IL47842A - Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing them - Google Patents

Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL47842A
IL47842A IL47842A IL4784275A IL47842A IL 47842 A IL47842 A IL 47842A IL 47842 A IL47842 A IL 47842A IL 4784275 A IL4784275 A IL 4784275A IL 47842 A IL47842 A IL 47842A
Authority
IL
Israel
Prior art keywords
group
preparation
pharmaceutical compositions
hydroxy
compositions containing
Prior art date
Application number
IL47842A
Other versions
IL47842A0 (en
Original Assignee
Suami T
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP49090266A external-priority patent/JPS5126876A/en
Priority claimed from JP12431974A external-priority patent/JPS5152128A/en
Priority claimed from JP3113175A external-priority patent/JPS51108043A/en
Application filed by Suami T filed Critical Suami T
Publication of IL47842A0 publication Critical patent/IL47842A0/en
Publication of IL47842A publication Critical patent/IL47842A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/66Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
    • C07C275/68N-nitroso ureas
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nitrosourea derivatives of the formula <IMAGE> in which A is a glycosyl group, a monovalent radical of methyl glucoside from which the 2-hydroxy group has been removed, a monovalent radical of an alditol from which the 2-hydroxy group has been removed, an N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n equals 1, or a tetravalent radical of ribostamycin from which the four amino groups have been removed when n equals 4, and R is a lower alkyl group or a halogen-substituted lower alkyl group, with R not being a methyl group when A is a glucosyl group, are obtained by treatment of a compound of the formula <IMAGE> in which A, R and n have the same meaning as indicated above, with a nitrosating agent. The compounds have high activity against leukaemia and tumours, with low toxicity.
IL47842A 1974-08-08 1975-07-30 Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing them IL47842A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP49090266A JPS5126876A (en) 1974-08-08 1974-08-08 Shinkina nitorosonyosojudotaino seizohoho
JP12431974A JPS5152128A (en) 1974-10-30 1974-10-30 NITOROSON YOSOJUDOTAINO SHINSEIZOHO
JP3113175A JPS51108043A (en) 1975-03-17 1975-03-17 NITOROSON YOSOKAGOBUTSUNOSEIHO

Publications (2)

Publication Number Publication Date
IL47842A0 IL47842A0 (en) 1975-10-15
IL47842A true IL47842A (en) 1980-07-31

Family

ID=27287217

Family Applications (1)

Application Number Title Priority Date Filing Date
IL47842A IL47842A (en) 1974-08-08 1975-07-30 Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing them

Country Status (11)

Country Link
AT (1) AT351555B (en)
CH (1) CH619967A5 (en)
DE (1) DE2535048C3 (en)
ES (1) ES440147A1 (en)
FR (1) FR2281102A1 (en)
GB (1) GB1507099A (en)
HU (1) HU175174B (en)
IL (1) IL47842A (en)
NL (1) NL7509445A (en)
SE (1) SE430340B (en)
YU (1) YU39743B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331664A (en) * 1976-09-02 1978-03-25 Suami T Production of novel nitroso urea derivatives
US4182757A (en) * 1977-07-29 1980-01-08 Tanabe Seiyaku Co., Ltd. Novel nitrosourea compounds and process for preparing the same
JPS5940400B2 (en) * 1980-03-24 1984-09-29 わかもと製薬株式会社 Novel D-allose derivative and antitumor agent containing the same as an active ingredient
DE3323095A1 (en) * 1983-06-27 1985-01-03 Institut organi&ccaron;eskoj chimii Akademii Nauk Kirgizskoj SSR, Frunze Process for the preparation of N-alkyl-N'-glycosyl- N-nitrosourethane
AU2390100A (en) * 1998-12-29 2000-07-31 Southern Research Institute Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518270A (en) * 1969-03-07 1972-01-31 Hoffmann La Roche Process for the preparation of nitrosourea compounds
JPS4843333B1 (en) * 1970-04-25 1973-12-18

Also Published As

Publication number Publication date
FR2281102A1 (en) 1976-03-05
AT351555B (en) 1979-08-10
HU175174B (en) 1980-05-28
SE7508840L (en) 1976-02-09
FR2281102B1 (en) 1979-04-06
GB1507099A (en) 1978-04-12
DE2535048B2 (en) 1979-06-07
ATA618475A (en) 1979-01-15
AU8380475A (en) 1977-02-10
DE2535048C3 (en) 1980-02-14
SE430340B (en) 1983-11-07
DE2535048A1 (en) 1976-02-19
CH619967A5 (en) 1980-10-31
YU39743B (en) 1985-04-30
IL47842A0 (en) 1975-10-15
ES440147A1 (en) 1977-06-16
YU203475A (en) 1982-02-28
NL7509445A (en) 1976-02-10

Similar Documents

Publication Publication Date Title
ES8304072A1 (en) preparation, compositions and intermediates.
TR199901578T2 (en) Clarithromycin form 0 crystals
ES308421A1 (en) Procedure for preparation of pesticide compounds. (Machine-translation by Google Translate, not legally binding)
ES334560A1 (en) A procedure for the preparation of a compound tetrahydro-halo-sulfamil-quinazolinonas. (Machine-translation by Google Translate, not legally binding)
GB1070413A (en) A process for preparing purine and pyrimidine nucleosides
GB1268894A (en) Substituted cinnamamides and compositions containing them
ES469425A1 (en) N-Alkyl-N-acyl derivatives of thienamycin
ES286383A1 (en) New therapeutic agents (Machine-translation by Google Translate, not legally binding)
FI961507A (en) Anthracycline derivatives and their use in amyloidosis
ES405082A1 (en) Herbicidal compositions
IL47842A (en) Nitroso urea glycosides and related compounds,their preparation and pharmaceutical compositions containing them
PT97571A (en) PROCESS FOR THE PREPARATION OF HYDRAZONES
JPS5242832A (en) Aniline derivative* preparation thereof and combating agent* against microorganisms* containing said coumpound as active component
DE3062340D1 (en) 1-n-alkylsisomicin derivatives, process for their preparation and their use as medicines
GB1235599A (en) Lincomycin phosphate derivatives and pharmaceutical compositions containing them
JPS6431752A (en) Amide derivative and skin external preparation containing said derivative
IL82925A0 (en) Tetrahydrobenzothiazoles,their preparation and pharmaceutical compositions containing them
DE3362009D1 (en) L-alanyl-d-isoglutaminyl-adamantyl amide, process for its preparation and pharmaceutical compositions containing this compound
ES442505A1 (en) Antibiotic aminoglycosides, processes of preparation and pharmaceutical compositions
DE58907341D1 (en) Cyclic azaaliphatics with nitroxy function, process for their preparation and medicaments containing these compounds.
ES373909A1 (en) Benzene-ring-substituted tetrahydro-quinazolines
ES363002A1 (en) O-Halophenylcarbamates
GB1108563A (en) 3ª‡-amino steroids and the preparation thereof
GB1360553A (en) Chemical compounds suitable for use as x-ray contrast agents
IL48365A (en) 10,11-dihydro-3-carboxycypro-heptadine and its n-oxide, their preparation and pharmaceutical compositions comprising them