JPWO2019195284A5 - - Google Patents
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- Publication number
- JPWO2019195284A5 JPWO2019195284A5 JP2020554536A JP2020554536A JPWO2019195284A5 JP WO2019195284 A5 JPWO2019195284 A5 JP WO2019195284A5 JP 2020554536 A JP2020554536 A JP 2020554536A JP 2020554536 A JP2020554536 A JP 2020554536A JP WO2019195284 A5 JPWO2019195284 A5 JP WO2019195284A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza
- ferritin
- polypeptide
- antigenic
- polypeptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010022000 influenza Diseases 0.000 claims 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims 38
- 229920001184 polypeptide Polymers 0.000 claims 37
- 102000004196 processed proteins & peptides Human genes 0.000 claims 37
- 238000008416 Ferritin Methods 0.000 claims 29
- 230000000890 antigenic effect Effects 0.000 claims 24
- 102000008857 Ferritin Human genes 0.000 claims 11
- 108050000784 Ferritin Proteins 0.000 claims 11
- 235000001014 amino acid Nutrition 0.000 claims 9
- 229940024606 amino acid Drugs 0.000 claims 9
- 235000018417 cysteine Nutrition 0.000 claims 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 101710154606 Hemagglutinin Proteins 0.000 claims 5
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 5
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 5
- 101710176177 Protein A56 Proteins 0.000 claims 5
- 239000000185 hemagglutinin Substances 0.000 claims 5
- 230000003308 immunostimulating effect Effects 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- -1 cysteine amino acid Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- ZUHQCDZJPTXVCU-UHFFFAOYSA-N C1#CCCC2=CC=CC=C2C2=CC=CC=C21 Chemical compound C1#CCCC2=CC=CC=C2C2=CC=CC=C21 ZUHQCDZJPTXVCU-UHFFFAOYSA-N 0.000 claims 2
- 241000590002 Helicobacter pylori Species 0.000 claims 2
- 102000005348 Neuraminidase Human genes 0.000 claims 2
- 108010006232 Neuraminidase Proteins 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 229940037467 helicobacter pylori Drugs 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- 102220623777 Pentraxin-4_S72C_mutation Human genes 0.000 claims 1
- 102220635826 Probable C-mannosyltransferase DPY19L1_S26C_mutation Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims 1
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims 1
- 102220417854 c.293A>T Human genes 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 102220272160 rs768754175 Human genes 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024006461A JP2024041980A (ja) | 2018-04-03 | 2024-01-19 | 抗原性インフルエンザ－フェリチンポリペプチド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862652204P | 2018-04-03 | 2018-04-03 | |
| US62/652,204 | 2018-04-03 | ||
| PCT/US2019/025377 WO2019195284A1 (en) | 2018-04-03 | 2019-04-02 | Antigenic influenza-ferritin polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024006461A Division JP2024041980A (ja) | 2018-04-03 | 2024-01-19 | 抗原性インフルエンザ－フェリチンポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021519600A JP2021519600A (ja) | 2021-08-12 |
| JPWO2019195284A5 true JPWO2019195284A5 (https=) | 2022-04-07 |
| JP2021519600A5 JP2021519600A5 (https=) | 2022-04-07 |
Family
ID=66175544
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554536A Pending JP2021519600A (ja) | 2018-04-03 | 2019-04-02 | 抗原性インフルエンザ−フェリチンポリペプチド |
| JP2024006461A Pending JP2024041980A (ja) | 2018-04-03 | 2024-01-19 | 抗原性インフルエンザ－フェリチンポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024006461A Pending JP2024041980A (ja) | 2018-04-03 | 2024-01-19 | 抗原性インフルエンザ－フェリチンポリペプチド |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3773703A1 (https=) |
| JP (2) | JP2021519600A (https=) |
| CN (1) | CN112512565A (https=) |
| WO (1) | WO2019195284A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112512566A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 抗原性爱泼斯坦-巴尔病毒多肽 |
| BR112020019938A2 (pt) | 2018-04-03 | 2021-01-26 | Sanofi | polipeptídeos antigênicos de vírus sincicial respiratório |
| CN112512564A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 铁蛋白蛋白 |
| BR112022021208A8 (pt) * | 2020-04-22 | 2023-02-23 | Medicago Inc | Supraestrutura compreendendo hemaglutinina de influenza modificada com interação reduzida com ácido siálico |
| WO2021231729A1 (en) * | 2020-05-13 | 2021-11-18 | Sanofi | Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza |
| US20240165224A1 (en) * | 2021-03-26 | 2024-05-23 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE509102T1 (de) | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| ATE356630T1 (de) | 1998-04-03 | 2007-04-15 | Univ Iowa Res Found | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
| WO2001075436A1 (en) | 2000-04-03 | 2001-10-11 | Board Of Trustees Of The Leland Stanford Junior University | A method for protein structure alignment |
| US7774185B2 (en) | 2004-09-14 | 2010-08-10 | International Business Machines Corporation | Protein structure alignment using cellular automata |
| JP5795184B2 (ja) * | 2011-04-22 | 2015-10-14 | 国立大学法人 奈良先端科学技術大学院大学 | 被検物質の電気化学的検出方法 |
| EP2515112B1 (en) * | 2011-04-22 | 2015-08-12 | Sysmex Corporation | Method for electrochemically detecting analyte |
| US9580475B2 (en) | 2011-06-20 | 2017-02-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for H1N1 influenza |
| CA2849822C (en) * | 2011-09-23 | 2021-05-11 | Gary J. Nabel, M.D. | Novel influenza hemagglutinin protein-based vaccines |
| RU2639551C2 (ru) | 2012-03-30 | 2017-12-21 | Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн | Оптимизированные с помощью вычислительных средств антигены с широким спектром реактивности для вирусов гриппа h5n1 и h1n1 |
| FI2970398T3 (fi) * | 2013-03-13 | 2024-08-06 | Us Health | Rsv f -prefuusioproteiineja ja niiden käyttö |
| CA2950085A1 (en) * | 2014-05-27 | 2015-12-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Stabilized influenza hemagglutinin stem region trimers and uses thereof |
| US9703095B2 (en) | 2015-01-05 | 2017-07-11 | Edward Pakhchyan | Light modulator for MEMS display |
| FI3471760T3 (fi) | 2016-06-17 | 2025-01-27 | Boehringer Ingelheim Vetmedica Gmbh | Lineaarisia tai haaroittuneita polyakryylihappopolymeeriadjuvantteja käsittäviä uusia immunogeenisiä formulaatioita |
-
2019
- 2019-04-02 CN CN201980035123.XA patent/CN112512565A/zh active Pending
- 2019-04-02 JP JP2020554536A patent/JP2021519600A/ja active Pending
- 2019-04-02 WO PCT/US2019/025377 patent/WO2019195284A1/en not_active Ceased
- 2019-04-02 EP EP19717704.1A patent/EP3773703A1/en active Pending
-
2024
- 2024-01-19 JP JP2024006461A patent/JP2024041980A/ja active Pending
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