JPWO2019246552A5 - - Google Patents

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Publication number
JPWO2019246552A5
JPWO2019246552A5 JP2020571366A JP2020571366A JPWO2019246552A5 JP WO2019246552 A5 JPWO2019246552 A5 JP WO2019246552A5 JP 2020571366 A JP2020571366 A JP 2020571366A JP 2020571366 A JP2020571366 A JP 2020571366A JP WO2019246552 A5 JPWO2019246552 A5 JP WO2019246552A5
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JP
Japan
Prior art keywords
composition according
gram
lactam antibiotic
seq
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020571366A
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English (en)
Japanese (ja)
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JP2021527699A (ja
JP2021527699A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/038525 external-priority patent/WO2019246552A1/en
Publication of JP2021527699A publication Critical patent/JP2021527699A/ja
Publication of JPWO2019246552A5 publication Critical patent/JPWO2019246552A5/ja
Publication of JP2021527699A5 publication Critical patent/JP2021527699A5/ja
Pending legal-status Critical Current

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JP2020571366A 2018-06-22 2019-06-21 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する Pending JP2021527699A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862688756P 2018-06-22 2018-06-22
US62/688,756 2018-06-22
PCT/US2019/038525 WO2019246552A1 (en) 2018-06-22 2019-06-21 Lysins and derivatives thereof resensitize staphylococcus aureus and gram-positive bacteria to antibiotics

Publications (3)

Publication Number Publication Date
JP2021527699A JP2021527699A (ja) 2021-10-14
JPWO2019246552A5 true JPWO2019246552A5 (https=) 2022-06-29
JP2021527699A5 JP2021527699A5 (https=) 2022-06-29

Family

ID=68983065

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020571366A Pending JP2021527699A (ja) 2018-06-22 2019-06-21 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する

Country Status (11)

Country Link
US (1) US20210260070A1 (https=)
EP (1) EP3809851A4 (https=)
JP (1) JP2021527699A (https=)
KR (1) KR20210024005A (https=)
CN (2) CN116850269A (https=)
AU (1) AU2019288723A1 (https=)
BR (1) BR112020026267A2 (https=)
CA (1) CA3104650A1 (https=)
IL (1) IL279596A (https=)
MX (1) MX2020013935A (https=)
WO (1) WO2019246552A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020210691A1 (en) * 2019-04-11 2020-10-15 Contrafect Corporation Method of treating and preventing bone and joint infections
US20220087266A1 (en) * 2020-09-22 2022-03-24 Mars, Incorporated Compositions and methods for controlling mycotoxin production
WO2022261360A1 (en) * 2021-06-09 2022-12-15 Contrafect Corporation Plyss2 lysins and variants thereof for use against multidrug resistant gram-positive bacteria
AU2022292185A1 (en) * 2021-06-15 2024-02-01 Ferring B.V. Bacteriophages against vancomycin-resistant enterococci
CN118308337A (zh) * 2023-01-09 2024-07-09 华中农业大学 一种细菌裂解酶LLysSA9.10及其应用
CN117965624B (zh) * 2023-10-11 2024-12-17 圆因(北京)生物科技有限公司 一种用于编码耐甲氧西林金黄色葡萄球菌内溶素的线性dna、线性rna及其质粒表达载体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2103308A1 (de) * 2008-03-20 2009-09-23 PhytoLine GmbH Verfahren zur Herstellung eines Gemisches von Bakteriophagen und deren Verwendung für die Therapie von Antibiotika-resistenten Staphylococcen
WO2010002959A2 (en) * 2008-07-03 2010-01-07 The Rockefeller University A chimeric bacteriophage lysin with activity against staphylococci bacteria
TW201028154A (en) * 2008-10-23 2010-08-01 Novozymes As Antibiotic synergism
RU2018121290A (ru) * 2012-05-09 2019-03-06 Контрафект Корпорейшн Комбинации лизина бактериофага и антибиотика против грам-положительных бактерий
EP4115897A1 (en) * 2015-09-17 2023-01-11 Contrafect Corporation Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby

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