JPWO2019173602A5 - - Google Patents
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- JPWO2019173602A5 JPWO2019173602A5 JP2020546962A JP2020546962A JPWO2019173602A5 JP WO2019173602 A5 JPWO2019173602 A5 JP WO2019173602A5 JP 2020546962 A JP2020546962 A JP 2020546962A JP 2020546962 A JP2020546962 A JP 2020546962A JP WO2019173602 A5 JPWO2019173602 A5 JP WO2019173602A5
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- virus
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2023176993A JP2024009953A (ja) | 2018-03-07 | 2023-10-12 | 4’-ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862639725P | 2018-03-07 | 2018-03-07 | |
US62/639,725 | 2018-03-07 | ||
PCT/US2019/021168 WO2019173602A1 (en) | 2018-03-07 | 2019-03-07 | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023176993A Division JP2024009953A (ja) | 2018-03-07 | 2023-10-12 | 4’-ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021517132A JP2021517132A (ja) | 2021-07-15 |
JPWO2019173602A5 true JPWO2019173602A5 (pt) | 2022-03-14 |
JP7371931B2 JP7371931B2 (ja) | 2023-10-31 |
Family
ID=67846796
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020546962A Active JP7371931B2 (ja) | 2018-03-07 | 2019-03-07 | 4’-ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
JP2023176993A Pending JP2024009953A (ja) | 2018-03-07 | 2023-10-12 | 4’-ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023176993A Pending JP2024009953A (ja) | 2018-03-07 | 2023-10-12 | 4’-ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用 |
Country Status (14)
Country | Link |
---|---|
US (2) | US20210308168A1 (pt) |
EP (1) | EP3762372A4 (pt) |
JP (2) | JP7371931B2 (pt) |
KR (1) | KR20200140274A (pt) |
CN (1) | CN112074506A (pt) |
AU (1) | AU2019231725B2 (pt) |
BR (1) | BR112020018209A2 (pt) |
CA (1) | CA3093222A1 (pt) |
EA (1) | EA202092117A1 (pt) |
GB (2) | GB2589205B (pt) |
IL (1) | IL277160B1 (pt) |
PH (1) | PH12020551404A1 (pt) |
SG (1) | SG11202008527WA (pt) |
WO (1) | WO2019173602A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2015370004B2 (en) | 2014-12-26 | 2021-03-11 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
SG11202004403QA (en) | 2017-12-07 | 2020-06-29 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
CN114867351B (zh) * | 2019-10-08 | 2024-04-23 | 埃默里大学 | 含4′-卤素的核苷酸和核苷治疗组合物以及其相关用途 |
EP4138847A4 (en) * | 2020-04-24 | 2024-05-22 | Memorial Sloan Kettering Cancer Center | TARGETED THERAPY TO TREAT AND PREVENT LIFE-THREATENING COMPLICATIONS OF INFECTION |
US20240025938A1 (en) * | 2020-08-27 | 2024-01-25 | Emory University | Novel forms of antiviral nucleosides |
CN114644666A (zh) * | 2020-12-18 | 2022-06-21 | 上海特化医药科技有限公司 | 5’-核苷前药的制备方法及中间体 |
WO2022133205A1 (en) * | 2020-12-18 | 2022-06-23 | Merck Sharp & Dohme Corp. | Synthesis of antiviral nucleosides |
CN112608357B (zh) * | 2020-12-21 | 2022-12-09 | 杭州科巢生物科技有限公司 | 一种抗病毒药物Molnupiravir的制备方法 |
CN112778387A (zh) * | 2021-01-15 | 2021-05-11 | 杭州科巢生物科技有限公司 | 一种Molnupiravir晶型A及其制备方法 |
WO2022174179A1 (en) * | 2021-02-15 | 2022-08-18 | Emory University | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
WO2022174194A1 (en) * | 2021-02-15 | 2022-08-18 | Emory University | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
US20240166680A1 (en) * | 2021-04-15 | 2024-05-23 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Nucleoside analog and use thereof |
US11407779B1 (en) | 2021-04-23 | 2022-08-09 | Divi's Laboratories Ltd. | Process for the preparation of molnupiravir |
CN112979733B (zh) * | 2021-04-25 | 2021-09-10 | 南京颐媛生物医学研究院有限公司 | 抗乙肝病毒的化合物及其制备方法和应用 |
CN113278040B (zh) * | 2021-06-16 | 2022-07-05 | 苏州立新制药有限公司 | 5’-异丁酰基-n4-羟基胞苷的制备方法 |
CN117642410A (zh) * | 2021-06-18 | 2024-03-01 | 苏州春海生物医药有限公司 | N4-羟基胞苷的酯衍生物及其用途 |
MX2024001645A (es) | 2021-08-06 | 2024-02-27 | Intervet Int Bv | Metodo para el tratamiento de las enfermedades virales veterinarias. |
AU2022343115A1 (en) | 2021-09-08 | 2024-03-14 | Aligos Therapeutics, Inc. | Modified short interfering nucleic acid (sina) molecules and uses thereof |
CN113880902A (zh) * | 2021-10-26 | 2022-01-04 | 江苏睿实生物科技有限公司 | 一种Molnupiravir药物中间体及其制备方法 |
US11541071B1 (en) | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
CN114478658A (zh) * | 2022-02-22 | 2022-05-13 | 苏州正济药业有限公司 | 一种莫那比拉韦的合成方法 |
WO2023202604A1 (zh) * | 2022-04-20 | 2023-10-26 | 中国科学院上海药物研究所 | 抗病毒核苷类似物及其药物组合物和用途 |
WO2024129985A2 (en) * | 2022-12-14 | 2024-06-20 | Lakewood Amedex, Inc. | Antiviral compounds, compositions, and uses thereof |
WO2024182446A2 (en) | 2023-02-28 | 2024-09-06 | Aligos Therapeutics, Inc. | Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof |
WO2024187038A1 (en) | 2023-03-07 | 2024-09-12 | Aligos Therapeutics, Inc. | Modified short inerfering nucleic acid (sina) molecules and uses thereof |
CN117567310A (zh) * | 2023-11-28 | 2024-02-20 | 重庆智合生物医药有限公司 | 一种神经酰胺np1的合成方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4207363A1 (de) * | 1992-03-04 | 1993-09-09 | Max Delbrueck Centrum | Antivirale nucleosidanaloga, ihre herstellung und ihre pharmazeutische verwendung |
JPWO2004024185A1 (ja) * | 2002-09-11 | 2006-01-26 | 道男 石橋 | 医薬または化粧料 |
US20100189772A1 (en) * | 2006-09-27 | 2010-07-29 | Coley Pharmaceutical Group, Inc | Compositions of TLR ligands and antivirals |
WO2009058800A2 (en) * | 2007-10-29 | 2009-05-07 | President And Fellows Of Harvard College | Synthesis of nucleosides |
US8962580B2 (en) * | 2008-09-23 | 2015-02-24 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
UA111761C2 (uk) * | 2011-12-20 | 2016-06-10 | Рібосаєнс Ллс | 2',4'-дифтор-2'-метилзаміщені нуклеозидні похідні як інгібітори реплікації phk вірусу гепатиту c |
AU2013266393B2 (en) * | 2012-05-22 | 2017-09-28 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
CN110684067A (zh) * | 2012-12-21 | 2020-01-14 | 艾丽奥斯生物制药有限公司 | 取代的核苷和核苷酸 |
EP2981542B1 (en) * | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
NZ714927A (en) * | 2013-05-16 | 2020-09-25 | Riboscience Llc | 4’-fluoro-2’-methyl substituted nucleoside derivatives |
US9815864B2 (en) * | 2013-06-26 | 2017-11-14 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10385088B2 (en) * | 2013-10-02 | 2019-08-20 | Modernatx, Inc. | Polynucleotide molecules and uses thereof |
SG10201804835VA (en) | 2013-10-11 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
CA3207106A1 (en) * | 2014-06-24 | 2015-12-30 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
AU2015280234B2 (en) | 2014-06-24 | 2021-04-01 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
MA41441A (fr) * | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
WO2016134056A1 (en) | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Anti-viral compounds |
WO2016134054A1 (en) | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Anti-viral compounds |
CA2992278A1 (en) * | 2015-08-06 | 2017-02-09 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents |
WO2017040895A1 (en) | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
WO2017040892A1 (en) | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
WO2017040896A1 (en) | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
US11963972B2 (en) * | 2016-03-23 | 2024-04-23 | Emory University | Antiviral agents and nucleoside analogs for treatment of Zika virus |
EP3471738A4 (en) * | 2016-06-20 | 2020-01-01 | Merck Sharp & Dohme Corp. | PHOSPHATE-SUBSTITUTED CYCLIC NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES |
-
2019
- 2019-03-07 GB GB2015827.5A patent/GB2589205B/en active Active
- 2019-03-07 US US16/979,108 patent/US20210308168A1/en not_active Abandoned
- 2019-03-07 SG SG11202008527WA patent/SG11202008527WA/en unknown
- 2019-03-07 AU AU2019231725A patent/AU2019231725B2/en active Active
- 2019-03-07 EA EA202092117A patent/EA202092117A1/ru unknown
- 2019-03-07 EP EP19764729.0A patent/EP3762372A4/en active Pending
- 2019-03-07 CN CN201980030574.4A patent/CN112074506A/zh active Pending
- 2019-03-07 IL IL277160A patent/IL277160B1/en unknown
- 2019-03-07 KR KR1020207028655A patent/KR20200140274A/ko not_active Application Discontinuation
- 2019-03-07 GB GB2218405.5A patent/GB2611644B/en active Active
- 2019-03-07 WO PCT/US2019/021168 patent/WO2019173602A1/en unknown
- 2019-03-07 BR BR112020018209-5A patent/BR112020018209A2/pt unknown
- 2019-03-07 JP JP2020546962A patent/JP7371931B2/ja active Active
- 2019-03-07 CA CA3093222A patent/CA3093222A1/en active Pending
-
2020
- 2020-09-07 PH PH12020551404A patent/PH12020551404A1/en unknown
-
2023
- 2023-07-26 US US18/359,435 patent/US20240180948A1/en active Pending
- 2023-10-12 JP JP2023176993A patent/JP2024009953A/ja active Pending
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