JPWO2019217684A5 - - Google Patents
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- Publication number
- JPWO2019217684A5 JPWO2019217684A5 JP2020563439A JP2020563439A JPWO2019217684A5 JP WO2019217684 A5 JPWO2019217684 A5 JP WO2019217684A5 JP 2020563439 A JP2020563439 A JP 2020563439A JP 2020563439 A JP2020563439 A JP 2020563439A JP WO2019217684 A5 JPWO2019217684 A5 JP WO2019217684A5
- Authority
- JP
- Japan
- Prior art keywords
- bound
- drug
- quencher
- amount
- surrogate peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 21
- 229940079593 drug Drugs 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 238000003556 assay Methods 0.000 claims 8
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims 3
- 230000002934 lysing effect Effects 0.000 claims 3
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 230000029087 digestion Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000003312 immunocapture Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024177293A JP2025011208A (ja) | 2018-05-10 | 2024-10-09 | インビボ受容体占有率を決定するためのアッセイ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862669442P | 2018-05-10 | 2018-05-10 | |
| US62/669,442 | 2018-05-10 | ||
| PCT/US2019/031524 WO2019217684A1 (en) | 2018-05-10 | 2019-05-09 | Assay to determine in vivo receptor occupancy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024177293A Division JP2025011208A (ja) | 2018-05-10 | 2024-10-09 | インビボ受容体占有率を決定するためのアッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523367A JP2021523367A (ja) | 2021-09-02 |
| JPWO2019217684A5 true JPWO2019217684A5 (enExample) | 2022-04-22 |
| JP7570925B2 JP7570925B2 (ja) | 2024-10-22 |
Family
ID=66821369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020563439A Active JP7570925B2 (ja) | 2018-05-10 | 2019-05-09 | インビボ受容体占有率を決定するためのアッセイ |
| JP2024177293A Withdrawn JP2025011208A (ja) | 2018-05-10 | 2024-10-09 | インビボ受容体占有率を決定するためのアッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024177293A Withdrawn JP2025011208A (ja) | 2018-05-10 | 2024-10-09 | インビボ受容体占有率を決定するためのアッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US12085564B2 (enExample) |
| EP (1) | EP3791183B1 (enExample) |
| JP (2) | JP7570925B2 (enExample) |
| KR (2) | KR20250021652A (enExample) |
| CN (2) | CN113804873B (enExample) |
| ES (1) | ES2992942T3 (enExample) |
| WO (1) | WO2019217684A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250021652A (ko) | 2018-05-10 | 2025-02-13 | 브리스톨-마이어스 스큅 컴퍼니 | 생체내 수용체 점유율을 결정하기 위한 검정 |
| CN115932261B (zh) * | 2022-08-15 | 2025-07-25 | 广州医科大学附属第五医院 | 一种btk受体占有率的检测方法 |
| CN116482345B (zh) * | 2023-06-16 | 2023-09-22 | 军科正源（北京）药物研究有限责任公司 | 用于检测双靶点药物受体占有率的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090062255A1 (en) * | 2007-08-17 | 2009-03-05 | Thallion Pharmaceuticals Inc. | Tumor-targeting evaluation methodology and compounds related thereto |
| WO2012010240A1 (en) * | 2010-07-19 | 2012-01-26 | Cellzome Ag | In vivo method for the evaluation of a compound-target interaction |
| EP3033625B1 (en) * | 2013-08-13 | 2020-01-22 | The Scripps Research Institute | Cysteine-reactive ligand discovery in proteomes |
| WO2016100593A1 (en) * | 2014-12-17 | 2016-06-23 | Pharmacyclics Llc | Methods and assays for quantification and normalization of kinase and ligand binding |
| KR20250021652A (ko) | 2018-05-10 | 2025-02-13 | 브리스톨-마이어스 스큅 컴퍼니 | 생체내 수용체 점유율을 결정하기 위한 검정 |
-
2019
- 2019-05-09 KR KR1020257003448A patent/KR20250021652A/ko active Pending
- 2019-05-09 JP JP2020563439A patent/JP7570925B2/ja active Active
- 2019-05-09 KR KR1020207035120A patent/KR102764357B1/ko active Active
- 2019-05-09 US US17/051,466 patent/US12085564B2/en active Active
- 2019-05-09 EP EP19729943.1A patent/EP3791183B1/en active Active
- 2019-05-09 CN CN202110955643.1A patent/CN113804873B/zh active Active
- 2019-05-09 WO PCT/US2019/031524 patent/WO2019217684A1/en not_active Ceased
- 2019-05-09 CN CN201980031353.9A patent/CN112105930B/zh active Active
- 2019-05-09 ES ES19729943T patent/ES2992942T3/es active Active
-
2024
- 2024-07-31 US US18/791,084 patent/US20250085279A1/en active Pending
- 2024-10-09 JP JP2024177293A patent/JP2025011208A/ja not_active Withdrawn
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