JPWO2020143548A5 - - Google Patents
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- JPWO2020143548A5 JPWO2020143548A5 JP2021539453A JP2021539453A JPWO2020143548A5 JP WO2020143548 A5 JPWO2020143548 A5 JP WO2020143548A5 JP 2021539453 A JP2021539453 A JP 2021539453A JP 2021539453 A JP2021539453 A JP 2021539453A JP WO2020143548 A5 JPWO2020143548 A5 JP WO2020143548A5
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- JP
- Japan
- Prior art keywords
- nrg
- mammal
- lveds
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- composition
- Prior art date
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- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 3
- 230000004217 heart function Effects 0.000 claims description 3
- 230000000747 cardiac effect Effects 0.000 claims description 2
- 108050003475 Neuregulin Proteins 0.000 claims 11
- 102000014413 Neuregulin Human genes 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 7
- 230000003680 myocardial damage Effects 0.000 claims 3
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 2
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 2
- 101000653754 Rattus norvegicus Sphingosine 1-phosphate receptor 5 Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- ZOXZWYWOECCBSH-UHFFFAOYSA-N 4 Methyl N-ethylcathinone Chemical compound CCNC(C)C(=O)C1=CC=C(C)C=C1 ZOXZWYWOECCBSH-UHFFFAOYSA-N 0.000 claims 1
- 102400000057 Neuregulin-2 Human genes 0.000 claims 1
- 101800000675 Neuregulin-2 Proteins 0.000 claims 1
- 102400000054 Neuregulin-3 Human genes 0.000 claims 1
- 101800000673 Neuregulin-3 Proteins 0.000 claims 1
- 102400000055 Neuregulin-4 Human genes 0.000 claims 1
- 101800002641 Neuregulin-4 Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000002592 echocardiography Methods 0.000 description 8
- 241000700159 Rattus Species 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 208000033774 Ventricular Remodeling Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024219524A JP7825894B2 (ja) | 2019-01-07 | 2024-12-16 | ニューレグリンを用いて心筋損傷を予防、治療、又は緩和するための方法及びそのための組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910015257.7 | 2019-01-07 | ||
| CN201910015257 | 2019-01-07 | ||
| CN201911412811.1 | 2019-12-31 | ||
| CN201911412811.1A CN111407881A (zh) | 2019-01-07 | 2019-12-31 | 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物 |
| PCT/CN2020/070299 WO2020143548A1 (zh) | 2019-01-07 | 2020-01-03 | 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024219524A Division JP7825894B2 (ja) | 2019-01-07 | 2024-12-16 | ニューレグリンを用いて心筋損傷を予防、治療、又は緩和するための方法及びそのための組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022516199A JP2022516199A (ja) | 2022-02-24 |
| JPWO2020143548A5 true JPWO2020143548A5 (https=) | 2022-12-19 |
| JP2022516199A5 JP2022516199A5 (https=) | 2022-12-19 |
| JP7630173B2 JP7630173B2 (ja) | 2025-02-17 |
Family
ID=71485079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021539453A Active JP7630173B2 (ja) | 2019-01-07 | 2020-01-03 | ニューレグリンを用いて心筋損傷を予防、治療、又は緩和するための方法及びそのための組成物 |
| JP2024219524A Active JP7825894B2 (ja) | 2019-01-07 | 2024-12-16 | ニューレグリンを用いて心筋損傷を予防、治療、又は緩和するための方法及びそのための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024219524A Active JP7825894B2 (ja) | 2019-01-07 | 2024-12-16 | ニューレグリンを用いて心筋損傷を予防、治療、又は緩和するための方法及びそのための組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220096599A1 (https=) |
| EP (1) | EP3909599A4 (https=) |
| JP (2) | JP7630173B2 (https=) |
| CN (1) | CN111407881A (https=) |
| AU (1) | AU2020206381B2 (https=) |
| CA (1) | CA3125377A1 (https=) |
| WO (1) | WO2020143548A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118236430B (zh) * | 2024-04-07 | 2025-08-26 | 中国人民解放军总医院第六医学中心 | 一种修复肿瘤治疗心肌损伤的药物组合物及其制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716930A (en) | 1991-04-10 | 1998-02-10 | Ludwig Institute For Cancer Research | Glial growth factors |
| US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US5912326A (en) | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
| US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| US20010041869A1 (en) | 2000-03-23 | 2001-11-15 | Causey James D. | Control tabs for infusion devices and methods of using the same |
| US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
| CN1498656A (zh) * | 2002-11-08 | 2004-05-26 | 上海泽生科技开发有限公司 | 神经调节蛋白用于心肌梗死治疗的方法和组合物 |
| WO2003099320A1 (en) * | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| US7144384B2 (en) | 2002-09-30 | 2006-12-05 | Insulet Corporation | Dispenser components and methods for patient infusion device |
| US7128727B2 (en) | 2002-09-30 | 2006-10-31 | Flaherty J Christopher | Components and methods for patient infusion device |
| US20050065760A1 (en) | 2003-09-23 | 2005-03-24 | Robert Murtfeldt | Method for advising patients concerning doses of insulin |
| US7686787B2 (en) | 2005-05-06 | 2010-03-30 | Medtronic Minimed, Inc. | Infusion device and method with disposable portion |
| JP5738516B2 (ja) * | 2005-12-30 | 2015-06-24 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド | 心機能改善のためのニューレグリンの徐放 |
| CN101394861A (zh) * | 2005-12-30 | 2009-03-25 | 上海泽生科技开发有限公司 | 纽兰格林持续给药能改善心脏功能 |
| CN103768582A (zh) * | 2006-12-29 | 2014-05-07 | 上海泽生科技开发有限公司 | 纽兰格林持续给药能改善心脏功能 |
| CN102245189B (zh) * | 2008-12-03 | 2015-06-17 | 阿莫塞特公司 | 改善梗死区灌注的组合物以及血管损伤修复方法 |
| CN102470161A (zh) * | 2009-06-09 | 2012-05-23 | 上海泽生科技开发有限公司 | 神经调节蛋白用于治疗心力衰竭的有效剂量 |
| JP6096262B2 (ja) * | 2009-08-25 | 2017-03-15 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． | ニューレグリンに基づく心不全の治療方法 |
| CN102139095A (zh) * | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| WO2013053076A1 (en) * | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| CN103127579B (zh) | 2011-11-21 | 2017-06-16 | 上海泽生科技开发股份有限公司 | 便携式注射泵的驱动系统 |
| US10894815B2 (en) * | 2012-10-08 | 2021-01-19 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Compositions and methods for treating heart failure in diabetic patients |
| EP2964249A1 (en) * | 2013-03-06 | 2016-01-13 | Acorda Therapeutics, Inc. | Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure |
| RU2015154737A (ru) * | 2013-05-22 | 2017-06-27 | Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи, Ко., Лтд. | Пролонгированное высвобождение нейрегулина для лечения сердечной недостаточности |
| CN105561298A (zh) * | 2014-10-17 | 2016-05-11 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
| CN108474787A (zh) * | 2015-09-25 | 2018-08-31 | 道格拉斯.B.索耶 | 用于治疗心脏损伤的方法 |
| WO2018052374A1 (en) * | 2016-09-14 | 2018-03-22 | Agency For Science, Technology And Research | Modulation of tjp1 expression to regulate regeneration of heart cells |
| JP2017125032A (ja) * | 2017-02-20 | 2017-07-20 | ゼンスン（シャンハイ）サイエンス アンド テクノロジー カンパニー リミテッド | 糖尿病患者における心不全の治療用組成物 |
-
2019
- 2019-12-31 CN CN201911412811.1A patent/CN111407881A/zh active Pending
-
2020
- 2020-01-03 US US17/420,974 patent/US20220096599A1/en active Pending
- 2020-01-03 JP JP2021539453A patent/JP7630173B2/ja active Active
- 2020-01-03 WO PCT/CN2020/070299 patent/WO2020143548A1/zh not_active Ceased
- 2020-01-03 CA CA3125377A patent/CA3125377A1/en active Pending
- 2020-01-03 AU AU2020206381A patent/AU2020206381B2/en active Active
- 2020-01-03 EP EP20738153.4A patent/EP3909599A4/en active Pending
-
2024
- 2024-12-16 JP JP2024219524A patent/JP7825894B2/ja active Active
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