JPS6411007B2 - - Google Patents

Info

Publication number
JPS6411007B2
JPS6411007B2 JP57212942A JP21294282A JPS6411007B2 JP S6411007 B2 JPS6411007 B2 JP S6411007B2 JP 57212942 A JP57212942 A JP 57212942A JP 21294282 A JP21294282 A JP 21294282A JP S6411007 B2 JPS6411007 B2 JP S6411007B2
Authority
JP
Japan
Prior art keywords
membered ring
acid
group
curve
macrolide antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP57212942A
Other languages
English (en)
Japanese (ja)
Other versions
JPS59104326A (ja
Inventor
Masataka Morishita
Masaru Oono
Yukio Sumita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP57212942A priority Critical patent/JPS59104326A/ja
Priority to GB08331772A priority patent/GB2132086B/en
Priority to IT23956/83A priority patent/IT1169476B/it
Priority to FR8319359A priority patent/FR2541287B1/fr
Publication of JPS59104326A publication Critical patent/JPS59104326A/ja
Priority to US06/900,231 priority patent/US4716153A/en
Publication of JPS6411007B2 publication Critical patent/JPS6411007B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP57212942A 1982-12-04 1982-12-04 マクロライド抗生物質の安定な経口用製剤および安定化法 Granted JPS59104326A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP57212942A JPS59104326A (ja) 1982-12-04 1982-12-04 マクロライド抗生物質の安定な経口用製剤および安定化法
GB08331772A GB2132086B (en) 1982-12-04 1983-11-29 Stable oral preparation of macrolide antibiotics and method for stabilising the same
IT23956/83A IT1169476B (it) 1982-12-04 1983-11-30 Preparazione orale stabile di antibiotici macrolidi e procedimento di stabilizzazione
FR8319359A FR2541287B1 (fr) 1982-12-04 1983-12-02 Preparation stable administrable par voie orale de macrolides antibiotiques et procede pour les stabiliser
US06/900,231 US4716153A (en) 1982-12-04 1986-08-25 Stable oral preparation of macrolide antibiotics and method for stabilizing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57212942A JPS59104326A (ja) 1982-12-04 1982-12-04 マクロライド抗生物質の安定な経口用製剤および安定化法

Publications (2)

Publication Number Publication Date
JPS59104326A JPS59104326A (ja) 1984-06-16
JPS6411007B2 true JPS6411007B2 (enExample) 1989-02-23

Family

ID=16630843

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57212942A Granted JPS59104326A (ja) 1982-12-04 1982-12-04 マクロライド抗生物質の安定な経口用製剤および安定化法

Country Status (5)

Country Link
US (1) US4716153A (enExample)
JP (1) JPS59104326A (enExample)
FR (1) FR2541287B1 (enExample)
GB (1) GB2132086B (enExample)
IT (1) IT1169476B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3524572A1 (de) * 1985-07-10 1987-01-15 Thomae Gmbh Dr K Feste arzneimittelformen zur peroralen anwendung enthaltend 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethyliden)-oxy)-(9s)-erythromycin und verfahren zu ihrer herstellung
IT1222309B (it) * 1987-07-08 1990-09-05 Menarini Sas Utilizzazione di forme farmaceutiche per uso topico contenenti miocamicina per la terapia delle infezione da germi sensibili alla miocamicina stessa
US4877615A (en) * 1988-09-23 1989-10-31 Microlife Technics, Inc. Antifungal product
IL129547A (en) * 1994-10-26 2001-01-11 Novartis Ag Pharmaceutical compositions comprising a macrolide and an acid
US7205279B2 (en) * 1995-10-25 2007-04-17 Novartis Ag Pharmaceutical compositions
DE4444051A1 (de) * 1994-12-10 1996-06-13 Rhone Poulenc Rorer Gmbh Pharmazeutische, oral anwendbare Zubereitung
AU6381201A (en) * 2000-03-28 2001-10-08 Biochemie Gmbh Granulated particles with masked taste
US6514537B1 (en) 2000-06-02 2003-02-04 Cumberland Swan Holdings, Inc. Magnesium citrate solution
ITMI20021725A1 (it) * 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
GB0230034D0 (en) * 2002-12-23 2003-01-29 Biochemie Gmbh Organic compounds
US7803817B2 (en) * 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) * 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2007120544A2 (en) * 2006-04-12 2007-10-25 Alexander Rayna L Compositions comprising pyruvate alkyl esters and uses thereof
AU2007278986B2 (en) * 2006-07-25 2010-09-16 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US12403095B2 (en) 2008-05-30 2025-09-02 Veloxis Pharmaceuticals, Inc. Stabilized tacrolimus composition
WO2011100975A2 (en) * 2010-02-17 2011-08-25 Lifecycle Pharma A/S Stabilized tacrolimus composition
US8604078B2 (en) * 2011-04-06 2013-12-10 Carlos Picornell Darder Fosfomycin pharmaceutical composition
WO2013148891A1 (en) * 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
WO2025111352A1 (en) * 2023-11-21 2025-05-30 Veterinary Pharmacy Corporation Formulations of penicillin and methods for stabilizing penicillin

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4064230A (en) * 1966-04-25 1977-12-20 Schmid Laboratories, Inc. Polyenic macrolide compositions
GB1375986A (en) * 1966-04-25 1974-12-04 Schmid Inc Julius Polyenic macrolide composition
US3891752A (en) * 1966-04-25 1975-06-24 Schmid Lab Polyenic macrolide compositions and methods of use
GB1380741A (en) * 1971-02-05 1975-01-15 Squibb & Sons Inc Antibiotic compositions and their preparation
GB1322306A (en) * 1971-04-15 1973-07-04 Meiji Seika Co Stabilized antibiotic preparation and manufacturing process therefor
JPS531328B2 (enExample) * 1971-12-13 1978-01-18
US4137307A (en) * 1973-11-15 1979-01-30 The Green Cross Corporation Process for preparing haptoglobin aqueous solution using strong anion exchanger
US4102999A (en) * 1975-02-10 1978-07-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing stable macromomycin powder
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
GB1550359A (en) * 1975-08-07 1979-08-15 Beecham Group Ltd Antibiotic compositions for oral administration
GB1511852A (en) * 1975-09-11 1978-05-24 Beecham Group Ltd Reconstitutable powders
AU514992B2 (en) * 1976-06-18 1981-03-12 Rockwell International Corporation Flexible tube, axial flow valve
ZA786259B (en) * 1977-11-09 1979-10-31 Procter & Gamble Therapeutic composition
JPS54115389A (en) * 1978-02-27 1979-09-07 Meiji Seika Kaisha Ltd Novel macrolide antibiotic derivative and its preparation
AU529422B2 (en) * 1978-10-20 1983-06-09 Eli Lilly And Company Stable erythromycin solution
ZA795508B (en) * 1978-10-23 1981-05-27 Schering Corp Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
JPS56135418A (en) * 1980-03-27 1981-10-22 Green Cross Corp:The Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human
US4340582A (en) * 1981-01-15 1982-07-20 Abbott Laboratories Erythromycin base tablets

Also Published As

Publication number Publication date
FR2541287A1 (fr) 1984-08-24
FR2541287B1 (fr) 1987-08-07
GB2132086A (en) 1984-07-04
US4716153A (en) 1987-12-29
GB8331772D0 (en) 1984-01-04
IT1169476B (it) 1987-05-27
IT8323956A0 (it) 1983-11-30
GB2132086B (en) 1986-05-21
JPS59104326A (ja) 1984-06-16

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