JPWO2020072896A5 - - Google Patents
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- Publication number
- JPWO2020072896A5 JPWO2020072896A5 JP2021517575A JP2021517575A JPWO2020072896A5 JP WO2020072896 A5 JPWO2020072896 A5 JP WO2020072896A5 JP 2021517575 A JP2021517575 A JP 2021517575A JP 2021517575 A JP2021517575 A JP 2021517575A JP WO2020072896 A5 JPWO2020072896 A5 JP WO2020072896A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- formulation
- antibody
- pharmaceutical formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 54
- 239000000203 mixture Substances 0.000 claims 54
- 239000008194 pharmaceutical composition Substances 0.000 claims 48
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 17
- 239000000872 buffer Substances 0.000 claims 17
- 229960002885 histidine Drugs 0.000 claims 16
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 16
- 229920001213 Polysorbate 20 Polymers 0.000 claims 15
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 15
- 229940068977 polysorbate 20 Drugs 0.000 claims 15
- 230000004845 protein aggregation Effects 0.000 claims 15
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 14
- 239000004475 Arginine Substances 0.000 claims 10
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 claims 10
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 claims 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 10
- 235000009697 arginine Nutrition 0.000 claims 10
- 229930006000 Sucrose Natural products 0.000 claims 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 9
- 239000005720 sucrose Substances 0.000 claims 9
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 8
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 8
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 8
- 229940126864 fibroblast growth factor Drugs 0.000 claims 8
- 239000012669 liquid formulation Substances 0.000 claims 8
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 5
- 229920000053 polysorbate 80 Polymers 0.000 claims 5
- 229940068968 polysorbate 80 Drugs 0.000 claims 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 4
- 239000010452 phosphate Substances 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024098544A JP2024138284A (ja) | 2018-10-05 | 2024-06-19 | 抗ｆｇｆｒ２抗体製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862741772P | 2018-10-05 | 2018-10-05 | |
| US62/741,772 | 2018-10-05 | ||
| PCT/US2019/054684 WO2020072896A1 (en) | 2018-10-05 | 2019-10-04 | Anti-fgfr2 antibody formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024098544A Division JP2024138284A (ja) | 2018-10-05 | 2024-06-19 | 抗ｆｇｆｒ２抗体製剤 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022503886A JP2022503886A (ja) | 2022-01-12 |
| JPWO2020072896A5 true JPWO2020072896A5 (https=) | 2022-09-29 |
| JP2022503886A5 JP2022503886A5 (https=) | 2022-09-29 |
| JP7595567B2 JP7595567B2 (ja) | 2024-12-06 |
Family
ID=68343457
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517575A Active JP7595567B2 (ja) | 2018-10-05 | 2019-10-04 | 抗ｆｇｆｒ２抗体製剤 |
| JP2024098544A Pending JP2024138284A (ja) | 2018-10-05 | 2024-06-19 | 抗ｆｇｆｒ２抗体製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024098544A Pending JP2024138284A (ja) | 2018-10-05 | 2024-06-19 | 抗ｆｇｆｒ２抗体製剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20220010020A1 (https=) |
| EP (1) | EP3860563A1 (https=) |
| JP (2) | JP7595567B2 (https=) |
| KR (1) | KR20210074286A (https=) |
| CN (1) | CN112804989A (https=) |
| AU (1) | AU2019355995B2 (https=) |
| BR (1) | BR112021005204A2 (https=) |
| CA (1) | CA3112215A1 (https=) |
| CO (1) | CO2021004985A2 (https=) |
| CR (1) | CR20210217A (https=) |
| EA (1) | EA202190878A1 (https=) |
| EC (1) | ECSP21031139A (https=) |
| IL (1) | IL281976A (https=) |
| MX (1) | MX2021003766A (https=) |
| MY (1) | MY208925A (https=) |
| PE (1) | PE20211213A1 (https=) |
| PH (1) | PH12021550670A1 (https=) |
| SG (1) | SG11202102875YA (https=) |
| UA (1) | UA130250C2 (https=) |
| WO (1) | WO2020072896A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102735988B1 (ko) | 2019-02-18 | 2024-12-03 | 일라이 릴리 앤드 캄파니 | 치료 항체 제제 |
| WO2022143728A1 (zh) * | 2020-12-29 | 2022-07-07 | 深圳福沃药业有限公司 | 抗fgfr2抗体及其用途 |
| TW202342527A (zh) * | 2022-02-25 | 2023-11-01 | 美商安進公司 | 鱗狀非小細胞肺癌之治療 |
| AU2023243773A1 (en) * | 2022-03-28 | 2024-10-24 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Novel anti-fgfr2 antibodies. |
| WO2024199362A1 (en) * | 2023-03-31 | 2024-10-03 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Novel anti-FGFR2 antibodies |
| WO2025067442A1 (zh) * | 2023-09-28 | 2025-04-03 | 南京维立志博生物科技股份有限公司 | 抗fgfr2抗体和包含其的多特异性结合分子 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| ATE296315T1 (de) | 1997-06-24 | 2005-06-15 | Genentech Inc | Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung |
| WO1999022764A1 (en) | 1997-10-31 | 1999-05-14 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1176195B1 (en) | 1999-04-09 | 2013-05-22 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| CA2388245C (en) | 1999-10-19 | 2012-01-10 | Kyowa Kirin Co., Ltd. | The use of serum-free adapted rat cells for producing heterologous polypeptides |
| ES2639222T5 (es) | 2000-10-06 | 2023-11-24 | Kyowa Kirin Co Ltd | Células que producen unas composiciones de anticuerpo |
| US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| EP2180044A1 (en) | 2001-08-03 | 2010-04-28 | GlycArt Biotechnology AG | Antibody glycosylation variants having increased anti-body-dependent cellular cytotoxicity |
| HUP0600342A3 (en) | 2001-10-25 | 2011-03-28 | Genentech Inc | Glycoprotein compositions |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| ATE503829T1 (de) | 2002-04-09 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins |
| CA2481920A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-containing medicament |
| EA200401325A1 (ru) | 2002-04-09 | 2005-04-28 | Киова Хакко Когио Ко., Лтд. | Клетки с модифицированным геномом |
| US20040259150A1 (en) | 2002-04-09 | 2004-12-23 | Kyowa Hakko Kogyo Co., Ltd. | Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa |
| US20040132140A1 (en) | 2002-04-09 | 2004-07-08 | Kyowa Hakko Kogyo Co., Ltd. | Production process for antibody composition |
| JP4832719B2 (ja) | 2002-04-09 | 2011-12-07 | 協和発酵キリン株式会社 | ＦｃγＲＩＩＩａ多型患者に適応する抗体組成物含有医薬 |
| EP3263596A1 (en) | 2002-12-16 | 2018-01-03 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
| US20080241884A1 (en) | 2003-10-08 | 2008-10-02 | Kenya Shitara | Fused Protein Composition |
| JPWO2005035778A1 (ja) | 2003-10-09 | 2006-12-21 | 協和醗酵工業株式会社 | α１，６−フコシルトランスフェラーゼの機能を抑制するＲＮＡを用いた抗体組成物の製造法 |
| ES2672640T3 (es) | 2003-11-05 | 2018-06-15 | Roche Glycart Ag | Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas |
| WO2005053742A1 (ja) | 2003-12-04 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | 抗体組成物を含有する医薬 |
| US7923538B2 (en) | 2005-07-22 | 2011-04-12 | Kyowa Hakko Kirin Co., Ltd | Recombinant antibody composition |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| ES2538990T3 (es) | 2007-01-24 | 2015-06-25 | Kyowa Hakko Kirin Co., Ltd. | Composición de anticuerpo genéticamente recombinante que tiene una actividad efectora mejorada |
| PL2365828T3 (pl) | 2008-11-07 | 2015-04-30 | Galaxy Biotech Llc | Przeciwciała monoklonalne swoiste dla receptora 2 czynnika wzrostu fibroblastów |
| PH12021552742A1 (en) * | 2013-08-01 | 2022-05-23 | Five Prime Therapeutics Inc | Afucosylated anti-fgfr2iiib antibodies |
| US20170145103A1 (en) | 2015-11-23 | 2017-05-25 | Five Prime Therapeutics, Inc. | Predicting response to cancer treatment with fgfr2 inhibitors |
-
2019
- 2019-10-04 US US17/282,589 patent/US20220010020A1/en active Pending
- 2019-10-04 KR KR1020217009515A patent/KR20210074286A/ko not_active Ceased
- 2019-10-04 JP JP2021517575A patent/JP7595567B2/ja active Active
- 2019-10-04 SG SG11202102875YA patent/SG11202102875YA/en unknown
- 2019-10-04 EA EA202190878A patent/EA202190878A1/ru unknown
- 2019-10-04 MX MX2021003766A patent/MX2021003766A/es unknown
- 2019-10-04 CA CA3112215A patent/CA3112215A1/en active Pending
- 2019-10-04 EP EP19794304.6A patent/EP3860563A1/en active Pending
- 2019-10-04 WO PCT/US2019/054684 patent/WO2020072896A1/en not_active Ceased
- 2019-10-04 CR CR20210217A patent/CR20210217A/es unknown
- 2019-10-04 BR BR112021005204-6A patent/BR112021005204A2/pt unknown
- 2019-10-04 MY MYPI2021001632A patent/MY208925A/en unknown
- 2019-10-04 AU AU2019355995A patent/AU2019355995B2/en active Active
- 2019-10-04 PE PE2021000414A patent/PE20211213A1/es unknown
- 2019-10-04 CN CN201980064961.XA patent/CN112804989A/zh active Pending
- 2019-10-04 UA UAA202102307A patent/UA130250C2/uk unknown
-
2021
- 2021-03-25 PH PH12021550670A patent/PH12021550670A1/en unknown
- 2021-04-01 IL IL281976A patent/IL281976A/en unknown
- 2021-04-19 CO CONC2021/0004985A patent/CO2021004985A2/es unknown
- 2021-05-03 EC ECSENADI202131139A patent/ECSP21031139A/es unknown
-
2024
- 2024-06-19 JP JP2024098544A patent/JP2024138284A/ja active Pending
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