JPWO2020146221A5 - - Google Patents
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- JPWO2020146221A5 JPWO2020146221A5 JP2021538982A JP2021538982A JPWO2020146221A5 JP WO2020146221 A5 JPWO2020146221 A5 JP WO2020146221A5 JP 2021538982 A JP2021538982 A JP 2021538982A JP 2021538982 A JP2021538982 A JP 2021538982A JP WO2020146221 A5 JPWO2020146221 A5 JP WO2020146221A5
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- Prior art keywords
- binding domain
- antigen binding
- polypeptide
- domain binds
- cancer
- Prior art date
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- 239000000427 antigen Substances 0.000 claims 89
- 102000036639 antigens Human genes 0.000 claims 89
- 108091007433 antigens Proteins 0.000 claims 89
- 108090000765 processed proteins & peptides Proteins 0.000 claims 59
- 229920001184 polypeptide Polymers 0.000 claims 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims 57
- 238000006467 substitution reaction Methods 0.000 claims 27
- 108010002350 Interleukin-2 Proteins 0.000 claims 22
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 21
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 21
- 150000001413 amino acids Chemical group 0.000 claims 20
- 210000001744 T-lymphocyte Anatomy 0.000 claims 11
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 10
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 9
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 8
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 101100044298 Drosophila melanogaster fand gene Proteins 0.000 claims 6
- 101150064015 FAS gene Proteins 0.000 claims 6
- 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 claims 6
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 5
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 5
- 102220503468 Superoxide dismutase [Cu-Zn]_D84S_mutation Human genes 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102220638990 Beta-enolase_H16A_mutation Human genes 0.000 claims 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 4
- 101150069255 KLRC1 gene Proteins 0.000 claims 4
- -1 Kabat amino acids Chemical class 0.000 claims 4
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 4
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 210000000822 natural killer cell Anatomy 0.000 claims 4
- 102220096696 rs62625272 Human genes 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 3
- 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 3
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 3
- 102000017578 LAG3 Human genes 0.000 claims 3
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 3
- 230000001093 anti-cancer Effects 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
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- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
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- 239000004471 Glycine Substances 0.000 claims 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims 2
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 2
- 102220498123 Protein LRATD2_E95S_mutation Human genes 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 2
- 229960000074 biopharmaceutical Drugs 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
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- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims 2
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- 239000004308 thiabendazole Substances 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
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- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
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- 102220638986 Beta-enolase_H16S_mutation Human genes 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
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- 102100038078 CD276 antigen Human genes 0.000 claims 1
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 102220603939 Clathrin heavy chain 1_P65N_mutation Human genes 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
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- 108700004922 F42A Proteins 0.000 claims 1
- 102220606752 Gap junction beta-1 protein_H16P_mutation Human genes 0.000 claims 1
- 101150112082 Gpnmb gene Proteins 0.000 claims 1
- 102100035943 HERV-H LTR-associating protein 2 Human genes 0.000 claims 1
- 101150046249 Havcr2 gene Proteins 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
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- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101001021491 Homo sapiens HERV-H LTR-associating protein 2 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 102220604965 Killer cell immunoglobulin-like receptor 3DL1_M23V_mutation Human genes 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 102220608429 Mitogen-activated protein kinase kinase kinase kinase 1_E95V_mutation Human genes 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102220505697 Palmitoyl-protein thioesterase 1_Y45F_mutation Human genes 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 102220503469 Superoxide dismutase [Cu-Zn]_D84A_mutation Human genes 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 102220610852 Thialysine N-epsilon-acetyltransferase_L72G_mutation Human genes 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 claims 1
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
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- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
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- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024185692A JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962789075P | 2019-01-07 | 2019-01-07 | |
| US62/789,075 | 2019-01-07 | ||
| PCT/US2020/012296 WO2020146221A1 (en) | 2019-01-07 | 2020-01-06 | Polypeptides comprising modified il-2 polypeptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024185692A Division JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022516557A JP2022516557A (ja) | 2022-02-28 |
| JPWO2020146221A5 true JPWO2020146221A5 (enrdf_load_stackoverflow) | 2023-01-19 |
| JP7594161B2 JP7594161B2 (ja) | 2024-12-04 |
Family
ID=69374426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021538982A Active JP7594161B2 (ja) | 2019-01-07 | 2020-01-06 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
| JP2024185692A Pending JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024185692A Pending JP2025013911A (ja) | 2019-01-07 | 2024-10-22 | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
Country Status (15)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA3071016A1 (en) | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | Cytokine conjugates for the treatment of autoimmune diseases |
| CA3089853A1 (en) | 2018-02-01 | 2019-08-08 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| MX2022002053A (es) | 2019-08-23 | 2022-03-17 | Synthorx Inc | Conjugados de il-15 y sus usos. |
| BR112022003335A2 (pt) | 2019-09-10 | 2022-05-24 | Synthorx Inc | Conjugados de il-2 e métodos de uso para tratar doenças autoimunes |
| AU2020355031A1 (en) * | 2019-09-24 | 2022-05-19 | The Regents Of The University Of California | Notch receptors with hinge domain |
| JP2023531876A (ja) * | 2020-06-30 | 2023-07-26 | ジーアイ イノベーション， インコーポレイテッド | 抗ｌａｇ－３抗体とｉｌ－２とを含む融合タンパク質及びその使用 |
| JP2023532904A (ja) * | 2020-07-02 | 2023-08-01 | インヒブルクス インコーポレイテッド | 修飾ｉｌ－２ポリペプチドを含むポリペプチド及びその使用 |
| JP2023548045A (ja) | 2020-10-23 | 2023-11-15 | アッシャー バイオセラピューティクス， インコーポレイテッド | 免疫細胞機能をモジュレートするためのｃｄ８抗原結合分子を有する融合物 |
| WO2022099090A1 (en) * | 2020-11-06 | 2022-05-12 | Xencor, Inc. | Heterodimeric antibodies that bind tgfbrii |
| EP4251187A4 (en) | 2020-11-25 | 2025-09-10 | Xilio Dev Inc | TUMOR-SPECIFIC CLASSIBLE LINKERS |
| CN112979782B (zh) * | 2021-03-08 | 2023-07-18 | 深圳市乐土生物医药有限公司 | 一种多肽及其用途 |
| WO2022212614A1 (en) * | 2021-03-31 | 2022-10-06 | Anwita Biosciences, Inc. | Fusion proteins, pharmaceutical compositions, and therapeutic applications |
| WO2023004305A1 (en) * | 2021-07-20 | 2023-01-26 | Inhibrx, Inc. | Cd8-targeted modified il-2 polypeptides and uses thereof |
| CA3225092A1 (en) * | 2021-07-20 | 2023-01-26 | John C. Timmer | Cd8-binding polypeptides and uses thereof |
| WO2023034741A1 (en) * | 2021-08-30 | 2023-03-09 | Inhibrx, Inc. | Nkp46-targeted modified il-2 polypeptides and uses thereof |
| WO2023034740A1 (en) * | 2021-08-30 | 2023-03-09 | Inhibrx, Inc. | Nkp46-binding polypeptides and uses thereof |
| KR20240067081A (ko) * | 2021-09-26 | 2024-05-16 | 우시 바이올로직스 아일랜드 리미티드 | Il-2 변이체 및 이의 융합 단백질 |
| WO2023133393A1 (en) * | 2022-01-05 | 2023-07-13 | Inhibrx, Inc. | Gamma delta t-cell-targeted modified il-2 polypeptides and uses thereof |
| US20240218037A1 (en) * | 2022-07-28 | 2024-07-04 | Proviva Therapeutics (Hong Kong) Limited | Il-2 procytokine antibody fusion proteins |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| WO1999029888A1 (en) | 1997-12-05 | 1999-06-17 | The Scripps Research Institute | Humanization of murine antibody |
| US7186804B2 (en) * | 2001-12-04 | 2007-03-06 | Emd Lexigen Research Center Corp. | IL-2 fusion proteins with modulated selectivity |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| ES2630224T3 (es) | 2003-10-22 | 2017-08-18 | Keck Graduate Institute | Métodos para sintetizar polipéptidos heteromultiméricos en levadura con el uso de una estrategia de apareamiento haploide |
| AU2005227263A1 (en) * | 2004-03-05 | 2005-10-06 | Novartis Vaccines And Diagnostics, Inc. | In vitro test system for predicting patient tolerability of therapeutic agents |
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| ZA200608130B (en) | 2004-03-31 | 2008-12-31 | Genentech Inc | Humanized anti-TGF-beta antibodies |
| CN102101885B (zh) * | 2010-09-01 | 2013-06-05 | 南京发士达生物科技有限公司 | 低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途 |
| SI2673294T1 (sl) * | 2011-02-10 | 2016-08-31 | Roche Glycart Ag | Mutirani polipeptidi interlevkina-2 |
| EP3795215A1 (en) * | 2012-05-30 | 2021-03-24 | Chugai Seiyaku Kabushiki Kaisha | Target tissue-specific antigen-binding molecule |
| LT3102595T (lt) * | 2014-02-06 | 2019-01-25 | F. Hoffmann-La Roche Ag | Interleukino-2 sulieti baltymai ir jų panaudojimas |
| WO2016164937A2 (en) | 2015-04-10 | 2016-10-13 | Amgen Inc. | Interleukin-2 muteins for the expansion of t-regulatory cells |
| CA3008440A1 (en) * | 2016-01-11 | 2017-07-20 | Universitat Zurich | Combination therapy comprising a superagonistic antibody against interleukin-2 and a checkpoint blockade agent |
| JP7148539B2 (ja) * | 2017-04-03 | 2022-10-05 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 免疫抱合体 |
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| JP2020521452A (ja) * | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| JP7433051B2 (ja) * | 2017-06-19 | 2024-02-19 | メディシナ セラピューティクス インコーポレイテッド | Ｉｌ－２スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法 |
-
2020
- 2020-01-06 MX MX2021008147A patent/MX2021008147A/es unknown
- 2020-01-06 JP JP2021538982A patent/JP7594161B2/ja active Active
- 2020-01-06 EP EP20702547.9A patent/EP3908596A1/en active Pending
- 2020-01-06 KR KR1020217024431A patent/KR20210113265A/ko active Pending
- 2020-01-06 US US17/418,458 patent/US20220089667A1/en active Pending
- 2020-01-06 AU AU2020206672A patent/AU2020206672A1/en active Pending
- 2020-01-06 TW TW109100336A patent/TWI874345B/zh active
- 2020-01-06 BR BR112021012294-0A patent/BR112021012294A2/pt unknown
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- 2020-01-06 CN CN202080018011.6A patent/CN113924311A/zh active Pending
- 2020-01-06 WO PCT/US2020/012296 patent/WO2020146221A1/en unknown
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2021
- 2021-07-05 IL IL284633A patent/IL284633A/en unknown
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2024
- 2024-10-22 JP JP2024185692A patent/JP2025013911A/ja active Pending
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