JPWO2020009248A5 - - Google Patents
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- Publication number
- JPWO2020009248A5 JPWO2020009248A5 JP2020529077A JP2020529077A JPWO2020009248A5 JP WO2020009248 A5 JPWO2020009248 A5 JP WO2020009248A5 JP 2020529077 A JP2020529077 A JP 2020529077A JP 2020529077 A JP2020529077 A JP 2020529077A JP WO2020009248 A5 JPWO2020009248 A5 JP WO2020009248A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- tissue
- fibrosis
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001519 tissue Anatomy 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 206010016654 Fibrosis Diseases 0.000 claims 11
- 230000004761 fibrosis Effects 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 230000001629 suppression Effects 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 102000003964 Histone deacetylase Human genes 0.000 claims 2
- 108090000353 Histone deacetylase Proteins 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 208000002352 blister Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000000795 conjunctiva Anatomy 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 210000001525 retina Anatomy 0.000 claims 2
- 230000036573 scar formation Effects 0.000 claims 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 claims 1
- 102100031168 CCN family member 2 Human genes 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 108010002156 Depsipeptides Proteins 0.000 claims 1
- 206010061818 Disease progression Diseases 0.000 claims 1
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 1
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 claims 1
- 101710159002 L-lactate oxidase Proteins 0.000 claims 1
- 101150043981 LOXL2 gene Proteins 0.000 claims 1
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 1
- 102100026858 Protein-lysine 6-oxidase Human genes 0.000 claims 1
- 108050000761 Serpin Proteins 0.000 claims 1
- 102000008847 Serpin Human genes 0.000 claims 1
- 108010046722 Thrombospondin 1 Proteins 0.000 claims 1
- 102100036034 Thrombospondin-1 Human genes 0.000 claims 1
- 102100029529 Thrombospondin-2 Human genes 0.000 claims 1
- 102000005354 Tissue Inhibitor of Metalloproteinase-2 Human genes 0.000 claims 1
- 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims 1
- 102000005406 Tissue Inhibitor of Metalloproteinase-3 Human genes 0.000 claims 1
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- -1 depsipeptide compound Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000003090 exacerbative effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003001 serine protease inhibitor Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 108010060887 thrombospondin 2 Proteins 0.000 claims 1
- 210000001585 trabecular meshwork Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024131200A JP7763438B2 (ja) | 2018-07-04 | 2024-08-07 | 眼組織の線維化抑制用組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018127738 | 2018-07-04 | ||
| JP2018127738 | 2018-07-04 | ||
| PCT/JP2019/027233 WO2020009248A1 (ja) | 2018-07-04 | 2019-07-03 | 眼組織の線維化抑制用組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024131200A Division JP7763438B2 (ja) | 2018-07-04 | 2024-08-07 | 眼組織の線維化抑制用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020009248A1 JPWO2020009248A1 (ja) | 2021-08-12 |
| JPWO2020009248A5 true JPWO2020009248A5 (https=) | 2022-08-09 |
| JP7542799B2 JP7542799B2 (ja) | 2024-09-02 |
Family
ID=69059196
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020529077A Active JP7542799B2 (ja) | 2018-07-04 | 2019-07-03 | 眼組織の線維化抑制用組成物 |
| JP2024131200A Active JP7763438B2 (ja) | 2018-07-04 | 2024-08-07 | 眼組織の線維化抑制用組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024131200A Active JP7763438B2 (ja) | 2018-07-04 | 2024-08-07 | 眼組織の線維化抑制用組成物 |
Country Status (2)
| Country | Link |
|---|---|
| JP (2) | JP7542799B2 (https=) |
| WO (1) | WO2020009248A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7542799B2 (ja) * | 2018-07-04 | 2024-09-02 | 京都府公立大学法人 | 眼組織の線維化抑制用組成物 |
| CN113057142B (zh) * | 2021-03-30 | 2022-12-09 | 四川大学华西医院 | 一种视网膜内和/或视网膜下纤维化动物模型的构建方法 |
| WO2023196555A1 (en) * | 2022-04-08 | 2023-10-12 | University Of North Texas Health Science Center At Fort Worth | Treatment for ocular fibrosis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405274B2 (en) * | 2003-06-04 | 2008-07-29 | Fibrogen, Inc. | Connective tissue growth factor antibodies |
| US7794713B2 (en) * | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| WO2012093125A1 (en) * | 2011-01-06 | 2012-07-12 | Glaxo Group Limited | Ligands that bind tgf-beta receptor ii |
| ES2897740T3 (es) * | 2011-12-28 | 2022-03-02 | Kyoto Prefectural Public Univ Corp | Normalización del cultivo de células endoteliales de la córnea |
| RU2016106641A (ru) * | 2013-07-30 | 2017-09-01 | Киото Прифекчурал Паблик Юниверсити Корпорэйшн | Терапевтические средства, направленные на ecm эндотелия роговицы |
| JP2016113379A (ja) * | 2014-12-11 | 2016-06-23 | 京都府公立大学法人 | 分子標的薬を用いる腫瘍治療及び予防用併用薬 |
| JP7542799B2 (ja) | 2018-07-04 | 2024-09-02 | 京都府公立大学法人 | 眼組織の線維化抑制用組成物 |
-
2019
- 2019-07-03 JP JP2020529077A patent/JP7542799B2/ja active Active
- 2019-07-03 WO PCT/JP2019/027233 patent/WO2020009248A1/ja not_active Ceased
-
2024
- 2024-08-07 JP JP2024131200A patent/JP7763438B2/ja active Active
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