ES2992942T3 - Assay to determine in vivo receptor occupancy - Google Patents
Assay to determine in vivo receptor occupancy Download PDFInfo
- Publication number
- ES2992942T3 ES2992942T3 ES19729943T ES19729943T ES2992942T3 ES 2992942 T3 ES2992942 T3 ES 2992942T3 ES 19729943 T ES19729943 T ES 19729943T ES 19729943 T ES19729943 T ES 19729943T ES 2992942 T3 ES2992942 T3 ES 2992942T3
- Authority
- ES
- Spain
- Prior art keywords
- bound
- drug
- btk
- quencher
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862669442P | 2018-05-10 | 2018-05-10 | |
| PCT/US2019/031524 WO2019217684A1 (en) | 2018-05-10 | 2019-05-09 | Assay to determine in vivo receptor occupancy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2992942T3 true ES2992942T3 (en) | 2024-12-20 |
Family
ID=66821369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19729943T Active ES2992942T3 (en) | 2018-05-10 | 2019-05-09 | Assay to determine in vivo receptor occupancy |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US12085564B2 (enExample) |
| EP (1) | EP3791183B1 (enExample) |
| JP (2) | JP7570925B2 (enExample) |
| KR (2) | KR20250021652A (enExample) |
| CN (2) | CN113804873B (enExample) |
| ES (1) | ES2992942T3 (enExample) |
| WO (1) | WO2019217684A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250021652A (ko) | 2018-05-10 | 2025-02-13 | 브리스톨-마이어스 스큅 컴퍼니 | 생체내 수용체 점유율을 결정하기 위한 검정 |
| CN115932261B (zh) * | 2022-08-15 | 2025-07-25 | 广州医科大学附属第五医院 | 一种btk受体占有率的检测方法 |
| CN116482345B (zh) * | 2023-06-16 | 2023-09-22 | 军科正源（北京）药物研究有限责任公司 | 用于检测双靶点药物受体占有率的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090062255A1 (en) * | 2007-08-17 | 2009-03-05 | Thallion Pharmaceuticals Inc. | Tumor-targeting evaluation methodology and compounds related thereto |
| WO2012010240A1 (en) * | 2010-07-19 | 2012-01-26 | Cellzome Ag | In vivo method for the evaluation of a compound-target interaction |
| EP3033625B1 (en) * | 2013-08-13 | 2020-01-22 | The Scripps Research Institute | Cysteine-reactive ligand discovery in proteomes |
| WO2016100593A1 (en) * | 2014-12-17 | 2016-06-23 | Pharmacyclics Llc | Methods and assays for quantification and normalization of kinase and ligand binding |
| KR20250021652A (ko) | 2018-05-10 | 2025-02-13 | 브리스톨-마이어스 스큅 컴퍼니 | 생체내 수용체 점유율을 결정하기 위한 검정 |
-
2019
- 2019-05-09 KR KR1020257003448A patent/KR20250021652A/ko active Pending
- 2019-05-09 JP JP2020563439A patent/JP7570925B2/ja active Active
- 2019-05-09 KR KR1020207035120A patent/KR102764357B1/ko active Active
- 2019-05-09 US US17/051,466 patent/US12085564B2/en active Active
- 2019-05-09 EP EP19729943.1A patent/EP3791183B1/en active Active
- 2019-05-09 CN CN202110955643.1A patent/CN113804873B/zh active Active
- 2019-05-09 WO PCT/US2019/031524 patent/WO2019217684A1/en not_active Ceased
- 2019-05-09 CN CN201980031353.9A patent/CN112105930B/zh active Active
- 2019-05-09 ES ES19729943T patent/ES2992942T3/es active Active
-
2024
- 2024-07-31 US US18/791,084 patent/US20250085279A1/en active Pending
- 2024-10-09 JP JP2024177293A patent/JP2025011208A/ja not_active Withdrawn
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| Publication number | Publication date |
|---|---|
| US12085564B2 (en) | 2024-09-10 |
| CN113804873B (zh) | 2024-06-18 |
| JP7570925B2 (ja) | 2024-10-22 |
| KR20210008028A (ko) | 2021-01-20 |
| KR102764357B1 (ko) | 2025-02-10 |
| KR20250021652A (ko) | 2025-02-13 |
| WO2019217684A1 (en) | 2019-11-14 |
| CN112105930A (zh) | 2020-12-18 |
| EP3791183A1 (en) | 2021-03-17 |
| EP3791183B1 (en) | 2024-07-24 |
| JP2021523367A (ja) | 2021-09-02 |
| CN112105930B (zh) | 2025-02-28 |
| US20210156854A1 (en) | 2021-05-27 |
| JP2025011208A (ja) | 2025-01-23 |
| US20250085279A1 (en) | 2025-03-13 |
| CN113804873A (zh) | 2021-12-17 |
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