IL47842A - Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing them - Google Patents
Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL47842A IL47842A IL47842A IL4784275A IL47842A IL 47842 A IL47842 A IL 47842A IL 47842 A IL47842 A IL 47842A IL 4784275 A IL4784275 A IL 4784275A IL 47842 A IL47842 A IL 47842A
- Authority
- IL
- Israel
- Prior art keywords
- group
- preparation
- pharmaceutical compositions
- hydroxy
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
- C07C275/68—N-nitroso ureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Nitrosourea derivatives of the formula <IMAGE> in which A is a glycosyl group, a monovalent radical of methyl glucoside from which the 2-hydroxy group has been removed, a monovalent radical of an alditol from which the 2-hydroxy group has been removed, an N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n equals 1, or a tetravalent radical of ribostamycin from which the four amino groups have been removed when n equals 4, and R is a lower alkyl group or a halogen-substituted lower alkyl group, with R not being a methyl group when A is a glucosyl group, are obtained by treatment of a compound of the formula <IMAGE> in which A, R and n have the same meaning as indicated above, with a nitrosating agent. The compounds have high activity against leukaemia and tumours, with low toxicity.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP49090266A JPS5126876A (en) | 1974-08-08 | 1974-08-08 | Shinkina nitorosonyosojudotaino seizohoho |
JP12431974A JPS5152128A (en) | 1974-10-30 | 1974-10-30 | NITOROSON YOSOJUDOTAINO SHINSEIZOHO |
JP3113175A JPS51108043A (en) | 1975-03-17 | 1975-03-17 | NITOROSON YOSOKAGOBUTSUNOSEIHO |
Publications (2)
Publication Number | Publication Date |
---|---|
IL47842A0 IL47842A0 (en) | 1975-10-15 |
IL47842A true IL47842A (en) | 1980-07-31 |
Family
ID=27287217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL47842A IL47842A (en) | 1974-08-08 | 1975-07-30 | Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing them |
Country Status (11)
Country | Link |
---|---|
AT (1) | AT351555B (en) |
CH (1) | CH619967A5 (en) |
DE (1) | DE2535048C3 (en) |
ES (1) | ES440147A1 (en) |
FR (1) | FR2281102A1 (en) |
GB (1) | GB1507099A (en) |
HU (1) | HU175174B (en) |
IL (1) | IL47842A (en) |
NL (1) | NL7509445A (en) |
SE (1) | SE430340B (en) |
YU (1) | YU39743B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5331664A (en) * | 1976-09-02 | 1978-03-25 | Suami T | Production of novel nitroso urea derivatives |
US4182757A (en) * | 1977-07-29 | 1980-01-08 | Tanabe Seiyaku Co., Ltd. | Novel nitrosourea compounds and process for preparing the same |
JPS5940400B2 (en) * | 1980-03-24 | 1984-09-29 | わかもと製薬株式会社 | Novel D-allose derivative and antitumor agent containing the same as an active ingredient |
DE3323095A1 (en) * | 1983-06-27 | 1985-01-03 | Institut organičeskoj chimii Akademii Nauk Kirgizskoj SSR, Frunze | Process for the preparation of N-alkyl-N'-glycosyl- N-nitrosourethane |
AU2390100A (en) * | 1998-12-29 | 2000-07-31 | Southern Research Institute | Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH518270A (en) * | 1969-03-07 | 1972-01-31 | Hoffmann La Roche | Process for the preparation of nitrosourea compounds |
JPS4843333B1 (en) * | 1970-04-25 | 1973-12-18 |
-
1975
- 1975-07-30 GB GB31941/75A patent/GB1507099A/en not_active Expired
- 1975-07-30 IL IL47842A patent/IL47842A/en unknown
- 1975-08-05 SE SE7508840A patent/SE430340B/en unknown
- 1975-08-06 HU HU75SU897A patent/HU175174B/en unknown
- 1975-08-06 FR FR7525015A patent/FR2281102A1/en active Granted
- 1975-08-06 DE DE2535048A patent/DE2535048C3/en not_active Expired
- 1975-08-07 CH CH1033175A patent/CH619967A5/en not_active IP Right Cessation
- 1975-08-07 NL NL7509445A patent/NL7509445A/en not_active Application Discontinuation
- 1975-08-07 YU YU2034/75A patent/YU39743B/en unknown
- 1975-08-08 AT AT618475A patent/AT351555B/en not_active IP Right Cessation
- 1975-08-08 ES ES440147A patent/ES440147A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2281102A1 (en) | 1976-03-05 |
AT351555B (en) | 1979-08-10 |
HU175174B (en) | 1980-05-28 |
SE7508840L (en) | 1976-02-09 |
FR2281102B1 (en) | 1979-04-06 |
GB1507099A (en) | 1978-04-12 |
DE2535048B2 (en) | 1979-06-07 |
ATA618475A (en) | 1979-01-15 |
AU8380475A (en) | 1977-02-10 |
DE2535048C3 (en) | 1980-02-14 |
SE430340B (en) | 1983-11-07 |
DE2535048A1 (en) | 1976-02-19 |
CH619967A5 (en) | 1980-10-31 |
YU39743B (en) | 1985-04-30 |
IL47842A0 (en) | 1975-10-15 |
ES440147A1 (en) | 1977-06-16 |
YU203475A (en) | 1982-02-28 |
NL7509445A (en) | 1976-02-10 |
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