JPWO2019204583A5 - - Google Patents

Info

Publication number

JPWO2019204583A5

JPWO2019204583A5 JP2020556835A JP2020556835A JPWO2019204583A5 JP WO2019204583 A5 JPWO2019204583 A5 JP WO2019204583A5 JP 2020556835 A JP2020556835 A JP 2020556835A JP 2020556835 A JP2020556835 A JP 2020556835A JP WO2019204583 A5 JPWO2019204583 A5 JP WO2019204583A5

Authority

JP

Japan

Prior art keywords

dry powder

inhalable dry

itraconazole

powder according

inhalable

Prior art date

2022-04-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000843 powder Substances 0.000 claims 33
• 239000000203 mixture Substances 0.000 claims 15
• VHVPQPYKVGDNFY-TUJWMRSMSA-N 2-[(2S)-butan-2-yl]-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-TUJWMRSMSA-N 0.000 claims 13
• 238000009472 formulation Methods 0.000 claims 13
• 229960004130 itraconazole Drugs 0.000 claims 13
• 239000007788 liquid Substances 0.000 claims 13
• 239000002245 particle Substances 0.000 claims 10
• 229940068968 Polysorbate 80 Drugs 0.000 claims 7
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 7
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 7
• 229920000053 polysorbate 80 Polymers 0.000 claims 7
• 150000001413 amino acids Chemical class 0.000 claims 4
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
• 239000002775 capsule Substances 0.000 claims 3
• PMZURENOXWZQFD-UHFFFAOYSA-L na2so4 Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 3
• 239000003380 propellant Substances 0.000 claims 3
• 239000011780 sodium chloride Substances 0.000 claims 3
• 229910052938 sodium sulfate Inorganic materials 0.000 claims 3
• 235000011152 sodium sulphate Nutrition 0.000 claims 3
• 208000006778 Allergic Bronchopulmonary Aspergillosis Diseases 0.000 claims 2
• 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 2
• -1 cation salt Chemical class 0.000 claims 2
• 229910052751 metal Inorganic materials 0.000 claims 2
• 239000002184 metal Substances 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 159000000000 sodium salts Chemical class 0.000 claims 2
• BLUGYPPOFIHFJS-UUFHNPECSA-N (2S)-N-[(2S)-1-[[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 1
• 206010003486 Aspergillus infection Diseases 0.000 claims 1
• 208000006673 Asthma Diseases 0.000 claims 1
• 229940112141 Dry Powder Inhaler Drugs 0.000 claims 1
• 206010017533 Fungal infection Diseases 0.000 claims 1
• 229950008882 Polysorbate Drugs 0.000 claims 1
• 206010038683 Respiratory disease Diseases 0.000 claims 1
• 230000001154 acute Effects 0.000 claims 1
• 150000001298 alcohols Chemical class 0.000 claims 1
• 201000002909 aspergillosis Diseases 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 235000014633 carbohydrates Nutrition 0.000 claims 1
• 201000003883 cystic fibrosis Diseases 0.000 claims 1
• 239000006185 dispersion Substances 0.000 claims 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
• 230000005713 exacerbation Effects 0.000 claims 1
• 239000010419 fine particle Substances 0.000 claims 1
• 159000000003 magnesium salts Chemical class 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229920000136 polysorbate Polymers 0.000 claims 1
• 210000002345 respiratory system Anatomy 0.000 claims 1
• 238000001694 spray drying Methods 0.000 claims 1
• 239000004094 surface-active agent Substances 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1