GB1507099A - Nitrosourea derivatives - Google Patents

Nitrosourea derivatives

Info

Publication number
GB1507099A
GB1507099A GB31941/75A GB3194175A GB1507099A GB 1507099 A GB1507099 A GB 1507099A GB 31941/75 A GB31941/75 A GB 31941/75A GB 3194175 A GB3194175 A GB 3194175A GB 1507099 A GB1507099 A GB 1507099A
Authority
GB
United Kingdom
Prior art keywords
group
hydroxy
substituted
equals
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31941/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP49090266A external-priority patent/JPS5126876A/en
Priority claimed from JP12431974A external-priority patent/JPS5152128A/en
Priority claimed from JP3113175A external-priority patent/JPS51108043A/en
Application filed by Individual filed Critical Individual
Publication of GB1507099A publication Critical patent/GB1507099A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
    • C07C275/68—N-nitroso ureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nitrosourea derivatives of the formula <IMAGE> in which A is a glycosyl group, a monovalent radical of methyl glucoside from which the 2-hydroxy group has been removed, a monovalent radical of an alditol from which the 2-hydroxy group has been removed, an N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n equals 1, or a tetravalent radical of ribostamycin from which the four amino groups have been removed when n equals 4, and R is a lower alkyl group or a halogen-substituted lower alkyl group, with R not being a methyl group when A is a glucosyl group, are obtained by treatment of a compound of the formula <IMAGE> in which A, R and n have the same meaning as indicated above, with a nitrosating agent. The compounds have high activity against leukaemia and tumours, with low toxicity.
GB31941/75A 1974-08-08 1975-07-30 Nitrosourea derivatives Expired GB1507099A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP49090266A JPS5126876A (en) 1974-08-08 1974-08-08 Shinkina nitorosonyosojudotaino seizohoho
JP12431974A JPS5152128A (en) 1974-10-30 1974-10-30 NITOROSON YOSOJUDOTAINO SHINSEIZOHO
JP3113175A JPS51108043A (en) 1975-03-17 1975-03-17 NITOROSON YOSOKAGOBUTSUNOSEIHO

Publications (1)

Publication Number Publication Date
GB1507099A true GB1507099A (en) 1978-04-12

Family

ID=27287217

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31941/75A Expired GB1507099A (en) 1974-08-08 1975-07-30 Nitrosourea derivatives

Country Status (11)

Country Link
AT (1) AT351555B (en)
CH (1) CH619967A5 (en)
DE (1) DE2535048C3 (en)
ES (1) ES440147A1 (en)
FR (1) FR2281102A1 (en)
GB (1) GB1507099A (en)
HU (1) HU175174B (en)
IL (1) IL47842A (en)
NL (1) NL7509445A (en)
SE (1) SE430340B (en)
YU (1) YU39743B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3323095A1 (en) * 1983-06-27 1985-01-03 Institut organi&ccaron;eskoj chimii Akademii Nauk Kirgizskoj SSR, Frunze Process for the preparation of N-alkyl-N'-glycosyl- N-nitrosourethane
WO2000038668A2 (en) * 1998-12-29 2000-07-06 Southern Research Institute Use of a nitrosourea derivative for prevention or treatment of acute allograft rejection

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331664A (en) * 1976-09-02 1978-03-25 Suami T Production of novel nitroso urea derivatives
US4182757A (en) * 1977-07-29 1980-01-08 Tanabe Seiyaku Co., Ltd. Novel nitrosourea compounds and process for preparing the same
JPS5940400B2 (en) * 1980-03-24 1984-09-29 わかもと製薬株式会社 Novel D-allose derivative and antitumor agent containing the same as an active ingredient

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518270A (en) * 1969-03-07 1972-01-31 Hoffmann La Roche Process for the preparation of nitrosourea compounds
JPS4843333B1 (en) * 1970-04-25 1973-12-18

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3323095A1 (en) * 1983-06-27 1985-01-03 Institut organi&ccaron;eskoj chimii Akademii Nauk Kirgizskoj SSR, Frunze Process for the preparation of N-alkyl-N'-glycosyl- N-nitrosourethane
WO2000038668A2 (en) * 1998-12-29 2000-07-06 Southern Research Institute Use of a nitrosourea derivative for prevention or treatment of acute allograft rejection
WO2000038668A3 (en) * 1998-12-29 2000-12-07 Southern Res Inst Use of a nitrosourea derivative for prevention or treatment of acute allograft rejection

Also Published As

Publication number Publication date
SE7508840L (en) 1976-02-09
SE430340B (en) 1983-11-07
DE2535048C3 (en) 1980-02-14
IL47842A (en) 1980-07-31
AU8380475A (en) 1977-02-10
FR2281102B1 (en) 1979-04-06
YU39743B (en) 1985-04-30
FR2281102A1 (en) 1976-03-05
ATA618475A (en) 1979-01-15
DE2535048B2 (en) 1979-06-07
NL7509445A (en) 1976-02-10
YU203475A (en) 1982-02-28
AT351555B (en) 1979-08-10
IL47842A0 (en) 1975-10-15
ES440147A1 (en) 1977-06-16
CH619967A5 (en) 1980-10-31
DE2535048A1 (en) 1976-02-19
HU175174B (en) 1980-05-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee