JPH0651058B2 - Plasma separator - Google Patents
Plasma separatorInfo
- Publication number
- JPH0651058B2 JPH0651058B2 JP61100579A JP10057986A JPH0651058B2 JP H0651058 B2 JPH0651058 B2 JP H0651058B2 JP 61100579 A JP61100579 A JP 61100579A JP 10057986 A JP10057986 A JP 10057986A JP H0651058 B2 JPH0651058 B2 JP H0651058B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- valve
- plasma
- replacement fluid
- pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【発明の詳細な説明】 〔産業上の利用分野〕 この発明は血液から、血球成分と血漿成分を分離する血
漿分離装置と、特に流路等に残留する血液等を自動的に
患者に戻す装置に関するものである。Description: TECHNICAL FIELD The present invention relates to a plasma separation device for separating blood cell components and plasma components from blood, and in particular to a device for automatically returning blood and the like remaining in a flow path to a patient. It is about.
腎不全、肝不全、自己免疫疾患等の治療法として、患者
の血液を血漿分離器で血漿成分と血球成分とに分離し、
分離された血漿成分を廃棄し、廃棄された血漿成分と等
量の補液を血球成分に加えて体内に返還する血漿分離法
が知られている。この種の血液処理方法では、血液を処
理した後に、血漿分離器および流路中に残存する血液と
補液を患者に戻す、いわゆる回収作業を行う必要があ
る。As a treatment method for renal failure, liver failure, autoimmune disease, etc., a patient's blood is separated into a plasma component and a blood cell component by a plasma separator,
There is known a plasma separation method in which the separated plasma component is discarded, and a replacement fluid in an amount equal to that of the discarded plasma component is added to the blood cell component and returned to the body. In this type of blood processing method, it is necessary to perform a so-called recovery operation of returning the blood and the replacement fluid remaining in the plasma separator and the flow path to the patient after processing the blood.
従来の回収作業は、装置全体が複雑であるため、各ポン
プの駆動と停止を繰り返したり、各ポンプの流量を調節
したり、あるいはペアン等を使用して流路を開閉するな
ど主に手作業で行なわれていた。Conventional recovery work is mainly manual work such as repeatedly driving and stopping each pump, adjusting the flow rate of each pump, or opening and closing the flow path using a pair, etc., because the entire device is complicated. It was done in.
上述の回収処理は面倒で、時間がかかり、操作が煩雑な
ため操作員（テクニシヤン）の習熟したテクニツクを必
要とした。Since the above-mentioned recovery process is troublesome, time-consuming, and complicated in operation, a technic skilled in the operator (technician) is required.
本発明は従来の上記問題を解消して、血漿分離器および
流路中に残つた血液と補液を効率よく、患者の体内に自
動的に回収する装置を提供することを目的とする。SUMMARY OF THE INVENTION It is an object of the present invention to solve the above-mentioned problems of the related art and to provide a plasma separator and an apparatus for efficiently collecting blood and replacement fluid remaining in a flow channel automatically into the body of a patient.
上記目的を達成するための、この発明の構成を第１図に
示す。The structure of the present invention for achieving the above object is shown in FIG.
血液循環流路１には、血液導出部H1から取り出された血
液を血球成分と血漿成分とに分離する血漿分離器３と、
血液ポンプ４とが接続され、分離された血球成分は血液
導入部H2より人体に戻される。血漿分離器３の血球成分
の出口側には流路を外部からピンチして開閉する第２の
バルブ１７があり、第２のバルブの下流側には気液を分
離するための静脈チヤンバー１８が接続されている。該
静脈チヤンバー１８の下流には流路中の空気の存在を見
判ける第２の検出器１９があり、その検出器１９と血液
導入部H2との間には、流路を外部からピンチして開閉す
る第１のバルブ２０が設けられている。静脈チヤンバー
１８にはチヤンバー内の液体レベルが適正レベル（通常
チヤンバーの下限より約2/3の位置）まで存在するか否
かを識別する第１の検出器１８Ｄが設けられている。In the blood circulation flow path 1, a plasma separator 3 for separating the blood extracted from the blood outlet H 1 into blood cell components and plasma components,
The blood cell 4 is connected, and the separated blood cell component is returned to the human body from the blood introducing portion H 2 . On the outlet side of the blood cell component of the plasma separator 3, there is a second valve 17 that opens and closes by pinching the flow path from the outside, and on the downstream side of the second valve there is a venous chamber 18 for separating gas and liquid. It is connected. A second detector 19 which can detect the presence of air in the flow path is provided downstream of the vein chamber 18, and the flow path is pinched from the outside between the detector 19 and the blood introducing portion H 2. There is provided a first valve 20 that opens and closes. The venous chamber 18 is provided with a first detector 18D for identifying whether or not the liquid level in the chamber is up to an appropriate level (usually about 2/3 of the lower limit of the chamber).
血漿流路１０には、血漿ポンプ（通常２連式のローラポ
ンプが使われており補液ポンプと共用される）７１が接
続され上記血漿分離器３で分離された血漿成分をドレン
開口Ｄから外部へ排出する。また補液は補液供給源９か
ら補液ポンプ７１で血漿成分と等量の補液が血漿分離器
３の下流の血液循環流路を経て血球成分と混合されて人
体へ送給される。A plasma pump (usually a double roller pump is commonly used as a replacement fluid pump) 71 is connected to the plasma channel 10, and the plasma component separated by the plasma separator 3 is discharged from the drain opening D to the outside. To discharge. Further, the replacement fluid is supplied from the replacement fluid supply source 9 by the replacement fluid pump 71 to the human body after mixing the same amount of the replacement fluid with the blood cell component through the blood circulation flow path downstream of the plasma separator 3.
補液流路２の下流側と血液循環流路１との間には、２つ
の流路の連通と遮断を行う第３のバルブ１１が設けられ
ている。A third valve 11 is provided between the downstream side of the replacement fluid flow path 2 and the blood circulation flow path 1 to connect and disconnect the two flow paths.
血漿分離器３の液（血漿）室の上部側壁に設けられた
開口には第４のバルブ２５が接続されており、この第４
のバルブ２５により、外部空気を液室内に導入でき
る。外部空気による汚染をさけるため、第４のバルブ２
５の空気取入口には除菌フイルターを設ける事が好まし
い。A fourth valve 25 is connected to the opening provided in the upper side wall of the liquid (plasma) chamber of the plasma separator 3, and the fourth valve 25 is connected to the opening.
The valve 25 allows external air to be introduced into the liquid chamber. 4th valve 2 to avoid contamination by external air
It is preferable to install a sterilization filter at the air intake port of No. 5.
一方、制御手段としては、血液回収手段１３、補液回収
手段１５および回収終了手段１６がある。On the other hand, as the control means, there are a blood collecting means 13, a replacement fluid collecting means 15, and a collection ending means 16.
血液処理が終了すると、血液導出部H1を人体から取り外
し、その後外部からの回収スタート信号を受ける。血液
回収手段１３は第１のバルブ２０および第２のバルブ１
７の開信号、第３のバルブ１１の閉信号を送り、血液ポ
ンプ４を駆動させて、血液循環流路中に残つた血液を血
液ポンプ４により血漿分離器３、静脈チヤンバー１８を
経由して血液導入部H2より人体に返却する。その際人体
から取り外された血液導出部H1からは空気が入るため血
漿分離器３に残留した血液が無くなると静脈チヤンバー
１８の血液レベルが低下して第１の検出器１８Ｄで気体
（空気）がある一定期間検出される。第１の検出器で気
体が検出されると血液の回収が終了したものとみなし、
次に補液回収手段１５により第２のバルブ１７の閉信
号、第３のバルブ１１および第４のバルブ２５の開信号
を送り血液ポンプ４の駆動を停止させ、補液（血漿）ポ
ンプ７１を駆動する。すると外部空気が第４のバルブ２
５からとり込まれ、血漿分離器３内の残血漿は血漿流路
１０より廃棄される。一方補液流路内の残補液は人体に
戻される。When the blood processing is completed, the blood outlet H 1 is removed from the human body, and then a collection start signal from the outside is received. The blood collecting means 13 includes a first valve 20 and a second valve 1.
An open signal of 7 and a close signal of the third valve 11 are sent to drive the blood pump 4 so that the blood remaining in the blood circulation channel is passed by the blood pump 4 through the plasma separator 3 and the vein chamber 18. It is returned to the human body from the blood introduction part H 2 . At that time, since air enters from the blood outlet H 1 removed from the human body, when the blood remaining in the plasma separator 3 disappears, the blood level in the venous chamber 18 decreases, and gas (air) is detected by the first detector 18D. Is detected for a certain period of time. When gas is detected by the first detector, it is considered that blood collection is completed,
Next, the replacement fluid recovery means 15 sends a closing signal for the second valve 17 and an opening signal for the third valve 11 and the fourth valve 25 to stop the driving of the blood pump 4 and drive the replacement fluid (plasma) pump 71. . Then, the outside air becomes the fourth valve 2
The residual plasma in the plasma separator 3 is taken from the plasma flow path 5 and discarded from the plasma flow path 10. On the other hand, the residual replacement fluid in the replacement fluid channel is returned to the human body.
補液容器９内の補液がなくなると、補液容器に取着され
た空気導入口（通常容器に注射針を穿刺する）より空気
が吸い込まれる。この補液容器内に吸い込まれた空気は
第３のバルブ１１を通り血液循環流路１の静脈チヤンバ
ー１８から第２の検出器１９へ至る。該第２の検知器１
９が上記空気（気体）を検出すると、この信号を受けて
回収終了手段１６により補液（血漿）ポンプ７１の駆動
を停止し、かつ第１のバルブ２０を閉止する。上記操作
により回収が終了するが、このとき血液循環流路１の第
２の検出器１９から血液導入部H2の間には補液が残留し
ている。この残留補液を回収する場合には、例えばスタ
ートスイツチ信号により、第１のバルブ２０の開信号を
送り、補液（血漿）ポンプ７１を起動し、残補液を血液
導入部H2に目視にて近接させる。その後ストツプ信号に
より補液（血漿）ポンプ７１を停止し、第１のバルブ２
０の閉信号を送る。上記操作は通常手動で行われる。When the replacement fluid in the replacement fluid container 9 is used up, air is sucked from the air introduction port attached to the replacement fluid container (usually a needle is punctured in the container). The air sucked into the replacement fluid container passes through the third valve 11 and reaches the second detector 19 from the vein chamber 18 of the blood circulation flow path 1. The second detector 1
When 9 detects the air (gas), the recovery end means 16 stops the drive of the replacement fluid (plasma) pump 71 and closes the first valve 20 in response to this signal. The recovery is completed by the above operation, but at this time, the replacement fluid remains between the second detector 19 of the blood circulation flow path 1 and the blood introduction part H 2 . When recovering this residual replacement fluid, for example, by a start switch signal, an opening signal of the first valve 20 is sent, the replacement fluid (plasma) pump 71 is started, and the residual replacement fluid is visually approached to the blood introducing part H 2 . Let After that, the replacement fluid (plasma) pump 71 is stopped by the stop signal, and the first valve 2
Send a close signal of 0. The above operation is usually performed manually.
血液の回収に生理食塩水を使用する場合には血液導出部
H1を生食ボトルに接続すればよい。その場合にも静脈チ
ヤンバー１８に設けられた第１の検出器１８Ｄが気体
（空気）を検出したときを回収終了とみなすことができ
る。生理食塩水で血液を回収すると第１の検出器１８Ｄ
は血液、次に生理食塩水を検出し、その次に気体（空
気）を検出するため、血液の回収に多少長時間を要する
ことになるだけで、上記の空気による血液の体内返却と
同一の工程で実施出来る。When using physiological saline to collect blood, the blood outlet
Simply connect H 1 to the saline bottle. Even in that case, when the first detector 18D provided in the vein chamber 18 detects gas (air), it can be considered that the recovery is completed. When blood is collected with physiological saline, the first detector 18D
Detects blood, then saline, and then gas (air), so it takes a little longer time to recover blood, which is the same as the above-mentioned return of blood by air. It can be implemented in the process.
上記構成によれば、血液処理終了後、血液導出部H1を人
体より取り外し、しかる後回収処理をスタートさせるこ
とにより、直ちに体外に導出された残血液を自動的に体
内に返出来る。しかも残補液も全て人体に返却されるた
め効率的な回収が出来る。According to the above configuration, after the blood treatment is completed, the blood outlet H 1 is removed from the human body, and then the recovery process is started, so that the residual blood that has been led out of the body can be automatically returned to the body. In addition, all the remaining replacement fluid is returned to the human body, which allows efficient recovery.
また血液回収手段、補液回収手段および回収終了手段が
継続して自動的に作動するため、操作が極めて簡単にな
り、スタート操作のみで残血液、残補液のほとんどすべ
てが回収される。Further, since the blood collecting means, the replacement fluid collecting means and the collection ending means operate continuously and automatically, the operation becomes extremely simple, and almost all of the residual blood and the residual replacement fluid are collected only by the start operation.
以上、この発明の実施例を図面にしたがつて説明する。 The embodiments of the present invention will be described with reference to the drawings.
第２図は血液処理時のフロー図であり、１は血液循環流
路、２は補液流路である。血液導入部H1（シヤント、注
射針などの通常の採血器や貯血器などと連絡できる部
分）から取り出された血液は、血液ポンプ４により昇圧
されて動脈圧チヤンバー１６に入り、ついで、上下方向
に設定された血漿分離器３の上側から血漿分離器内に導
入され、血球成分と血漿成分とに分離される。この血漿
分離器３には、血漿分離膜、たとえばポリビニルアルコ
ール（ＰＶＡ）系の共重合体などからなる平板状、チユ
ーブ状、または中空糸状の分離膜が収容されている。通
常は、中空糸状の分離膜を多数寄せ集めたものが用いら
れる。FIG. 2 is a flow chart at the time of blood processing, in which 1 is a blood circulation channel and 2 is a replacement fluid channel. Blood taken from the blood introducing part H 1 (a part that can communicate with a normal blood collecting device such as a shunt or an injection needle or a blood reservoir) is pressurized by the blood pump 4 into the arterial pressure chamber 16 and then in the vertical direction. It is introduced into the plasma separator from the upper side of the plasma separator 3 set to, and is separated into a blood cell component and a plasma component. The plasma separator 3 contains a plasma separation membrane, for example, a flat plate-shaped, tube-shaped, or hollow fiber-shaped separation membrane made of a polyvinyl alcohol (PVA) -based copolymer. Usually, a collection of a large number of hollow fiber-shaped separation membranes is used.
上記血漿分離器３で分離された血球成分は、第２のバル
ブ１７を経て静脈圧チヤンバー１８に入り気泡検知器１
９、第１のバルブ２０を経て血液導出部H2（シヤントや
点滴セツトなどに連結できる部分）より人体へ返還され
る。静脈圧チヤンバーには、チヤンバー内レベルをモニ
ターする検知器１８Ｄが設けられている。The blood cell component separated by the plasma separator 3 enters the venous pressure chamber 18 through the second valve 17 and the bubble detector 1
9. The blood is returned to the human body from the blood outlet H 2 (portion that can be connected to a shunt or drip set) via the first valve 20. The venous pressure chamber is provided with a detector 18D for monitoring the level inside the chamber.
さらに、上記血液ポンプ４の上流側には、膨張・収縮可
能な袋状体からなるピローセンサ２１が設けられてお
り、脱血が困難になつたときに、流路の陰圧を検知して
作動し、血液ポンプ４を停止させ、陰圧がなくなつたと
き、血液ポンプ４を再始動する。また、上記動脈圧チヤ
ンバー１６には、血液中にヘパリンを少量だけ混入させ
て、処理中の血液の凝固を防止するヘパリン注入器２２
と、動脈圧センサ２３とが接続されている。また上記血
漿分離器３には、過圧センサ２４と空気導入バルブ２
５とが接続されている。上記静脈圧チヤンバー１８に
は、静脈圧センサ２６が接続されている。Further, on the upstream side of the blood pump 4, there is provided a pillow sensor 21 formed of an inflatable / contractible bag-like body for detecting negative pressure in the flow channel when it becomes difficult to remove blood. When activated, the blood pump 4 is stopped, and when the negative pressure disappears, the blood pump 4 is restarted. In addition, the arterial pressure chamber 16 has a heparin injector 22 which mixes a small amount of heparin into blood to prevent the blood from coagulating during processing.
And the arterial pressure sensor 23 are connected. Further, the plasma separator 3 includes an overpressure sensor 24 and an air introduction valve 2.
And 5 are connected. A venous pressure sensor 26 is connected to the venous pressure chamber 18.
上記血漿分離器３で分離された血漿成分は、血漿流路１
０に設けた補液（血漿）ポンプ７１によりドレン開口Ｄ
を経て外部へ排出される。また補液導入部（点滴セツト
などに連結できる部分）が、アルブミンやＨＥＳ等の補
液を供給する補液供給源９に接続され、補液が上記（補
液）血漿ポンプ７１により補液流路２から循環血液流路
１を経て人体へ返される。The plasma component separated by the plasma separator 3 is the plasma channel 1
Drain opening D by the replacement fluid (plasma) pump 71 provided at 0.
It is then discharged to the outside. Further, a replacement fluid introduction part (a portion that can be connected to a drip set or the like) is connected to a replacement fluid supply source 9 for supplying a replacement fluid such as albumin or HES, and the replacement fluid is circulated from the replacement fluid channel 2 by the (replacement fluid) plasma pump 71. Returned to the human body via Road 1.
また、血漿分離器３の下流側に、第２のバルブ１７が設
けられ、上記補液流路２の下流側と血液循環流路１の第
２のバルブ１７よりも下流側との間には、連通およびし
や断を行なう第３のバルブ１１が設けられている。In addition, a second valve 17 is provided on the downstream side of the plasma separator 3, and between the downstream side of the replacement fluid channel 2 and the downstream side of the second valve 17 of the blood circulation channel 1, A third valve 11 is provided for communicating and connecting and disconnecting.
さらに上記血液ポンプ４には、この血液ポンプ４の回転
数に基づいて血液循環流路１の流量を検知する血液量検
知器５が接続されている。また上記補液（血漿）ポンプ
７１には、この補液（血漿）ポンプ７１の回転数に基づ
いて補液流路２の流量を検知する補液量（血漿量）検知
器８１が接続されている。Further, the blood pump 4 is connected to a blood volume detector 5 that detects the flow rate of the blood circulation flow path 1 based on the rotation speed of the blood pump 4. Further, the replacement fluid (plasma) pump 71 is connected to a replacement fluid amount (plasma volume) detector 81 that detects the flow rate of the replacement fluid flow path 2 based on the rotation speed of the replacement fluid (plasma) pump 71.
４８はマイクロコンピユータからなる制御装置であり、
臨床時には、この制御装置４８により、上記各検知器
５、８１からの流量検知信号と、各圧力センサ２３、２
４、２６からの圧力検知信号とを見ながら、血液循環流
路１内と血漿流路１０内および補液流路２内の各流量、
および血漿分離器３の膜圧が適正値となるように、上記
各ポンプ４、７１の回転数を制御し、血液の処理を行な
う。ここで、上記（補液）血漿ポンプ７１は血漿成分の
排出と補液の供給とを兼ねているが、これとは異なり、
血漿成分の排出と補液の供給とを別固のポンプで行なう
ようにしてもよい。ただし、この実施例のように、兼用
構成とすれば、特に制御しなくても、高分子量成分の排
出量と、補液の供給量とが常に等しくなるので好都合で
ある。Reference numeral 48 is a control device composed of a micro computer,
At the clinical time, the control device 48 causes the flow rate detection signals from the detectors 5 and 81 and the pressure sensors 23 and 2 to be detected.
Each flow rate in the blood circulation flow channel 1, the plasma flow channel 10, and the replacement fluid flow channel 2 while observing the pressure detection signals from 4, 4 and 26,
And, the number of revolutions of each of the pumps 4 and 71 is controlled so that the membrane pressure of the plasma separator 3 becomes an appropriate value, and the blood is processed. Here, the (replacement fluid) plasma pump 71 both discharges the plasma component and supplies the replacement fluid, but unlike this,
The discharge of the plasma component and the supply of the replacement fluid may be performed by separate pumps. However, if the dual-use configuration is used as in this embodiment, the discharge amount of the high-molecular weight component and the supply amount of the replacement fluid are always equal to each other without any special control, which is convenient.
つぎに上記構成の血液処理装置の回収操作について第３
図〜第６図のフロー図および第７〜８図のフローチヤー
トにより説明する。Next, regarding the recovery operation of the blood processing apparatus having the above-mentioned configuration,
This will be described with reference to the flowcharts of FIGS. 6 to 6 and the flowcharts of FIGS. 7 to 8.
第３図は血液処理が終了した時の状態を示しており、血
液循環流路には血液、補液流路には補液が充満してい
る。また血液導出部H1は人体から取り外され、血液導入
部H2は人体に接続されている。FIG. 3 shows a state when the blood treatment is completed, in which the blood circulation channel is filled with blood and the replacement fluid channel is filled with the replacement fluid. The blood outlet H 1 is removed from the human body, and the blood inlet H 2 is connected to the human body.
血液ポンプ４、補液（血漿）ポンプ７１は停止してお
り、バルブ２０、１７は開放されバルブ１１、２５は閉
止されている。Blood pump 4 and replacement fluid (plasma) pump 71 are stopped, valves 20 and 17 are open, and valves 11 and 25 are closed.
以上が血液処理終了、すなわち回収のスタート前の状態
であり、第７図のフローチヤートのステツプK1である。
外部からの回収スタート信号を受けると、制御装置４８
が作動し血液ポンプ４が、例えば４０ml／分の流量で回
転を始め、血液導出部H1からは外部空気が吸入され、血
液循環流路中の残血液は血液導入部H2より人体に返却さ
れる。この状態は第７図のフローチヤートのステツプK2
であり、第４図にこの状態を示す。このステツプK2の状
態が続くと、血漿分離器３の血液がなくなり、次いで静
脈チヤンバー１８の血液レベルが低下し、該チヤンバー
に設けられた検出器１８Ｄが空気を検出する。検出器１
８Ｄが作動すると次のステツプK3に進む。静脈チヤンバ
ー１８は、このステツプK2の終りには、空気が混入する
ので、短期間（例えば１秒以内）の空気検出では次のス
テツプに進まない様な安全策が施されている。The above is the state before the blood treatment is completed, that is, before the start of collection, which is step K 1 of the flow chart in FIG.
When receiving a recovery start signal from the outside, the control device 48
The blood pump 4 starts to rotate at a flow rate of, for example, 40 ml / min, external air is sucked from the blood outlet H 1 , and the residual blood in the blood circulation channel is returned to the human body from the blood inlet H 2. To be done. This state is the flow chart step K 2 in FIG.
This is shown in FIG. When the state of step K 2 continues, the plasma separator 3 is depleted of blood, and then the blood level of the venous chamber 18 decreases, and the detector 18D provided in the chamber detects air. Detector 1
When 8D is activated, it proceeds to the next step K 3 . Since air is mixed into the vein chamber 18 at the end of this step K 2 , a safety measure is taken so as not to proceed to the next step in the air detection for a short period (for example, within 1 second).
血液導出部H1は上述のように外部開放せず、生理食塩水
貯留器に接続してもよい、その場合にはK2のステツプの
処理時間が長くなるが、血漿分離器３内の残血液がより
完全に追い出され、血液回収効率が上昇する。生理食塩
水が無くなると空気がとり込まれるので、上記と同様な
フローで適応出来る。The blood outlet H 1 may be connected to a physiological saline reservoir instead of being opened to the outside as described above. In that case, the processing time for the step of K 2 is long, but the remaining portion in the plasma separator 3 remains. Blood is expelled more completely and blood collection efficiency is increased. Since air is taken in when the physiological saline solution disappears, the same flow as above can be applied.
K3ステツプでは第５図に示すようにバルブ２５、２０、
１１が開放し、バルブ１７が閉止して、血液ポンプ４を
停止させ、補液（血漿）ポンプ７１を、例えば４０ml／
分の流量で回転させる。すると血漿分離器３の残血漿が
バルブ２５から空気を入れることによりドレン開口Ｄよ
り排出し、同時に補液供給源９の残補液が血液循環流路
を経由して人体に返還される。In the K 3 step, the valves 25, 20,
11 is opened, the valve 17 is closed, the blood pump 4 is stopped, and the replacement fluid (plasma) pump 71 is, for example, 40 ml /
Spin at a flow rate of minutes. Then, the residual plasma in the plasma separator 3 is discharged from the drain opening D by introducing air from the valve 25, and at the same time, the residual replacement liquid in the replacement fluid supply source 9 is returned to the human body via the blood circulation flow path.
補液がなくなると、補液供給源９に取り付けた空気導入
口より空気が入り、この空気は補液流路２を経て静脈圧
チヤンバー１８を経由して検出器１９を通過する。検知
器１９が空気を検出すると第６図に示すようにバルブ２
０を閉じて、補液（血漿）ポンプを停止し、回収操作が
終了する。When the replacement fluid is exhausted, air enters from the air introduction port attached to the replacement fluid supply source 9, and this air passes through the replacement fluid passage 2 and the venous pressure chamber 18 and passes through the detector 19. When the detector 19 detects air, as shown in FIG.
0 is closed, the replacement fluid (plasma) pump is stopped, and the collection operation is completed.
この状態では補液は血液循環流路１の検出器１９と血液
導出部H2の間に残つている。この残りの補液も回収する
場合にはK5、K6のステツプに示す様、手動作操で補液ポ
ンプを駆動させて補液を血液導入部H2の近くまで追い込
んでストツプスイツチで補液ポンプの駆動を止めること
により、残りの補液も完全に回収することが出来る。In this state, the replacement fluid remains between the detector 19 of the blood circulation flow path 1 and the blood outlet H 2 . As shown in the step of K 5, K 6 in the case of also collecting the remaining fluid replacement, the driving of the replacement fluid pump Sutotsupusuitsuchi is drove the replacement fluid by driving the replacement fluid pump manually operating steering close to the blood introducing section H 2 By stopping, the remaining replacement fluid can be completely recovered.
以上説明したように、この発明によれば、臨床処理終了
後、血液導出部を人体から取り外し回収スタートスイツ
チを押すだけで、血液循環流路中の残血液と補液流路中
の残補液を自動的に安全に回収できる。As described above, according to the present invention, after the clinical treatment is completed, the blood lead-out portion is removed from the human body and the recovery start switch is simply pressed to automatically remove the residual blood in the blood circulation channel and the residual fluid in the fluid replacement channel. Can be safely collected.
第１図はこの発明の構成を示す回路図、第２図はこの発
明に係る血漿分離装置の血液処理時の状態を示す回路
図、第３図ないし第６図は同実施例の動作を示す簡略化
した回路図、第７図と第８図は同実施例の制御方法を示
すフローチヤートである。 １……血液循環流路、２……補液流路、３……血漿分離
器、４……血液ポンプ、１８Ｄ……第１の検知器、９…
…補液供給源、１１……第３のバルブ、１３……血液回
収手段、１４……血漿回収手段、１５……回収終了手
段、１７……第２のバルブ、１９……第１の検知器、２
０……第１のバルブ、２５……第４のバルブFIG. 1 is a circuit diagram showing the configuration of the present invention, FIG. 2 is a circuit diagram showing the state of blood plasma processing of the plasma separation device according to the present invention, and FIGS. 3 to 6 show the operation of the same embodiment. A simplified circuit diagram, FIGS. 7 and 8 are flow charts showing the control method of the embodiment. 1 ... Blood circulation flow path, 2 ... Replacement fluid flow path, 3 ... Plasma separator, 4 ... Blood pump, 18D ... First detector, 9 ...
... Replacement fluid supply source, 11 ... Third valve, 13 ... Blood collecting means, 14 ... Plasma collecting means, 15 ... Collection ending means, 17 ... Second valve, 19 ... First detector Two
0 ... first valve, 25 ... fourth valve
Claims (1)
血液を血球成分と血漿成分とに分離し、血球成分を血液
循環流路１を経て人体に返還するとともに、分離された
血漿成分を廃棄し、該廃棄された血漿成分と等量の補液
を補液流路２を通じて、血漿分離器よりも下流の血液循
環流路１を経て人体へ返還する血漿分離装置において、 該血漿分離器３の下流の血液循環流路１内の流体を識別
する、互いに離間して設けた第１および第２の検知器１
８Ｄ、１９と、 該第２の検知器１９の下流の血液循環流路１を開閉する
第１のバルブ２０と、 該血漿分離器３の下流の血液循環流路１を開閉する第２
のバルブ１７と、 該補液流路２と該血漿分離器３よりも下流の血液循環流
路１との連通および遮断を行う第３のバルブ１１と、 該血漿分離器３の液室の上部に設けた空気導入口を開
閉する第４のバルブ２５と、 外部からの回収スタート信号を受けて、血液ポンプ４を
駆動し、第３のバルブ１１を閉止し、第１のバルブ２０
と第２のバルブ１７を開放する血液回収手段１３と 該第１の検知器１８Ｄからの気体検知信号を受けて、第
２のバルブ１７を閉止し、第３のバルブ１１と第１のバ
ルブ２０と第４のバルブ２５を開放するとともに、血液
ポンプの駆動４を停止し、補液ポンプ７１を駆動する補
液回収手段１５と、 該第２の検知器１９からの気体検知信号を受けて、第１
のバルブ２０を閉止し、補液ポンプ７１の駆動を停止す
る回収終了手段１６ を備え、血漿分離処理後、血液導入部H1を人体から取り
外し、血漿分離器３、血液循環流路１および補液流路２
内に残留する血液および補液を自動的に人体に戻すよう
構成したことを特徴とする血漿分離装置。1. A blood pump 4 separates blood supplied to a plasma separator 3 into blood cell components and plasma components, returns the blood cell components to a human body through a blood circulation flow path 1, and separates the plasma components. In the plasma separation apparatus, which discards the blood plasma and returns the same amount of the replacement fluid as the discarded plasma component to the human body through the replacement fluid channel 2 and the blood circulation channel 1 downstream of the plasma separator. First and second detectors 1 spaced apart from each other for identifying the fluid in the blood circulation flow path 1 downstream of the
8D and 19; a first valve 20 that opens and closes the blood circulation channel 1 downstream of the second detector 19; and a second valve 20 that opens and closes the blood circulation channel 1 downstream of the plasma separator 3.
Valve 17, a third valve 11 for connecting and disconnecting the replacement fluid flow path 2 and the blood circulation flow path 1 downstream of the plasma separator 3, and an upper part of the liquid chamber of the plasma separator 3. The fourth valve 25 that opens and closes the air inlet provided, and the blood pump 4 is driven in response to a recovery start signal from the outside, the third valve 11 is closed, and the first valve 20
Receiving the gas detection signal from the blood collecting means 13 for opening the second valve 17 and the first detector 18D, closing the second valve 17, and closing the third valve 11 and the first valve 20. And the fourth valve 25 is opened, the driving 4 of the blood pump is stopped, and the replacement fluid recovery means 15 that drives the replacement fluid pump 71 and the gas detection signal from the second detector 19 are received,
Is provided with a recovery termination means 16 for closing the valve 20 of the above and stopping the drive of the replacement fluid pump 71, and after the plasma separation process, the blood introducing part H 1 is removed from the human body, and the plasma separator 3, the blood circulation flow path 1 and the replacement fluid flow. Road 2
A plasma separation device characterized in that blood and fluid replacement remaining therein are automatically returned to the human body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61100579A JPH0651058B2 (en) | 1986-04-28 | 1986-04-28 | Plasma separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61100579A JPH0651058B2 (en) | 1986-04-28 | 1986-04-28 | Plasma separator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62254766A JPS62254766A (en) | 1987-11-06 |
| JPH0651058B2 true JPH0651058B2 (en) | 1994-07-06 |
Family
ID=14277800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61100579A Expired - Lifetime JPH0651058B2 (en) | 1986-04-28 | 1986-04-28 | Plasma separator |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0651058B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3932448A4 (en) * | 2019-04-01 | 2022-11-30 | Nikkiso Co., Ltd. | Blood purification device |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0620530Y2 (en) * | 1988-01-08 | 1994-06-01 | 株式会社クラレ | Exchange blood transfusion device for newborns |
-
1986
- 1986-04-28 JP JP61100579A patent/JPH0651058B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3932448A4 (en) * | 2019-04-01 | 2022-11-30 | Nikkiso Co., Ltd. | Blood purification device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62254766A (en) | 1987-11-06 |
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