JPWO2019160829A5 - - Google Patents
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- JPWO2019160829A5 JPWO2019160829A5 JP2020564805A JP2020564805A JPWO2019160829A5 JP WO2019160829 A5 JPWO2019160829 A5 JP WO2019160829A5 JP 2020564805 A JP2020564805 A JP 2020564805A JP 2020564805 A JP2020564805 A JP 2020564805A JP WO2019160829 A5 JPWO2019160829 A5 JP WO2019160829A5
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- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 36
- 239000006143 cell culture medium Substances 0.000 claims 27
- 239000005557 antagonist Substances 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 108010002350 Interleukin-2 Proteins 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 230000007704 transition Effects 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- PWTBZOIUWZOPFT-UHFFFAOYSA-N 4-[2-[[7-amino-2-(2-furanyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol Chemical compound N=1C2=NC(C=3OC=CC=3)=NN2C(N)=NC=1NCCC1=CC=C(O)C=C1 PWTBZOIUWZOPFT-UHFFFAOYSA-N 0.000 claims 2
- KURQKNMKCGYWRJ-HNNXBMFYSA-N 7-(5-methylfuran-2-yl)-3-[[6-[[(3s)-oxolan-3-yl]oxymethyl]pyridin-2-yl]methyl]triazolo[4,5-d]pyrimidin-5-amine Chemical compound O1C(C)=CC=C1C1=NC(N)=NC2=C1N=NN2CC1=CC=CC(CO[C@@H]2COCC2)=N1 KURQKNMKCGYWRJ-HNNXBMFYSA-N 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- UTLPKQYUXOEJIL-UHFFFAOYSA-N LSM-3822 Chemical compound N1=CC=2C3=NC(C=4OC=CC=4)=NN3C(N)=NC=2N1CCC1=CC=CC=C1 UTLPKQYUXOEJIL-UHFFFAOYSA-N 0.000 claims 2
- XNBRWUQWSKXMPW-UHFFFAOYSA-N Tozadenant Chemical compound C1=2SC(NC(=O)N3CCC(C)(O)CC3)=NC=2C(OC)=CC=C1N1CCOCC1 XNBRWUQWSKXMPW-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 229960005305 adenosine Drugs 0.000 claims 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- DTYWJKSSUANMHD-UHFFFAOYSA-N preladenant Chemical compound C1=CC(OCCOC)=CC=C1N1CCN(CCN2C3=C(C4=NC(=NN4C(N)=N3)C=3OC=CC=3)C=N2)CC1 DTYWJKSSUANMHD-UHFFFAOYSA-N 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- JEEJMSUHUZNTCD-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-4-(furan-2-yl)pyrazolo[3,4-d]pyrimidin-6-amine Chemical compound C=12C=NN(CC=3C(=CC=CC=3)F)C2=NC(N)=NC=1C1=CC=CO1 JEEJMSUHUZNTCD-UHFFFAOYSA-N 0.000 claims 1
- HQSBCDPYXDGTCL-UHFFFAOYSA-N 3-[(4-amino-3-methylphenyl)methyl]-7-(furan-2-yl)triazolo[4,5-d]pyrimidin-5-amine Chemical compound C1=C(N)C(C)=CC(CN2C3=NC(N)=NC(=C3N=N2)C=2OC=CC=2)=C1 HQSBCDPYXDGTCL-UHFFFAOYSA-N 0.000 claims 1
- WBWFIUAVMCNYPG-BQYQJAHWSA-N 8-(3-chlorostyryl)caffeine Chemical compound N=1C=2N(C)C(=O)N(C)C(=O)C=2N(C)C=1\C=C\C1=CC=CC(Cl)=C1 WBWFIUAVMCNYPG-BQYQJAHWSA-N 0.000 claims 1
- -1 ADZ4635 Chemical compound 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108091092878 Microsatellite Proteins 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000002136 bile duct sarcoma Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- IQVRBWUUXZMOPW-PKNBQFBNSA-N istradefylline Chemical compound CN1C=2C(=O)N(CC)C(=O)N(CC)C=2N=C1\C=C\C1=CC=C(OC)C(OC)=C1 IQVRBWUUXZMOPW-PKNBQFBNSA-N 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000033607 mismatch repair Effects 0.000 claims 1
- JZAMQDDHRXHDFR-UHFFFAOYSA-N sch-412348 Chemical compound N1=CC=2C3=NC(C=4OC=CC=4)=NN3C(N)=NC=2N1CCN(CC1)CCN1C1=CC=C(F)C=C1F JZAMQDDHRXHDFR-UHFFFAOYSA-N 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000001502 supplementing effect Effects 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
- 229950003008 vipadenant Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023204262A JP7851289B2 (ja) | 2018-02-13 | 2023-12-01 | アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ |
| JP2025244543A JP2026062687A (ja) | 2018-02-13 | 2025-12-10 | アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862630010P | 2018-02-13 | 2018-02-13 | |
| US62/630,010 | 2018-02-13 | ||
| US201862637603P | 2018-03-02 | 2018-03-02 | |
| US62/637,603 | 2018-03-02 | ||
| US201862684698P | 2018-06-13 | 2018-06-13 | |
| US62/684,698 | 2018-06-13 | ||
| PCT/US2019/017572 WO2019160829A1 (en) | 2018-02-13 | 2019-02-12 | Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023204262A Division JP7851289B2 (ja) | 2018-02-13 | 2023-12-01 | アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021512962A JP2021512962A (ja) | 2021-05-20 |
| JP2021512962A5 JP2021512962A5 (https=) | 2022-02-22 |
| JPWO2019160829A5 true JPWO2019160829A5 (https=) | 2022-02-22 |
Family
ID=65763752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564805A Pending JP2021512962A (ja) | 2018-02-13 | 2019-02-12 | アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ |
| JP2025244543A Pending JP2026062687A (ja) | 2018-02-13 | 2025-12-10 | アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025244543A Pending JP2026062687A (ja) | 2018-02-13 | 2025-12-10 | アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210137930A1 (https=) |
| EP (1) | EP3752600A1 (https=) |
| JP (2) | JP2021512962A (https=) |
| CA (1) | CA3090795A1 (https=) |
| MA (1) | MA51875A (https=) |
| WO (1) | WO2019160829A1 (https=) |
Families Citing this family (22)
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|---|---|---|---|---|
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| WO2019018584A1 (en) | 2017-07-18 | 2019-01-24 | GiraFpharma LLC | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS |
| EP3654982A4 (en) | 2017-07-18 | 2021-04-14 | Nuvation Bio Inc. | 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES |
| CN109536444B (zh) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法 |
| EP3911324A4 (en) | 2019-01-18 | 2022-08-17 | Nuvation Bio Inc. | 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES |
| EP3911323A4 (en) | 2019-01-18 | 2022-11-16 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS |
| WO2021123832A1 (en) | 2019-12-20 | 2021-06-24 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
| JP7817937B2 (ja) * | 2020-02-27 | 2026-02-19 | ターンストーン バイオロジクス コーポレイション | 腫瘍反応性ｔ細胞のエクスビボ富化および増大のための方法ならびに関連するその組成物 |
| WO2021203058A2 (en) * | 2020-04-03 | 2021-10-07 | Trishula Therapeutics, Inc. | Combination therapy involving anti-cd39 antibodies and adoptive cell therapy |
| US12365871B2 (en) | 2020-04-28 | 2025-07-22 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| TW202237824A (zh) | 2020-11-23 | 2022-10-01 | 美商萊爾免疫藥物股份有限公司 | 培養免疫細胞之方法 |
| CA3202483A1 (en) | 2020-12-17 | 2022-06-23 | Maria Fardis | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
| TW202241508A (zh) * | 2021-01-29 | 2022-11-01 | 美商艾歐凡斯生物治療公司 | 細胞介素相關之腫瘤浸潤性淋巴球組合物及方法 |
| KR20230150833A (ko) | 2021-02-25 | 2023-10-31 | 라이엘 이뮤노파마, 인크. | 세포 배양 방법 |
| AU2022246174A1 (en) | 2021-03-25 | 2023-09-14 | Iovance Biotherapeutics, Inc. | Methods and compositions for t-cell coculture potency assays and use with cell therapy products |
| WO2023049859A1 (en) * | 2021-09-24 | 2023-03-30 | The Regents Of The University Of California | Methods to predict the efficacy of neoadjuvant anti-pd-1 therapy in resectable oral-cavity squamous cell carcinoma and target post-surgical relapses |
| WO2023077034A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
| WO2025006811A1 (en) | 2023-06-27 | 2025-01-02 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
| WO2025101484A1 (en) | 2023-11-06 | 2025-05-15 | Iovance Biotherapeutics, Inc. | Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies |
| WO2025221958A1 (en) * | 2024-04-17 | 2025-10-23 | Corvus Pharmaceuticals, Inc. | Adenosine a2a receptor antagonists to treat rem sleep behavior disorder and prevent synucleinopathies |
| WO2026006604A1 (en) | 2024-06-26 | 2026-01-02 | Lyell Immunopharma, Inc. | Feeder cell replacement |
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-
2019
- 2019-02-12 CA CA3090795A patent/CA3090795A1/en active Pending
- 2019-02-12 EP EP19710828.5A patent/EP3752600A1/en active Pending
- 2019-02-12 JP JP2020564805A patent/JP2021512962A/ja active Pending
- 2019-02-12 WO PCT/US2019/017572 patent/WO2019160829A1/en not_active Ceased
- 2019-02-12 US US16/969,362 patent/US20210137930A1/en active Pending
- 2019-02-12 MA MA051875A patent/MA51875A/fr unknown
-
2025
- 2025-12-10 JP JP2025244543A patent/JP2026062687A/ja active Pending
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