JPWO2013073074A1 - 物質の測定方法 - Google Patents
物質の測定方法 Download PDFInfo
- Publication number
- JPWO2013073074A1 JPWO2013073074A1 JP2013544086A JP2013544086A JPWO2013073074A1 JP WO2013073074 A1 JPWO2013073074 A1 JP WO2013073074A1 JP 2013544086 A JP2013544086 A JP 2013544086A JP 2013544086 A JP2013544086 A JP 2013544086A JP WO2013073074 A1 JPWO2013073074 A1 JP WO2013073074A1
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- 238000000034 method Methods 0.000 title claims abstract description 27
- 239000000126 substance Substances 0.000 title claims description 39
- 238000005259 measurement Methods 0.000 claims abstract description 132
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 53
- 230000003647 oxidation Effects 0.000 claims abstract description 49
- 238000006243 chemical reaction Methods 0.000 claims abstract description 47
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 46
- 239000013076 target substance Substances 0.000 claims abstract description 42
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- 108090000790 Enzymes Proteins 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 230000001590 oxidative effect Effects 0.000 claims description 8
- 238000000354 decomposition reaction Methods 0.000 claims description 7
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- 229940088598 enzyme Drugs 0.000 description 25
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 20
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 19
- 239000008103 glucose Substances 0.000 description 19
- -1 polyethylene terephthalate Polymers 0.000 description 14
- 238000001514 detection method Methods 0.000 description 12
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 108010015776 Glucose oxidase Proteins 0.000 description 5
- 239000005020 polyethylene terephthalate Substances 0.000 description 5
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- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
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- YPUDISCJWPUYAX-VRPWFDPXSA-N (3S,4S,5R)-2-amino-2,5-bis(hydroxymethyl)oxolane-3,4-diol Chemical compound OCC1(N)O[C@H](CO)[C@@H](O)[C@@H]1O YPUDISCJWPUYAX-VRPWFDPXSA-N 0.000 description 1
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- LJCNDNBULVLKSG-UHFFFAOYSA-N 2-aminoacetic acid;butane Chemical compound CCCC.CCCC.NCC(O)=O LJCNDNBULVLKSG-UHFFFAOYSA-N 0.000 description 1
- 102000034279 3-hydroxybutyrate dehydrogenases Human genes 0.000 description 1
- 108090000124 3-hydroxybutyrate dehydrogenases Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108010077078 Creatinase Proteins 0.000 description 1
- 108010066906 Creatininase Proteins 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 108010042687 Pyruvate Oxidase Proteins 0.000 description 1
- 108010060059 Sarcosine Oxidase Proteins 0.000 description 1
- 102000008118 Sarcosine oxidase Human genes 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229920003064 carboxyethyl cellulose Polymers 0.000 description 1
- 229940033631 carrageenan sodium Drugs 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- FBELJLCOAHMRJK-UHFFFAOYSA-L disodium;2,2-bis(2-ethylhexyl)-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCC(CC)CC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CC(CC)CCCC FBELJLCOAHMRJK-UHFFFAOYSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000012209 glucono delta-lactone Nutrition 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- UETZVSHORCDDTH-UHFFFAOYSA-N iron(2+);hexacyanide Chemical compound [Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] UETZVSHORCDDTH-UHFFFAOYSA-N 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002907 osmium Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 150000004059 quinone derivatives Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003303 ruthenium Chemical class 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- General Physics & Mathematics (AREA)
- Emergency Medicine (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013544086A JPWO2013073074A1 (ja) | 2011-11-18 | 2012-07-10 | 物質の測定方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011252765 | 2011-11-18 | ||
| JP2011252765 | 2011-11-18 | ||
| JP2013544086A JPWO2013073074A1 (ja) | 2011-11-18 | 2012-07-10 | 物質の測定方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPWO2013073074A1 true JPWO2013073074A1 (ja) | 2015-04-02 |
Family
ID=48429179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544086A Withdrawn JPWO2013073074A1 (ja) | 2011-11-18 | 2012-07-10 | 物質の測定方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140246336A1 (https=) |
| EP (1) | EP2781915A1 (https=) |
| JP (1) | JPWO2013073074A1 (https=) |
| CN (1) | CN103946701A (https=) |
| IN (1) | IN2014CN03415A (https=) |
| WO (1) | WO2013073074A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10690619B2 (en) | 2014-09-17 | 2020-06-23 | I-Sens, Inc. | Apparatus and method for measuring concentration of an analyte in whole blood samples |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6116080B1 (ja) * | 2016-04-26 | 2017-04-19 | 日本航空電子工業株式会社 | 電気化学測定方法、電気化学測定装置及びトランスデューサ |
| EP4266036A4 (en) | 2020-12-21 | 2024-09-11 | Fujidenolo Co., Ltd. | MEASURING DEVICE AND MEASURING METHODS |
| CN113358726B (zh) * | 2021-05-18 | 2025-02-18 | 北京大学第一医院 | 用于电化学方法检测肌酐的电极、试纸及其制备方法 |
| CN118318161A (zh) * | 2022-01-27 | 2024-07-09 | 普和希控股公司 | 试料测定装置、试料测定方法以及试料测定程序 |
| JP2024070325A (ja) * | 2022-11-11 | 2024-05-23 | 東洋紡株式会社 | 試料中の基質の測定方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000162176A (ja) * | 1998-09-22 | 2000-06-16 | Omron Corp | バイオセンサを用いた測定方法及び測定装置 |
| EP3115777B1 (en) * | 2004-04-19 | 2020-01-08 | PHC Holdings Corporation | Method for measuring blood components |
| US7566392B2 (en) * | 2006-04-12 | 2009-07-28 | Dionex Corporation | Pulsed electrochemical detection method |
| EP3543348B1 (en) * | 2006-09-22 | 2020-11-18 | Ascensia Diabetes Care Holdings AG | Biosensor system having enhanced stability and hematocrit performance |
| JP4582076B2 (ja) * | 2006-10-03 | 2010-11-17 | パナソニック株式会社 | 基質の定量方法 |
| US8778168B2 (en) * | 2007-09-28 | 2014-07-15 | Lifescan, Inc. | Systems and methods of discriminating control solution from a physiological sample |
| WO2009119118A1 (ja) * | 2008-03-27 | 2009-10-01 | パナソニック株式会社 | 試料測定装置、試料測定システム及び試料測定方法 |
| US9212380B2 (en) * | 2009-08-31 | 2015-12-15 | Panasonic Healthcare Holdings Co., Ltd. | Sensor and concentration measurement method |
-
2012
- 2012-07-10 JP JP2013544086A patent/JPWO2013073074A1/ja not_active Withdrawn
- 2012-07-10 CN CN201280055939.7A patent/CN103946701A/zh active Pending
- 2012-07-10 IN IN3415CHN2014 patent/IN2014CN03415A/en unknown
- 2012-07-10 WO PCT/JP2012/004442 patent/WO2013073074A1/ja not_active Ceased
- 2012-07-10 EP EP12849902.7A patent/EP2781915A1/en not_active Withdrawn
-
2014
- 2014-05-15 US US14/278,539 patent/US20140246336A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10690619B2 (en) | 2014-09-17 | 2020-06-23 | I-Sens, Inc. | Apparatus and method for measuring concentration of an analyte in whole blood samples |
| US11378540B2 (en) | 2014-09-17 | 2022-07-05 | I-Sens, Inc. | Apparatus and method for measuring concentration of an analyte in bio-samples |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013073074A1 (ja) | 2013-05-23 |
| EP2781915A1 (en) | 2014-09-24 |
| CN103946701A (zh) | 2014-07-23 |
| US20140246336A1 (en) | 2014-09-04 |
| IN2014CN03415A (https=) | 2015-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20150305 |