|
US35764A
(en)
|
|
1862-07-01 |
|
Improvement in seeding-machines |
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
|
US4289872A
(en)
|
1979-04-06 |
1981-09-15 |
Allied Corporation |
Macromolecular highly branched homogeneous compound based on lysine units
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
EP0052322B1
(fr)
|
1980-11-10 |
1985-03-27 |
Gersonde, Klaus, Prof. Dr. |
Méthode de préparation de vésicules lipidiques par traitement aux ultra-sons, utilisation de ce procédé et l'appareillage ainsi utilisé
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
FR2504010B1
(fr)
|
1981-04-15 |
1985-10-25 |
Sanofi Sa |
Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
JPS57206622A
(en)
|
1981-06-10 |
1982-12-18 |
Ajinomoto Co Inc |
Blood substitute
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
DE3218121A1
(de)
|
1982-05-14 |
1983-11-17 |
Leskovar, Peter, Dr.-Ing., 8000 München |
Arzneimittel zur tumorbehandlung
|
|
EP0102324A3
(fr)
|
1982-07-29 |
1984-11-07 |
Ciba-Geigy Ag |
Lipides et composés tensio-actifs en phase aqueuse
|
|
US4511503A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4512922A
(en)
|
1982-12-22 |
1985-04-23 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511502A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4820352A
(en)
|
1983-01-10 |
1989-04-11 |
Bausch & Lomb Incorporated |
Cleaning and conditioning solutions for contact lenses and methods of use
|
|
JPS59166086A
(ja)
|
1983-03-09 |
1984-09-19 |
Teruhiko Beppu |
新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
US4870008A
(en)
|
1983-08-12 |
1989-09-26 |
Chiron Corporation |
Secretory expression in eukaryotes
|
|
ATE59966T1
(de)
|
1983-09-26 |
1991-02-15 |
Ehrenfeld Udo |
Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
|
|
US4615885A
(en)
|
1983-11-01 |
1986-10-07 |
Terumo Kabushiki Kaisha |
Pharmaceutical composition containing urokinase
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
US4931373A
(en)
|
1984-05-25 |
1990-06-05 |
Zymogenetics, Inc. |
Stable DNA constructs for expression of α-1 antitrypsin
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4659839A
(en)
|
1984-10-10 |
1987-04-21 |
Mallinckrodt, Inc. |
Coupling agents for radiolabeled antibody fragments
|
|
GB8430252D0
(en)
|
1984-11-30 |
1985-01-09 |
Beecham Group Plc |
Compounds
|
|
DE3680924D1
(de)
|
1985-01-14 |
1991-09-26 |
Neorx Corp |
Metall-radionuklid markiertes protein fuer diagnose und therapie.
|
|
EP0206448B1
(fr)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hémoglobine liée à un poly(oxyde d'alkylène)
|
|
EP0229108B1
(fr)
|
1985-06-26 |
1990-12-27 |
Cetus Corporation |
Solubilisation de proteines pour des compositions pharmaceutiques utilisant une conjugaison de polymeres
|
|
US4680338A
(en)
|
1985-10-17 |
1987-07-14 |
Immunomedics, Inc. |
Bifunctional linker
|
|
WO1987002670A1
(fr)
|
1985-10-25 |
1987-05-07 |
Mackay Vivian L |
Procede d'utilisation de bar1 pour la secretion de proteines etrangeres
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
JPS63123383A
(ja)
|
1986-11-11 |
1988-05-27 |
Mitsubishi Kasei Corp |
ハイブリツドプロモ−タ−、発現調節ｄｎａ配列および発現ベクタ−
|
|
US5229490A
(en)
|
1987-05-06 |
1993-07-20 |
The Rockefeller University |
Multiple antigen peptide system
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US4847325A
(en)
|
1988-01-20 |
1989-07-11 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
|
GB8824591D0
(en)
|
1988-10-20 |
1988-11-23 |
Royal Free Hosp School Med |
Fractionation process
|
|
US5047335A
(en)
|
1988-12-21 |
1991-09-10 |
The Regents Of The University Of Calif. |
Process for controlling intracellular glycosylation of proteins
|
|
EP0401384B1
(fr)
|
1988-12-22 |
1996-03-13 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US4902502A
(en)
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
DE69033192T3
(de)
|
1989-04-19 |
2004-05-19 |
Enzon, Inc. |
Aktive karbonate von polyalkylenoxyden zur modifizierung von polypeptiden
|
|
ATE136315T1
(de)
|
1989-05-27 |
1996-04-15 |
Sumitomo Pharma |
Verfahren für die herstellung von polyethylenglykolderivate und modifizierte proteine.
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
EP0513332A4
(en)
|
1990-11-14 |
1993-03-17 |
Cargill, Incorporated |
Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
CA2101918A1
(fr)
|
1991-03-18 |
1992-09-19 |
Samuel Zalipsky |
Conjugues de polypeptides et de glycopolypeptides avec des polymeres contenant de l'hydrazine
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
IT1260468B
(it)
|
1992-01-29 |
1996-04-09 |
|
Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
|
|
CA2118130A1
(fr)
|
1992-04-14 |
1993-10-28 |
Jean M. J. Frechet |
Macromolecules composees de polymeres dendritiques et methode de production
|
|
ZA933926B
(en)
|
1992-06-17 |
1994-01-03 |
Amgen Inc |
Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
|
|
AU5006993A
(en)
|
1992-08-21 |
1994-03-15 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
NZ250375A
(en)
|
1992-12-09 |
1995-07-26 |
Ortho Pharma Corp |
Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
AU6029594A
(en)
|
1993-01-15 |
1994-08-15 |
Enzon, Inc. |
Factor viii - polymeric conjugates
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
IL104734A0
(en)
|
1993-02-15 |
1993-06-10 |
Univ Bar Ilan |
Bioactive conjugates of cellulose with amino compounds
|
|
WO1994028024A1
(fr)
|
1993-06-01 |
1994-12-08 |
Enzon, Inc. |
Polymere modifie aux glucides presentant une activite erythropoïetique
|
|
WO1995000162A1
(fr)
|
1993-06-21 |
1995-01-05 |
Enzon, Inc. |
Synthese de peptides conjuges modifies, sur des sites specifiques
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
DK0730470T3
(da)
|
1993-11-10 |
2002-06-03 |
Enzon Inc |
Forbedrede interferonpolymerkonjugater
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5473034A
(en)
|
1994-03-18 |
1995-12-05 |
Hyogo Prefectural Government |
Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
|
|
US5629384A
(en)
|
1994-05-17 |
1997-05-13 |
Consiglio Nazionale Delle Ricerche |
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
|
|
AU2826495A
(en)
|
1994-06-02 |
1996-01-04 |
Enzon, Inc. |
Method of solubilizing substantially water insoluble materials
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US5650234A
(en)
|
1994-09-09 |
1997-07-22 |
Surface Engineering Technologies, Division Of Innerdyne, Inc. |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
WO1996041813A2
(fr)
|
1994-11-09 |
1996-12-27 |
Offord Robin E |
Polymeres fonctionnalises destines a une ligation dirigee
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
IL116085A
(en)
|
1994-12-16 |
1999-12-31 |
Ortho Pharma Corp |
Spray dried erythropoietin
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
AU5893696A
(en)
|
1995-06-07 |
1996-12-30 |
Novo Nordisk A/S |
Modification of polypeptides
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US5747639A
(en)
|
1996-03-06 |
1998-05-05 |
Amgen Boulder Inc. |
Use of hydrophobic interaction chromatography to purify polyethylene glycols
|
|
TW517067B
(en)
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
IL128229A0
(en)
|
1996-08-02 |
1999-11-30 |
Ortho Mcneil Pharm Inc |
Polypeptides having a single covalently bound n-terminal water-soluble polymer
|
|
US5980948A
(en)
|
1996-08-16 |
1999-11-09 |
Osteotech, Inc. |
Polyetherester copolymers as drug delivery matrices
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
JP2001508783A
(ja)
|
1997-01-29 |
2001-07-03 |
ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー |
Ｐｅｇ化法
|
|
WO1998047089A1
(fr)
|
1997-04-11 |
1998-10-22 |
California Institute Of Technology |
Dispositif et methode permettant une mise au point informatisee de proteines
|
|
EP0981548A4
(fr)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
Proteines a chaine unique fixant les antigenes capables de glycosylation, production et utilisations de ces dernieres
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
ATE469166T1
(de)
|
1997-06-06 |
2010-06-15 |
Kyowa Hakko Kirin Co Ltd |
Chemisch modifizierte polypeptide
|
|
EP1881005B1
(fr)
|
1997-07-14 |
2013-04-03 |
Bolder Biotechnology, Inc. |
Dérivés de G-CSF et protéines associées
|
|
GB9715660D0
(en)
|
1997-07-25 |
1997-10-01 |
Zeneca Ltd |
Proteins
|
|
ATE462004T1
(de)
|
1997-09-16 |
2010-04-15 |
Centocor Inc |
Methoden zur kompletten chemischen synthese und zusammensetzung von genen und genomen
|
|
WO1999016318A1
(fr)
|
1997-09-26 |
1999-04-08 |
Uab Research Foundation |
Cellule antigene reduite et ses utilisations
|
|
US6201072B1
(en)
|
1997-10-03 |
2001-03-13 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
US6004573A
(en)
|
1997-10-03 |
1999-12-21 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
DE19748489A1
(de)
|
1997-11-03 |
1999-05-06 |
Roche Diagnostics Gmbh |
Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
|
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
DE69921102T2
(de)
|
1998-03-05 |
2006-02-02 |
Chiron Corp., Emeryville |
Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen
|
|
ATE399809T1
(de)
|
1998-03-12 |
2008-07-15 |
Nektar Therapeutics Al Corp |
Verfahren zur herstellung von polymerkonjugaten
|
|
CN1330675A
(zh)
|
1998-08-28 |
2002-01-09 |
格莱风科学公司 |
精确长度的聚酰胺链、其制备方法和其与蛋白质的缀合物
|
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
US6403312B1
(en)
|
1998-10-16 |
2002-06-11 |
Xencor |
Protein design automatic for protein libraries
|
|
US6451346B1
(en)
|
1998-12-23 |
2002-09-17 |
Amgen Inc |
Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
|
|
US6281211B1
(en)
|
1999-02-04 |
2001-08-28 |
Euro-Celtique S.A. |
Substituted semicarbazides and the use thereof
|
|
CA2370357C
(fr)
|
1999-04-16 |
2007-04-10 |
Wm. Marsh Rice University |
Poly(propylene fumarate) reticule avec du poly(ethylene glycol)
|
|
US7144574B2
(en)
|
1999-08-27 |
2006-12-05 |
Maxygen Aps |
Interferon β variants and conjugates
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
CA2393638C
(fr)
|
1999-12-22 |
2009-10-20 |
Shearwater Corporation |
Procede de preparation d'esters de 1-benzotriazolyl carbonate de poly(ethylene glycol)
|
|
AU781839B2
(en)
|
1999-12-22 |
2005-06-16 |
Nektar Therapeutics |
Sterically hindered derivatives of water soluble polymers
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
US6646110B2
(en)
|
2000-01-10 |
2003-11-11 |
Maxygen Holdings Ltd. |
G-CSF polypeptides and conjugates
|
|
WO2001062827A2
(fr)
|
2000-02-22 |
2001-08-30 |
Shearwater Corporation |
Derives de polymere n-maleimidyle
|
|
AU2001257577A1
(en)
|
2000-02-28 |
2001-09-03 |
Shearwater Corporation |
Water-soluble polymer conjugates of artelinic acid
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
|
EP2796546B1
(fr)
|
2001-04-19 |
2017-08-09 |
The Scripps Research Institute |
Incorporation d'acides aminés artificiels
|
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
KR100948532B1
(ko)
|
2001-11-07 |
2010-03-23 |
넥타르 테라퓨틱스 |
분지형 중합체 및 그의 공액체
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
WO2003070740A1
(fr)
|
2002-02-15 |
2003-08-28 |
The Research Foundation Of State University Of New York |
Ribozymes a large activite d'aminoacylation de l'arn de transfert
|
|
AU2003240482B2
(en)
|
2002-05-30 |
2009-03-12 |
The Scripps Research Institute |
Copper-catalysed ligation of azides and acetylenes
|
|
EP2357006B1
(fr)
|
2002-07-31 |
2015-09-16 |
Seattle Genetics, Inc. |
Conjugués de médicaments et leur utilisation pour traiter le cancer, maladie auto-immune ou maladie infectieuse
|
|
WO2004035605A2
(fr)
|
2002-10-16 |
2004-04-29 |
The Scripps Research Institute |
Synthese de glycoproteines
|
|
WO2005007870A2
(fr)
|
2003-07-07 |
2005-01-27 |
The Scripps Research Institute |
Compositions de paires orthogonales de leucyl-trna et aminoacyl-trna-synthetase et leurs utilisations
|
|
EP1666604B1
(fr)
|
2003-07-07 |
2008-02-13 |
The Scripps Research Institute |
Compositions comprenant une paire orthogonale lysyl-ARNt et aminoacyl-ARNt synthétase et leur utilisations
|
|
EP1658366A4
(fr)
|
2003-07-07 |
2006-08-09 |
Scripps Research Inst |
Compositions de paires orthogonales de glutamyl-arnt et d'aminoacyl-arnt synthetases et leurs utilisations
|
|
WO2005007121A2
(fr)
*
|
2003-07-18 |
2005-01-27 |
Massachusetts Institute Of Technology |
Polypeptides de l'interleukine-2(il-2) mutante
|
|
RU2006135112A
(ru)
*
|
2004-03-05 |
2008-04-10 |
Чирон Корпорейшн (Us) |
Тест-система in vitro для прогнозирования устойчивости пациента к терапевтическим средствам
|
|
CN1799625B
(zh)
*
|
2004-12-14 |
2012-09-26 |
诺华疫苗和诊断公司 |
制备用于药用的白介素
|
|
MX2007007590A
(es)
|
2004-12-22 |
2007-12-10 |
Ambrx Inc |
Composiciones que contienen, metodos que involucran y usos de aminoacidos no naturales y polipeptidos.
|
|
CN101374536B
(zh)
*
|
2004-12-22 |
2013-09-25 |
Ambrx公司 |
包含非天然编码的氨基酸的人生长激素配方
|
|
EP1836298B1
(fr)
|
2004-12-22 |
2012-01-18 |
Ambrx, Inc. |
Compositions de synthetase d'aminoacyl-arnt et utilisations correspondantes
|
|
KR101285904B1
(ko)
|
2005-08-18 |
2013-07-15 |
암브룩스, 인코포레이티드 |
ｔＲＮＡ 조성물 및 이의 용도
|
|
CN101400646A
(zh)
|
2005-11-08 |
2009-04-01 |
Ambrx公司 |
用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂
|
|
AU2006332809A1
(en)
*
|
2005-12-30 |
2007-07-12 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
SI1999259T1
(sl)
|
2006-03-03 |
2014-11-28 |
California Institute Of Technology |
Usmerjeno vključevanje amino kislin v molekule
|
|
JP4616237B2
(ja)
|
2006-11-07 |
2011-01-19 |
日本電信電話株式会社 |
シリコン化合物薄膜の形成方法
|
|
PT2637694T
(pt)
*
|
2010-11-12 |
2021-05-05 |
Nektar Therapeutics |
Conjugados de uma fração de il-2 e um polímero
|
|
US9428567B2
(en)
*
|
2010-12-22 |
2016-08-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Antagonists of interleukin-2 receptor
|
|
DK3489255T3
(da)
*
|
2011-02-10 |
2021-08-23 |
Roche Glycart Ag |
Muterede interleukin-2-polypeptider
|
|
GB201106203D0
(en)
*
|
2011-04-12 |
2011-05-25 |
Univ Geneve |
Decorated macromolecular scaffolds
|
|
CA2946398A1
(fr)
*
|
2014-04-24 |
2015-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Superagonistes, agonistes et antagonistes partiels de l'interleukine-2
|
|
SG11201700629TA
(en)
*
|
2014-08-11 |
2017-02-27 |
Delinia Inc |
Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
|
|
CN115819494A
(zh)
*
|
2015-11-23 |
2023-03-21 |
百时美施贵宝公司 |
用于蛋白质聚乙二醇化的添加剂体系
|
|
US20200181220A1
(en)
|
2017-08-03 |
2020-06-11 |
Synthorx, Inc. |
Cytokine conjugates for the treatment of proliferative and infectious diseases
|
|
EP3665303A4
(fr)
*
|
2017-08-09 |
2021-04-28 |
Orionis Biosciences, Inc. |
Agents de liaison à clec9a et utilisations associées
|