JPS6339868B2 - - Google Patents
Info
- Publication number
- JPS6339868B2 JPS6339868B2 JP55138625A JP13862580A JPS6339868B2 JP S6339868 B2 JPS6339868 B2 JP S6339868B2 JP 55138625 A JP55138625 A JP 55138625A JP 13862580 A JP13862580 A JP 13862580A JP S6339868 B2 JPS6339868 B2 JP S6339868B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- glass
- particles
- centrifugation
- beads
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004369 blood Anatomy 0.000 claims description 44
- 239000008280 blood Substances 0.000 claims description 44
- 238000005119 centrifugation Methods 0.000 claims description 31
- 102000009123 Fibrin Human genes 0.000 claims description 26
- 108010073385 Fibrin Proteins 0.000 claims description 26
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 26
- 229950003499 fibrin Drugs 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 25
- 238000012360 testing method Methods 0.000 claims description 21
- 239000011521 glass Substances 0.000 claims description 18
- 239000011324 bead Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 230000005484 gravity Effects 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 8
- 230000002787 reinforcement Effects 0.000 claims description 6
- 238000002513 implantation Methods 0.000 claims 3
- 230000003014 reinforcing effect Effects 0.000 claims 3
- 210000003743 erythrocyte Anatomy 0.000 description 13
- 210000002966 serum Anatomy 0.000 description 11
- 238000010586 diagram Methods 0.000 description 6
- 238000001994 activation Methods 0.000 description 5
- 230000004913 activation Effects 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000000701 coagulant Substances 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
- 108010007568 Protamines Proteins 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229950008679 protamine sulfate Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO793190A NO146616C (no) | 1979-10-04 | 1979-10-04 | Fremgangsmaate og anordning ved preparering til undersoekelse av ukoagulert blod. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5660350A JPS5660350A (en) | 1981-05-25 |
| JPS6339868B2 true JPS6339868B2 (index.php) | 1988-08-08 |
Family
ID=19885073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13862580A Granted JPS5660350A (en) | 1979-10-04 | 1980-10-03 | Method of and element for facilitating detection of unhardened blood |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4379849A (index.php) |
| JP (1) | JPS5660350A (index.php) |
| AU (1) | AU546175B2 (index.php) |
| CA (1) | CA1163464A (index.php) |
| DE (1) | DE3036220A1 (index.php) |
| GB (1) | GB2061498B (index.php) |
| NO (1) | NO146616C (index.php) |
| SE (1) | SE444733B (index.php) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8300261A1 (es) * | 1980-05-08 | 1982-11-16 | Terumo Corp | Aparato para separacion de la sangre |
| DE3632303C2 (de) * | 1985-09-23 | 1995-04-13 | Sarstedt Kunststoff | Verfahren zum Gewinnen von menschlichem Speichel |
| JPH04228097A (ja) * | 1990-07-02 | 1992-08-18 | Toyo Ink Mfg Co Ltd | ミルク試料からの細胞分離および濃縮方法とそのキット |
| US5321975A (en) * | 1991-10-04 | 1994-06-21 | Levine Robert A | Differential erythrocyte counts |
| US5455009A (en) * | 1993-09-14 | 1995-10-03 | Becton, Dickinson And Company | Blood collection assembly including clot-accelerating plastic insert |
| US5634474A (en) * | 1995-04-28 | 1997-06-03 | Becton, Dickinson And Company | Blood collection assembly including clot-accelerating glass insert |
| US7947236B2 (en) | 1999-12-03 | 2011-05-24 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US7845499B2 (en) * | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| AU2003249642A1 (en) * | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| DK1848473T3 (da) * | 2005-02-07 | 2013-09-02 | Hanuman Llc | Plasmakoncentrationsanordning |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| JP5479319B2 (ja) | 2007-04-12 | 2014-04-23 | バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー | ブイ式懸濁液分画システム |
| US10106587B2 (en) | 2008-02-27 | 2018-10-23 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| US8337711B2 (en) * | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
| AU2009274096B2 (en) | 2008-07-21 | 2012-08-02 | Becton, Dickinson And Company | Density phase separation device |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| EP4119228B1 (en) | 2009-05-15 | 2024-07-24 | Becton, Dickinson and Company | Density phase separation device |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920557A (en) * | 1974-02-27 | 1975-11-18 | Becton Dickinson Co | Serum/plasma separator--beads-plus-adhesive type |
| CA1041903A (en) * | 1974-11-07 | 1978-11-07 | Corning Glass Works | Blood coagulation and separation |
| NO137663C (no) * | 1976-09-30 | 1978-03-29 | Ken Heimreid | Fremgangsmaate ved undersoekelse av ukoagulert blod |
| DE2701012A1 (de) * | 1977-01-12 | 1978-07-13 | Sparlab Gmbh Herstellung Und V | Stopfen fuer zentrifugenglaeser |
-
1979
- 1979-10-04 NO NO793190A patent/NO146616C/no unknown
-
1980
- 1980-09-25 DE DE19803036220 patent/DE3036220A1/de not_active Ceased
- 1980-09-26 US US06/191,818 patent/US4379849A/en not_active Expired - Lifetime
- 1980-09-26 CA CA000361766A patent/CA1163464A/en not_active Expired
- 1980-09-30 SE SE8006839A patent/SE444733B/sv not_active IP Right Cessation
- 1980-10-03 JP JP13862580A patent/JPS5660350A/ja active Granted
- 1980-10-03 GB GB8032007A patent/GB2061498B/en not_active Expired
- 1980-10-03 AU AU62956/80A patent/AU546175B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NO146616B (no) | 1982-07-26 |
| GB2061498B (en) | 1984-03-21 |
| AU6295680A (en) | 1981-04-16 |
| GB2061498A (en) | 1981-05-13 |
| CA1163464A (en) | 1984-03-13 |
| NO146616C (no) | 1982-11-03 |
| US4379849A (en) | 1983-04-12 |
| JPS5660350A (en) | 1981-05-25 |
| SE444733B (sv) | 1986-04-28 |
| AU546175B2 (en) | 1985-08-22 |
| DE3036220A1 (de) | 1981-04-23 |
| NO793190L (no) | 1981-04-07 |
| SE8006839L (sv) | 1981-04-05 |
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