JPS6479195A - Glycolipid derivative and dermal agent containing said derivative for external use - Google Patents

Glycolipid derivative and dermal agent containing said derivative for external use

Info

Publication number
JPS6479195A
JPS6479195A JP63133426A JP13342688A JPS6479195A JP S6479195 A JPS6479195 A JP S6479195A JP 63133426 A JP63133426 A JP 63133426A JP 13342688 A JP13342688 A JP 13342688A JP S6479195 A JPS6479195 A JP S6479195A
Authority
JP
Japan
Prior art keywords
derivative
formula
compound expressed
external use
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63133426A
Other languages
Japanese (ja)
Other versions
JP2598678B2 (en
Inventor
Akira Kawamata
Shinji Yamada
Yoshihiro Minematsu
Shuichi Akasaki
Mitsuko Zama
Genji Imokawa
Naotake Takaishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Priority to JP63133426A priority Critical patent/JP2598678B2/en
Publication of JPS6479195A publication Critical patent/JPS6479195A/en
Application granted granted Critical
Publication of JP2598678B2 publication Critical patent/JP2598678B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound expressed by formula I (R1 is 10-26C alkyl; R2 is 9-25C alkyl; X and Y are H or saccharide residue and both will not be H at the same time). EXAMPLE:N-( 3-Hexadecyloxy-2-hydroxypropyl)-N-(2-O-D-glucopyranosyl)ethyl )hexadecanamide. USE:A dermal agent for external use. PREPARATION:For example, a glycidyl ether expressed by formula II is reacted with ethanolamine and only the amino group of the resultant product is selective ly acylated to provide a compound expressed by formula III. Either of primary and secondary hydroxyl groups in the resultant compound expressed by formula III is then protected and the protected compound is subsequently reacted with O-(2,3,4,6-tetra-O-benzyl-alpha-D-glycopyranosyl)trichloroacet-imidate in the presence of boron trifluoride etherate. The protecting group is subsequently removed to afford the aimed compound expressed by formula I.
JP63133426A 1987-06-02 1988-05-31 Glycolipid derivative and external preparation for skin containing the same Expired - Fee Related JP2598678B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63133426A JP2598678B2 (en) 1987-06-02 1988-05-31 Glycolipid derivative and external preparation for skin containing the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-138727 1987-06-02
JP13872787 1987-06-02
JP63133426A JP2598678B2 (en) 1987-06-02 1988-05-31 Glycolipid derivative and external preparation for skin containing the same

Publications (2)

Publication Number Publication Date
JPS6479195A true JPS6479195A (en) 1989-03-24
JP2598678B2 JP2598678B2 (en) 1997-04-09

Family

ID=26467795

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63133426A Expired - Fee Related JP2598678B2 (en) 1987-06-02 1988-05-31 Glycolipid derivative and external preparation for skin containing the same

Country Status (1)

Country Link
JP (1) JP2598678B2 (en)

Also Published As

Publication number Publication date
JP2598678B2 (en) 1997-04-09

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Legal Events

Date Code Title Description
R250 Receipt of annual fees

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LAPS Cancellation because of no payment of annual fees