JPWO2019175217A5 - - Google Patents
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- JPWO2019175217A5 JPWO2019175217A5 JP2020547399A JP2020547399A JPWO2019175217A5 JP WO2019175217 A5 JPWO2019175217 A5 JP WO2019175217A5 JP 2020547399 A JP2020547399 A JP 2020547399A JP 2020547399 A JP2020547399 A JP 2020547399A JP WO2019175217 A5 JPWO2019175217 A5 JP WO2019175217A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- acd25
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 6
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 6
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 102000000588 Interleukin-2 Human genes 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 3
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 3
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 3
- 229940124060 PD-1 antagonist Drugs 0.000 claims 2
- 230000009824 affinity maturation Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862642232P | 2018-03-13 | 2018-03-13 | |
US201862642218P | 2018-03-13 | 2018-03-13 | |
US201862642230P | 2018-03-13 | 2018-03-13 | |
US201862642248P | 2018-03-13 | 2018-03-13 | |
US201862642243P | 2018-03-13 | 2018-03-13 | |
PCT/EP2018/056312 WO2018167104A1 (en) | 2017-03-17 | 2018-03-13 | Fc-optimized anti-cd25 for tumour specific cell depletion |
GBGB1804028.7A GB201804028D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
EPPCT/EP2018/056312 | 2018-03-13 | ||
US62/642230 | 2018-03-13 | ||
US62/642248 | 2018-03-13 | ||
GBGB1804029.5A GB201804029D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
US62/642243 | 2018-03-13 | ||
GB1804028.7 | 2018-03-13 | ||
GBGB1804027.9A GB201804027D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
GB1804027.9 | 2018-03-13 | ||
US62/642218 | 2018-03-13 | ||
US62/642232 | 2018-03-13 | ||
GB1804029.5 | 2018-03-13 | ||
PCT/EP2019/056249 WO2019175217A1 (en) | 2018-03-13 | 2019-03-13 | Anti-cd25 for tumour specific cell depletion |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021533726A JP2021533726A (ja) | 2021-12-09 |
JPWO2019175217A5 true JPWO2019175217A5 (hr) | 2022-03-18 |
JP7451415B2 JP7451415B2 (ja) | 2024-03-18 |
Family
ID=67903878
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020547331A Active JP7563979B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗cd25抗体剤 |
JP2020547333A Active JP7510348B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
JP2020547399A Active JP7451415B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25抗体 |
JP2020547326A Active JP7563978B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020547331A Active JP7563979B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗cd25抗体剤 |
JP2020547333A Active JP7510348B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25抗体 |
JP2020547326A Active JP7563978B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗cd25 |
Country Status (14)
Country | Link |
---|---|
US (11) | US11919960B2 (hr) |
EP (8) | EP3765507B1 (hr) |
JP (7) | JP7563979B2 (hr) |
KR (3) | KR20200131862A (hr) |
CN (8) | CN112020516A (hr) |
AU (3) | AU2019233575A1 (hr) |
BR (3) | BR112020016501A2 (hr) |
CA (3) | CA3088659A1 (hr) |
CR (3) | CR20200465A (hr) |
MA (1) | MA51993A (hr) |
PE (3) | PE20210289A1 (hr) |
SG (3) | SG11202008784RA (hr) |
TW (3) | TW201938588A (hr) |
WO (8) | WO2019175224A1 (hr) |
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CA3182362A1 (en) | 2020-05-14 | 2021-11-18 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-cd25 antibodies, antigen-binding fragments thereof, and medical uses thereof |
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CN116744962A (zh) * | 2020-11-13 | 2023-09-12 | 艾比欧公司 | Cd25抗体 |
JP2023550446A (ja) * | 2020-11-20 | 2023-12-01 | インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) | 抗cd25抗体 |
JP2024504547A (ja) * | 2020-11-20 | 2024-02-01 | インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) | 抗cd25抗体 |
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CN117916266A (zh) | 2021-09-02 | 2024-04-19 | 弗哈夫曼拉罗切有限公司 | 用于治疗aml的抗体 |
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CN115181181B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种抗cd25的单域抗体及其应用 |
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CN118240080A (zh) * | 2022-12-22 | 2024-06-25 | 深圳市福元生物科技有限公司 | 一种cd25单域抗体、人源化抗体、及制备方法 |
CN116004636B (zh) * | 2023-01-10 | 2024-03-12 | 广西师范大学 | 一种不结合红细胞的差异化cd47核酸适体及其应用 |
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-
2019
- 2019-03-13 TW TW108108451A patent/TW201938588A/zh unknown
- 2019-03-13 CN CN201980019256.8A patent/CN112020516A/zh active Pending
- 2019-03-13 AU AU2019233575A patent/AU2019233575A1/en not_active Abandoned
- 2019-03-13 JP JP2020547331A patent/JP7563979B2/ja active Active
- 2019-03-13 US US16/979,933 patent/US11919960B2/en active Active
- 2019-03-13 CN CN201980019235.6A patent/CN112041345A/zh active Pending
- 2019-03-13 EP EP19710416.9A patent/EP3765507B1/en active Active
- 2019-03-13 CA CA3088659A patent/CA3088659A1/en not_active Abandoned
- 2019-03-13 US US16/979,931 patent/US11851494B2/en active Active
- 2019-03-13 CA CA3088671A patent/CA3088671A1/en active Pending
- 2019-03-13 PE PE2020001320A patent/PE20210289A1/es unknown
- 2019-03-13 US US16/979,932 patent/US11873341B2/en active Active
- 2019-03-13 WO PCT/EP2019/056258 patent/WO2019175224A1/en unknown
- 2019-03-13 PE PE2020001292A patent/PE20210287A1/es unknown
- 2019-03-13 CR CR20200465A patent/CR20200465A/es unknown
- 2019-03-13 JP JP2020547415A patent/JP2021515568A/ja active Pending
- 2019-03-13 SG SG11202008784RA patent/SG11202008784RA/en unknown
- 2019-03-13 JP JP2020547363A patent/JP7451414B2/ja active Active
- 2019-03-13 TW TW108108452A patent/TW201940515A/zh unknown
- 2019-03-13 SG SG11202008733YA patent/SG11202008733YA/en unknown
- 2019-03-13 PE PE2020001299A patent/PE20210288A1/es unknown
- 2019-03-13 AU AU2019233576A patent/AU2019233576A1/en not_active Abandoned
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