JPWO2020139171A5 - - Google Patents
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- Publication number
- JPWO2020139171A5 JPWO2020139171A5 JP2021537704A JP2021537704A JPWO2020139171A5 JP WO2020139171 A5 JPWO2020139171 A5 JP WO2020139171A5 JP 2021537704 A JP2021537704 A JP 2021537704A JP 2021537704 A JP2021537704 A JP 2021537704A JP WO2020139171 A5 JPWO2020139171 A5 JP WO2020139171A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- pharmaceutical composition
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 23
- 239000000427 antigen Substances 0.000 claims description 22
- 108091007433 antigens Proteins 0.000 claims description 22
- 102000036639 antigens Human genes 0.000 claims description 22
- 239000012634 fragment Substances 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 208000035475 disorder Diseases 0.000 claims description 11
- 101000844040 Homo sapiens T cell receptor beta variable 9 Proteins 0.000 claims description 9
- 102100032166 T cell receptor beta variable 9 Human genes 0.000 claims description 9
- 108091008874 T cell receptors Proteins 0.000 claims description 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 5
- 208000015943 Coeliac disease Diseases 0.000 claims description 5
- 208000000389 T-cell leukemia Diseases 0.000 claims description 5
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims description 5
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 5
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 5
- 230000001404 mediated effect Effects 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 108020003175 receptors Proteins 0.000 claims description 3
- 230000004071 biological effect Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 239000003270 steroid hormone Substances 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims description 2
- 239000003708 ampul Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2018146029 | 2018-12-25 | ||
| RU2018146029A RU2711871C3 (ru) | 2018-12-25 | Моноклональные антитела, которые специфически связываются с участком бета цепи семейства TRBV-9 Т-клеточного рецептора человека, и способы их применения | |
| PCT/RU2019/050257 WO2020139171A1 (ru) | 2018-12-25 | 2019-12-24 | Моноклональные антитела, специфически связывающиеся с trbv-9 человека |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022515820A JP2022515820A (ja) | 2022-02-22 |
| JP2022515820A5 JP2022515820A5 (https=) | 2023-01-10 |
| JPWO2020139171A5 true JPWO2020139171A5 (https=) | 2023-01-10 |
| JP7507160B2 JP7507160B2 (ja) | 2024-06-27 |
Family
ID=69184146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021537704A Active JP7507160B2 (ja) | 2018-12-25 | 2019-12-24 | ヒトｔｒｂｖ９に特異的に結合するモノクローナル抗体 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US12297269B2 (https=) |
| EP (2) | EP4721817A2 (https=) |
| JP (1) | JP7507160B2 (https=) |
| KR (1) | KR20210118843A (https=) |
| CN (1) | CN113692412B (https=) |
| AR (1) | AR117735A1 (https=) |
| AU (1) | AU2019416787A1 (https=) |
| BR (1) | BR112021012550A2 (https=) |
| CA (1) | CA3124800A1 (https=) |
| CL (1) | CL2021001704A1 (https=) |
| CO (1) | CO2021008204A2 (https=) |
| CR (1) | CR20210353A (https=) |
| EA (1) | EA202100199A1 (https=) |
| EC (1) | ECSP21046332A (https=) |
| IL (1) | IL284367A (https=) |
| JO (1) | JOP20210168B1 (https=) |
| MA (1) | MA53688B1 (https=) |
| MX (1) | MX2021007718A (https=) |
| MY (1) | MY206214A (https=) |
| NZ (1) | NZ778430A (https=) |
| PE (1) | PE20211792A1 (https=) |
| PH (1) | PH12021551535A1 (https=) |
| SG (1) | SG11202106974SA (https=) |
| WO (1) | WO2020139171A1 (https=) |
| ZA (1) | ZA202104356B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2694412C9 (ru) | 2017-12-25 | 2019-09-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Моноклональные антитела и способы их применения |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| AU2020224681A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| WO2025075529A1 (en) * | 2023-10-04 | 2025-04-10 | Joint Stock Company "Biocad" | Antibody binds to trbv5-1 segment of human tor domain |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766947A (en) | 1988-12-14 | 1998-06-16 | Astra Ab | Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor |
| US5223426A (en) | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
| MXPA05000511A (es) * | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| CN102459643B (zh) | 2009-06-25 | 2016-06-01 | 弗雷德哈钦森癌症研究中心 | 检测获得性免疫的方法 |
| WO2012008397A1 (ja) | 2010-07-12 | 2012-01-19 | 第一三共株式会社 | 抗ｅｐｈａ２抗体及びその用途 |
| US20130273089A1 (en) * | 2011-11-03 | 2013-10-17 | Tolera Therapeutics, Inc. | Antibody and methods for selective inhibition of t-cell responses |
| PL2991683T3 (pl) | 2013-05-02 | 2020-03-31 | Glykos Finland Oy | Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem |
| EP3202784A1 (en) * | 2016-02-08 | 2017-08-09 | Polybiocept AB | T-cell receptor sequences for active immunotherapy |
| EP3472208B9 (en) | 2016-06-17 | 2023-10-04 | Medigene Immunotherapies GmbH | T cell receptors and uses thereof |
| EP3538113A4 (en) | 2016-11-14 | 2020-08-19 | Fred Hutchinson Cancer Research Center | HIGH AFFINITY MERKEL CELL POLYOMAVIRUS T ANTIGEN SPECIFIC TCRs AND THEIR USES |
| JP7162607B2 (ja) * | 2017-02-27 | 2022-10-28 | 中外製薬株式会社 | 抗ｈｌａ－ｄｑ２．５／８抗体およびセリアック病の治療のためのその使用 |
| CN107502671B (zh) * | 2017-10-12 | 2020-05-05 | 中国医学科学院肿瘤医院 | 利用trbv家族成员预测曲妥珠单抗新辅助治疗乳腺癌患者疗效试剂盒及其应用 |
| RU2694412C9 (ru) | 2017-12-25 | 2019-09-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Моноклональные антитела и способы их применения |
-
2019
- 2019-12-23 AR ARP190103841A patent/AR117735A1/es unknown
- 2019-12-24 EP EP26157540.1A patent/EP4721817A2/en active Pending
- 2019-12-24 WO PCT/RU2019/050257 patent/WO2020139171A1/ru not_active Ceased
- 2019-12-24 MA MA53688A patent/MA53688B1/fr unknown
- 2019-12-24 MY MYPI2021003582A patent/MY206214A/en unknown
- 2019-12-24 MX MX2021007718A patent/MX2021007718A/es unknown
- 2019-12-24 CR CR20210353A patent/CR20210353A/es unknown
- 2019-12-24 AU AU2019416787A patent/AU2019416787A1/en active Pending
- 2019-12-24 NZ NZ778430A patent/NZ778430A/en unknown
- 2019-12-24 EP EP19904442.1A patent/EP3904387B1/en active Active
- 2019-12-24 EA EA202100199A patent/EA202100199A1/ru unknown
- 2019-12-24 CA CA3124800A patent/CA3124800A1/en active Pending
- 2019-12-24 PE PE2021001079A patent/PE20211792A1/es unknown
- 2019-12-24 BR BR112021012550-7A patent/BR112021012550A2/pt unknown
- 2019-12-24 KR KR1020217023567A patent/KR20210118843A/ko active Pending
- 2019-12-24 CN CN201980092914.6A patent/CN113692412B/zh active Active
- 2019-12-24 SG SG11202106974SA patent/SG11202106974SA/en unknown
- 2019-12-24 US US17/417,570 patent/US12297269B2/en active Active
- 2019-12-24 JP JP2021537704A patent/JP7507160B2/ja active Active
-
2021
- 2021-06-23 CO CONC2021/0008204A patent/CO2021008204A2/es unknown
- 2021-06-24 EC ECSENADI202146332A patent/ECSP21046332A/es unknown
- 2021-06-24 JO JOJO/P/2021/0168A patent/JOP20210168B1/ar active
- 2021-06-24 IL IL284367A patent/IL284367A/en unknown
- 2021-06-24 CL CL2021001704A patent/CL2021001704A1/es unknown
- 2021-06-24 ZA ZA2021/04356A patent/ZA202104356B/en unknown
- 2021-06-25 PH PH12021551535A patent/PH12021551535A1/en unknown
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