JP2021519600A - 抗原性インフルエンザ−フェリチンポリペプチド - Google Patents

抗原性インフルエンザ−フェリチンポリペプチド Download PDF

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Publication number
JP2021519600A
JP2021519600A JP2020554536A JP2020554536A JP2021519600A JP 2021519600 A JP2021519600 A JP 2021519600A JP 2020554536 A JP2020554536 A JP 2020554536A JP 2020554536 A JP2020554536 A JP 2020554536A JP 2021519600 A JP2021519600 A JP 2021519600A
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Japan
Prior art keywords
ferritin
influenza
polypeptide
antigenic
cysteine
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Pending
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JP2020554536A
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English (en)
Japanese (ja)
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JPWO2019195284A5 (https=
JP2021519600A5 (https=
Inventor
ゲイリー・ジェイ・ナーベル
チィ−ジェン・ウェイ
レベッカ・ルディセル
ニコル・ダリカレレ
カート・スワンソン
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Sanofi SA
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Sanofi SA
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Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JP2021519600A publication Critical patent/JP2021519600A/ja
Publication of JPWO2019195284A5 publication Critical patent/JPWO2019195284A5/ja
Publication of JP2021519600A5 publication Critical patent/JP2021519600A5/ja
Priority to JP2024006461A priority Critical patent/JP2024041980A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020554536A 2018-04-03 2019-04-02 抗原性インフルエンザ−フェリチンポリペプチド Pending JP2021519600A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024006461A JP2024041980A (ja) 2018-04-03 2024-01-19 抗原性インフルエンザ－フェリチンポリペプチド

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862652204P 2018-04-03 2018-04-03
US62/652,204 2018-04-03
PCT/US2019/025377 WO2019195284A1 (en) 2018-04-03 2019-04-02 Antigenic influenza-ferritin polypeptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024006461A Division JP2024041980A (ja) 2018-04-03 2024-01-19 抗原性インフルエンザ－フェリチンポリペプチド

Publications (3)

Publication Number Publication Date
JP2021519600A true JP2021519600A (ja) 2021-08-12
JPWO2019195284A5 JPWO2019195284A5 (https=) 2022-04-07
JP2021519600A5 JP2021519600A5 (https=) 2022-04-07

Family

ID=66175544

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020554536A Pending JP2021519600A (ja) 2018-04-03 2019-04-02 抗原性インフルエンザ−フェリチンポリペプチド
JP2024006461A Pending JP2024041980A (ja) 2018-04-03 2024-01-19 抗原性インフルエンザ－フェリチンポリペプチド

Family Applications After (1)

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JP2024006461A Pending JP2024041980A (ja) 2018-04-03 2024-01-19 抗原性インフルエンザ－フェリチンポリペプチド

Country Status (4)

Country Link
EP (1) EP3773703A1 (https=)
JP (2) JP2021519600A (https=)
CN (1) CN112512565A (https=)
WO (1) WO2019195284A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112512566A (zh) 2018-04-03 2021-03-16 赛诺菲 抗原性爱泼斯坦-巴尔病毒多肽
BR112020019938A2 (pt) 2018-04-03 2021-01-26 Sanofi polipeptídeos antigênicos de vírus sincicial respiratório
CN112512564A (zh) 2018-04-03 2021-03-16 赛诺菲 铁蛋白蛋白
BR112022021208A8 (pt) * 2020-04-22 2023-02-23 Medicago Inc Supraestrutura compreendendo hemaglutinina de influenza modificada com interação reduzida com ácido siálico
WO2021231729A1 (en) * 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
US20240165224A1 (en) * 2021-03-26 2024-05-23 Glaxosmithkline Biologicals Sa Immunogenic compositions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012225885A (ja) * 2011-04-22 2012-11-15 Nara Institute Of Science & Technology 被検物質の電気化学的検出方法
WO2013044203A2 (en) * 2011-09-23 2013-03-28 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPTARTMENT OF HEALTH & HUMAN SERVICES Novel influenza hemagglutinin protein-based vaccines
WO2015183969A1 (en) * 2014-05-27 2015-12-03 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Stabilized influenza hemagglutinin stem region trimers and uses thereof
JP2016519658A (ja) * 2013-03-13 2016-07-07 アメリカ合衆国 融合前ｒｓｖｆタンパク質およびそれらの使用

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ATE509102T1 (de) 1994-07-15 2011-05-15 Univ Iowa Res Found Immunomodulatorische oligonukleotide
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
WO1998037919A1 (en) 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
AU7690898A (en) 1997-05-20 1998-12-11 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
ATE356630T1 (de) 1998-04-03 2007-04-15 Univ Iowa Res Found Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine
WO2001075436A1 (en) 2000-04-03 2001-10-11 Board Of Trustees Of The Leland Stanford Junior University A method for protein structure alignment
US7774185B2 (en) 2004-09-14 2010-08-10 International Business Machines Corporation Protein structure alignment using cellular automata
EP2515112B1 (en) * 2011-04-22 2015-08-12 Sysmex Corporation Method for electrochemically detecting analyte
US9580475B2 (en) 2011-06-20 2017-02-28 University of Pittsburgh—of the Commonwealth System of Higher Education Computationally optimized broadly reactive antigens for H1N1 influenza
RU2639551C2 (ru) 2012-03-30 2017-12-21 Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн Оптимизированные с помощью вычислительных средств антигены с широким спектром реактивности для вирусов гриппа h5n1 и h1n1
US9703095B2 (en) 2015-01-05 2017-07-11 Edward Pakhchyan Light modulator for MEMS display
FI3471760T3 (fi) 2016-06-17 2025-01-27 Boehringer Ingelheim Vetmedica Gmbh Lineaarisia tai haaroittuneita polyakryylihappopolymeeriadjuvantteja käsittäviä uusia immunogeenisiä formulaatioita

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012225885A (ja) * 2011-04-22 2012-11-15 Nara Institute Of Science & Technology 被検物質の電気化学的検出方法
WO2013044203A2 (en) * 2011-09-23 2013-03-28 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPTARTMENT OF HEALTH & HUMAN SERVICES Novel influenza hemagglutinin protein-based vaccines
JP2016519658A (ja) * 2013-03-13 2016-07-07 アメリカ合衆国 融合前ｒｓｖｆタンパク質およびそれらの使用
WO2015183969A1 (en) * 2014-05-27 2015-12-03 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Stabilized influenza hemagglutinin stem region trimers and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEM. SOC. REV., vol. 45, JPN6023008985, 2016, pages 1691 - 1719, ISSN: 0005006603 *
J. MED. CHEM., vol. 42, JPN6023008988, 1999, pages 4640 - 4649, ISSN: 0005006601 *
JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 47, JPN6024008834, 1992, pages 161 - 174, ISSN: 0005273584 *
SCIENTIFIC REPORTS, vol. 6:36298, JPN6023008989, 2016, pages 1 - 11, ISSN: 0005006600 *
化学と生物, vol. 52, no. 4, JPN6023008986, 2014, pages 233 - 240, ISSN: 0005153856 *

Also Published As

Publication number Publication date
CN112512565A (zh) 2021-03-16
WO2019195284A1 (en) 2019-10-10
JP2024041980A (ja) 2024-03-27
EP3773703A1 (en) 2021-02-17

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