JPS63292964A - Plasma treatment apparatus - Google Patents

Abstract

PURPOSE:To perform automatic priming treatment in such a state that a circuit is connected to a membrane module, by changing the ratio of the flow rate of a plasma pump and that of a drain pump at the time of priming. CONSTITUTION:The supply source 17 of a priming liquid composed of a physiological saline solution is connected to the plasma introducing part H1 of a plasma circuit 1 and the replenishing liquid introducing part H2 of a replenishing liquid circuit 3 is connected to the drain outlet of a membrane module M. By the reception of the start signal from the outside, the priming liquid is allowed to flow to the membrane module M in an upward direction while the flow rate of the plasma pump 6 and that of the drain pump 7 are held almost equal. A detection signal is received from a flow rate detector 9 by a plasma pump flow rate change-over means 11 and, when the flow rate of the priming liquid supplied to the membrane module reaches the first set value, the rotational speed of the plasma pump 6 is increased to supply the priming liquid to the membrane module while the amount of the priming liquid supplied to the membrane module is held so as to be made larger than the drain amount thereof discharged by the drain pump 7.

Description

[Detailed Description of the Invention] (Industrial Application Field) The present invention relates to a plasma processing device that uses a membrane module to remove pathogen-related substances and harmful substances contained in plasma, and particularly to a device that automatically performs priming. .

(Prior technology) Traditionally, as a treatment for kidney failure, liver failure, autoimmune diseases, etc., blood that has been suffocated is separated into blood cells and plasma using a centrifugal separator or a membrane module containing a plasma separation membrane. Plasma is separated into high-molecular-weight substances and low-molecular-weight substances in a family module, and purified plasma from which high-molecular weight substances have been removed is returned to the human body together with blood cells.

Before processing plasma in this type of device, it is necessary to perform a so-called briming process in which physiological saline is run through the circuit in order to clean the circuit and make it easier for the plasma to adapt to the membrane module.

(Problems to be Solved by the Invention) In the conventional briming process, each circuit and group module are individually brimmed, and then the membrane module is connected to the circuit again, which makes the briming process troublesome and time-consuming. There was a problem that the operation was complicated and required the operator's skill.

(Means for Solving the Problems) This invention has been made to solve the above-mentioned conventional problems, and provides a plasma processing apparatus that automatically performs briming processing in a state where a circuit and a membrane module are connected. The purpose is to provide

In order to achieve the above object, the structure of the present invention is shown in FIG.

The plasma circuit 1 includes a membrane module M that separates plasma supplied from the plasma introduction section H into high molecular weight substances and low molecular weight substances.
, a plasma pump 6, and a flow rate detector 9 for detecting the flow rate of the plasma circuit.

The membrane module is installed vertically so that the plasma inlet is located at the bottom.

During plasma processing, instead of the drain circuit connected to the outlet of the high molecular weight substance of the membrane module, the replacement fluid inlet H2 of the replacement fluid circuit 3, which is connected to a replacement fluid bag (not shown), is connected to the outlet of the high molecular weight substance of the membrane module. has been done.

Further, numeral 17 is a priming fluid supply source to which a plasma introduction section is connected in order to supply priming fluid to the plasma circuit and purified plasma circuit.

On the other hand, as a control means, pump drive means 10. A plasma pump flow rate switching means 11 and a pump stopping means 12 are provided. The pump driving means receives an external start signal and supplies the priming liquid to the membrane module M while keeping the flow rates of the plasma pump 6 and the drain pump 7 almost equal.
Flow from the bottom to the top. Further, the plasma pump flow rate switching means 11 changes the rotational speed of the plasma pump 6 when the flow rate of the priming liquid supplied to the membrane module reaches a first set value in response to a detection signal from the flow rate detector 9. The amount of priming liquid supplied to the membrane module is larger than the amount of drain discharged by the drain pump 7.

Roughly speaking, when the pump stop means 12 receives a detection signal from the flow rate detector 9 and the flow rate of the priming liquid supplied to the membrane module M reaches a second set value, the plasma pump stops. 6 and the drain pump 7 are stopped, and briming is completed.

(Function) According to the above configuration, the air inside the membrane module is smoothly discharged to the outside by the priming liquid flowing from the lower side of the membrane module toward the upper side. In addition, the flow rates of the plasma pump and drain pump are made equal, and the priming solution is flowed until the flow rate reaches the first set value, so the surface of the membrane that comes in contact with plasma (in the case of hollow fibers, the inner surface of the hollow fibers) can be cleaned. I can do it well.

Roughly increase the rotation speed of the plasma pump, in other words! If the flow rate is increased (creating a pressure difference across the membrane), a portion of the priming liquid is allowed to permeate through the membrane until the flow rate reaches the second set value, so that sufficient cleaning power of the membrane module is maintained.

(Example) An example of the present invention will be described below with reference to the drawings.

First, before explaining the briming operation, the plasma processing apparatus will be explained.

FIG. 2 is a flow diagram during plasma processing. Plasma separated by a centrifugal separator or membrane module is introduced into the plasma circuit 1 from the plasma introduction part H1 by the plasma pump 6, and is supplied to the membrane module M through the chamber 22. I'm going to have a good time. A pressure gauge 23 is connected to the chamber to detect the inlet pressure of the membrane module.

This membrane module accommodates a plasma processing membrane, for example, a plate-shaped, tube-shaped, or hollow fiber-shaped separation membrane made of an ethylene-vinyl alcohol copolymer.

Usually, a hollow fiber separation membrane is used. ・All polymeric substances, including pathogenic substances, separated by the membrane module 3 are discharged to the outside through the drain opening by the drain pump 7. ・On the other hand, low molecular weight substances that have passed through the membrane The substance is extracted from the plasma extraction part ■3,
It is mixed with blood cells separated in a centrifuge or family module and then returned to the human body.

3 is a fluid replacement circuit, and a fluid replacement inlet Ii2 is connected to a fluid replacement bag 15 that stores fluid replacement such as albumin and HES. A replacement fluid in an amount equal to the high molecular weight substance to be discarded is supplied from the replacement fluid bag to the membrane module by the dual roller pump (drain pump) 7, and mixed with the low molecular weight substance separated by the membrane module.

Roughly speaking, a plasma flow rate detector 9 is connected to the plasma pump 6 to detect the flow rate of plasma supplied to the membrane module based on the rotational speed of the plasma pump. Also connected to the drain pump 7 is a drain flow rate detector 13 that detects the amount of drain based on the rotation speed of the drain pump.

14 is a control device consisting of a microcomputer;
During clinical practice, this control device controls each of the above detectors 9.13.
While monitoring the flow rate detection signal from the pressure gauge 23 and the pressure detection signal from the pressure gauge 23, the drive and stop of each pump is controlled so that the flow rates in the plasma circuit and the drain circuit and the membrane pressure in the membrane module are at appropriate values. and process the plasma.

Next, the briming operation of the plasma processing apparatus having the above configuration will be explained with reference to the flowchart shown in FIG.

In FIG. 3, a briming solution supply source 17 that supplies a briming solution consisting of physiological saline is connected to the plasma introduction section H of the plasma circuit 1, and the replacement fluid introduction section R2 of the replacement fluid circuit is connected to the drain outlet I of the membrane module. be done. Also, the control device f
The It14 includes a pump driving means 10 for driving the plasma pump 6 and the drain pump 7, respectively, a plasma pump flow rate switching means 11, and a pump stopping means 12.

With all the pumps 6 and 7 stopped, the control device operates in response to an external start signal to drive the plasma pump 6 and drain pump 7 at the same flow rate (for example, 40 mlZ). By each of the pumps mentioned above, the briming solution passes from the plasma storage bag through the plasma flow path (inside the hollow fiber in the case of hollow fibers) of the membrane module (2), from the replacement fluid inlet H2 connected to the drain outlet, through the replacement fluid circuit 3, and back into the membrane module. From the replacement fluid inlet, the purified plasma side of the membrane module (in the case of hollow fibers, the outside of the hollow fiber) passes through the purified plasma outlet of the membrane module, passes through the purified plasma circuit 2, and is discharged to the outside from the purified plasma outlet H3.

In response to a detection signal from the plasma flow rate detector 9, when the briming flow rate supplied to the membrane module reaches a first predetermined value (for example, 320rnJ), the plasma contacting surface of the membrane module is sufficiently cleaned. As a control device! 11
4, the flow rate of the plasma pump 6 is switched to be larger than the flow rate of the drain pump 7 (for example, 80 ml/Z) and the briming liquid is supplied to the membrane module. A part of the briming solution supplied to the membrane module by straining passes through the membrane, and is combined with the briming solution that did not pass through the membrane in the tran pump, and is sent from the purified plasma outlet of the gland module to the purified plasma circuit 2 and purified plasma. The purified plasma is discharged to the outside through the bag 5 from the purified plasma outlet H3.

The control device 14 receives a detection signal from the plasma flow rate detector 9 and controls the plasma circuit, purified plasma circuit, and Assuming that cleaning and air bleeding in the fluid replacement circuit has been completed, all pumps 6
．． 7 is stopped, and the briming process is completed.

After the above-mentioned brimming is completed, the replacement fluid introduction part H2 of the replacement fluid circuit 3
is removed and connected to the replacement fluid bag 15, and a drain circuit is connected to the outlet of the high molecular weight substance of the capture module. When the connection of the circuit is completed, the control device is operated again to start plasma processing.

(Effects of the Invention) As explained above, according to the present invention, since the flow rate ratio of the plasma pump and the drain pump is changed during briming, not only the surface of the membrane but also the cross section of the membrane can be sufficiently cleaned, and the operation Priming processing can be easily performed regardless of the skill level of the person.

[Brief explanation of drawings]

FIG. 1 is a circuit diagram showing the configuration of the present invention, FIG. 2 is a circuit diagram showing the state of the plasma processing apparatus according to the present invention during plasma processing, and FIG. 3 is a circuit diagram showing an embodiment of the present invention. FIG. 4 is a flowchart showing the control method of the present invention.

Claims (1)

[Scope of Claims] A plasma circuit 1 in which plasma is introduced from a plasma inlet H_1 by a plasma pump 6 into a membrane module M having a built-in plasma processing membrane and separated into high molecular weight substances and low molecular weight substances, and A drain circuit 15 connected to the outlet of the high molecular weight substance, a purified plasma circuit 2 connected to the outlet of the low molecular weight substance of the membrane module and leading out the purified plasma from the plasma outlet part H_3, and fluid replacement with the drain pump 7. In a plasma processing apparatus equipped with a fluid replacement circuit 3 that introduces replacement fluid from the introduction part H_2 into the replacement fluid inlet of the membrane module and mixes it with the low molecular weight substance separated by the membrane module, the plasma introduction port H_1 of the plasma circuit 1 is primed. Connect the fluid supply source 17 and connect the fluid replacement inlet H_2 of the fluid replacement circuit 3 to the outlet of the high molecular weight substance of the membrane module from which the drain circuit has been removed, and perform priming while keeping the flow rate of the plasma pump 7 equal using the pump driving means 10. The plasma pump flow rate switching means 11 is configured to increase the rotational speed of the plasma pump in response to a detection signal from the priming liquid flow rate detector 9 when the priming liquid reaches a predetermined amount while causing the liquid to flow through the membrane module. A plasma processing device characterized by: