JPWO2020006296A5 - - Google Patents
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- Publication number
- JPWO2020006296A5 JPWO2020006296A5 JP2020573524A JP2020573524A JPWO2020006296A5 JP WO2020006296 A5 JPWO2020006296 A5 JP WO2020006296A5 JP 2020573524 A JP2020573524 A JP 2020573524A JP 2020573524 A JP2020573524 A JP 2020573524A JP WO2020006296 A5 JPWO2020006296 A5 JP WO2020006296A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- pharmaceutically acceptable
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 36
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- 229940002612 prodrug Drugs 0.000 claims 35
- 239000000651 prodrug Substances 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 35
- 239000012453 solvate Substances 0.000 claims 34
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 150000002431 hydrogen Chemical class 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 125000000753 cycloalkyl group Chemical group 0.000 claims 20
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 19
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 18
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 17
- 125000003107 substituted aryl group Chemical group 0.000 claims 16
- 150000001420 substituted heterocyclic compounds Chemical class 0.000 claims 13
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006193 alkinyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000007111 proteostasis Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024094936A JP2024138260A (ja) | 2018-06-27 | 2024-06-12 | プロテアソーム活性増強化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690563P | 2018-06-27 | 2018-06-27 | |
| US201862690565P | 2018-06-27 | 2018-06-27 | |
| US62/690,565 | 2018-06-27 | ||
| US62/690,563 | 2018-06-27 | ||
| PCT/US2019/039600 WO2020006296A1 (en) | 2018-06-27 | 2019-06-27 | Proteasome activity enhancing compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094936A Division JP2024138260A (ja) | 2018-06-27 | 2024-06-12 | プロテアソーム活性増強化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021529792A JP2021529792A (ja) | 2021-11-04 |
| JP2021529792A5 JP2021529792A5 (https=) | 2022-06-29 |
| JPWO2020006296A5 true JPWO2020006296A5 (https=) | 2022-06-29 |
| JP7561632B2 JP7561632B2 (ja) | 2024-10-04 |
Family
ID=67439356
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573524A Active JP7561632B2 (ja) | 2018-06-27 | 2019-06-27 | プロテアソーム活性増強化合物 |
| JP2024094936A Withdrawn JP2024138260A (ja) | 2018-06-27 | 2024-06-12 | プロテアソーム活性増強化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094936A Withdrawn JP2024138260A (ja) | 2018-06-27 | 2024-06-12 | プロテアソーム活性増強化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11560385B2 (https=) |
| EP (1) | EP3814338A1 (https=) |
| JP (2) | JP7561632B2 (https=) |
| KR (1) | KR20210024588A (https=) |
| CN (1) | CN112585132B (https=) |
| AU (1) | AU2019295765B2 (https=) |
| BR (2) | BR112020026580A2 (https=) |
| CA (1) | CA3103954A1 (https=) |
| CL (1) | CL2020003380A1 (https=) |
| CR (1) | CR20200652A (https=) |
| IL (1) | IL279698A (https=) |
| MA (1) | MA53014A (https=) |
| MX (1) | MX2020014082A (https=) |
| PE (1) | PE20211804A1 (https=) |
| PH (1) | PH12020552261A1 (https=) |
| SG (1) | SG11202013026WA (https=) |
| WO (1) | WO2020006296A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112654621B (zh) | 2018-06-27 | 2024-05-14 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
| JP7640458B2 (ja) | 2018-10-05 | 2025-03-05 | アンナプルナ バイオ インコーポレイテッド | Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物 |
| CN111423353B (zh) * | 2020-04-29 | 2022-03-22 | 湖北省生物农药工程研究中心 | 多取代n-芳基吡咯类化合物及其制备方法 |
| CN112142642B (zh) * | 2020-10-15 | 2022-03-04 | 华侨大学 | 一种1,2,3-三取代-5-三氟甲基吡咯衍生物的制备方法 |
| WO2023107597A2 (en) * | 2021-12-08 | 2023-06-15 | Kineta, Inc. | Bicyclic heteroaromatic amide compounds and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1142508A (en) | 1966-04-27 | 1969-02-12 | Whitefin Holding Sa | Pyrrole derivatives |
| GB1154744A (en) | 1966-05-17 | 1969-06-11 | Whitefin Holding Sa | Disubstituted Aminoethanols |
| AP9801302A0 (en) | 1997-07-23 | 2000-01-23 | Pfizer | Indole compounds as anti-inflammatory/analgesic agents.. |
| CZ20002669A3 (cs) | 1998-01-23 | 2001-11-14 | National Jewish Medical And Research Center | Pouľití proteinů tepelného ąoku nebo molekuly nukleové kyseliny, která jej kóduje, přípravek tyto látky obsahující, způsob výběru léčby přecitlivělosti nebo nedostatečnosti průchodu dýchacích cest |
| US7842470B2 (en) | 2001-10-09 | 2010-11-30 | Oregon Health & Science University | Method for pharmacoperones correction of GnRHR mutant protein misfolding |
| US20060148767A1 (en) | 2001-12-06 | 2006-07-06 | George Cioca | Use of acyl salicylates as heat shock inducers |
| EP1682504B1 (en) | 2003-11-12 | 2012-12-26 | Amicus Therapeutics Inc. | Hydroxy piperidine derivatives to treat gaucher disease |
| EP2932982B1 (en) | 2005-05-17 | 2018-10-03 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| CN101541172A (zh) | 2005-06-08 | 2009-09-23 | 阿米库斯治疗学公司 | 溶酶体酶编码基因突变相关的cns紊乱的治疗 |
| US20070207992A1 (en) | 2006-02-21 | 2007-09-06 | Board Of Trustees Of Michigan State University | Geldanamycin derivatives and method of use thereof |
| WO2007131034A1 (en) | 2006-05-03 | 2007-11-15 | The Regents Of The University Of Michigan | Pyrimidone derivatives which are modulators of heat shock protein (hsp) 70 |
| ES2573498T3 (es) | 2006-05-16 | 2016-06-08 | Amicus Therapeutics, Inc. | Opciones de tratamiento para la enfermedad de Fabry |
| PT1860101E (pt) | 2006-05-24 | 2011-07-12 | Amicus Therapeutics Inc | Sal de tartrato da isofagomina e métodos de uso |
| JP5303458B2 (ja) | 2006-06-23 | 2013-10-02 | アミークス セラピューティックス インコーポレイテッド | β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法 |
| US20080119457A1 (en) | 2006-08-24 | 2008-05-22 | Serenex, Inc. | Benzene, Pyridine, and Pyridazine Derivatives |
| WO2009118292A1 (en) | 2008-03-24 | 2009-10-01 | Novartis Ag | Arylsulfonamide-based matrix metalloprotease inhibitors |
| MX336731B (es) * | 2010-01-28 | 2016-01-28 | Harvard College | Composiciones y metodos para potenciar la actividad de proteasoma. |
| DK2707101T3 (da) * | 2011-05-12 | 2019-05-13 | Proteostasis Therapeutics Inc | Proteostaseregulatorer |
| US9849135B2 (en) * | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
| AU2014282886A1 (en) | 2013-06-17 | 2015-12-17 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
| FR3008977A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2015073528A1 (en) * | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
-
2019
- 2019-06-27 BR BR112020026580-2A patent/BR112020026580A2/pt unknown
- 2019-06-27 BR BR122023023216-0A patent/BR122023023216A2/pt unknown
- 2019-06-27 WO PCT/US2019/039600 patent/WO2020006296A1/en not_active Ceased
- 2019-06-27 KR KR1020217002233A patent/KR20210024588A/ko not_active Ceased
- 2019-06-27 AU AU2019295765A patent/AU2019295765B2/en not_active Ceased
- 2019-06-27 MX MX2020014082A patent/MX2020014082A/es unknown
- 2019-06-27 CA CA3103954A patent/CA3103954A1/en active Pending
- 2019-06-27 MA MA053014A patent/MA53014A/fr unknown
- 2019-06-27 SG SG11202013026WA patent/SG11202013026WA/en unknown
- 2019-06-27 CR CR20200652A patent/CR20200652A/es unknown
- 2019-06-27 JP JP2020573524A patent/JP7561632B2/ja active Active
- 2019-06-27 PE PE2020002159A patent/PE20211804A1/es unknown
- 2019-06-27 EP EP19744945.7A patent/EP3814338A1/en not_active Withdrawn
- 2019-06-27 CN CN201980055152.2A patent/CN112585132B/zh active Active
-
2020
- 2020-12-23 PH PH12020552261A patent/PH12020552261A1/en unknown
- 2020-12-23 US US17/133,372 patent/US11560385B2/en active Active
- 2020-12-23 IL IL279698A patent/IL279698A/en unknown
- 2020-12-23 CL CL2020003380A patent/CL2020003380A1/es unknown
-
2022
- 2022-11-18 US US18/057,020 patent/US12319698B2/en active Active
-
2024
- 2024-06-12 JP JP2024094936A patent/JP2024138260A/ja not_active Withdrawn
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