JPS643166A - Production of thiol - Google Patents

Production of thiol

Info

Publication number
JPS643166A
JPS643166A JP15750187A JP15750187A JPS643166A JP S643166 A JPS643166 A JP S643166A JP 15750187 A JP15750187 A JP 15750187A JP 15750187 A JP15750187 A JP 15750187A JP S643166 A JPS643166 A JP S643166A
Authority
JP
Japan
Prior art keywords
alkyl
formula
compound
reaction
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15750187A
Other languages
Japanese (ja)
Other versions
JPH013166A (en
Inventor
Tsunemasa Ueno
Yutaka Morimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shokubai Co Ltd
Original Assignee
Nippon Shokubai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shokubai Co Ltd filed Critical Nippon Shokubai Co Ltd
Priority to JP62-157501A priority Critical patent/JPH013166A/en
Priority claimed from JP62-157501A external-priority patent/JPH013166A/en
Publication of JPS643166A publication Critical patent/JPS643166A/en
Publication of JPH013166A publication Critical patent/JPH013166A/en
Pending legal-status Critical Current

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  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain a thiol which is useful as an intermediate of medicines advantageously through a substantially one-step process without isolation of the intermediate by allowing hydrochloric acid to react with a reaction product from 2,2-disubstituted-thiazolidine and a nitroethene derivative.
CONSTITUTION: The reaction between a compound of formula I (R1 is 1W4C alkyl; R2 is 1W4C alkyl, acetate) and another compound of formula II (R3 is 1W4C alkyl; P is eliminable group) in a solvent, preferably water and/or lower alcohol, is followed by action of hydrochloric acid on the reaction mixture to give a subject compound of formula IV, which is useful as an intermediate of a compound of formula III (R1, R2 are H, 1W4C alkyl; R3, alk are 1W4C alkyl) which is used as a medicine. Thus, the reaction process, operations are much improved, installation costs are saved, and the yield of the product exceeds 80%. The compound of formula I is readily prepared from an sulfate ester of 2-aminoalcohol and has high stability.
COPYRIGHT: (C)1989,JPO&Japio
JP62-157501A 1987-06-26 Method for producing thiols Pending JPH013166A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62-157501A JPH013166A (en) 1987-06-26 Method for producing thiols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62-157501A JPH013166A (en) 1987-06-26 Method for producing thiols

Publications (2)

Publication Number Publication Date
JPS643166A true JPS643166A (en) 1989-01-06
JPH013166A JPH013166A (en) 1989-01-06

Family

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