JPWO2019092283A5 - - Google Patents
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- Publication number
- JPWO2019092283A5 JPWO2019092283A5 JP2020544151A JP2020544151A JPWO2019092283A5 JP WO2019092283 A5 JPWO2019092283 A5 JP WO2019092283A5 JP 2020544151 A JP2020544151 A JP 2020544151A JP 2020544151 A JP2020544151 A JP 2020544151A JP WO2019092283 A5 JPWO2019092283 A5 JP WO2019092283A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- strand
- nucleotides
- formula
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17201449.0 | 2017-11-13 | ||
| EP17201449.0A EP3483270A1 (en) | 2017-11-13 | 2017-11-13 | Products and compositions |
| EP18179175.7 | 2018-06-21 | ||
| EP18179175.7A EP3483271A3 (en) | 2017-11-13 | 2018-06-21 | Products and compositions |
| GB201815915 | 2018-09-28 | ||
| GB1815915.2 | 2018-09-28 | ||
| PCT/EP2018/081106 WO2019092283A1 (en) | 2017-11-13 | 2018-11-13 | Nucleic acids for inhibiting expression of lpa in a cell |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502120A JP2021502120A (ja) | 2021-01-28 |
| JPWO2019092283A5 true JPWO2019092283A5 (sr) | 2022-08-25 |
| JP7245254B2 JP7245254B2 (ja) | 2023-03-23 |
Family
ID=66439085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544151A Active JP7245254B2 (ja) | 2017-11-13 | 2018-11-13 | 細胞におけるｌｐａの発現を抑制するための核酸 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11319537B2 (sr) |
| EP (2) | EP3710586B1 (sr) |
| JP (1) | JP7245254B2 (sr) |
| KR (1) | KR102553382B1 (sr) |
| CN (1) | CN111465694A (sr) |
| AU (1) | AU2018363840B2 (sr) |
| BR (1) | BR112020009152A2 (sr) |
| CA (1) | CA3081905C (sr) |
| DK (1) | DK3710586T3 (sr) |
| ES (1) | ES2938193T3 (sr) |
| FI (1) | FI3710586T3 (sr) |
| HR (1) | HRP20230127T1 (sr) |
| HU (1) | HUE061265T2 (sr) |
| IL (1) | IL274503B1 (sr) |
| LT (1) | LT3710586T (sr) |
| MX (1) | MX2020004897A (sr) |
| PL (1) | PL3710586T3 (sr) |
| RS (1) | RS63955B1 (sr) |
| SG (1) | SG11202003230UA (sr) |
| SI (1) | SI3710586T1 (sr) |
| WO (1) | WO2019092283A1 (sr) |
| ZA (1) | ZA202003371B (sr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016370962B2 (en) | 2015-12-16 | 2020-09-24 | 6K Inc. | Spheroidal dehydrogenated metals and metal alloy particles |
| RS63836B1 (sr) * | 2017-04-05 | 2023-01-31 | Silence Therapeutics Gmbh | Proizvodi i sastavi |
| US11661603B2 (en) | 2018-01-16 | 2023-05-30 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting ALDH2 expression |
| ES2932295T3 (es) | 2018-11-13 | 2023-01-17 | Silence Therapeutics Gmbh | Acidos nucleicos para inhibir la expresión de LPA en una célula |
| EP3947683A1 (en) * | 2019-04-04 | 2022-02-09 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting gene expression in the central nervous system |
| JP2022530648A (ja) | 2019-04-30 | 2022-06-30 | シックスケー インコーポレイテッド | 機械的に合金化された粉末原料 |
| CA3153254A1 (en) | 2019-11-18 | 2021-06-17 | 6K Inc. | Unique feedstocks for spherical powders and methods of manufacturing |
| AU2020399636A1 (en) * | 2019-12-09 | 2022-06-02 | Amgen Inc. | RNAi constructs and methods for inhibiting LPA expression |
| AU2021297476A1 (en) | 2020-06-25 | 2022-12-15 | 6K Inc. | Microcomposite alloy structure |
| TW202220673A (zh) | 2020-08-05 | 2022-06-01 | 美商戴瑟納製藥股份有限公司 | 抑制ｌｐａ表現之組合物及方法 |
| US11963287B2 (en) | 2020-09-24 | 2024-04-16 | 6K Inc. | Systems, devices, and methods for starting plasma |
| EP4229201A1 (en) | 2020-10-16 | 2023-08-23 | Sanofi | Rna compositions and methods for inhibiting lipoprotein(a) |
| JP2023548325A (ja) | 2020-10-30 | 2023-11-16 | シックスケー インコーポレイテッド | 球状化金属粉末の合成のためのシステムおよび方法 |
| KR20230104200A (ko) * | 2020-11-05 | 2023-07-07 | 암젠 인크 | LPA-표적화된 RNAi 작제물을 이용하여 죽상경화성 심혈관질환을 치료하는 방법 |
| JP2024500035A (ja) | 2020-12-23 | 2024-01-04 | アルゴノート アールエヌエー リミテッド | 心血管疾患の治療 |
| WO2023041508A2 (en) | 2021-09-14 | 2023-03-23 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| AU2022393572A1 (en) * | 2021-11-18 | 2024-04-11 | Novartis Ag | Compounds targeting pmp22 for the treatment of charcot-marie-tooth disease |
| US20240043836A1 (en) * | 2021-11-24 | 2024-02-08 | ADARx Pharmaceuticals, Inc | Complement factor b-modulating compositions and methods of use thereof |
| CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
| WO2023220744A2 (en) | 2022-05-13 | 2023-11-16 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
| WO2024006999A2 (en) | 2022-06-30 | 2024-01-04 | Alnylam Pharmaceuticals, Inc. | Cyclic-disulfide modified phosphate based oligonucleotide prodrugs |
| CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
| US7259150B2 (en) * | 2001-08-07 | 2007-08-21 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein (a) expression |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| WO2009151644A2 (en) * | 2008-06-13 | 2009-12-17 | Yale University | Small molecule inhibitors of autotaxin methods of use |
| US10125362B2 (en) * | 2012-05-22 | 2018-11-13 | Olix Pharmaceuticals, Inc. | RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor |
| WO2016149020A1 (en) * | 2015-03-17 | 2016-09-22 | Arrowhead Research Corporation | Rna interference agents |
| JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| EP3228326A1 (en) | 2016-04-05 | 2017-10-11 | Silence Therapeutics GmbH | Nucleic acid linked to a trivalent glycoconjugate |
| RS63836B1 (sr) | 2017-04-05 | 2023-01-31 | Silence Therapeutics Gmbh | Proizvodi i sastavi |
| EP3735461A1 (en) | 2017-11-13 | 2020-11-11 | Silence Therapeutics GmbH | Nucleic acids for inhibiting expression of aldh2 in a cell |
| ES2932295T3 (es) | 2018-11-13 | 2023-01-17 | Silence Therapeutics Gmbh | Acidos nucleicos para inhibir la expresión de LPA en una célula |
-
2018
- 2018-11-13 SG SG11202003230UA patent/SG11202003230UA/en unknown
- 2018-11-13 BR BR112020009152-9A patent/BR112020009152A2/pt not_active Application Discontinuation
- 2018-11-13 KR KR1020207016884A patent/KR102553382B1/ko active IP Right Grant
- 2018-11-13 EP EP18803644.6A patent/EP3710586B1/en active Active
- 2018-11-13 HR HRP20230127TT patent/HRP20230127T1/hr unknown
- 2018-11-13 CN CN201880073189.3A patent/CN111465694A/zh active Pending
- 2018-11-13 JP JP2020544151A patent/JP7245254B2/ja active Active
- 2018-11-13 HU HUE18803644A patent/HUE061265T2/hu unknown
- 2018-11-13 SI SI201830845T patent/SI3710586T1/sl unknown
- 2018-11-13 MX MX2020004897A patent/MX2020004897A/es unknown
- 2018-11-13 DK DK18803644.6T patent/DK3710586T3/da active
- 2018-11-13 CA CA3081905A patent/CA3081905C/en active Active
- 2018-11-13 IL IL274503A patent/IL274503B1/en unknown
- 2018-11-13 WO PCT/EP2018/081106 patent/WO2019092283A1/en unknown
- 2018-11-13 LT LTEPPCT/EP2018/081106T patent/LT3710586T/lt unknown
- 2018-11-13 US US16/763,458 patent/US11319537B2/en active Active
- 2018-11-13 FI FIEP18803644.6T patent/FI3710586T3/fi active
- 2018-11-13 ES ES18803644T patent/ES2938193T3/es active Active
- 2018-11-13 RS RS20230097A patent/RS63955B1/sr unknown
- 2018-11-13 PL PL18803644.6T patent/PL3710586T3/pl unknown
- 2018-11-13 EP EP22208120.0A patent/EP4219716A3/en active Pending
- 2018-11-13 AU AU2018363840A patent/AU2018363840B2/en active Active
-
2020
- 2020-06-05 ZA ZA2020/03371A patent/ZA202003371B/en unknown
-
2022
- 2022-03-17 US US17/697,405 patent/US20220290144A1/en active Pending
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