JPS63310818A - シ−ト状口腔粘膜付着製剤 - Google Patents
シ−ト状口腔粘膜付着製剤Info
- Publication number
- JPS63310818A JPS63310818A JP14520187A JP14520187A JPS63310818A JP S63310818 A JPS63310818 A JP S63310818A JP 14520187 A JP14520187 A JP 14520187A JP 14520187 A JP14520187 A JP 14520187A JP S63310818 A JPS63310818 A JP S63310818A
- Authority
- JP
- Japan
- Prior art keywords
- pullulan
- sheet
- oral mucosa
- preparation
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 210000002200 mouth mucosa Anatomy 0.000 title claims abstract description 10
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- 229920001218 Pullulan Polymers 0.000 claims abstract description 28
- 235000019423 pullulan Nutrition 0.000 claims abstract description 28
- 239000000853 adhesive Substances 0.000 claims abstract description 18
- 230000001070 adhesive effect Effects 0.000 claims description 16
- 229940079593 drug Drugs 0.000 abstract description 33
- 239000003814 drug Substances 0.000 abstract description 33
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- 229920001577 copolymer Polymers 0.000 abstract description 5
- 150000002148 esters Chemical class 0.000 abstract description 5
- 239000004014 plasticizer Substances 0.000 abstract description 3
- 150000005846 sugar alcohols Polymers 0.000 abstract description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract description 2
- 150000001408 amides Chemical class 0.000 abstract description 2
- 229920002678 cellulose Polymers 0.000 abstract description 2
- 239000001913 cellulose Substances 0.000 abstract description 2
- 210000004877 mucosa Anatomy 0.000 abstract description 2
- 210000004400 mucous membrane Anatomy 0.000 description 13
- 210000004379 membrane Anatomy 0.000 description 7
- 239000012528 membrane Substances 0.000 description 7
- 230000003232 mucoadhesive effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- -1 xylitol Chemical compound 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
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- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 description 1
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- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- 229960001907 nitrofurazone Drugs 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 229960003207 papaverine hydrochloride Drugs 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229950000964 pepstatin Drugs 0.000 description 1
- 108010091212 pepstatin Proteins 0.000 description 1
- FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
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- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 1
- 229960001544 sulfathiazole Drugs 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- IHZBEYOBDAOPDZ-UHFFFAOYSA-M trimethyl-(4-methyl-3-oxopent-4-enyl)azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)CC[N+](C)(C)C IHZBEYOBDAOPDZ-UHFFFAOYSA-M 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14520187A JPS63310818A (ja) | 1987-06-12 | 1987-06-12 | シ−ト状口腔粘膜付着製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14520187A JPS63310818A (ja) | 1987-06-12 | 1987-06-12 | シ−ト状口腔粘膜付着製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63310818A true JPS63310818A (ja) | 1988-12-19 |
| JPH044296B2 JPH044296B2 (enrdf_load_stackoverflow) | 1992-01-27 |
Family
ID=15379746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14520187A Granted JPS63310818A (ja) | 1987-06-12 | 1987-06-12 | シ−ト状口腔粘膜付着製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63310818A (enrdf_load_stackoverflow) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000018365A3 (en) * | 1998-09-25 | 2000-11-16 | Warner Lambert Co | Fast dissolving orally consumable films |
| JP2002512950A (ja) * | 1998-04-29 | 2002-05-08 | バイロテックス コーポレイション | 粘膜表面への、薬剤化合物の送達に適する薬剤キャリアデバイス |
| WO2003026654A1 (fr) * | 2001-09-25 | 2003-04-03 | Kyukyu Pharmaceutical Co.,Ltd. | Preparation pour film contenant de la nicotine |
| US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
| US7579019B2 (en) | 1996-10-18 | 2009-08-25 | Arius Two, Inc. | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
| EP1648362A4 (en) * | 2003-07-01 | 2012-01-11 | Todd Maibach | THERAPEUTIC AGENTS WITH FILM |
| US9597288B2 (en) | 2006-07-21 | 2017-03-21 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5278286A (en) * | 1976-09-16 | 1977-07-01 | Hayashibara Biochem Lab Inc | Production on pullulan ester |
| JPS56100714A (en) * | 1980-01-16 | 1981-08-12 | Teijin Ltd | Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane |
| JPS5843915A (ja) * | 1981-09-09 | 1983-03-14 | Teijin Ltd | 口腔粘膜接着形製剤 |
| JPS58128314A (ja) * | 1982-01-26 | 1983-07-30 | Nitto Electric Ind Co Ltd | 粘膜製剤 |
| JPS58174307A (ja) * | 1982-04-06 | 1983-10-13 | Teikoku Seiyaku Kk | 可食性口腔内貼付薬 |
| JPS59204117A (ja) * | 1983-04-28 | 1984-11-19 | Nitto Electric Ind Co Ltd | 外用治療部材 |
| JPS61246239A (ja) * | 1985-04-25 | 1986-11-01 | Nichiban Co Ltd | 粘着性組成物 |
| JPS62223114A (ja) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 徐放性歯周病治療剤 |
| JPS6393717A (ja) * | 1986-10-09 | 1988-04-25 | Sekisui Chem Co Ltd | 口腔粘膜用粘着剤もしくは接着剤 |
| JPS63101316A (ja) * | 1986-10-16 | 1988-05-06 | Nichiban Co Ltd | 医療用製剤 |
-
1987
- 1987-06-12 JP JP14520187A patent/JPS63310818A/ja active Granted
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5278286A (en) * | 1976-09-16 | 1977-07-01 | Hayashibara Biochem Lab Inc | Production on pullulan ester |
| JPS56100714A (en) * | 1980-01-16 | 1981-08-12 | Teijin Ltd | Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane |
| JPS5843915A (ja) * | 1981-09-09 | 1983-03-14 | Teijin Ltd | 口腔粘膜接着形製剤 |
| JPS58128314A (ja) * | 1982-01-26 | 1983-07-30 | Nitto Electric Ind Co Ltd | 粘膜製剤 |
| JPS58174307A (ja) * | 1982-04-06 | 1983-10-13 | Teikoku Seiyaku Kk | 可食性口腔内貼付薬 |
| JPS59204117A (ja) * | 1983-04-28 | 1984-11-19 | Nitto Electric Ind Co Ltd | 外用治療部材 |
| JPS61246239A (ja) * | 1985-04-25 | 1986-11-01 | Nichiban Co Ltd | 粘着性組成物 |
| JPS62223114A (ja) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 徐放性歯周病治療剤 |
| JPS6393717A (ja) * | 1986-10-09 | 1988-04-25 | Sekisui Chem Co Ltd | 口腔粘膜用粘着剤もしくは接着剤 |
| JPS63101316A (ja) * | 1986-10-16 | 1988-05-06 | Nichiban Co Ltd | 医療用製剤 |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7579019B2 (en) | 1996-10-18 | 2009-08-25 | Arius Two, Inc. | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
| JP2005325140A (ja) * | 1998-04-29 | 2005-11-24 | Virotex Corp | 粘膜表面への、薬剤化合物の送達に適する薬剤キャリアデバイス |
| JP2002512950A (ja) * | 1998-04-29 | 2002-05-08 | バイロテックス コーポレイション | 粘膜表面への、薬剤化合物の送達に適する薬剤キャリアデバイス |
| US7491406B2 (en) | 1998-09-25 | 2009-02-17 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films |
| JP2002525306A (ja) * | 1998-09-25 | 2002-08-13 | ワーナー−ランバート・カンパニー | 急速溶解性口内消耗性フィルム |
| US6923981B2 (en) | 1998-09-25 | 2005-08-02 | Warner-Lambert Company | Fast dissolving orally consumable films |
| US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| US7025983B2 (en) | 1998-09-25 | 2006-04-11 | Warner-Lambert Company Llc | Fast dissolving orally consumable films |
| WO2000018365A3 (en) * | 1998-09-25 | 2000-11-16 | Warner Lambert Co | Fast dissolving orally consumable films |
| EP1676557A3 (en) * | 1998-09-25 | 2006-09-06 | Warner-Lambert Company LLC | Fast dissolving orally consumable films |
| EP1674078A3 (en) * | 2000-03-23 | 2007-07-25 | Warner-Lambert Company LLC | Fast dissolving orally consumable filsm containing an ion exchange resin as a taste masking agent |
| US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
| US7648712B2 (en) | 2000-03-23 | 2010-01-19 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films containing a taste masking agent |
| CN1332665C (zh) * | 2001-09-25 | 2007-08-22 | 救急药品工业株式会社 | 含有尼古丁的薄膜制剂 |
| WO2003026654A1 (fr) * | 2001-09-25 | 2003-04-03 | Kyukyu Pharmaceutical Co.,Ltd. | Preparation pour film contenant de la nicotine |
| EP1648362A4 (en) * | 2003-07-01 | 2012-01-11 | Todd Maibach | THERAPEUTIC AGENTS WITH FILM |
| US9597288B2 (en) | 2006-07-21 | 2017-03-21 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| US9655843B2 (en) | 2006-07-21 | 2017-05-23 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH044296B2 (enrdf_load_stackoverflow) | 1992-01-27 |
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