JPH0576929B2 - - Google Patents

Info

Publication number
JPH0576929B2
JPH0576929B2 JP62188484A JP18848487A JPH0576929B2 JP H0576929 B2 JPH0576929 B2 JP H0576929B2 JP 62188484 A JP62188484 A JP 62188484A JP 18848487 A JP18848487 A JP 18848487A JP H0576929 B2 JPH0576929 B2 JP H0576929B2
Authority
JP
Japan
Prior art keywords
group
alcohol
water ratio
compound residue
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62188484A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6431727A (en
Inventor
Kunihiko Oobuchi
Tatsuo Nomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Industries Ltd filed Critical Mitsubishi Chemical Industries Ltd
Priority to JP62188484A priority Critical patent/JPS6431727A/ja
Priority to DE8888401968T priority patent/DE3866303D1/de
Priority to EP88401968A priority patent/EP0301970B1/en
Priority to DE122005000056C priority patent/DE122005000056I2/de
Publication of JPS6431727A publication Critical patent/JPS6431727A/ja
Priority to US07/851,248 priority patent/US5214052A/en
Publication of JPH0576929B2 publication Critical patent/JPH0576929B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP62188484A 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides Granted JPS6431727A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP62188484A JPS6431727A (en) 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides
DE8888401968T DE3866303D1 (de) 1987-07-28 1988-07-28 Verfahren zum loesen von argininamiden und sie enthaltende pharmazeutische mittel.
EP88401968A EP0301970B1 (en) 1987-07-28 1988-07-28 Method for dissolving arginineamides and pharmaceutical compositions containing them
DE122005000056C DE122005000056I2 (de) 1987-07-28 1988-07-28 Verfahren zum Lösen von Argininamiden und sie enthaltende pharmazeutische Mittel.
US07/851,248 US5214052A (en) 1987-07-28 1992-03-13 Method for dissolving arginineamides and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62188484A JPS6431727A (en) 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides

Publications (2)

Publication Number Publication Date
JPS6431727A JPS6431727A (en) 1989-02-02
JPH0576929B2 true JPH0576929B2 (en, 2012) 1993-10-25

Family

ID=16224539

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62188484A Granted JPS6431727A (en) 1987-07-28 1987-07-28 Dissolution of argininamide and drug composition containing argininamides

Country Status (3)

Country Link
EP (1) EP0301970B1 (en, 2012)
JP (1) JPS6431727A (en, 2012)
DE (2) DE122005000056I2 (en, 2012)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053057T3 (es) * 1990-04-03 1994-07-16 Friedrich Geb Elemento de proteccion para las superficies de hermeticidad en la construccion de vertederos y procedimiento para elaborar una capa protectora.
JPH06219948A (ja) * 1993-01-25 1994-08-09 Mitsubishi Kasei Corp 抗トロンビン剤及びその製造方法
JPH06219949A (ja) * 1993-01-25 1994-08-09 Mitsubishi Kasei Corp 抗トロンビン剤及びその製造方法
DE69417087T2 (de) * 1993-04-22 1999-07-15 Mitsubishi Chemical Corp., Tokio/Tokyo Wässrige Arzneizubereitungen enthaltend Argatroban und Cyclodextrin oder Coffein
FR2715566B1 (fr) * 1994-02-03 1996-03-08 Synthelabo Solutions aqueuses concentrées d'argatroban.
KR101010547B1 (ko) * 2003-03-20 2011-01-24 미쓰비시 타나베 파마 코퍼레이션 알기닌아미드류를 함유하는 의약 제제
JP2006008696A (ja) * 2003-03-20 2006-01-12 Mitsubishi Pharma Corp アルギニンアミド類を含有する医薬製剤
US7915290B2 (en) 2008-02-29 2011-03-29 Baxter International Inc. Argatroban formulations and methods for making and using same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2854380A (en) * 1955-09-06 1958-09-30 Upjohn Co Aqueous therapeutic composition comprising reserpine, propylene glycol and sorbitol
US4258192A (en) * 1977-12-16 1981-03-24 Mitsubishi Chemical Industries Limited N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
JPS5692213A (en) * 1979-12-25 1981-07-25 Mitsubishi Chem Ind Ltd Anticoagulant comprising n2-arylsulfonyl-l-arginine amide or its salt as active ingredient
JPS5782314A (en) * 1980-11-13 1982-05-22 Mitsubishi Chem Ind Ltd Carcinostatic agent

Also Published As

Publication number Publication date
EP0301970B1 (en) 1991-11-21
DE122005000056I1 (de) 2006-02-23
DE3866303D1 (de) 1992-01-02
EP0301970A1 (en) 1989-02-01
JPS6431727A (en) 1989-02-02
DE122005000056I2 (de) 2008-10-02

Similar Documents

Publication Publication Date Title
JPH057371B2 (en, 2012)
SK10095A3 (en) Injection and injection kit containing omeprazole and its analogs
DK165902B (da) Etoposid-praeparat
EP1352654B1 (en) Famotidine injections
JPH0576929B2 (en, 2012)
US5214052A (en) Method for dissolving arginineamides and pharmaceutical compositions containing them
US4259331A (en) Oxytetracycline compositions
JP2906513B2 (ja) 血糖上昇抑制剤
JPS625975A (ja) フロセミド誘導体
RU2084226C1 (ru) Композиция, обладающая противоопухолевым действием
EP0608831A1 (en) Compositions containing argatroban analogs
JPS63192714A (ja) 非経口用溶液
JP5624766B2 (ja) アルコールを含まないアルガトロバン製剤
US4772589A (en) Etoposide solution in NMP
US4696814A (en) Parenteral phenytoin compositions
JPH01246219A (ja) 抗真菌外用クリーム組成物
JP3781308B2 (ja) アルギニンアミド類を含有する医薬製剤
US4032645A (en) Injectable metronidazole composition
US6048874A (en) Parenteral metolazone formulations
WO2008045410A2 (en) Alcohol free formulation of argatroban
JPH0144172B2 (en, 2012)
JPH05112527A (ja) ２−オキシインドール−１−カルボキシアミド誘導体を含有する直腸投与用薬剤組成物
JP2628020B2 (ja) 医薬製剤用水溶液
US20100076019A1 (en) Alcohol free formulation of argatroban
JP2006008696A (ja) アルギニンアミド類を含有する医薬製剤

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

EXPY Cancellation because of completion of term
FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071025

Year of fee payment: 14