YU39743B - Process for preparing nitrosourea derivatives - Google Patents

Process for preparing nitrosourea derivatives

Info

Publication number
YU39743B
YU39743B YU2034/75A YU203475A YU39743B YU 39743 B YU39743 B YU 39743B YU 2034/75 A YU2034/75 A YU 2034/75A YU 203475 A YU203475 A YU 203475A YU 39743 B YU39743 B YU 39743B
Authority
YU
Yugoslavia
Prior art keywords
group
hydroxy
substituted
equals
formula
Prior art date
Application number
YU2034/75A
Other versions
YU203475A (en
Inventor
T Suami
T Machinami
T Hisamatsu
Original Assignee
Tetsuo Sumai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP49090266A external-priority patent/JPS5126876A/en
Priority claimed from JP12431974A external-priority patent/JPS5152128A/en
Priority claimed from JP3113175A external-priority patent/JPS51108043A/en
Application filed by Tetsuo Sumai filed Critical Tetsuo Sumai
Publication of YU203475A publication Critical patent/YU203475A/en
Publication of YU39743B publication Critical patent/YU39743B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
    • C07C275/68—N-nitroso ureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nitrosourea derivatives of the formula <IMAGE> in which A is a glycosyl group, a monovalent radical of methyl glucoside from which the 2-hydroxy group has been removed, a monovalent radical of an alditol from which the 2-hydroxy group has been removed, an N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n equals 1, or a tetravalent radical of ribostamycin from which the four amino groups have been removed when n equals 4, and R is a lower alkyl group or a halogen-substituted lower alkyl group, with R not being a methyl group when A is a glucosyl group, are obtained by treatment of a compound of the formula <IMAGE> in which A, R and n have the same meaning as indicated above, with a nitrosating agent. The compounds have high activity against leukaemia and tumours, with low toxicity.
YU2034/75A 1974-08-08 1975-08-07 Process for preparing nitrosourea derivatives YU39743B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP49090266A JPS5126876A (en) 1974-08-08 1974-08-08 Shinkina nitorosonyosojudotaino seizohoho
JP12431974A JPS5152128A (en) 1974-10-30 1974-10-30 NITOROSON YOSOJUDOTAINO SHINSEIZOHO
JP3113175A JPS51108043A (en) 1975-03-17 1975-03-17 NITOROSON YOSOKAGOBUTSUNOSEIHO

Publications (2)

Publication Number Publication Date
YU203475A YU203475A (en) 1982-02-28
YU39743B true YU39743B (en) 1985-04-30

Family

ID=27287217

Family Applications (1)

Application Number Title Priority Date Filing Date
YU2034/75A YU39743B (en) 1974-08-08 1975-08-07 Process for preparing nitrosourea derivatives

Country Status (11)

Country Link
AT (1) AT351555B (en)
CH (1) CH619967A5 (en)
DE (1) DE2535048C3 (en)
ES (1) ES440147A1 (en)
FR (1) FR2281102A1 (en)
GB (1) GB1507099A (en)
HU (1) HU175174B (en)
IL (1) IL47842A (en)
NL (1) NL7509445A (en)
SE (1) SE430340B (en)
YU (1) YU39743B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331664A (en) * 1976-09-02 1978-03-25 Suami T Production of novel nitroso urea derivatives
US4182757A (en) * 1977-07-29 1980-01-08 Tanabe Seiyaku Co., Ltd. Novel nitrosourea compounds and process for preparing the same
JPS5940400B2 (en) * 1980-03-24 1984-09-29 わかもと製薬株式会社 Novel D-allose derivative and antitumor agent containing the same as an active ingredient
DE3323095A1 (en) * 1983-06-27 1985-01-03 Institut organi&ccaron;eskoj chimii Akademii Nauk Kirgizskoj SSR, Frunze Process for the preparation of N-alkyl-N'-glycosyl- N-nitrosourethane
AU2390100A (en) * 1998-12-29 2000-07-31 Southern Research Institute Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518270A (en) * 1969-03-07 1972-01-31 Hoffmann La Roche Process for the preparation of nitrosourea compounds
JPS4843333B1 (en) * 1970-04-25 1973-12-18

Also Published As

Publication number Publication date
FR2281102A1 (en) 1976-03-05
AT351555B (en) 1979-08-10
HU175174B (en) 1980-05-28
SE7508840L (en) 1976-02-09
FR2281102B1 (en) 1979-04-06
GB1507099A (en) 1978-04-12
DE2535048B2 (en) 1979-06-07
ATA618475A (en) 1979-01-15
AU8380475A (en) 1977-02-10
DE2535048C3 (en) 1980-02-14
SE430340B (en) 1983-11-07
DE2535048A1 (en) 1976-02-19
CH619967A5 (en) 1980-10-31
IL47842A (en) 1980-07-31
IL47842A0 (en) 1975-10-15
ES440147A1 (en) 1977-06-16
YU203475A (en) 1982-02-28
NL7509445A (en) 1976-02-10

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