピリジン－４－イル）メチル）尿素誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962801716P | 2019-02-06 | 2019-02-06 | |
| US62/801,716 | 2019-02-06 | ||
| US201962811038P | 2019-02-27 | 2019-02-27 | |
| US62/811,038 | 2019-02-27 | ||
| PCT/US2020/016499 WO2020163268A1 (en) | 2019-02-06 | 2020-02-04 | 1-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)urea derivatives as kcnq potentiators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024033668A Division JP2024063191A (ja) | 2019-02-06 | 2024-03-06 | Ｋｃｎｑ増強剤としての１－（（２－（２，２，２－トリフルオロエトキシ）ピリジン－４－イル）メチル）尿素誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022519744A JP2022519744A (ja) | 2022-03-24 |
| JPWO2020163268A5 true JPWO2020163268A5 (enrdf_load_stackoverflow) | 2023-02-13 |
| JP7451543B2 JP7451543B2 (ja) | 2024-03-18 |
Family
ID=69743945
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546360A Active JP7451543B2 (ja) | 2019-02-06 | 2020-02-04 | Ｋｃｎｑ増強剤としての１－（（２－（２，２，２－トリフルオロエトキシ）ピリジン－４－イル）メチル）尿素誘導体 |
| JP2024033668A Withdrawn JP2024063191A (ja) | 2019-02-06 | 2024-03-06 | Ｋｃｎｑ増強剤としての１－（（２－（２，２，２－トリフルオロエトキシ）ピリジン－４－イル）メチル）尿素誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024033668A Withdrawn JP2024063191A (ja) | 2019-02-06 | 2024-03-06 | Ｋｃｎｑ増強剤としての１－（（２－（２，２，２－トリフルオロエトキシ）ピリジン－４－イル）メチル）尿素誘導体 |
Country Status (24)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3921030T (pt) * | 2019-02-06 | 2024-01-12 | Lilly Co Eli | Derivados de 1-((2-(2,2,2-trifluoroetoxi)piridin-4- il)metil)ureia como potenciadores de kcnq |
| CA3183298A1 (en) | 2020-06-25 | 2021-12-30 | Olivier Bezencon | Cyclobutyl-urea derivatives |
| TW202330471A (zh) * | 2021-09-30 | 2023-08-01 | 日商住友製藥股份有限公司 | 環丙醯胺衍生物 |
| JP2024542881A (ja) | 2021-11-19 | 2024-11-18 | アイカジェン・エルエルシー | Ｋｖ７．２阻害剤としての新規ヘテロアリール－尿素化合物 |
| JP2024540583A (ja) | 2021-11-19 | 2024-10-31 | アイカジェン・エルエルシー | Ｋｖ７．２エンハンサーとしてのピリジン化合物 |
| JP2025502712A (ja) | 2021-12-22 | 2025-01-28 | アイカジェン・エルエルシー | シクロプロピル化合物 |
| JP2025506201A (ja) | 2022-02-15 | 2025-03-07 | アイカジェン・エルエルシー | 新規なビシクロペンタン誘導体 |
| IT202200024963A1 (it) | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio Kv7.2/Kv7.3 |
| IT202200024948A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio KV7.2/KV7.3 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1257481A (zh) * | 1997-03-25 | 2000-06-21 | 英国阿斯特拉药品有限公司 | 新的吡啶衍生物及其含有它们的药用组合物 |
| CN100345823C (zh) * | 2003-01-14 | 2007-10-31 | 赛特凯恩蒂克公司 | 化合物、组合物及方法 |
| EP1737852A2 (en) | 2004-04-13 | 2007-01-03 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
| CA2575003C (en) * | 2004-07-29 | 2010-02-16 | Merck & Co., Inc. | Potassium channel inhibitors |
| WO2010036316A1 (en) * | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
| JP5586692B2 (ja) * | 2009-06-08 | 2014-09-10 | ギリアード サイエンシーズ， インコーポレイテッド | アルカノイルアミノベンズアミドアニリンｈｄａｃインヒビター化合物 |
| EP3009427B1 (en) * | 2011-03-03 | 2019-12-18 | Zalicus Pharmaceuticals Ltd. | Benzimidazole inhibitors of the sodium channel |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| CN103709097A (zh) | 2012-09-28 | 2014-04-09 | 中国科学院上海药物研究所 | 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用 |
| PH12015502336B1 (en) * | 2013-03-15 | 2022-07-15 | Deciphera Pharmaceuticals Llc | N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities |
| EP3110794A1 (en) * | 2014-02-27 | 2017-01-04 | Merck Patent GmbH | Heterocyclic compounds as nav channel inhibitors and uses thereof |
| ES2871673T3 (es) | 2014-10-24 | 2021-10-29 | Ono Pharmaceutical Co | Activador de los canales KCNQ2-5 |
| JP6943239B2 (ja) * | 2016-04-22 | 2021-09-29 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル活性化剤 |
| PT3921030T (pt) * | 2019-02-06 | 2024-01-12 | Lilly Co Eli | Derivados de 1-((2-(2,2,2-trifluoroetoxi)piridin-4- il)metil)ureia como potenciadores de kcnq |
-
2020
- 2020-02-04 PT PT207094095T patent/PT3921030T/pt unknown
- 2020-02-04 WO PCT/US2020/016499 patent/WO2020163268A1/en active Application Filing
- 2020-02-04 AU AU2020218180A patent/AU2020218180B2/en active Active
- 2020-02-04 ES ES20709409T patent/ES2968807T3/es active Active
- 2020-02-04 CA CA3128975A patent/CA3128975A1/en active Pending
- 2020-02-04 MX MX2021009396A patent/MX2021009396A/es unknown
- 2020-02-04 IL IL285113A patent/IL285113B1/en unknown
- 2020-02-04 SI SI202030316T patent/SI3921030T1/sl unknown
- 2020-02-04 JP JP2021546360A patent/JP7451543B2/ja active Active
- 2020-02-04 PL PL20709409.5T patent/PL3921030T3/pl unknown
- 2020-02-04 BR BR112021015544-9A patent/BR112021015544A2/pt unknown
- 2020-02-04 SG SG11202108599SA patent/SG11202108599SA/en unknown
- 2020-02-04 DK DK20709409.5T patent/DK3921030T3/da active
- 2020-02-04 RS RS20240009A patent/RS65040B1/sr unknown
- 2020-02-04 SM SM20240003T patent/SMT202400003T1/it unknown
- 2020-02-04 HU HUE20709409A patent/HUE064734T2/hu unknown
- 2020-02-04 US US16/781,148 patent/US11208383B2/en active Active
- 2020-02-04 FI FIEP20709409.5T patent/FI3921030T3/fi active
- 2020-02-04 CN CN202080012797.0A patent/CN113692304B/zh active Active
- 2020-02-04 KR KR1020217028040A patent/KR20210126040A/ko active Pending
- 2020-02-04 LT LTEPPCT/US2020/016499T patent/LT3921030T/lt unknown
- 2020-02-04 EP EP20709409.5A patent/EP3921030B1/en active Active
- 2020-02-04 HR HRP20240012TT patent/HRP20240012T1/hr unknown
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2021
- 2021-08-05 SA SA521422733A patent/SA521422733B1/ar unknown
- 2021-11-19 US US17/531,000 patent/US11840516B2/en active Active
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2023
- 2023-11-09 US US18/388,299 patent/US12344584B2/en active Active
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2024
- 2024-03-06 JP JP2024033668A patent/JP2024063191A/ja not_active Withdrawn