JPWO2016104429A1 - 癌細胞増殖抑制組成物および癌細胞増殖の抑制方法 - Google Patents
癌細胞増殖抑制組成物および癌細胞増殖の抑制方法 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
Abstract
Description
本発明の癌細胞増殖抑制組成物は、緑茶抽出物およびローズマリー抽出物を10:1〜1:10の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で含む。
本発明の癌細胞増殖抑制組成物の有効成分である緑茶抽出物は、チャノキ(Camellia sinensis)(全体または一部)を適当な溶媒を用い抽出することによって、得られる。ここで、抽出の対象となるチャノキの部分は、特に制限されず、植物体全体、葉、茎、芽、花(ガク、花弁、めしべ、おしべ等を含む)、木質部、木皮部(樹皮)、果実(花托(果肉)、子房、果皮(内果皮、中果皮、外果皮)等を含む)、種子等の地上部;根、根茎、塊茎等の地下部などの植物体の一部などを包含する。上記植物の部分は、単独で抽出に供せられてもあるいは2種以上の混合物の形態で抽出に供せられてもよい。これらのうち、癌細胞増殖抑制/防止効果、安全性などを考慮すると、チャノキの葉(茶葉)を原料として使用することが好ましい。または、チャノキの葉(茶葉)を発酵を防止するために加熱処理したものを抽出に使用してもよい。具体的には、抽出の対象となるチャノキの部分は、チャノキの生葉(茶葉)を蒸して揉み潰し、茶葉の型を整えつつ乾燥する(蒸熱⇒冷却⇒葉打ち⇒粗揉⇒揉捻⇒中揉⇒精捻⇒乾燥⇒篩分と切断⇒木茎分離)ことによって作製される。なお、本明細書では、抽出の対象となるチャノキの部分を、単に「緑茶原料」とも称する。
本発明の癌細胞増殖抑制組成物の有効成分であるローズマリー抽出物は、ローズマリー(Rosmarinus officinalis L.)(全体または一部)を適当な溶媒を用い抽出することによって、得られる。ここで、抽出の対象となるローズマリーの部分は、特に制限されず、植物体全体、葉、茎、芽、花(ガク、花弁、めしべ、おしべ等を含む)、木質部、木皮部(樹皮)、果実(花托(果肉)、子房、果皮(内果皮、中果皮、外果皮)等を含む)、種子等の地上部;根、根茎、塊茎等の地下部などの植物体の一部などを包含する。上記植物の部分は、単独で抽出に供せられてもあるいは2種以上の混合物の形態で抽出に供せられてもよい。これらのうち、癌細胞増殖抑制/防止効果、安全性などを考慮すると、ローズマリーの葉を原料として使用することが好ましい。なお、本明細書では、抽出の対象となるローズマリーの部分を、単に「ローズマリー原料」とも称する。
本発明の癌細胞増殖抑制組成物は、医療用途(治療または予防目的)で使用されてもまたは健康食品として使用されてもよく、本発明の癌細胞増殖抑制組成物を有効成分として含む以外は、従来と同様の剤形で使用できる。すなわち、本発明の癌細胞増殖抑制組成物は、賦形剤などの製薬上許容できる添加剤と混合して非経口投与、経口投与または外部投与に適した、医薬品、医薬部外品、食品組成物の形態で使用することができる。
ローズマリー抽出物(三菱化学フーズ(株)製、RM−21Bベース)および緑茶抽出物(三井農林(株)製、ポリフェノン(登録商標)70A、カフェイン含有量:0.5%以下)を、ローズマリー抽出物と緑茶抽出物の重量比(ローズマリー抽出物:緑茶抽出物の混合重量比)が20:1(比較例1)、10:1(実施例1)、5:1(実施例2)、2:1(実施例3)、1:1(実施例4)、1:2(実施例5)、1:5(実施例6)、1:10(実施例7)および1:20(比較例2)となるようにジメチルスルホキシド(DMSO)で調製した(ローズマリー抽出物および緑茶抽出物の混合物の濃度(合計濃度):10mg/ml)。また、比較対象として、ローズマリー抽出物(比較例3)および緑茶抽出物(比較例4)をそれぞれ、DMSOで10mg/mlに調製した。
ローズマリー抽出物と緑茶抽出物の重量比(ローズマリー抽出物:緑茶抽出物の混合重量比)が1:1になるようにDMSOで調製した(ローズマリー抽出物および緑茶抽出物の混合物の濃度(合計濃度):5mg/ml、10mg/mlおよび15mg/ml)。また、比較対象として、ローズマリー抽出物と緑茶抽出物をそれぞれ、DMSOで5mg/ml、10mg/ml、15mg/mlに調製した。なお、本例において、ローズマリー抽出物として、三菱化学フーズ(株)製、RM−21Bベースを使用し、および緑茶抽出物として、三井農林(株)製、ポリフェノン(登録商標)70A(カフェイン含有量:0.5%以下)を使用した。
生存率50%をはさんでいる2種の濃度溶液の細胞生存率から下記式(2)に示す計算式により算出する。
ローズマリー抽出物および緑茶抽出物をそれぞれ単独で使用した場合の癌細胞増殖抑制率がx%に達した時の濃度を(Dx)1、(Dx)2とし、同じく癌細胞増殖抑制率がx%に達した時の混合物におけるローズマリー抽出物と緑茶抽出物の濃度をD1、D2とし、下記式(3)に示す計算式より算出する。
ローズマリー抽出物(三菱化学フーズ(株)製、RM−21Bベース)および緑茶抽出物(三井農林(株)製、ポリフェノン(登録商標)70A)を、ローズマリー抽出物と緑茶抽出物の重量比(ローズマリー抽出物:緑茶抽出物の混合重量比)が20:1(比較例13)、10:1(実施例11)、5:1(実施例12)、2:1(実施例13)、1:1(実施例14)、1:2(実施例15)、1:5(実施例16)、1:10(実施例17)および1:20(比較例14)となるようにジメチルスルホキシド(DMSO)で調製した(ローズマリー抽出物および緑茶抽出物の混合物の濃度(合計濃度):10mg/ml)。また、比較対象として、ローズマリー抽出物(比較例15)および緑茶抽出物(比較例16)をそれぞれ、DMSOで10mg/mlに調製した。
ローズマリー抽出物と緑茶抽出物の重量比(ローズマリー抽出物:緑茶抽出物の混合重量比)が1:1になるようにDMSOで調製した(ローズマリー抽出物および緑茶抽出物の混合物の濃度(合計濃度):5mg/ml、10mg/mlおよび15mg/ml)。また、比較対象として、ローズマリー抽出物と緑茶抽出物をそれぞれ、DMSOで5mg/ml、10mg/ml、15mg/mlに調製した。なお、本例において、ローズマリー抽出物として、三菱化学フーズ(株)製、RM−21Bベースを使用し、および緑茶抽出物として、三井農林(株)製、ポリフェノン(登録商標)70A(カフェイン含有量:0.5%以下)を使用した。
Claims (9)
- 緑茶抽出物およびローズマリー抽出物を10:1〜1:10の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で含む、癌細胞増殖抑制組成物。
- 緑茶抽出物およびローズマリー抽出物を5:1〜1:5の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で含む、請求項1に記載の癌細胞増殖抑制組成物。
- 造血器系の癌、消化器系の癌、生殖器系の癌、悪性黒色腫(メラノーマ)、肥満細胞腫、および基底細胞癌からなる群より選択される少なくとも一種の疾患の予防および/または治療に使用される、請求項1または2に記載の癌細胞増殖抑制組成物。
- ヒトまたはイヌ、ネコおよびウサギからなる群より選択される少なくとも一種のペット動物に経口的に使用される、請求項1〜3のいずれか1項に記載の癌細胞増殖抑制組成物。
- ヒト用健康食品またはペットフード組成物である、請求項1〜4のいずれか1項に記載の癌細胞増殖抑制組成物。
- 10:1〜1:10の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で緑茶抽出物およびローズマリー抽出物を、癌細胞増殖を抑制する必要のある被検者に投与することを有する、癌細胞増殖の抑制方法。
- 前記緑茶抽出物およびローズマリー抽出物を5:1〜1:5の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で投与する、請求項6に記載の方法。
- 造血器系の癌、消化器系の癌、生殖器系の癌、悪性黒色腫(メラノーマ)、肥満細胞腫、および基底細胞癌からなる群より選択される少なくとも一種の疾患の予防および/または治療を目的として使用される、請求項6または7に記載の方法。
- 前記緑茶抽出物およびローズマリー抽出物を、ヒトまたはイヌ、ネコおよびウサギからなる群より選択される少なくとも一種のペット動物に経口で投与する、請求項6〜8のいずれか1項に記載の方法。
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63267726A (ja) * | 1987-04-24 | 1988-11-04 | Terumo Corp | 抗腫瘍剤 |
JPS63277628A (ja) * | 1987-04-24 | 1988-11-15 | Terumo Corp | 抗腫瘍剤 |
JP2007513176A (ja) * | 2003-12-05 | 2007-05-24 | ニュー・チャプター・インコーポレーテッド | 前立腺癌を草本組成物で治療する方法 |
JP2008247797A (ja) * | 2007-03-30 | 2008-10-16 | Univ Of Miyazaki | 成人t細胞性白血病の予防剤、治療剤、及びその医薬品組成物 |
JP2008543852A (ja) * | 2005-06-14 | 2008-12-04 | ニュー チャプター,インコーポレイテッド | エイコサノイド代謝を調節する方法 |
JP2011513340A (ja) * | 2008-03-06 | 2011-04-28 | 莉 張 | 腫瘍の予防または治療用医薬の製造における茶ポリフェノールの使用 |
US20130315983A1 (en) * | 2012-05-24 | 2013-11-28 | The Research Foundation Of The City University Of New York | Methods and compositions for the treatment of cancer |
-
2015
- 2015-12-21 WO PCT/JP2015/085680 patent/WO2016104429A1/ja active Application Filing
- 2015-12-21 JP JP2016566349A patent/JP6592010B2/ja active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63267726A (ja) * | 1987-04-24 | 1988-11-04 | Terumo Corp | 抗腫瘍剤 |
JPS63277628A (ja) * | 1987-04-24 | 1988-11-15 | Terumo Corp | 抗腫瘍剤 |
JP2007513176A (ja) * | 2003-12-05 | 2007-05-24 | ニュー・チャプター・インコーポレーテッド | 前立腺癌を草本組成物で治療する方法 |
JP2008543852A (ja) * | 2005-06-14 | 2008-12-04 | ニュー チャプター,インコーポレイテッド | エイコサノイド代謝を調節する方法 |
JP2008247797A (ja) * | 2007-03-30 | 2008-10-16 | Univ Of Miyazaki | 成人t細胞性白血病の予防剤、治療剤、及びその医薬品組成物 |
JP2011513340A (ja) * | 2008-03-06 | 2011-04-28 | 莉 張 | 腫瘍の予防または治療用医薬の製造における茶ポリフェノールの使用 |
US20130315983A1 (en) * | 2012-05-24 | 2013-11-28 | The Research Foundation Of The City University Of New York | Methods and compositions for the treatment of cancer |
Non-Patent Citations (7)
Title |
---|
CENI.-MILOSEVI D, ET AL: "Antiproliferative effects of Camelliasinensis, Frangula alnus and Rosmarinus officinalis", ARCHIVESOF BIOLOGICAL SCIENCE BELGRADE, vol. 65, no. 3, JPN7019001818, 2013, pages 885 - 891, ISSN: 0004050373 * |
小村美穂 ほか: "県内産農産物のHL60 細胞増殖抑制活性", 宮崎県工業技術センター・宮崎県食品開発センター研究報告, vol. 平成16年度・第49号, JPN7019001815, 30 November 2005 (2005-11-30), pages 81 - 84, ISSN: 0004050370 * |
茂木弘之 ほか: "香辛料抽出物によるヒト白血病Molt 4B 細胞の増殖抑制作用", 日本食品科学工学会誌, vol. 第49巻,第10号, JPN7019001820, 15 October 2002 (2002-10-15), pages 688 - 691, ISSN: 0004050375 * |
菅沼雅美,岡部幸子: "緑茶による発癌の抑制", 医学のあゆみ, vol. 第176巻,第12号, JPN7019001819, 23 March 1996 (1996-03-23), pages 760 - 761, ISSN: 0004050374 * |
酒井美穂 ほか: "県産農産物のがん細胞増殖抑制活性", 宮崎県工業技術センター・宮崎県食品開発センター研究報告, vol. 平成17年度・第50号, JPN7019001816, February 2007 (2007-02-01), pages 87 - 93, ISSN: 0004050371 * |
長尾常敦 ほか: "腫瘍細胞増殖抑制作用を有するフェノール性植物成分と構造活性相関", 食品・食品添加物研究誌, vol. 第209巻,第1号, JPN7019001817, 1 January 2004 (2004-01-01), pages 3 - 12, ISSN: 0004050372 * |
阿知和弓子 ほか: "ウルソール酸の子宮内膜細胞に対する抗腫瘍効果と作用機序", 日本農芸化学会大会講演要旨集 2002年度(平成14年度)大会[仙台], JPN7019001821, 5 March 2002 (2002-03-05), pages 23, ISSN: 0004050376 * |
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