JPS5636441A - Preparation of encephaline derivative - Google Patents

Preparation of encephaline derivative

Info

Publication number
JPS5636441A
JPS5636441A JP11219179A JP11219179A JPS5636441A JP S5636441 A JPS5636441 A JP S5636441A JP 11219179 A JP11219179 A JP 11219179A JP 11219179 A JP11219179 A JP 11219179A JP S5636441 A JPS5636441 A JP S5636441A
Authority
JP
Japan
Prior art keywords
derivative
encephaline
lower alkyl
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11219179A
Other languages
Japanese (ja)
Other versions
JPS6225160B2 (en
Inventor
Yoshiaki Kiso
Shizuo Nakamura
Kaoru Ito
Yukimi Kitagawa
Tadashi Akita
Hideki Moritoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP11219179A priority Critical patent/JPS5636441A/en
Publication of JPS5636441A publication Critical patent/JPS5636441A/en
Publication of JPS6225160B2 publication Critical patent/JPS6225160B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To prepare the titled compound having low toxicity and long-acting effectivity, and useful as an analgesic, etc., economically in an industrial scale, by reacting a specific encephaline derivative with trifluoromethanesulfonic acid as an agent for eliminating the protecting group, and a specific thioether derivative.
CONSTITUTION: The objective compound of formula III (R1 is lower alkyl) is prepared by reacting an encephaline derivative of formula I (R2 is aralkyloxycarbonyl, or alkoxycarbonyl; R3 is lower alkyl) with trifluoromethanesulfonic acid as an agent for eliminating the protecting group and a thioether derivative of formula II (R4 is lower alkyl), e.g. thioanisole, etc., in trifluoroacetic acid at -20W+50°C.
USE: The compound has agonist-activating activity to opiate-receptor, and useful as an analgesic, a narcotic antagonist, and an antidiarrhetic.
COPYRIGHT: (C)1981,JPO&Japio
JP11219179A 1979-08-31 1979-08-31 Preparation of encephaline derivative Granted JPS5636441A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11219179A JPS5636441A (en) 1979-08-31 1979-08-31 Preparation of encephaline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11219179A JPS5636441A (en) 1979-08-31 1979-08-31 Preparation of encephaline derivative

Publications (2)

Publication Number Publication Date
JPS5636441A true JPS5636441A (en) 1981-04-09
JPS6225160B2 JPS6225160B2 (en) 1987-06-01

Family

ID=14580530

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11219179A Granted JPS5636441A (en) 1979-08-31 1979-08-31 Preparation of encephaline derivative

Country Status (1)

Country Link
JP (1) JPS5636441A (en)

Also Published As

Publication number Publication date
JPS6225160B2 (en) 1987-06-01

Similar Documents

Publication Publication Date Title
ES8204739A1 (en) their starting compounds and their preparation.
FI891176A (en) PEPTIDFOERENINGAR, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE PHARMACEUTISKA BLANDNINGAR.
DE68925223D1 (en) 3-alkenyl-1-azabicyclo (3.2.0) hept-2-en-2-carboxylic acid compounds
ES2057016T3 (en) ACID COMPOUNDS 3-PIRROLIDINYLTIO-1-AZABICICLO (3.2.0) HEPT-2-ENO-2-CARBOXILICO.
ZA81978B (en) Substituted imidazole derivatives and their preparation and use
ATE50575T1 (en) 2-OXIMINO-2-AMINOTHIAZOLYLACETIC ACID DERIVATIVES AND PROCESS FOR THEIR PRODUCTION.
ES8704153A1 (en) Pyrimidine derivatives, processes for preparation thereof and composition of the same.
JPS5636441A (en) Preparation of encephaline derivative
JPS5488242A (en) Novel derivative of fortimicin b and its preparation
JPS5716855A (en) 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation
IE810396L (en) SALTS OF 4'-(9-ACRIDINYLAMINO)-METHANESULPHONE-m-ANISIDIDE
ES435274A1 (en) Substituted benzamides
JPS5721400A (en) Novel fortimicin derivative
JPS5479227A (en) Glucosamine derivative and its preparation
JPS55143993A (en) Azetidinone derivative and its preparation
JPS5610150A (en) Preparation of nitrotoluene derivative
ES8101591A1 (en) A procedure for the preparation of cefalosporine analogues. (Machine-translation by Google Translate, not legally binding)
JPS5626855A (en) Enkephalin derivative and its preparation
ES8300709A1 (en) Heterocyclic compounds, compositions thereof, their preparation and use.
JPS643189A (en) Novel damavaricin fc carbamate derivative
JPS5683410A (en) Plant growth regulator
JPS55104266A (en) Novel pyridone derivative
JPS5634688A (en) Preparation of cephapirin
ES8503004A1 (en) Penicillin derivatives.
ES8305307A1 (en) Peptide, process for preparation thereof and use thereof.