JPWO2019213074A5 - - Google Patents
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- JPWO2019213074A5 JPWO2019213074A5 JP2021510264A JP2021510264A JPWO2019213074A5 JP WO2019213074 A5 JPWO2019213074 A5 JP WO2019213074A5 JP 2021510264 A JP2021510264 A JP 2021510264A JP 2021510264 A JP2021510264 A JP 2021510264A JP WO2019213074 A5 JPWO2019213074 A5 JP WO2019213074A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- formula
- composition according
- mpn
- myelofibrosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 6
- 206010028537 myelofibrosis Diseases 0.000 claims 6
- 229940083338 MDM2 inhibitor Drugs 0.000 claims 5
- 239000012819 MDM2-Inhibitor Substances 0.000 claims 5
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000037244 polycythemia vera Diseases 0.000 claims 4
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 3
- 208000005485 Thrombocytosis Diseases 0.000 claims 2
- 208000003476 primary myelofibrosis Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002144 L01XE18 - Ruxolitinib Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000012953 feeding on blood of other organism Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical compound C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 claims 1
- 229960000215 ruxolitinib Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024008582A JP2024050668A (ja) | 2018-04-30 | 2024-01-24 | がんの治療方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862664673P | 2018-04-30 | 2018-04-30 | |
| US62/664,673 | 2018-04-30 | ||
| US201862701088P | 2018-07-20 | 2018-07-20 | |
| US62/701,088 | 2018-07-20 | ||
| US201862781942P | 2018-12-19 | 2018-12-19 | |
| US62/781,942 | 2018-12-19 | ||
| US201962834848P | 2019-04-16 | 2019-04-16 | |
| US62/834,848 | 2019-04-16 | ||
| PCT/US2019/029906 WO2019213074A1 (en) | 2018-04-30 | 2019-04-30 | Methods of treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024008582A Division JP2024050668A (ja) | 2018-04-30 | 2024-01-24 | がんの治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523220A JP2021523220A (ja) | 2021-09-02 |
| JP2021523220A5 JP2021523220A5 (https=) | 2022-05-09 |
| JPWO2019213074A5 true JPWO2019213074A5 (https=) | 2022-05-09 |
Family
ID=68386769
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510264A Pending JP2021523220A (ja) | 2018-04-30 | 2019-04-30 | がんの治療方法 |
| JP2024008582A Pending JP2024050668A (ja) | 2018-04-30 | 2024-01-24 | がんの治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024008582A Pending JP2024050668A (ja) | 2018-04-30 | 2024-01-24 | がんの治療方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US12115153B2 (https=) |
| EP (1) | EP3787625A4 (https=) |
| JP (2) | JP2021523220A (https=) |
| KR (2) | KR20250130704A (https=) |
| CN (2) | CN120037232A (https=) |
| AU (2) | AU2019263064B2 (https=) |
| BR (1) | BR112020022148A2 (https=) |
| CA (1) | CA3098606A1 (https=) |
| CL (1) | CL2020002833A1 (https=) |
| CO (1) | CO2020014599A2 (https=) |
| CR (1) | CR20200576A (https=) |
| IL (3) | IL308399B2 (https=) |
| JO (1) | JOP20200273A1 (https=) |
| MX (2) | MX2020011608A (https=) |
| PE (1) | PE20211653A1 (https=) |
| PH (1) | PH12020551820A1 (https=) |
| SG (1) | SG11202010793UA (https=) |
| TN (1) | TN2020000210A1 (https=) |
| TW (3) | TW202529759A (https=) |
| WO (1) | WO2019213074A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114450008A (zh) * | 2019-09-16 | 2022-05-06 | 诺华股份有限公司 | Mdm2抑制剂用于治疗骨髓纤维化的用途 |
| TW202128156A (zh) * | 2019-11-14 | 2021-08-01 | 美商夸格智財控股有限公司 | 用於癌症治療之btk抑制劑及mdm2抑制劑之組合 |
| CN113337602A (zh) * | 2020-03-02 | 2021-09-03 | 苏州亚盛药业有限公司 | Mdm2抑制剂的治疗方法和生物标志物 |
| WO2022219128A1 (en) * | 2021-04-15 | 2022-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | In vitro tests allowing to identify the potential for mdm2 inhibitors to induce the selection of mutations in patients suffering from a myeloproliferative neoplasm |
| WO2023039161A1 (en) * | 2021-09-09 | 2023-03-16 | Kartos Therapeutics | Methods of treating cancer dependent on myc gene expresssion |
| US20250134876A1 (en) * | 2021-09-09 | 2025-05-01 | Kartos Therapeutics, Inc. | Methods of treating a cancer overexpressing one or more bcl-2 family proteins |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| UA128370C2 (uk) * | 2012-12-07 | 2024-06-26 | Джерон Корпорейшн | Використання інгібітора теломерази для лікування мієлопроліферативних неоплазм |
| CA2902856C (en) * | 2013-02-28 | 2021-02-16 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| CN105358530A (zh) * | 2013-06-10 | 2016-02-24 | 美国安进公司 | 制备mdm2抑制剂的方法及其结晶形式 |
| HRP20220718T1 (hr) | 2013-11-11 | 2022-09-30 | Amgen Inc. | Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka |
| WO2015081127A2 (en) * | 2013-11-26 | 2015-06-04 | Gilead Sciences, Inc. | Therapies for treating myeloproliferative disorders |
| CA2931073C (en) * | 2013-12-23 | 2021-10-26 | Novartis Ag | Pharmaceutical combinations |
| AU2015211021B2 (en) * | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| TW201613576A (en) * | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
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2019
- 2019-04-29 IL IL308399A patent/IL308399B2/en unknown
- 2019-04-29 IL IL319432A patent/IL319432A/en unknown
- 2019-04-30 CN CN202510038924.9A patent/CN120037232A/zh active Pending
- 2019-04-30 KR KR1020257027602A patent/KR20250130704A/ko active Pending
- 2019-04-30 TW TW113138550A patent/TW202529759A/zh unknown
- 2019-04-30 KR KR1020207034245A patent/KR102849513B1/ko active Active
- 2019-04-30 CR CR20200576A patent/CR20200576A/es unknown
- 2019-04-30 WO PCT/US2019/029906 patent/WO2019213074A1/en not_active Ceased
- 2019-04-30 JO JOP/2020/0273A patent/JOP20200273A1/ar unknown
- 2019-04-30 US US17/052,040 patent/US12115153B2/en active Active
- 2019-04-30 AU AU2019263064A patent/AU2019263064B2/en active Active
- 2019-04-30 TN TNP/2020/000210A patent/TN2020000210A1/en unknown
- 2019-04-30 TW TW110132121A patent/TW202146387A/zh unknown
- 2019-04-30 BR BR112020022148-1A patent/BR112020022148A2/pt unknown
- 2019-04-30 IL IL278345A patent/IL278345B2/en unknown
- 2019-04-30 JP JP2021510264A patent/JP2021523220A/ja active Pending
- 2019-04-30 CN CN201980043405.4A patent/CN112512525A/zh active Pending
- 2019-04-30 SG SG11202010793UA patent/SG11202010793UA/en unknown
- 2019-04-30 MX MX2020011608A patent/MX2020011608A/es unknown
- 2019-04-30 PE PE2020001785A patent/PE20211653A1/es unknown
- 2019-04-30 EP EP19796292.1A patent/EP3787625A4/en active Pending
- 2019-04-30 CA CA3098606A patent/CA3098606A1/en active Pending
- 2019-04-30 TW TW108115047A patent/TWI741286B/zh active
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2020
- 2020-10-30 PH PH12020551820A patent/PH12020551820A1/en unknown
- 2020-10-30 MX MX2024003655A patent/MX2024003655A/es unknown
- 2020-10-30 CL CL2020002833A patent/CL2020002833A1/es unknown
- 2020-11-25 CO CONC2020/0014599A patent/CO2020014599A2/es unknown
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2024
- 2024-01-24 JP JP2024008582A patent/JP2024050668A/ja active Pending
- 2024-09-26 US US18/898,634 patent/US20250090517A1/en active Pending
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2025
- 2025-03-07 AU AU2025201686A patent/AU2025201686A1/en active Pending