JPWO2020059828A1 - バイオフィルム形成抑制剤 - Google Patents
バイオフィルム形成抑制剤 Download PDFInfo
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- JPWO2020059828A1 JPWO2020059828A1 JP2020549092A JP2020549092A JPWO2020059828A1 JP WO2020059828 A1 JPWO2020059828 A1 JP WO2020059828A1 JP 2020549092 A JP2020549092 A JP 2020549092A JP 2020549092 A JP2020549092 A JP 2020549092A JP WO2020059828 A1 JPWO2020059828 A1 JP WO2020059828A1
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- echinacea
- biofilm formation
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- hot water
- formation inhibitor
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Abstract
Description
項2.エキナセアの熱水抽出物のみを有効成分として含む、項1に記載のバイオフィルム形成抑制剤。
項3.前記エキナセアとして、エキナセアの葉を使用する、項1又は2に記載のバイオフィルム形成抑制剤。
項4.前記ストレプトコッカス属菌が、ストレプトコッカス・ミュータンスである、項1〜3のいずれか一項に記載のバイオフィルム形成抑制剤。
項5.ガム、マウスウォッシュ、歯磨剤、キャンデー、又は茶飲料である、項1〜4のいずれか一項に記載のバイオフィルム形成抑制剤。
項6.ヒト用である、項1〜5のいずれか一項に記載のバイオフィルム形成抑制剤。
項7.エキナセアの熱水抽出物の有効量を哺乳動物に投与する工程を含む、ストレプトコッカス属菌のバイオフィルム形成を抑制させる方法。
項8.前記エキナセアとして、エキナセアの葉を使用する、項7に記載の方法。
項9.前記ストレプトコッカス属菌が、ストレプトコッカス・ミュータンスである、項7又は8に記載の方法。
項10.前記エキナセアの熱水抽出物が、ガム、マウスウォッシュ、歯磨剤、キャンデー、又は茶飲料の形態で投与される、項7〜9のいずれか一項に記載の方法。
項11.前記哺乳動物がヒトである、項7〜10のいずれか一項に記載の方法。
項12.ストレプトコッカス属菌のバイオフィルム形成抑制剤の製造における、エキナセアの熱水抽出物の使用。
項13.前記エキナセアとして、エキナセアの葉を使用する、項12に記載の使用。
項14.前記ストレプトコッカス属菌が、ストレプトコッカス・ミュータンスである、項12又は13に記載の使用。
項15.前記バイオフィルム形成抑制剤が、ガム、マウスウォッシュ、歯磨剤、キャンデー、又は茶飲料である、項12〜14のいずれか一項に記載の使用。
項16.前記バイオフィルム形成抑制剤が、ヒト用である、項12〜15のいずれか一項に記載の使用。
項17.エキナセアの熱水抽出物を有効成分として含む、ストレプトコッカス属菌のバイオフィルム形成抑制用組成物。
項18.前記エキナセアとして、エキナセアの葉を使用する、項17に記載の組成物。
項19.前記ストレプトコッカス属菌が、ストレプトコッカス・ミュータンスである、項17又は18に記載の組成物。
項20.ガム、マウスウォッシュ、歯磨剤、キャンデー、又は茶飲料である、項17〜19のいずれか一項に記載の組成物。
項21.ヒト用である、項17〜20のいずれか一項に記載の組成物。
グルカンシュークラーゼは乳酸菌目のストレプトコッカス属、ラクトコッカス属、ロイコノストック属、ワイセラ属、又はラクトバチルス属の菌により産生されバイオフィルムを形成することが確認されている。その中でもストレプトコッカス属のストレプトコッカス・ミュータンス及びストレプトコッカス・ダウネイは虫歯の原因菌である。本試験ではその中でも、虫歯の原因菌として一般的に知られる、ストレプトコッカス・ミュータンスによるグルカンシュークラーゼ活性、及びバイオフィルム形成に着目して試験を実施した。
エキナセア又は緑茶の乾燥物0.5 gを25 mLの水で溶解し、10分間熱水抽出した後、定性濾紙No.2 (ADVATEC )にて濾過し、遠心エバポレーターGenevac EZ-2にて乾燥し、蒸留水にて所定濃度に調整し、試験を実施した。グルカンシュークラーゼ阻害活性、ストレプトコッカス・ミュータンス菌に対する抗菌作用、ストレプトコッカス・ミュータンス菌によるバイオフィルム形成抑制作用の評価を行った。
グルカンシュークラーゼ阻害活性の試験結果を以下の表1に示す。
1) Hattori M, Kusumoto IT, Namba T, Ishigami T, Hara Y., Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans., Chem Pharm Bull (Tokyo). 38(3), 717-20, 1990.
エキナセア葉の乾燥物1.0 gを20 mLの蒸留水にて、60分間熱水抽出し、定性濾紙No.2 (ADVATEC)にて濾過した。ろ過残渣を用いて更に2回熱水抽出を行った。また、エキナセア葉の乾燥物1.0 gを20 mLの95%エタノールにて、10分間振とう抽出し、定性濾紙No.2 (ADVATEC)にて濾過した。ろ過残渣を用いて更に2回振とう抽出を行った。得られたろ液を遠心エバポレーターmiVAC及び凍結乾燥器FREEZE DRYER FD-5Nにて乾燥し、得られた抽出物粉末重量より、抽出効率を算出した。その結果を表3に示す。その結果、エタノール抽出4%に対して熱水抽出はその8倍の32%の抽出効率であった。
Claims (6)
- エキナセアの熱水抽出物を有効成分として含む、ストレプトコッカス属菌のバイオフィルム形成抑制剤。
- エキナセアの熱水抽出物のみを有効成分として含む、請求項1に記載のバイオフィルム形成抑制剤。
- 前記エキナセアとして、エキナセアの葉を使用する、請求項1又は2に記載のバイオフィルム形成抑制剤。
- 前記ストレプトコッカス属菌が、ストレプトコッカス・ミュータンスである、請求項1〜3のいずれか一項に記載のバイオフィルム形成抑制剤。
- ガム、マウスウォッシュ、歯磨剤、キャンデー、又は茶飲料である、請求項1〜4のいずれか一項に記載のバイオフィルム形成抑制剤。
- ヒト用である、請求項1〜5のいずれか一項に記載のバイオフィルム形成抑制剤。
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