JP2021527699A5 - - Google Patents

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Publication number
JP2021527699A5
JP2021527699A5 JP2020571366A JP2020571366A JP2021527699A5 JP 2021527699 A5 JP2021527699 A5 JP 2021527699A5 JP 2020571366 A JP2020571366 A JP 2020571366A JP 2020571366 A JP2020571366 A JP 2020571366A JP 2021527699 A5 JP2021527699 A5 JP 2021527699A5
Authority
JP
Japan
Prior art keywords
composition according
gram
positive bacteria
lactam antibiotic
amino acid
Prior art date
Application number
JP2020571366A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021527699A (ja
JPWO2019246552A5 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/038525 external-priority patent/WO2019246552A1/en
Publication of JP2021527699A publication Critical patent/JP2021527699A/ja
Publication of JPWO2019246552A5 publication Critical patent/JPWO2019246552A5/ja
Publication of JP2021527699A5 publication Critical patent/JP2021527699A5/ja
Pending legal-status Critical Current

Links

JP2020571366A 2018-06-22 2019-06-21 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する Pending JP2021527699A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862688756P 2018-06-22 2018-06-22
US62/688,756 2018-06-22
PCT/US2019/038525 WO2019246552A1 (en) 2018-06-22 2019-06-21 Lysins and derivatives thereof resensitize staphylococcus aureus and gram-positive bacteria to antibiotics

Publications (3)

Publication Number Publication Date
JP2021527699A JP2021527699A (ja) 2021-10-14
JPWO2019246552A5 JPWO2019246552A5 (https=) 2022-06-29
JP2021527699A5 true JP2021527699A5 (https=) 2022-06-29

Family

ID=68983065

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020571366A Pending JP2021527699A (ja) 2018-06-22 2019-06-21 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する

Country Status (11)

Country Link
US (1) US20210260070A1 (https=)
EP (1) EP3809851A4 (https=)
JP (1) JP2021527699A (https=)
KR (1) KR20210024005A (https=)
CN (2) CN116850269A (https=)
AU (1) AU2019288723A1 (https=)
BR (1) BR112020026267A2 (https=)
CA (1) CA3104650A1 (https=)
IL (1) IL279596A (https=)
MX (1) MX2020013935A (https=)
WO (1) WO2019246552A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020210691A1 (en) * 2019-04-11 2020-10-15 Contrafect Corporation Method of treating and preventing bone and joint infections
US20220087266A1 (en) * 2020-09-22 2022-03-24 Mars, Incorporated Compositions and methods for controlling mycotoxin production
WO2022261360A1 (en) * 2021-06-09 2022-12-15 Contrafect Corporation Plyss2 lysins and variants thereof for use against multidrug resistant gram-positive bacteria
AU2022292185A1 (en) * 2021-06-15 2024-02-01 Ferring B.V. Bacteriophages against vancomycin-resistant enterococci
CN118308337A (zh) * 2023-01-09 2024-07-09 华中农业大学 一种细菌裂解酶LLysSA9.10及其应用
CN117965624B (zh) * 2023-10-11 2024-12-17 圆因(北京)生物科技有限公司 一种用于编码耐甲氧西林金黄色葡萄球菌内溶素的线性dna、线性rna及其质粒表达载体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2103308A1 (de) * 2008-03-20 2009-09-23 PhytoLine GmbH Verfahren zur Herstellung eines Gemisches von Bakteriophagen und deren Verwendung für die Therapie von Antibiotika-resistenten Staphylococcen
WO2010002959A2 (en) * 2008-07-03 2010-01-07 The Rockefeller University A chimeric bacteriophage lysin with activity against staphylococci bacteria
TW201028154A (en) * 2008-10-23 2010-08-01 Novozymes As Antibiotic synergism
RU2018121290A (ru) * 2012-05-09 2019-03-06 Контрафект Корпорейшн Комбинации лизина бактериофага и антибиотика против грам-положительных бактерий
EP4115897A1 (en) * 2015-09-17 2023-01-11 Contrafect Corporation Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby

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