JPWO2020005887A5 - - Google Patents
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- JPWO2020005887A5 JPWO2020005887A5 JP2020572525A JP2020572525A JPWO2020005887A5 JP WO2020005887 A5 JPWO2020005887 A5 JP WO2020005887A5 JP 2020572525 A JP2020572525 A JP 2020572525A JP 2020572525 A JP2020572525 A JP 2020572525A JP WO2020005887 A5 JPWO2020005887 A5 JP WO2020005887A5
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- JP
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- Prior art keywords
- substituted
- pharmaceutically acceptable
- unsubstituted
- acceptable salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 48
- 150000003839 salts Chemical class 0.000 claims description 46
- 208000019622 heart disease Diseases 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000304 alkynyl group Chemical group 0.000 claims description 6
- -1 aminocarbonylamino, aminocarbonyloxy Chemical group 0.000 claims description 6
- 230000000747 cardiac effect Effects 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 6
- 210000002235 sarcomere Anatomy 0.000 claims description 6
- 230000002861 ventricular Effects 0.000 claims description 6
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 4
- 206010052337 Diastolic dysfunction Diseases 0.000 claims description 4
- 206010019280 Heart failures Diseases 0.000 claims description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 230000000414 obstructive effect Effects 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 208000031229 Cardiomyopathies Diseases 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 206010002383 Angina Pectoris Diseases 0.000 claims description 2
- 208000004990 Cardiorenal syndrome Diseases 0.000 claims description 2
- 208000002330 Congenital Heart Defects Diseases 0.000 claims description 2
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims description 2
- 208000021908 Myocardial disease Diseases 0.000 claims description 2
- 206010061876 Obstruction Diseases 0.000 claims description 2
- 206010039163 Right ventricular failure Diseases 0.000 claims description 2
- 208000033774 Ventricular Remodeling Diseases 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 125000004442 acylamino group Chemical group 0.000 claims description 2
- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 230000032683 aging Effects 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims description 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims description 2
- 125000005102 carbonylalkoxy group Chemical group 0.000 claims description 2
- 208000028831 congenital heart disease Diseases 0.000 claims description 2
- 208000029078 coronary artery disease Diseases 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 208000015210 hypertensive heart disease Diseases 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 210000004165 myocardium Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000004001 thioalkyl group Chemical group 0.000 claims description 2
- 150000003573 thiols Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 10
- 238000000034 method Methods 0.000 description 19
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 206010053185 Glycogen storage disease type II Diseases 0.000 description 3
- 208000011518 Danon disease Diseases 0.000 description 2
- 208000024720 Fabry Disease Diseases 0.000 description 2
- 208000001500 Glycogen Storage Disease Type IIb Diseases 0.000 description 2
- 208000035148 Glycogen storage disease due to LAMP-2 deficiency Diseases 0.000 description 2
- 206010047295 Ventricular hypertrophy Diseases 0.000 description 2
- 230000009787 cardiac fibrosis Effects 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 208000007345 glycogen storage disease Diseases 0.000 description 2
- 201000006938 muscular dystrophy Diseases 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 208000003017 Aortic Valve Stenosis Diseases 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 206010027727 Mitral valve incompetence Diseases 0.000 description 1
- 206010029748 Noonan syndrome Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 206010002022 amyloidosis Diseases 0.000 description 1
- 206010002906 aortic stenosis Diseases 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000028208 end stage renal disease Diseases 0.000 description 1
- 201000000523 end stage renal failure Diseases 0.000 description 1
- 201000004502 glycogen storage disease II Diseases 0.000 description 1
- 208000018578 heart valve disease Diseases 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690248P | 2018-06-26 | 2018-06-26 | |
| US62/690,248 | 2018-06-26 | ||
| PCT/US2019/038907 WO2020005887A1 (en) | 2018-06-26 | 2019-06-25 | Cardiac sarcomere inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021529185A JP2021529185A (ja) | 2021-10-28 |
| JPWO2020005887A5 true JPWO2020005887A5 (https=) | 2022-07-04 |
| JP2021529185A5 JP2021529185A5 (https=) | 2022-07-04 |
| JP7438148B2 JP7438148B2 (ja) | 2024-02-26 |
Family
ID=67211970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020572525A Active JP7438148B2 (ja) | 2018-06-26 | 2019-06-25 | 心臓サルコメア阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11964967B2 (https=) |
| EP (1) | EP3814342B1 (https=) |
| JP (1) | JP7438148B2 (https=) |
| WO (1) | WO2020005887A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020014428A2 (pt) | 2018-01-19 | 2020-12-01 | Cytokinetics, Inc. | composto, composição farmacêutica, e, métodos para o tratamento de uma doença cardíaca em um indivíduo, para o tratamento de uma doença ou condição que está associada com cavidade ventricular esquerda pequena e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia do miocárdio ou fibrose cardíaca, para o tratamento de uma doença ou condição selecionada dentre distrofias musculares e doenças de armazenamento do glicogênio e para inibição do sarcômero cardíaco |
| JP7610985B2 (ja) * | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| EP3814342B1 (en) | 2018-06-26 | 2022-07-27 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| JP7447089B2 (ja) | 2018-08-31 | 2024-03-11 | サイトキネティックス， インコーポレイテッド | 心筋サルコメア阻害剤 |
| CA3190060A1 (en) | 2020-08-28 | 2022-03-03 | MyoKardia, Inc. | Methods of treatment with myosin modulator |
| MX2023010125A (es) | 2021-03-04 | 2023-09-11 | Cytokinetics Inc | Inhibidores del sarcomero cardiaco. |
| AU2023213659A1 (en) * | 2022-01-27 | 2024-08-29 | Soter Biopharma Pte. Ltd. | Crystal form of 7-azaspiro[4,5]decane-6,10-dione compound and preparation method therefor |
| US20230338378A1 (en) | 2022-04-26 | 2023-10-26 | MyoKardia, Inc. | Methods of Administering Myosin Inhibitors |
| CN115894361A (zh) * | 2022-12-28 | 2023-04-04 | 上海合全药业股份有限公司 | 一种钯催化合成1-乙酰基-6-氰基-四氢喹啉的方法 |
| WO2025096779A2 (en) | 2023-11-01 | 2025-05-08 | Bristol Myers Squibb Company | Methods of treatment with a myosin inhibitor using protein levels |
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| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5919785A (en) | 1996-04-03 | 1999-07-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO2003059265A2 (en) | 2001-12-21 | 2003-07-24 | Cytokinetics, Inc. | Compositions and methods for treating heart failure |
| CA2511970C (en) | 2003-01-14 | 2012-06-26 | Cytokinetics, Inc. | Urea derivatives useful in the treatment of heart failure |
| WO2004064760A2 (en) | 2003-01-21 | 2004-08-05 | Archemix Corp. | Aptamer therapeutics useful in ocular pharmacotherapy |
| ES2378620T3 (es) | 2003-03-27 | 2012-04-16 | Cytokinetics, Inc. | Sulfonamidas para el tratamiento de insuficiencia cardiaca congestiva, sus composiciones y usos. |
| US7393852B2 (en) | 2003-06-20 | 2008-07-01 | Amgen Inc. | Piperazine derivatives and methods of use |
| JP5080970B2 (ja) | 2004-06-17 | 2012-11-21 | サイトキネティクス・インコーポレーテッド | 心疾患を治療するための置換尿素誘導体 |
| US20060173183A1 (en) | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
| MX2007012883A (es) | 2005-04-22 | 2007-12-10 | Wyeth Corp | Derivados de dihidrobenzofurano y usos de los mismos. |
| EP1959962A2 (en) | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| RU2318818C1 (ru) | 2006-04-12 | 2008-03-10 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты) |
| SA08290245B1 (ar) | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
| US20090192168A1 (en) | 2008-01-04 | 2009-07-30 | Alex Muci | Compounds, Compositions and Methods |
| US20110275673A1 (en) | 2008-09-19 | 2011-11-10 | Yibin Xiang | Inhibitors of sphingosine kinase 1 |
| HRP20140371T1 (hr) | 2009-05-15 | 2014-05-23 | Novartis Ag | Arilpiridini kao inhibitori sinteze aldosterona |
| US8592426B2 (en) | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
| US8759380B2 (en) * | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
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| EA024204B1 (ru) | 2012-01-20 | 2016-08-31 | Актелион Фармасьютиклз Лтд. | Производные гетероциклических амидов в качестве антагонистов p2xрецептора |
| SMT202000071T1 (it) | 2013-06-21 | 2020-03-13 | Myokardia Inc | Composti di pirimidinadione contro le condizioni cardiache |
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| BR112018012390B1 (pt) | 2015-12-17 | 2023-03-14 | Syngenta Participations Ag | Derivados de oxadiazol microbiocidas |
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| EP3519416B1 (en) | 2016-09-27 | 2021-03-31 | Merck Sharp & Dohme Corp. | Chromane, isochromane and dihydroisobenzofuran derivatives as mglur2-negative allosteric modulators, compositions, and their use |
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| WO2018156883A1 (en) | 2017-02-23 | 2018-08-30 | Board Of Regents, The University Of Texas System | Methods of treatment for cancer, sterol homeostasis, and neurological diseases |
| JP7123956B2 (ja) * | 2017-02-28 | 2022-08-23 | ヘリオイースト・ファーマシューティカル・カンパニー・リミテッド | スピロ化合物およびその使用 |
| FI3661514T3 (fi) | 2017-08-04 | 2025-12-12 | Myokardia Inc | Mavakamteeni käytettäväksi hypertrofisen kardiomyopatian hoidossa |
| BR112020014428A2 (pt) * | 2018-01-19 | 2020-12-01 | Cytokinetics, Inc. | composto, composição farmacêutica, e, métodos para o tratamento de uma doença cardíaca em um indivíduo, para o tratamento de uma doença ou condição que está associada com cavidade ventricular esquerda pequena e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia do miocárdio ou fibrose cardíaca, para o tratamento de uma doença ou condição selecionada dentre distrofias musculares e doenças de armazenamento do glicogênio e para inibição do sarcômero cardíaco |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US10710994B2 (en) | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
| EP3814342B1 (en) | 2018-06-26 | 2022-07-27 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| JP7610985B2 (ja) | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| JP7447089B2 (ja) | 2018-08-31 | 2024-03-11 | サイトキネティックス， インコーポレイテッド | 心筋サルコメア阻害剤 |
| KR20210054510A (ko) | 2018-08-31 | 2021-05-13 | 제논 파마슈티칼스 인크. | 헤테로아릴-치환된 술폰아미드 화합물 및 치료제로서의 그의 용도 |
| EP3999180B1 (en) | 2019-07-17 | 2024-05-08 | Cytokinetics, Inc. | Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide |
| CA3144974A1 (en) | 2019-07-17 | 2021-01-21 | Norma TOM | Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide |
| HRP20240200T1 (hr) | 2019-07-17 | 2024-04-26 | Cytokinetics, Inc. | Oralne formulacije inhibitora kardijskih sarkomera |
| CA3190060A1 (en) | 2020-08-28 | 2022-03-03 | MyoKardia, Inc. | Methods of treatment with myosin modulator |
| MX2023010125A (es) | 2021-03-04 | 2023-09-11 | Cytokinetics Inc | Inhibidores del sarcomero cardiaco. |
| EP4370116B1 (en) | 2021-07-16 | 2025-01-15 | Cytokinetics, Inc. | Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy |
| US20230338378A1 (en) | 2022-04-26 | 2023-10-26 | MyoKardia, Inc. | Methods of Administering Myosin Inhibitors |
-
2019
- 2019-06-25 EP EP19737444.0A patent/EP3814342B1/en active Active
- 2019-06-25 JP JP2020572525A patent/JP7438148B2/ja active Active
- 2019-06-25 WO PCT/US2019/038907 patent/WO2020005887A1/en not_active Ceased
- 2019-06-25 US US17/255,336 patent/US11964967B2/en active Active
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