JPWO2018146826A1 - 超臨界流体装置 - Google Patents
超臨界流体装置 Download PDFInfo
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- JPWO2018146826A1 JPWO2018146826A1 JP2018566739A JP2018566739A JPWO2018146826A1 JP WO2018146826 A1 JPWO2018146826 A1 JP WO2018146826A1 JP 2018566739 A JP2018566739 A JP 2018566739A JP 2018566739 A JP2018566739 A JP 2018566739A JP WO2018146826 A1 JPWO2018146826 A1 JP WO2018146826A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/22—Injection in high pressure liquid systems
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/202—Injection using a sampling valve rotary valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Fluid Mechanics (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
4 分析流路
6 超臨界流体抽出部
8 試料導入装置
10 分析カラム
11 カラムオーブン
12,38 背圧制御部(BPR)
14 検出器
16,18 送液ポンプ
20 ニードル
22 注入ポート
24 サンプルループ(試料保持部)
26 切替バルブ
28 バイパス流路
34 分岐部分
36 スプリット流路
42 メイクアップポンプ
44 抽出容器
Claims (3)
- 分析流路と、
超臨界流体を構成する移動相を前記分析流路中で送液する送液部と、
前記分析流路内の移動相が超臨界状態となるように前記分析流路内の圧力を制御する背圧制御部と、
試料を保持する試料保持部、及び前記試料保持部を前記分析流路に導入した状態と導入しない状態との間で切り替える切替バルブを有する試料導入装置と、
一端が前記試料導入装置よりも上流の位置に接続され、他端が前記分析流路における前記試料導入装置よりも下流の位置に接続されたバイパス流路と、
前記分析流路上における前記バイパス流路の前記他端が接続されている位置よりも下流に設けられ、前記試料導入装置により導入された試料を分離する分析カラムと、を備えた超臨界流体装置。 - 前記分析流路上における前記バイパス流路の前記一端が接続されている位置よりも上流に、前記送液部からの移動相によって試料成分を抽出する超臨界抽出部が設けられている請求項1に記載の超臨界流体装置。
- 前記分析流路における前記バイパス流路の前記他端が接続されている位置よりも下流で前記分析カラムよりも上流の位置で前記分析流路から分岐したスプリット流路をさらに備えている請求項2に記載の超臨界流体装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762458107P | 2017-02-13 | 2017-02-13 | |
US62/458107 | 2017-02-13 | ||
PCT/JP2017/010937 WO2018146826A1 (ja) | 2017-02-13 | 2017-03-17 | 超臨界流体装置 |
Publications (2)
Publication Number | Publication Date |
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JPWO2018146826A1 true JPWO2018146826A1 (ja) | 2019-11-07 |
JP6828755B2 JP6828755B2 (ja) | 2021-02-10 |
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JP2018566739A Active JP6828755B2 (ja) | 2017-02-13 | 2017-03-17 | 超臨界流体装置 |
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US (1) | US11243193B2 (ja) |
JP (1) | JP6828755B2 (ja) |
CN (1) | CN110291392B (ja) |
WO (1) | WO2018146826A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP7310968B2 (ja) * | 2018-11-22 | 2023-07-19 | 株式会社島津製作所 | 分析支援方法および分析支援装置 |
JP7063249B2 (ja) | 2018-11-22 | 2022-05-09 | 株式会社島津製作所 | 分析支援方法、分析支援装置、分析支援プログラムおよび分析システム |
CN111896634A (zh) * | 2019-05-05 | 2020-11-06 | 株式会社岛津制作所 | 番茄红素在线分析方法 |
WO2021130922A1 (ja) * | 2019-12-25 | 2021-07-01 | 株式会社島津製作所 | 分析システム |
CN111721883B (zh) * | 2020-06-24 | 2021-10-08 | 华南理工大学 | 超临界选择性脱水萃取-变压聚焦超临界流体色谱在线分析系统及分析方法 |
JP7468845B2 (ja) * | 2020-07-27 | 2024-04-16 | 株式会社島津製作所 | 分析支援装置、分析支援方法、分析支援プログラムおよび分析システム |
CN117031055A (zh) * | 2023-08-25 | 2023-11-10 | 北京宝德仪器有限公司 | 一种气泡间隔连续流动和流动注射可切换的流动分析系统 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2010101875A (ja) * | 2008-09-29 | 2010-05-06 | Jasco Corp | 超臨界流体クロマトグラフィーにおける試料注入装置及び方法 |
WO2015183290A1 (en) * | 2014-05-29 | 2015-12-03 | Agilent Technologies, Inc. | Apparatus and method for introducing a sample into a separation unit of a chromatography system |
WO2016031008A1 (ja) * | 2014-08-28 | 2016-03-03 | 株式会社島津製作所 | 分析装置 |
US20160187304A1 (en) * | 2014-12-30 | 2016-06-30 | Agilent Technologies, Inc. | Apparatus and method for introducing sample into a separation unit of a chromatography system without disrupting a mobile phase |
Family Cites Families (8)
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US6632353B2 (en) * | 2000-06-26 | 2003-10-14 | Berger Instruments, Inc. | Rapid sample collection in supercritical fluid chromatography |
CN1936572A (zh) * | 2005-09-23 | 2007-03-28 | 中国科学院大连化学物理研究所 | 一种超临界流体萃取-高效液相色谱联用系统 |
US9114330B2 (en) * | 2010-09-20 | 2015-08-25 | Agilent Technologies, Inc. | System and process for an active drain for gas-liquid separators |
GB2491168B (en) * | 2011-05-26 | 2014-09-10 | Thermo Electron Mfg Ltd | Method and apparatus for improved resolution chromatography |
CN102445503B (zh) * | 2011-09-22 | 2014-08-06 | 中国海洋大学 | 一种亚临界流体萃取-液相色谱联用分析装置 |
JP6141234B2 (ja) * | 2014-03-26 | 2017-06-07 | フロンティア・ラボ株式会社 | 気相成分分析装置 |
JP6458504B2 (ja) * | 2015-01-14 | 2019-01-30 | 株式会社島津製作所 | 超臨界流体−液体クロマトグラフとその分析方法 |
JP6428410B2 (ja) * | 2015-03-18 | 2018-11-28 | 株式会社島津製作所 | 液化二酸化炭素送液ポンプとそれを備えた超臨界流体クロマトグラフ |
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- 2017-03-17 JP JP2018566739A patent/JP6828755B2/ja active Active
- 2017-03-17 WO PCT/JP2017/010937 patent/WO2018146826A1/ja active Application Filing
- 2017-03-17 CN CN201780086418.0A patent/CN110291392B/zh active Active
- 2017-03-17 US US16/485,006 patent/US11243193B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2010101875A (ja) * | 2008-09-29 | 2010-05-06 | Jasco Corp | 超臨界流体クロマトグラフィーにおける試料注入装置及び方法 |
WO2015183290A1 (en) * | 2014-05-29 | 2015-12-03 | Agilent Technologies, Inc. | Apparatus and method for introducing a sample into a separation unit of a chromatography system |
WO2016031008A1 (ja) * | 2014-08-28 | 2016-03-03 | 株式会社島津製作所 | 分析装置 |
US20160187304A1 (en) * | 2014-12-30 | 2016-06-30 | Agilent Technologies, Inc. | Apparatus and method for introducing sample into a separation unit of a chromatography system without disrupting a mobile phase |
Also Published As
Publication number | Publication date |
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US20200025725A1 (en) | 2020-01-23 |
US11243193B2 (en) | 2022-02-08 |
JP6828755B2 (ja) | 2021-02-10 |
CN110291392A (zh) | 2019-09-27 |
WO2018146826A1 (ja) | 2018-08-16 |
CN110291392B (zh) | 2021-08-20 |
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