JPWO2019220125A5 - - Google Patents
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- Publication number
- JPWO2019220125A5 JPWO2019220125A5 JP2021514493A JP2021514493A JPWO2019220125A5 JP WO2019220125 A5 JPWO2019220125 A5 JP WO2019220125A5 JP 2021514493 A JP2021514493 A JP 2021514493A JP 2021514493 A JP2021514493 A JP 2021514493A JP WO2019220125 A5 JPWO2019220125 A5 JP WO2019220125A5
- Authority
- JP
- Japan
- Prior art keywords
- infections
- alkyl
- compound
- group
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 22
- 208000015181 infectious disease Diseases 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 201000010099 disease Diseases 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 12
- 206010035664 Pneumonia Diseases 0.000 claims 10
- 206010040047 Sepsis Diseases 0.000 claims 8
- 241000894006 Bacteria Species 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 206010062255 Soft tissue infection Diseases 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 206010040872 skin infection Diseases 0.000 claims 6
- 208000019206 urinary tract infection Diseases 0.000 claims 6
- 239000003242 anti bacterial agent Substances 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 206010060968 Arthritis infective Diseases 0.000 claims 4
- 206010011409 Cross infection Diseases 0.000 claims 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims 4
- 206010027202 Meningitis bacterial Diseases 0.000 claims 4
- 206010029379 Neutrophilia Diseases 0.000 claims 4
- 230000001154 acute effect Effects 0.000 claims 4
- 201000009904 bacterial meningitis Diseases 0.000 claims 4
- 206010014665 endocarditis Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 230000002458 infectious effect Effects 0.000 claims 4
- 102000020235 metallo-beta-lactamase Human genes 0.000 claims 4
- 108060004734 metallo-beta-lactamase Proteins 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 241000588914 Enterobacter Species 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 208000037815 bloodstream infection Diseases 0.000 claims 2
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical group C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000007912 intraperitoneal administration Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960002260 meropenem Drugs 0.000 claims 2
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 208000013223 septicemia Diseases 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- KEDAXBWZURNCHS-GPODMPQUSA-N (4r,5s,6s)-3-[(3s,5s)-5-[(3s)-3-[[2-(diaminomethylideneamino)acetyl]amino]pyrrolidine-1-carbonyl]-1-methylpyrrolidin-3-yl]sulfanyl-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound O=C([C@@H]1C[C@@H](CN1C)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)N1CC[C@H](NC(=O)CN=C(N)N)C1 KEDAXBWZURNCHS-GPODMPQUSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- HGGAKXAHAYOLDJ-FHZUQPTBSA-N 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid Chemical compound S([C@@H]1[C@H](C(N1C=1C(O)=O)=O)[C@H](O)C)C=1[C@H]1CCCO1 HGGAKXAHAYOLDJ-FHZUQPTBSA-N 0.000 claims 1
- CWXYHOHYCJXYFQ-UHFFFAOYSA-N Betamipron Chemical compound OC(=O)CCNC(=O)C1=CC=CC=C1 CWXYHOHYCJXYFQ-UHFFFAOYSA-N 0.000 claims 1
- 241000589562 Brucella Species 0.000 claims 1
- 241001453380 Burkholderia Species 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 241000588923 Citrobacter Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- JUZNIMUFDBIJCM-ANEDZVCMSA-N Invanz Chemical compound O=C([C@H]1NC[C@H](C1)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)NC1=CC=CC(C(O)=O)=C1 JUZNIMUFDBIJCM-ANEDZVCMSA-N 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000588621 Moraxella Species 0.000 claims 1
- TYMABNNERDVXID-DLYFRVTGSA-N Panipenem Chemical compound C([C@@H]1[C@H](C(N1C=1C(O)=O)=O)[C@H](O)C)C=1S[C@H]1CCN(C(C)=N)C1 TYMABNNERDVXID-DLYFRVTGSA-N 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 229950007599 betamipron Drugs 0.000 claims 1
- 229960003169 biapenem Drugs 0.000 claims 1
- MRMBZHPJVKCOMA-YJFSRANCSA-N biapenem Chemical compound C1N2C=NC=[N+]2CC1SC([C@@H]1C)=C(C([O-])=O)N2[C@H]1[C@@H]([C@H](O)C)C2=O MRMBZHPJVKCOMA-YJFSRANCSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 229960000895 doripenem Drugs 0.000 claims 1
- AVAACINZEOAHHE-VFZPANTDSA-N doripenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](CNS(N)(=O)=O)C1 AVAACINZEOAHHE-VFZPANTDSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229960002770 ertapenem Drugs 0.000 claims 1
- 229960000379 faropenem Drugs 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 claims 1
- 229960002182 imipenem Drugs 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 229950011346 panipenem Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- -1 razpenem Chemical compound 0.000 claims 1
- SNUDIPVBUUXCDG-QHSBEEBCSA-N tebipenem pivoxil Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(=O)OCOC(=O)C(C)(C)C)=O)[C@H](O)C)SC(C1)CN1C1=NCCS1 SNUDIPVBUUXCDG-QHSBEEBCSA-N 0.000 claims 1
- 229950003816 tomopenem Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1807966.5A GB201807966D0 (en) | 2018-05-16 | 2018-05-16 | Antibacterial compounds |
| GB1807966.5 | 2018-05-16 | ||
| GB1905174.7 | 2019-04-11 | ||
| GBGB1905174.7A GB201905174D0 (en) | 2019-04-11 | 2019-04-11 | Antibacterial compounds |
| PCT/GB2019/051349 WO2019220125A1 (en) | 2018-05-16 | 2019-05-16 | Antibacterial compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021524866A JP2021524866A (ja) | 2021-09-16 |
| JPWO2019220125A5 true JPWO2019220125A5 (https=) | 2022-05-20 |
| JP2021524866A5 JP2021524866A5 (https=) | 2022-05-20 |
| JP7386853B2 JP7386853B2 (ja) | 2023-11-27 |
Family
ID=66641162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021514493A Active JP7386853B2 (ja) | 2018-05-16 | 2019-05-16 | 抗菌化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11459296B2 (https=) |
| EP (1) | EP3793990B1 (https=) |
| JP (1) | JP7386853B2 (https=) |
| KR (1) | KR102807772B1 (https=) |
| CN (2) | CN118307515A (https=) |
| AU (1) | AU2019269544B2 (https=) |
| BR (1) | BR112020023155A2 (https=) |
| CA (1) | CA3098138A1 (https=) |
| ES (1) | ES2952981T3 (https=) |
| IL (1) | IL278571B2 (https=) |
| MX (1) | MX2020012263A (https=) |
| SG (1) | SG11202011298YA (https=) |
| WO (1) | WO2019220125A1 (https=) |
| ZA (1) | ZA202006612B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019269544B2 (en) | 2018-05-16 | 2024-03-21 | Infex Therapeutics Limited | Antibacterial compounds |
| GB201901559D0 (en) * | 2019-02-05 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compositions |
| GB201916915D0 (en) | 2019-11-20 | 2020-01-01 | Amr Centre Ltd | Compounds |
| GB202015885D0 (en) | 2020-10-07 | 2020-11-18 | Infex Therapeutics Ltd | Synthesis of pyrrole acid derivatives |
| GB2602096A (en) * | 2020-12-17 | 2022-06-22 | Infex Therapeutics Ltd | Compounds |
| IL314027B2 (en) | 2022-01-30 | 2025-04-01 | Xtend Ai Inc | Offline operation method of a smart, multi-purpose robot |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143776A (en) * | 2000-02-02 | 2000-11-07 | Sunesis Pharmaceuticals, Inc. | Tosylproline analogs as thymidylate synthase inhibitors |
| CN1871248A (zh) * | 2003-08-21 | 2006-11-29 | 格里菲斯大学 | 新型次磺酰胺氧化物 |
| EP2511263A1 (en) * | 2011-04-14 | 2012-10-17 | Phenex Pharmaceuticals AG | Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
| TWI651300B (zh) | 2013-05-17 | 2019-02-21 | 健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| GB201310542D0 (en) | 2013-06-13 | 2013-07-31 | Antabio Sas | Compounds |
| WO2015112441A1 (en) * | 2014-01-22 | 2015-07-30 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors |
| CN107405333A (zh) * | 2015-02-27 | 2017-11-28 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物 |
| WO2016187521A1 (en) | 2015-05-21 | 2016-11-24 | South Connecticut State University | 5-substituted 1 h-tetrazole compounds, methods of synthesizing and therapeutic use |
| GB201521059D0 (en) | 2015-11-30 | 2016-01-13 | Isis Innovation | Inhibitors of metallo-beta-lactamases |
| EP3272739A1 (en) | 2016-07-20 | 2018-01-24 | NodThera Limited | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity |
| GB201708457D0 (en) | 2017-05-26 | 2017-07-12 | Univ Oxford Innovation Ltd | Inhibitors of metallo-beta-lactamases |
| AU2019269544B2 (en) | 2018-05-16 | 2024-03-21 | Infex Therapeutics Limited | Antibacterial compounds |
| GB201916915D0 (en) * | 2019-11-20 | 2020-01-01 | Amr Centre Ltd | Compounds |
-
2019
- 2019-05-16 AU AU2019269544A patent/AU2019269544B2/en active Active
- 2019-05-16 CN CN202410414602.5A patent/CN118307515A/zh active Pending
- 2019-05-16 BR BR112020023155-0A patent/BR112020023155A2/pt active Search and Examination
- 2019-05-16 ES ES19726097T patent/ES2952981T3/es active Active
- 2019-05-16 CN CN201980048368.6A patent/CN112449638A/zh active Pending
- 2019-05-16 WO PCT/GB2019/051349 patent/WO2019220125A1/en not_active Ceased
- 2019-05-16 SG SG11202011298YA patent/SG11202011298YA/en unknown
- 2019-05-16 KR KR1020207035409A patent/KR102807772B1/ko active Active
- 2019-05-16 MX MX2020012263A patent/MX2020012263A/es unknown
- 2019-05-16 IL IL278571A patent/IL278571B2/en unknown
- 2019-05-16 JP JP2021514493A patent/JP7386853B2/ja active Active
- 2019-05-16 US US17/055,506 patent/US11459296B2/en active Active
- 2019-05-16 CA CA3098138A patent/CA3098138A1/en active Pending
- 2019-05-16 EP EP19726097.9A patent/EP3793990B1/en active Active
-
2020
- 2020-10-23 ZA ZA2020/06612A patent/ZA202006612B/en unknown
-
2022
- 2022-09-16 US US17/946,587 patent/US11845725B2/en active Active
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