JPWO2020086505A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020086505A5 JPWO2020086505A5 JP2021522502A JP2021522502A JPWO2020086505A5 JP WO2020086505 A5 JPWO2020086505 A5 JP WO2020086505A5 JP 2021522502 A JP2021522502 A JP 2021522502A JP 2021522502 A JP2021522502 A JP 2021522502A JP WO2020086505 A5 JPWO2020086505 A5 JP WO2020086505A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- triazolo
- piperidin
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 2 Chemical compound 0.000 claims 30
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 239000011780 sodium chloride Substances 0.000 claims 9
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- 150000001204 N-oxides Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 230000001684 chronic Effects 0.000 claims 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 200000000018 inflammatory disease Diseases 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 201000010874 syndrome Diseases 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862749924P | 2018-10-24 | 2018-10-24 | |
| US62/749,924 | 2018-10-24 | ||
| PCT/US2019/057315 WO2020086505A1 (en) | 2018-10-24 | 2019-10-22 | Substituted indole dimer compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022505827A JP2022505827A (ja) | 2022-01-14 |
| JPWO2020086505A5 true JPWO2020086505A5 (de) | 2022-10-31 |
Family
ID=68468875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021522502A Pending JP2022505827A (ja) | 2018-10-24 | 2019-10-22 | 置換インドール二量体の化合物 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3870589B1 (de) |
| JP (1) | JP2022505827A (de) |
| KR (1) | KR20210080462A (de) |
| CN (1) | CN112912382A (de) |
| ES (1) | ES2963696T3 (de) |
| WO (1) | WO2020086505A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL307203A (en) | 2021-04-16 | 2023-11-01 | Gilead Sciences Inc | THIENOPYRROLE COMPOUNDS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10071079B2 (en) * | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| AU2017307208B2 (en) * | 2016-07-30 | 2021-01-21 | Bristol-Myers Squibb Company | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors |
| EP3510024B1 (de) * | 2016-09-09 | 2021-11-17 | Bristol-Myers Squibb Company | Pyridylsubstituierte indolverbindungen |
| SG11202005696YA (en) * | 2017-12-19 | 2020-07-29 | Bristol Myers Squibb Co | Substituted indole compounds useful as tlr inhibitors |
-
2019
- 2019-10-22 WO PCT/US2019/057315 patent/WO2020086505A1/en unknown
- 2019-10-22 EP EP19798498.2A patent/EP3870589B1/de active Active
- 2019-10-22 CN CN201980070010.3A patent/CN112912382A/zh active Pending
- 2019-10-22 JP JP2021522502A patent/JP2022505827A/ja active Pending
- 2019-10-22 ES ES19798498T patent/ES2963696T3/es active Active
- 2019-10-22 KR KR1020217015032A patent/KR20210080462A/ko unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7398391B2 (ja) | Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物 | |
| JP2014037426A5 (de) | ||
| CN104507923B (zh) | 作为激酶抑制剂的取代的吡咯类活性剂 | |
| JP2012532112A5 (de) | ||
| CA2565852A1 (en) | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands | |
| JP2010513283A (ja) | 新規なオキサジアゾール化合物 | |
| JP2007519694A5 (de) | ||
| RU2019120990A (ru) | Бициклические гетероарильные производные в качестве стимуляторов cftr | |
| JP2009534406A5 (de) | ||
| JP2013515074A5 (de) | ||
| JP2017512786A5 (de) | ||
| WO2000047558A1 (fr) | Composes amide et leur utilisation medicinale | |
| JP2007538031A5 (de) | ||
| JP2022542595A (ja) | ガンを処置するためのｂｃｌ－ｘｌタンパク質阻害剤及びアポトーシス促進剤としての、６，７－ジヒドロ－５ｈ－ピリド［２，３－ｃ］ピリダジン誘導体及び関連化合物。 | |
| JP2009534407A5 (de) | ||
| PT1539753E (pt) | Compostos de pirazolo(3,4-b)piridina e sua utilização como inibidores da fosfodiesterase | |
| JP2013533883A5 (de) | ||
| CA2584567A1 (en) | Pyrazolo (1,5-alpha) pyrimidinyl derivatives useful as corticotropin-releasing factor (crf) receptor antagonists | |
| JP2009534405A5 (de) | ||
| CA2647036A1 (en) | Tetrahydropyridothienopyrimidine compounds and methods of use thereof | |
| JP2013530236A5 (de) | ||
| JP2008516936A (ja) | ２型糖尿病および肥満の処置において有用であるフェノキシベンズアミド化合物 | |
| JP2017523223A5 (de) | ||
| RU2016141647A (ru) | ИНГИБИТОРЫ TrkA КИНАЗЫ, ОСНОВАННЫЕ НА НИХ КОМПОЗИЦИИ И СПОСОБЫ | |
| JP2019514956A5 (de) |