JPS6431727A - Dissolution of argininamide and drug composition containing argininamides - Google Patents

Dissolution of argininamide and drug composition containing argininamides

Info

Publication number
JPS6431727A
JPS6431727A JP62188484A JP18848487A JPS6431727A JP S6431727 A JPS6431727 A JP S6431727A JP 62188484 A JP62188484 A JP 62188484A JP 18848487 A JP18848487 A JP 18848487A JP S6431727 A JPS6431727 A JP S6431727A
Authority
JP
Japan
Prior art keywords
argininamide
alcohol
water
dissolution
argininamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62188484A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0576929B2 (en, 2012
Inventor
Kunihiko Obuchi
Tatsuo Nomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Kasei Corp
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp, Mitsubishi Chemical Industries Ltd filed Critical Mitsubishi Kasei Corp
Priority to JP62188484A priority Critical patent/JPS6431727A/ja
Priority to DE8888401968T priority patent/DE3866303D1/de
Priority to EP88401968A priority patent/EP0301970B1/en
Priority to DE122005000056C priority patent/DE122005000056I2/de
Publication of JPS6431727A publication Critical patent/JPS6431727A/ja
Priority to US07/851,248 priority patent/US5214052A/en
Publication of JPH0576929B2 publication Critical patent/JPH0576929B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP62188484A 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides Granted JPS6431727A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP62188484A JPS6431727A (en) 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides
DE8888401968T DE3866303D1 (de) 1987-07-28 1988-07-28 Verfahren zum loesen von argininamiden und sie enthaltende pharmazeutische mittel.
EP88401968A EP0301970B1 (en) 1987-07-28 1988-07-28 Method for dissolving arginineamides and pharmaceutical compositions containing them
DE122005000056C DE122005000056I2 (de) 1987-07-28 1988-07-28 Verfahren zum Lösen von Argininamiden und sie enthaltende pharmazeutische Mittel.
US07/851,248 US5214052A (en) 1987-07-28 1992-03-13 Method for dissolving arginineamides and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62188484A JPS6431727A (en) 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides

Publications (2)

Publication Number Publication Date
JPS6431727A true JPS6431727A (en) 1989-02-02
JPH0576929B2 JPH0576929B2 (en, 2012) 1993-10-25

Family

ID=16224539

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62188484A Granted JPS6431727A (en) 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides

Country Status (3)

Country Link
EP (1) EP0301970B1 (en, 2012)
JP (1) JPS6431727A (en, 2012)
DE (2) DE122005000056I2 (en, 2012)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215408A (en) * 1990-04-03 1993-06-01 Gebruder Friedrich Protective element for protecting sealed tracks in trash-dump construction and method for sealing trash-dump bottoms
WO2004083201A1 (ja) * 2003-03-20 2004-09-30 Mitsubishi Pharma Corporation アルギニンアミド類を含有する医薬製剤
JP2006008696A (ja) * 2003-03-20 2006-01-12 Mitsubishi Pharma Corp アルギニンアミド類を含有する医薬製剤

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06219948A (ja) * 1993-01-25 1994-08-09 Mitsubishi Kasei Corp 抗トロンビン剤及びその製造方法
JPH06219949A (ja) * 1993-01-25 1994-08-09 Mitsubishi Kasei Corp 抗トロンビン剤及びその製造方法
DE69417087T2 (de) * 1993-04-22 1999-07-15 Mitsubishi Chemical Corp., Tokio/Tokyo Wässrige Arzneizubereitungen enthaltend Argatroban und Cyclodextrin oder Coffein
FR2715566B1 (fr) * 1994-02-03 1996-03-08 Synthelabo Solutions aqueuses concentrées d'argatroban.
US7915290B2 (en) 2008-02-29 2011-03-29 Baxter International Inc. Argatroban formulations and methods for making and using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692213A (en) * 1979-12-25 1981-07-25 Mitsubishi Chem Ind Ltd Anticoagulant comprising n2-arylsulfonyl-l-arginine amide or its salt as active ingredient
JPS5782314A (en) * 1980-11-13 1982-05-22 Mitsubishi Chem Ind Ltd Carcinostatic agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2854380A (en) * 1955-09-06 1958-09-30 Upjohn Co Aqueous therapeutic composition comprising reserpine, propylene glycol and sorbitol
US4258192A (en) * 1977-12-16 1981-03-24 Mitsubishi Chemical Industries Limited N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692213A (en) * 1979-12-25 1981-07-25 Mitsubishi Chem Ind Ltd Anticoagulant comprising n2-arylsulfonyl-l-arginine amide or its salt as active ingredient
JPS5782314A (en) * 1980-11-13 1982-05-22 Mitsubishi Chem Ind Ltd Carcinostatic agent

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215408A (en) * 1990-04-03 1993-06-01 Gebruder Friedrich Protective element for protecting sealed tracks in trash-dump construction and method for sealing trash-dump bottoms
US5423629A (en) * 1990-04-03 1995-06-13 Gebruder Friedrich Gmbh Protective element for protecting sealed tracks in trash-dump construction and method for sealing trash-dump bottoms
WO2004083201A1 (ja) * 2003-03-20 2004-09-30 Mitsubishi Pharma Corporation アルギニンアミド類を含有する医薬製剤
JP2006008696A (ja) * 2003-03-20 2006-01-12 Mitsubishi Pharma Corp アルギニンアミド類を含有する医薬製剤

Also Published As

Publication number Publication date
EP0301970B1 (en) 1991-11-21
DE122005000056I1 (de) 2006-02-23
DE3866303D1 (de) 1992-01-02
EP0301970A1 (en) 1989-02-01
DE122005000056I2 (de) 2008-10-02
JPH0576929B2 (en, 2012) 1993-10-25

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