JPWO2018054989A5 - - Google Patents
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- Publication number
- JPWO2018054989A5 JPWO2018054989A5 JP2019515523A JP2019515523A JPWO2018054989A5 JP WO2018054989 A5 JPWO2018054989 A5 JP WO2018054989A5 JP 2019515523 A JP2019515523 A JP 2019515523A JP 2019515523 A JP2019515523 A JP 2019515523A JP WO2018054989 A5 JPWO2018054989 A5 JP WO2018054989A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- optionally substituted
- halo
- heterocyclic ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 21
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000005843 halogen group Chemical group 0.000 description 5
- 125000001072 heteroaryl group Chemical group 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- -1 racemic mixtures Chemical class 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 description 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 101100240522 Caenorhabditis elegans nhr-18 gene Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306203.7 | 2016-09-20 | ||
| EP16306203 | 2016-09-20 | ||
| PCT/EP2017/073801 WO2018054989A1 (en) | 2016-09-20 | 2017-09-20 | Benzoimidazole derivatives as anticancer agents |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019531294A JP2019531294A (ja) | 2019-10-31 |
| JPWO2018054989A5 true JPWO2018054989A5 (https=) | 2022-09-07 |
| JP2019531294A5 JP2019531294A5 (https=) | 2022-09-07 |
| JP7278945B2 JP7278945B2 (ja) | 2023-05-22 |
Family
ID=57113229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515523A Active JP7278945B2 (ja) | 2016-09-20 | 2017-09-20 | 抗癌剤としてのベンゾイミダゾール誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11384081B2 (https=) |
| EP (1) | EP3515904B1 (https=) |
| JP (1) | JP7278945B2 (https=) |
| CN (1) | CN110234640B (https=) |
| CA (1) | CA3037424A1 (https=) |
| ES (1) | ES2973850T3 (https=) |
| WO (1) | WO2018054989A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| CN110101685B (zh) * | 2019-05-21 | 2021-03-30 | 河南大学 | 一种仿生纳米药物、其制备方法及应用 |
| EP4412610A1 (en) * | 2021-10-08 | 2024-08-14 | Université Claude Bernard Lyon 1 | Benzimidazole derivatives for use in the treatment or prevention of a histiocytosis or a craniopharyngioma |
| CN114133355B (zh) * | 2021-11-29 | 2023-09-15 | 郑州大学第一附属医院 | 一种2-苯基-1h-苯并咪唑类衍生物及其应用 |
| CN118908896B (zh) * | 2024-09-02 | 2026-01-06 | 广东海洋大学 | 4-（1H-苯并[d]咪唑-2-基）-N，N-双（2-氯乙基）苯胺衍生物及其制备方法与应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000516611A (ja) * | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体 |
| CA2352554C (en) * | 1998-11-27 | 2006-10-10 | Basf Aktiengesellschaft | Substituted benzimidazoles and their use as parp inhibitors |
| SI1194425T1 (sl) * | 1999-06-23 | 2005-12-31 | Sanofi Aventis Deutschland | Substituirani benzimidazoli |
| US6759425B2 (en) * | 1999-10-21 | 2004-07-06 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| BR0208010A (pt) | 2001-03-12 | 2004-12-21 | Avanir Pharmaceuticals | Composto de benzimidazol para modulação de ige e inibição de proliferação celular |
| EP1435947B1 (en) * | 2001-10-19 | 2007-08-15 | Ortho-McNeil Pharmaceutical, Inc. | 2-phenyl benzimidazoles and imidazo-¬4,5|-pyridines as cds1/chk2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer |
| WO2005030206A1 (en) * | 2003-09-24 | 2005-04-07 | Imclone Systems Incorporated | Aryl-1,3-azole derivatives and methods for inhibiting heparnase activity |
| EP1960382A1 (en) * | 2005-11-03 | 2008-08-27 | ChemBridge Research Laboratories, Inc. | Heterocyclic compounds as tyrosine kinase modulators |
| AR063311A1 (es) | 2006-10-18 | 2009-01-21 | Novartis Ag | Compuestos organicos |
| CN101553468A (zh) * | 2006-10-18 | 2009-10-07 | 诺瓦提斯公司 | 有机化合物 |
| WO2008073451A2 (en) | 2006-12-11 | 2008-06-19 | Sirtris Pharmaceuticals, Inc. | Benzoimidazole derivatives as sirtuin (sir) modulating compounds |
| BRPI0909183A2 (pt) | 2008-03-20 | 2015-08-25 | Forest Lab Holdings Ltd | Composto, composição farmacêutica e método de tratamento de condição que responde a inibidor de estearoil-coa dessaturase |
| US8242284B1 (en) * | 2009-09-21 | 2012-08-14 | The United States Of America As Represented By The United States Department Of Energy | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making |
| JP5819305B2 (ja) * | 2009-10-13 | 2015-11-24 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 造血成長因子模倣小分子化合物およびそれらの使用 |
| WO2012102937A2 (en) | 2011-01-25 | 2012-08-02 | Irm Llc | Compounds that expand hematopoietic stem cells |
| US20140128352A1 (en) * | 2012-09-20 | 2014-05-08 | Buck Institute For Research On Aging | Compounds and methods for modulating mitochondrial metabolism and reactive oxygen species production |
-
2017
- 2017-09-20 ES ES17769091T patent/ES2973850T3/es active Active
- 2017-09-20 US US16/334,513 patent/US11384081B2/en active Active
- 2017-09-20 CA CA3037424A patent/CA3037424A1/en active Pending
- 2017-09-20 CN CN201780070287.7A patent/CN110234640B/zh active Active
- 2017-09-20 WO PCT/EP2017/073801 patent/WO2018054989A1/en not_active Ceased
- 2017-09-20 EP EP17769091.4A patent/EP3515904B1/en active Active
- 2017-09-20 JP JP2019515523A patent/JP7278945B2/ja active Active
-
2022
- 2022-06-03 US US17/831,592 patent/US12509465B2/en active Active
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