JPWO2010095478A1 - 薬物徐放性ハイドロゲルコンタクトレンズ及び薬物徐放性ハイドロゲルコンタクトレンズを用いた薬物放出方法 - Google Patents
薬物徐放性ハイドロゲルコンタクトレンズ及び薬物徐放性ハイドロゲルコンタクトレンズを用いた薬物放出方法 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Description
クロモグリク酸ナトリウムの取り込み量の測定
クロモグリク酸ナトリウムを含有したコンタクトレンズを生理食塩水中に48時間以上浸漬して含有しているクロモグリク酸ナトリウムをすべて生理食塩水中へ放出させた。放出後の生理食塩水中のクロモグリク酸ナトリウムを高速液体クロマトグラフィー(HPLC、日本分光(株)社製)で定量し、レンズ中のクロモグリク酸ナトリウム取り込み量とした。
白色家兎にクロモグリク酸ナトリウムを含有したコンタクトレンズを4時間及び18時間装着させ、取り外したコンタクトレンズを生理食塩水中に48時間以上浸漬して残存しているクロモグリク酸ナトリウムをすべて生理食塩水中へ放出させた。放出後の生理食塩水中のクロモグリク酸ナトリウムを高速液体クロマトグラフィー(HPLC、日本分光(株)社製)で定量し、レンズ中のクロモグリク酸ナトリウム残存量とした。この残存量から放出率を算出した。
クロモグリク酸ナトリウム放出前と放出後のコンタクトレンズを生理食塩水中で、コンタクトレンズ投影機を用いてレンズサイズを測定した。放出前後でサイズ変化、変形がない場合は○、サイズ変化、変形が認められた場合は×とした。
クロモグリク酸ナトリウムを含有したコンタクトレンズをヒトに装着し、装着初期の刺激及び異物感を評価した。刺激や異物を感じない場合は○、ごくわずかな刺激や異物を感じた場合は△、刺激や異物感が有る場合を×とした。
含水状の共重合体を減圧下、常温にて1昼夜乾燥させ、その際の重量(W2)を測定した。その後、純水に浸漬してレンズを水で完全に飽和させ、その際の重量(W1)を測定した。これらの重量から、下記式に従い、含水率を求めた。
W1:飽和含水時の重量
W2:レンズの脱水乾燥時の重量
表1に示す割合で2−ヒドロキシエチルメタクリレート(HEMA)(46.2g;0.35モル)、2−ヒドロキシプロピルメタクリレート(HPMA)(37.6g;0.26モル)、メタクリルアミドプロピルトリメチルアンモニウムクロライド(MAPTAC)(12.2g;0.055モル)、メタクリルオキシエチルコハク酸(MOESA)(3.2g;0.013モル)、エチレングリコールジメタクリレート(EDMA)(0.8g;0.004モル)、及びアゾビスイソブチロニトリル(AIBN)3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、モノマー混合液をコンタクトレンズ用の成形型に入れ、50〜100℃の範囲で24時間かけて昇温させ、重合体を得た。得られた重合体を室温に戻し、容器から取り出し、約60℃の蒸留水中に約4時間浸漬することで水和膨潤させた。このコンタクトレンズを、あらかじめ調製しておいたクロモグリク酸ナトリウム(DSCG)の0.05wt%水溶液10mL中に25℃、3時間浸漬させることでコンタクトレンズ中にクロモグリク酸ナトリウムを含有させた。
表1に示す割合でHEMA(46.2g;0.35モル)、HPMA(37.6g;0.26モル)、MAPTAC(12.9g;0.058モル)、MOESA(2.5g;0.011モル)、EDMA(0.8g;0.004モル)、及びAIBN3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、実施例1と同様に重合、水和膨潤し、クロモグリク酸ナトリウムを含有させた。
表1に示す割合でHEMA(46.2g;0.35モル)、HPMA(37.6g;0.26モル)、MAPTAC(13.3g;0.060モル)、MOESA(2.1g;0.009モル)、EDMA(0.8g;0.004モル)、及びAIBN3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、実施例1と同様に重合、水和膨潤し、クロモグリク酸ナトリウムを含有させた。
表1に示す割合でHEMA(54.4g;0.42モル)、HPMA(37.6g;0.26モル)、MAPTAC(6.65g;0.03モル)、MOESA(1.5g;0.007モル)、EDMA(0.7g;0.003モル)、及びAIBN3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、実施例1と同様に重合、水和膨潤し、クロモグリク酸ナトリウムを含有させた。
表1に示す割合でHEMA(41.6g;0.32モル)、HPMA(37.6g;0.26モル)、MAPTAC(24.2g;0.11モル)、MOESA(6.21g;0.027モル)、EDMA(0.8g;0.004モル)、及びAIBN3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、実施例1と同様に重合、水和膨潤し、クロモグリク酸ナトリウムを含有させた。
表1に示す割合でHEMA(49.1g;0.38モル)、HPMA(22.2g;0.15モル)、MAPTAC(28.9g;0.13モル)、MOESA(7.13g;0.031モル)、EDMA(0.7g;0.004モル)、及びAIBN3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、実施例1と同様に重合、水和膨潤し、クロモグリク酸ナトリウムを含有させた。
表1に示す割合でHEMA(40.0g;0.51モル)、MAPTAC(11.37g;0.051モル)、メタクリロイルオキシエチルフォスフェート(MOEP)(5.41g;0.025モル)、EDMA(0.7g;0.004モル)、及びAIBN3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、実施例1と同様に重合、水和膨潤し、クロモグリク酸ナトリウムを含有させた。
表1に示す割合でHEMA(51.2g;0.39モル)、HPMA(35.4g;0.24モル)、MAPTAC(6.4g;0.028モル)、MOESA(6.4g;0.028モル)、EDMA(0.6g;0.003モル)、及びAIBN3000ppm(外部)を混合し、十分に窒素置換をしながら約1時間撹拌した。撹拌後、実施例1と同様に重合、水和膨潤し、クロモグリク酸ナトリウムを含有させた。
HPMA:2−ヒドロキシプロピルメタクリレート(親水性モノマー)
MAPTAC:メタクリルアミドプロピルトリメチルアンモニウムクロライド(カチオン性モノマー)
MOESA:メタクリルオキシエチルコハク酸(アニオン性モノマー)
EDMA:エチレングリコールジメタクリレート(架橋性モノマー)
MOEP:メタクリロイルオキシエチルフォスフェート(アニオン性モノマー)
AIBN:アゾビスイソブチロニトリル(重合開始剤)
DSCG:クロモグリク酸ナトリウム(アニオン性薬剤)
Claims (4)
- 薬物を徐放的に放出するための薬物徐放性ハイドロゲルコンタクトレンズであって、装用開始から4時間程度までの初期放出量が含有される薬剤の総量の50%以下であり且つ少なくとも14時間で、当該薬物徐放性ハイドロゲルコンタクトレンズに含まれる前記薬物の80%以上を放出することを特徴とする薬物徐放性ハイドロゲルコンタクトレンズ。
- 少なくともカチオン性モノマー及びアニオン性モノマーであるイオン性モノマーからなるハイドロゲルであって、
前記イオン性モノマーの構成比率は、前記ゲルを構成するモノマーの総量に対して、5モル%以上20モル%以下であり、
前記カチオン性モノマーに対する前記アニオン性モノマーの含量は、15モル%以上25モル%以下であることを特徴とする請求項1に記載の薬物徐放性ハイドロゲルコンタクトレンズ。 - 少なくとも1つ以上のカルボキシル基を有するアニオン性薬剤を0.5〜5.0mg含有することを特徴とする請求項1又は2に記載の薬物徐放性ハイドロゲルコンタクトレンズ。
- 前記アニオン性薬剤は、クロモグリク酸ナトリウム、クロモグリク酸カリウムであることを特徴とする請求項1乃至3のいずれか一項に記載の薬物徐放性ハイドロゲルコンタクトレンズ。
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WO2011158321A1 (ja) * | 2010-06-14 | 2011-12-22 | 株式会社メニコン | イオン性化合物、組成物、硬化物、ハイドロゲル及び眼用レンズ |
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IL300064A (en) * | 2016-12-02 | 2023-03-01 | Univ Florida | Removing preservative from eye drops |
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US8940318B2 (en) | 2015-01-27 |
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