CN113804873B - 确定体内受体占有率的测定 - Google Patents
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| CN115932261B (zh) * | 2022-08-15 | 2025-07-25 | 广州医科大学附属第五医院 | 一种btk受体占有率的检测方法 |
| CN116482345B (zh) * | 2023-06-16 | 2023-09-22 | 军科正源（北京）药物研究有限责任公司 | 用于检测双靶点药物受体占有率的方法 |
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| US20090062255A1 (en) | 2007-08-17 | 2009-03-05 | Thallion Pharmaceuticals Inc. | Tumor-targeting evaluation methodology and compounds related thereto |
| WO2012010240A1 (en) | 2010-07-19 | 2012-01-26 | Cellzome Ag | In vivo method for the evaluation of a compound-target interaction |
| EP3033625B1 (en) | 2013-08-13 | 2020-01-22 | The Scripps Research Institute | Cysteine-reactive ligand discovery in proteomes |
| WO2016100593A1 (en) * | 2014-12-17 | 2016-06-23 | Pharmacyclics Llc | Methods and assays for quantification and normalization of kinase and ligand binding |
| EP3791183B1 (en) | 2018-05-10 | 2024-07-24 | Bristol-Myers Squibb Company | Assay to determine in vivo receptor occupancy |
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| Title |
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| 李荣珊 等.LC-MS/MS法测定恒河猴血浆中巴替非班的浓度及药代动力学研究.中国新药杂志.2012,(第15期),第1798-1802页. * |
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| CN112105930A (zh) | 2020-12-18 |
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| ES2992942T3 (en) | 2024-12-20 |
| US20250085279A1 (en) | 2025-03-13 |
| KR20210008028A (ko) | 2021-01-20 |
| US12085564B2 (en) | 2024-09-10 |
| CN112105930B (zh) | 2025-02-28 |
| EP3791183A1 (en) | 2021-03-17 |
| CN113804873A (zh) | 2021-12-17 |
| EP3791183B1 (en) | 2024-07-24 |
| KR20250021652A (ko) | 2025-02-13 |
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