JPH0117704B2 - - Google Patents
Info
- Publication number
- JPH0117704B2 JPH0117704B2 JP60284797A JP28479785A JPH0117704B2 JP H0117704 B2 JPH0117704 B2 JP H0117704B2 JP 60284797 A JP60284797 A JP 60284797A JP 28479785 A JP28479785 A JP 28479785A JP H0117704 B2 JPH0117704 B2 JP H0117704B2
- Authority
- JP
- Japan
- Prior art keywords
- plasma
- blood
- pump
- valve
- detector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004369 blood Anatomy 0.000 claims description 97
- 239000008280 blood Substances 0.000 claims description 97
- 239000012530 fluid Substances 0.000 claims description 30
- 230000017531 blood circulation Effects 0.000 claims description 27
- 210000000601 blood cell Anatomy 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 description 28
- 238000000926 separation method Methods 0.000 description 14
- 238000012545 processing Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 238000011084 recovery Methods 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 4
- 230000004872 arterial blood pressure Effects 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 2
- 238000002637 fluid replacement therapy Methods 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- RZXDTJIXPSCHCI-UHFFFAOYSA-N hexa-1,5-diene-2,5-diol Chemical compound OC(=C)CCC(O)=C RZXDTJIXPSCHCI-UHFFFAOYSA-N 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Description
６２
を備えたことを特徴とする二重過型血液処理装
置。62. A double-type blood processing device characterized by comprising:
〔産業上の利用分野〕
この発明は血液から、血球成分と血漿成分を分
離する血漿分離器と、分離した血漿から高分子量
成分を除去する血漿成分分離器とを有する二重
過型血液処理装置、特に血漿分離器、血漿成分分
離器、血液循環流路及び血漿流路に残留する血液
等を自動的に患者に戻す装置に関するものであ
る。
[Industrial Application Field] The present invention provides a double-pass type blood processing device having a plasma separator that separates blood cell components and plasma components from blood, and a plasma component separator that removes high molecular weight components from the separated plasma. In particular, the present invention relates to a plasma separator, a plasma component separator, a blood circulation channel, and a device for automatically returning blood remaining in the plasma channel to a patient.
腎不全、肝不全、自己免疫疾患等の治療法とし
て、患者の血液を血漿分離器で血漿成分と血球成
分とに分離し、分離した血漿成分を、血漿成分分
離器で有害物質が含まれる高分子量成分と、アル
プミン等の人体に有害な物質が含まれる低分子量
成分とに分離し、低分子量成分に高分子量成分と
等量の補液を加えて体内に返還する二重過血漿
分離交換法が知られている（特公昭60―40302号
公報など）。この種の血液処理方法では、血液を
処理した後に、血漿分離器、血漿成分分離器およ
び流路中に残存する血液や血漿などを患者に戻
す、いわゆる回収処理を施す必要がある。
As a treatment for kidney failure, liver failure, autoimmune diseases, etc., a patient's blood is separated into plasma components and blood cell components using a plasma separator, and the separated plasma components are separated into high concentrations containing harmful substances using a plasma component separator. The double hyperplasma separation and exchange method separates molecular weight components from low molecular weight components that contain substances harmful to the human body such as albumin, and returns the low molecular weight components to the body after adding replacement fluid in the same amount as the high molecular weight components. It is known (Special Publication No. 40302 of 1988, etc.). In this type of blood processing method, after blood is processed, it is necessary to perform a so-called recovery process in which the blood, plasma, etc. remaining in the plasma separator, plasma component separator, and flow path are returned to the patient.
従来の回収処理は、上記したように分離器が２
つ設けられていて、装置全体が複雑であるため、
各ポンプの駆動と停止を繰り返したり、各ポンプ
の流量を調節したり、あるいはペアン等を使用し
て流路を開閉する操作をすべて手作業で行なつて
いた。 In the conventional recovery process, as mentioned above, there are two separators.
Since the entire device is complicated,
All operations were performed manually, such as repeatedly driving and stopping each pump, adjusting the flow rate of each pump, and opening and closing the flow channels using a Pean or the like.
上述の回収処理は装置が複雑なため、操作が煩
雑で操作員の習塾したテクニツクを必要とし、し
かも、回収処理に時間がかかるという問題があつ
た。
The above-mentioned recovery process has problems in that the apparatus is complicated, the operation is complicated, the operator requires well-trained techniques, and the recovery process takes a long time.
本発明は従来の上記問題を解消して、血漿分離
器、血漿成分分離器、流路中に残つた血液や血漿
等を効率よく、患者の体内に自動的に回収する二
重過型血液処理装置を提供することを目的とす
る。 The present invention solves the above-mentioned conventional problems, and provides a plasma separator, a plasma component separator, and a double-pass type blood processing system that efficiently and automatically collects blood, plasma, etc. remaining in the flow path into the patient's body. The purpose is to provide equipment.
上記目的を達成するための、この発明の構成を
第１図に示す。
The structure of the present invention for achieving the above object is shown in FIG.
血液循環流路１には、血液導出部H1から取り
出された血液を血球成分と血漿成分とに分離する
血漿分離器３と、血液ポンプ４とが接続され、分
離された血球成分は静脈圧チヤンバー１８を経由
して、血液導入部H2より、人体に戻される。血
漿分離器３の血球成分の出口側には流路を外部か
らピンチして開閉する第２のバルブ１７があり、
第２のバルブの下流側には気液を分離するための
静脈チヤンバー１８が接続されている。該静脈チ
ヤンバー１８の下流には流路中の空気の存在を識
別する第２の検出器１９があり、その検出器１９
と血液導入部H2間には、流路を外部からピンチ
して開閉する第１のバルブ２０が設けられてい
る。静脈チヤンバー１８にはチヤンバー内の液体
レベルが適正レベル（チヤンバーの下限より約2/
３の位置）まで存在するか否かを識別する第１の
検出器１８Ｄを備えてある。 A blood pump 4 and a plasma separator 3 that separates the blood taken out from the blood outlet section H1 into blood cell components and plasma components are connected to the blood circulation channel 1, and the separated blood cell components are separated by venous pressure. The blood is returned to the human body via the chamber 18 from the blood introduction section H2 . There is a second valve 17 on the blood cell component outlet side of the plasma separator 3 that opens and closes the flow path by pinching from the outside.
A venous chamber 18 for separating gas and liquid is connected downstream of the second valve. Downstream of the venous chamber 18 is a second detector 19 that identifies the presence of air in the flow path;
A first valve 20 that opens and closes the flow path by pinching from the outside is provided between the blood introduction portion H2 and the blood introduction portion H2 . In the venous chamber 18, the fluid level in the chamber is at an appropriate level (approximately 2/2 below the lower limit of the chamber).
A first detector 18D is provided for determining whether or not the position up to position 3) is present.
血漿流路２には、上記血漿分離器３で分離され
た血漿成分を高分子量成分と低分子量成分に分離
する血漿成分分離器６、血漿ポンプ７１および補
液ポンプ７２と血漿流路２の流量を検知する検知
器８１が接続され、分離された低分子量成分を、
上記血漿分離器３の下流の血液循環流路１を経て
人体へ戻す。一方分離された高分子量成分はドレ
ン開口Ｄから外部へ排出される。また補液は補液
供給限９から高分子量成分と等量の補液を血漿成
分分離器６に供給し、低分子量成分と混合して人
体へ送給される。 The plasma flow path 2 includes a plasma component separator 6 that separates the plasma components separated by the plasma separator 3 into high molecular weight components and low molecular weight components, a plasma pump 71, a fluid replacement pump 72, and a flow rate of the plasma flow path 2. A detector 81 is connected to detect the separated low molecular weight components.
The blood is returned to the human body through the blood circulation channel 1 downstream of the plasma separator 3. On the other hand, the separated high molecular weight components are discharged from the drain opening D to the outside. Further, the replacement fluid is supplied from the replacement fluid supply limit 9 to the plasma component separator 6 in an amount equal to the high molecular weight component, mixed with the low molecular weight component, and then delivered to the human body.
血漿流路２の血漿ポンプ７１と、血漿成分分離
器６の間には液体と気体を分離する２次膜チヤン
バー３２が備えられている。このチヤンバー３２
には、圧力を検知する第３の検出器３７が接続さ
れ、また該チヤンバー３２には液体レベルが適正
レベルまで存在するか否かを識別する第４の検出
器３９が備えられている。 A secondary membrane chamber 32 for separating liquid and gas is provided between the plasma pump 71 of the plasma flow path 2 and the plasma component separator 6. This chamber 32
A third detector 37 is connected to the chamber 32 for sensing pressure, and the chamber 32 is equipped with a fourth detector 39 for determining whether the liquid level is up to the correct level.
血漿流路２の下流側と血液循環流路１との間に
は、２つの流路の連通と遮断を行う第３のバルブ
１１が設けられている。 A third valve 11 is provided between the downstream side of the plasma flow path 2 and the blood circulation flow path 1 for communicating and blocking the two flow paths.
血漿分離器３の液（血漿）室の上部側壁に設
けた開口には第４のバルブ２５が接続されてお
り、この第４のバルブ２５により、外部空気を
液室内に導入できる。外部空気による汚染をさけ
るため、第４のバルブ２５の空気取入口には除菌
フイルターを設ける事が好ましい。 A fourth valve 25 is connected to an opening provided in the upper side wall of the liquid (plasma) chamber of the plasma separator 3, and this fourth valve 25 allows external air to be introduced into the liquid chamber. In order to avoid contamination by external air, it is preferable to provide a sterilization filter at the air intake port of the fourth valve 25.
一方、制御手段としては第１のポンプ制御手段
１３１と第１のバルブ制御手段１３２からなる血
液回収手段１３、第２のバルブ制御手段１４１と
第２のポンプ制御手段１４２からなる血漿回収手
段１５、第３のポンプ制御手段１４および第３の
バルブ制御手段１６１と第４のポンプ制御手段１
６２からなる回収終了手段１６がある。 On the other hand, the control means includes a blood collection means 13 consisting of a first pump control means 131 and a first valve control means 132, a plasma collection means 15 consisting of a second valve control means 141 and a second pump control means 142, Third pump control means 14 and third valve control means 161 and fourth pump control means 1
There is a collection termination means 16 consisting of 62.
血液処理が終了すると、血液導出部H1を人体
から取り外し、その後外部からのスタート信号を
受ける。血液回収手段１３は第１のバルブ制御手
段１３２から第１のバルブ２０および第２のバル
ブ１７の開信号、第３のバルブ１１の閉信号を送
つて各バルブを開閉する。また第１のポンプ制御
手段１３１から駆動信号を送つて、血液ポンプ４
を駆動させて、血液循環流路中に残つた血液を血
液ポンプ４により血漿分離器３、静脈チヤンバー
１８を経由して血液導入部H2より人体に返却す
る。その際人体から取り外された血液導出部H1
からは空気が入る。そして血漿分離器３の残血液
が無くなると静脈チヤンバー１８の血液レベルが
低下し、第１の検出器１８Ｄで気体（空気）があ
る一定期間検出される。すると血液の回収が終了
したものとみなし、血漿回収手段１４により第２
のバルブ制御手段１４１から第２のバルブ１７の
閉信号、第３のバルブ１１および第４のバルブ２
５の開信号を送り各バルブを開閉する。また第２
のポンプ制御手段１４２から停止信号を送つて血
液ポンプ４の駆動を停止させ、駆動信号を送つて
血漿ポンプ７１を駆動する。すると外部空気が第
４のバルブ２５からとり込まれ、血漿分離器３内
の残血漿は２次膜チヤンバー３２を経由して、血
漿成分分離器６に送り込まれる。この残血漿は血
漿成分分離器内の分離膜を通過して第３のバルブ
１１を通り、血液循環流路１の静脈チヤンバー１
８を経由して、血液導入部H2から体内に戻され
る。血漿分離器３から残血漿が送り出されてしば
らくすると、２次膜チヤンバー３２に第４のバル
ブ２５からとり込まれた空気が送り込まれ、チヤ
ンバー内の液体（血漿）レベルが低下して２次膜
チヤンバー３２に設けられた第４の検出器３９が
気体（空気）を検出すると同時に流量計８により
累積流量を算出し、その累積流量が所定値（血漿
成分分離器６の分離膜容積に相当する量）に到達
すると、第３のポンプ制御手段１５からの駆動信
号により補液ポンプ７２を駆動して、補液流路内
の残補液及び血漿成分分離器６内の残血漿を人体
に戻す。この時、２次膜チヤンバー３２に接続さ
れて該チヤンバー内の圧力を検出する第３の検出
器３７が所望の圧力になる様、血漿ポンプ７１は
起動停止（又は連続的な回転上昇下降）する。そ
の際少くとも血漿成分分離器の分離膜内に血漿が
逆流しない様に考慮する必要がある。 When blood processing is completed, the blood lead-out section H1 is removed from the human body, and then a start signal is received from the outside. The blood collection means 13 opens and closes each valve by sending an open signal for the first valve 20 and the second valve 17 and a close signal for the third valve 11 from the first valve control means 132. In addition, the first pump control means 131 sends a drive signal to the blood pump 4.
The blood remaining in the blood circulation channel is returned to the human body from the blood introduction part H2 via the plasma separator 3 and the venous chamber 18 by the blood pump 4. Blood outlet H 1 removed from the human body at that time
Air comes in from. When the remaining blood in the plasma separator 3 disappears, the blood level in the venous chamber 18 decreases, and gas (air) is detected for a certain period of time by the first detector 18D. Then, it is assumed that the blood collection has been completed, and the plasma collection means 14 collects the second blood.
A closing signal for the second valve 17, the third valve 11 and the fourth valve 2 from the valve control means 141 of
5 open signal is sent to open and close each valve. Also the second
The pump control means 142 sends a stop signal to stop driving the blood pump 4, and sends a drive signal to drive the plasma pump 71. Then, external air is taken in from the fourth valve 25, and the remaining plasma in the plasma separator 3 is sent to the plasma component separator 6 via the secondary membrane chamber 32. This remaining plasma passes through the separation membrane in the plasma component separator, passes through the third valve 11, and enters the venous chamber 1 of the blood circulation channel 1.
8 and is returned to the body from the blood introduction part H2 . After a while after the residual plasma is sent out from the plasma separator 3, the air taken in from the fourth valve 25 is sent into the secondary membrane chamber 32, and the liquid (plasma) level in the chamber decreases and the secondary membrane is removed. At the same time as the fourth detector 39 provided in the chamber 32 detects gas (air), the flow meter 8 calculates the cumulative flow rate, and the cumulative flow rate is a predetermined value (corresponding to the separation membrane volume of the plasma component separator 6). When the replacement fluid amount reaches the amount), the replacement fluid pump 72 is driven by the drive signal from the third pump control means 15, and the remaining replacement fluid in the replacement fluid flow path and the remaining plasma in the plasma component separator 6 are returned to the human body. At this time, the plasma pump 71 starts and stops (or continuously rotates up and down) so that the third detector 37 connected to the secondary membrane chamber 32 and detects the pressure inside the chamber reaches the desired pressure. . At this time, it is necessary to take into account at least the possibility that plasma will not flow back into the separation membrane of the plasma component separator.
補液容器９内の補液がなくなると、補液容器に
取着された空気導入口（通常容器に注射針を穿刺
する）より空気が吸い込まれ、この空気は血漿成
分分離器６、第３のバルブ１１を通り血液循環流
路１の静脈チヤンバー１８から第２の検出器１９
へ至る。該第２の検知器１９が上記空気（気体）
を検出すると、この信号を受けて回収終了手段１
５により第４のポンプ制御手段１６２から駆動信
号を送つて血漿ポンプ７１と補液ポンプ７２の駆
動を停止し、かつ第３のバルブ制御手段１６１か
ら閉止信号を送つて第１のバルブ２０を閉止す
る。上記により回収が終了するが、このとき血液
循環流路１の第２の検出器１９から血液導入部
H2の間には血漿が残留している。この残留血漿
をも回収する場合には例えばスタートスイツチ信
号により、第１のバルブ２０の開信号を送り、補
液ポンプ７２を起動し、残血漿を血液導入部H2
に目視にて近接させる。その後ストツプスイツチ
信号により補液ポンプ７２を停止し、第１のバル
ブ２０の閉信号を送る。上記操作は通常手動で行
われる。 When the replacement fluid in the replacement fluid container 9 runs out, air is sucked in through the air inlet (usually a needle is inserted into the container) attached to the replacement fluid container, and this air is passed through the plasma component separator 6 and the third valve 11. from the venous chamber 18 of the blood circulation channel 1 through the second detector 19
leading to. The second detector 19 detects the air (gas)
is detected, the collection termination means 1 receives this signal.
5, the fourth pump control means 162 sends a drive signal to stop driving the plasma pump 71 and the replacement fluid pump 72, and the third valve control means 161 sends a closing signal to close the first valve 20. . The collection is completed as described above, but at this time, the blood introduction section from the second detector 19 of the blood circulation channel 1
Plasma remains between the H2 . If this remaining plasma is also to be collected, for example, a start switch signal is used to send an opening signal to the first valve 20, start the fluid replacement pump 72, and transfer the remaining plasma to the blood introduction section H2.
Visually approach. Thereafter, the replacement fluid pump 72 is stopped by a stop switch signal, and a signal to close the first valve 20 is sent. The above operations are usually performed manually.
血液の回収に生理食塩水を使用する場合には血
液導出部H1を生食ボトルに接続すればよい。そ
の場合にも静脈チヤンバー１８に設けられた第１
の検出器１８Ｄが気体（空気）を検出したときを
回収終了とみなすことができる。生理食塩水で血
液を回収すると第１の検出器１８Ｄは血液、次に
生理食塩水を検出し、その次に気体（空気）を検
出するため、血液の回収に多少長時間を要するこ
とになるだけで、上記の空気による血液の体内返
却と同一の工程で実施出来る。 When using physiological saline to collect blood, the blood outlet H1 may be connected to a saline bottle. In that case as well, the first
When the detector 18D detects gas (air), it can be considered that the collection is completed. When blood is collected using physiological saline, the first detector 18D detects the blood, then the physiological saline, and then detects gas (air), so it takes some time to collect the blood. It can be carried out in the same process as the above-mentioned return of blood into the body using air.
上記構成によれば、血液処理終了後、血液導出
部H1を人体より取り外し、しかる後回収処理を
スタートさせることにより、直ちに体外に導出さ
れた残血液を大部分、体内に返却出来る。
According to the above configuration, most of the remaining blood drawn out of the body can be immediately returned to the body by removing the blood lead-out section H1 from the human body and then starting the collection process after the blood treatment is completed.
また、残血漿のすべては血漿成分分離器６へ送
られ、低分子量成分のみ分離膜を通過して人体に
返却される。しかも残補液も全て人体に返却され
るため効率的な回収が出来る。 Further, all of the remaining plasma is sent to the plasma component separator 6, and only low molecular weight components pass through the separation membrane and are returned to the human body. Furthermore, all remaining replacement fluid is returned to the human body, allowing for efficient recovery.
また血液回収手段、血漿回収手段、第３のポン
プ制御手段および回収終了手段が継続して自動的
に作動する為、操作が極めて簡単になり、スター
ト操作のみで残血液、残血漿のほとんどすべてが
回収される。 In addition, since the blood collection means, plasma collection means, third pump control means, and collection termination means operate continuously and automatically, the operation is extremely simple, and almost all of the remaining blood and plasma can be removed with just the start operation. It will be collected.
以下、この発明の実施例を図面にしたがつて説
明する。
Embodiments of the present invention will be described below with reference to the drawings.
まず、二重過型血液処理装置について説明す
る。 First, a double-pass type blood processing device will be explained.
第２図は血液処理時のフロー図であり、１は血
液循環流路、２は血漿流路である。血液導入部
H1（シヤント、注射針などの通常の採血器や貯血
器などと連絡できる部分）から取り出された血液
は、血液ポンプ４により昇圧されて動脈圧チヤン
バー１６に入り、ついで、上下方向に設定された
血漿分離器３に上側から導入され、血球成分と血
漿成分とに分離される。この血漿分離器３には、
血漿分離膜、たとえばポリビニルアルコール
（PVA）系の共重合体などからなる平板状、チユ
ーブ状、または中空糸状の分離膜が収容されてい
る。通常は、中空糸状の分離膜を多数寄せ集めた
ものが用いられる。 FIG. 2 is a flow diagram during blood processing, where 1 is a blood circulation channel and 2 is a plasma channel. Blood introduction part
Blood taken out from H 1 (the part that can communicate with a normal blood sampler or blood reservoir such as a shunt or a syringe needle) is pressurized by the blood pump 4 and enters the arterial pressure chamber 16, and is then set in the vertical direction. The blood is introduced from above into the plasma separator 3, where it is separated into blood cell components and plasma components. This plasma separator 3 includes
A plasma separation membrane, for example, a plate-shaped, tube-shaped, or hollow fiber-shaped separation membrane made of a polyvinyl alcohol (PVA) copolymer is housed. Usually, a collection of a large number of hollow fiber separation membranes is used.
上記血漿分離器３で分離された血球成分は、第
２のバルブ１７を経て静脈圧チヤンバー１８に入
り気泡検知器１９、第１のバルブ２０を経て血液
導出部H2（シヤントや点滴セツトなどに連結でき
る部分）へ戻る。静脈圧チヤンバーには、チヤン
バー内レベルをモニターする検知器１８Ｄが設け
られている。 The blood cell components separated by the plasma separator 3 enter the venous pressure chamber 18 via the second valve 17, pass through the air bubble detector 19 and the first valve 20, and then enter the blood outlet H2 (to a shunt, drip set, etc.). Return to parts that can be connected. The venous pressure chamber is equipped with a detector 18D that monitors the level within the chamber.
さらに、上記血液ポンプ４の上流側には、膨
張・収縮可能な袋状体からなるピローセンサ２１
が設けられており、脱血が困難になつたときに、
流路の陰圧を検知して作動し、血液ポンプ４を停
止させ、陰圧がなくなつたとき、血液ポンプ４を
再始動する。また、上記動脈圧チヤンバー１６に
は、血液中にヘパリンを少量だけ混入させて、処
理中の血液の凝固を防止するヘパリン注入器２２
と、動脈圧センサ２３とが接続され、上記血漿分
離器３には、過圧センサ２４と空気導入バルブ
２５とが接続され、上記静脈圧チヤンバー１８に
は、静脈圧センサー２６が接続されている。 Furthermore, on the upstream side of the blood pump 4, a pillow sensor 21 consisting of a bag-like body that can be expanded and contracted is provided.
is provided, and when it becomes difficult to remove blood,
It is activated by detecting the negative pressure in the flow path, stops the blood pump 4, and restarts the blood pump 4 when the negative pressure disappears. The arterial pressure chamber 16 also includes a heparin injector 22 that mixes a small amount of heparin into the blood to prevent blood from coagulating during treatment.
and an arterial pressure sensor 23 are connected to the plasma separator 3, an overpressure sensor 24 and an air introduction valve 25 are connected to the plasma separator 3, and a venous pressure sensor 26 is connected to the venous pressure chamber 18. .
上記血漿分離器３で分離された血漿成分は、血
漿流路２の血漿ポンプ７１により昇圧されて２次
膜圧チヤンバー３２に入り、上下方向に設定され
た血漿成分分離器６に下側から導入されて、高分
子量成分と低分子量成分とに分離される。この血
漿成分分離器６には、血漿処理膜、たとえばエチ
レンビニルアルコール（EVA）系の共重合体な
どからなる平板状、チユーブ状、または中空糸状
の分離膜が収容されている。通常は、中空糸状の
分離膜を多数寄せ集めたものが用いられる。 The plasma component separated by the plasma separator 3 is pressurized by the plasma pump 71 of the plasma flow path 2, enters the secondary membrane pressure chamber 32, and is introduced from below into the plasma component separator 6 set in the vertical direction. is separated into high molecular weight components and low molecular weight components. The plasma component separator 6 accommodates a plasma processing membrane, for example, a plate-shaped, tube-shaped, or hollow fiber-shaped separation membrane made of an ethylene vinyl alcohol (EVA) copolymer. Usually, a collection of a large number of hollow fiber separation membranes is used.
上記血漿成分分離器６で分離された高分子量成
分は、ドレンポンプ７２により、血漿成分分離器
６の上方からドレン開口Ｄを経て外部へ排出され
る。一方、低分子量成分は、血漿分離器３よりも
下流の血液循環流路１を経て人体へ戻される。 The high molecular weight components separated by the plasma component separator 6 are discharged from above the plasma component separator 6 to the outside through the drain opening D by the drain pump 72. On the other hand, the low molecular weight components are returned to the human body via the blood circulation channel 1 downstream of the plasma separator 3.
上記２次膜圧チヤンバー３２には、２次膜圧セ
ンサ３７、空気放出バルブ３８および液面検知セ
ンサ３９が接続され、上記血漿成分分離器６に
は、上記ドレンポンプ７２および気泡検知器４０
を介して、補液導入部（点滴セツトなどに連結で
きる部分）が、アルブミンやHES等の補液を供
給する補液供給源９に接続され、補液が上記ドレ
ンポンプ７２により血漿成分分離器６内へ送られ
て、低分子量成分に混入される。 A secondary membrane pressure sensor 37, an air release valve 38, and a liquid level detection sensor 39 are connected to the secondary membrane pressure chamber 32, and the drain pump 72 and the air bubble detector 40 are connected to the plasma component separator 6.
A replacement fluid introduction part (a part that can be connected to an IV drip set, etc.) is connected to a replacement fluid supply source 9 that supplies replacement fluid such as albumin or HES, and the replacement fluid is sent into the plasma component separator 6 by the drain pump 72. and mixed into the low molecular weight components.
また、血漿分離器３の下流側に、第２のバルブ
１７が設けられ、上記血漿流路２の下流側と血液
循環流路１の第２のバルブ１７よりも下流側との
間には、連通およびしや断を行なう第３のバルブ
１１が設けられている。 Further, a second valve 17 is provided downstream of the plasma separator 3, and between the downstream side of the plasma flow path 2 and the downstream side of the second valve 17 of the blood circulation flow path 1, A third valve 11 for communication and disconnection is provided.
さらに上記血液ポンプ４には、この血液ポンプ
４の回転数に基づいて血液循環流路１の流量を検
知する血液量検知器５が、上記血漿ポンプ７１に
は、この血漿ポンプ７１の回転数に基づいて血漿
流路２の流量を検知する血漿量検知器８１が、上
記ドレンポンプ７２には、このドレンポンプ７２
の回転数に基づいてドレン量を検知するドレン量
検知器８２が、それぞれ接続されている。 Furthermore, the blood pump 4 is equipped with a blood volume detector 5 that detects the flow rate of the blood circulation channel 1 based on the rotation speed of the blood pump 4, and the plasma pump 71 is equipped with a blood volume detector 5 that detects the flow rate of the blood circulation channel 1 based on the rotation speed of the blood pump 4. The drain pump 72 is equipped with a plasma volume detector 81 that detects the flow rate of the plasma flow path 2 based on the flow rate of the plasma flow path 2.
A drain amount detector 82 that detects the amount of drain based on the number of revolutions of is connected to each of the drain amount detectors 82 .
４８はマイクロコンピユータからなる制御装置
であり、臨床時には、この制御装置４８により、
上記各検知器５，８１，８２からの流量検知信号
と、各圧力センサ２３，２４，２６，３７からの
圧力検知信号とを見ながら、血液循環流路１内と
血漿流路２内の各流量、および血漿分離器３と血
漿成分分離６内の膜圧が適正値となるように、上
記各ポンプ４，７１，７２の回転数を制御し、血
液の処理を行なう。ここで、上記ドレンポンプ７
２は高分子量成分の排出と補液の供給とを兼ねて
いるが、これとは異なり、高分子量成分の排出と
補液の供給とを別固のポンプで行なうようにして
もよい。ただし、この実施例のように、兼用構成
とすれば、特に制御しなくても、高分子量成分の
排出量と、補液の供給量とが常に等しくなるので
好都合である。 48 is a control device consisting of a microcomputer, and during clinical practice, this control device 48 allows
While checking the flow rate detection signals from each of the above-mentioned detectors 5, 81, 82 and the pressure detection signals from each pressure sensor 23, 24, 26, 37, Blood is processed by controlling the rotational speed of each of the pumps 4, 71, and 72 so that the flow rate and the membrane pressure within the plasma separator 3 and plasma component separation 6 are at appropriate values. Here, the drain pump 7
2 serves both to discharge the high molecular weight component and to supply the replacement fluid, but unlike this, the discharge of the high molecular weight component and the supply of the replacement fluid may be performed using separate pumps. However, if the dual-use structure is used as in this embodiment, it is convenient because the discharge amount of the high molecular weight component and the supply amount of the replacement fluid are always equal to each other without any particular control.
上記血液循環流路１および血漿流路２は、第３
図に示す取付台５０の前面５０ａに取り付けられ
る。この前面５０ａには第４図に示すように、塩
化ビニール管で形成された血液循環流路１および
血漿流路２が装着され、これら血液循環流路１お
よび血漿流路２の中途に、血漿分離器３、血漿成
分分離器６などが接続され、取付台５０の上部に
は、血液ポンプ４、血漿ポンプ７１、ドレンポン
プ７２、および、操作の指示等を表示する画面５
１が配置されている。 The blood circulation channel 1 and the plasma channel 2 have a third
It is attached to the front surface 50a of the mounting base 50 shown in the figure. As shown in FIG. 4, the front surface 50a is equipped with a blood circulation channel 1 and a plasma channel 2 formed of vinyl chloride pipes. A separator 3, a plasma component separator 6, etc. are connected, and a blood pump 4, a plasma pump 71, a drain pump 72, and a screen 5 for displaying operation instructions, etc. are installed on the top of the mounting base 50.
1 is placed.
つぎに上記構成の血液処理装置の回収操作につ
いて第５図〜第１１図のフロー図および第１２図
〜第１３図のフローチヤートにより説明する。 Next, the recovery operation of the blood processing apparatus having the above configuration will be explained with reference to the flowcharts shown in FIGS. 5 to 11 and the flowcharts shown in FIGS. 12 to 13.
第５図において、血液処理が終了した時、血液
循環流路には血液、血漿循環流路には血漿が充満
している。 In FIG. 5, when blood processing is completed, the blood circulation channel is filled with blood and the plasma circulation channel is filled with plasma.
血液導出部H1は人体から取り外され、血液導
入部H2は人体に接続されている。 The blood outlet H1 is removed from the human body, and the blood inlet H2 is connected to the human body.
また血液ポンプ４、血漿ポンプ７１、ドレンポ
ンプ７２は停止しており、バルブ１１，１７は開
放されバルブ２０，２５，３８は閉止されてい
る。 Furthermore, the blood pump 4, plasma pump 71, and drain pump 72 are stopped, the valves 11 and 17 are open, and the valves 20, 25, and 38 are closed.
以上が回収のスタート前の状態であり、第１２
図のフローチヤートのステツプK1であり、第６
図にこの状態を示す。外部からの回収スタート信
号を受けると、制御装置４８が作動しバルブ１
７，２０は開放し、バルブ１１，２５，３８は閉
止する。また血液ポンプ４が、例えば40ml／分の
流量で回転を始め、血液導出部H1からは外部空
気が吸入され、血液循環流路中の残血液は血液導
入部H2より人体に返却される。この状態は第１
２図のフローチヤートのステツプK2であり、第
７図にこの状態を示す。このステツプK2の状態
が続くと、血漿分離器３の血液がなくなり、次い
で静脈チヤンバ１８の血液レベルが低下し、該チ
ヤンバーに設けられた検出器１８Ｄが空気を検出
し、次のステツプK3に進む。静脈チヤンバー１
８は、このステツプK2の終期には、空気が混入
するので、短期間（例えば１秒以内）の空気検出
では次のステツプに進まない様な安全策が施され
ている。 The above is the state before the start of collection, and the 12th
This is step K1 of the flowchart in Figure 6.
This situation is shown in the figure. Upon receiving a collection start signal from the outside, the control device 48 operates and valve 1 is activated.
7 and 20 are opened, and valves 11, 25, and 38 are closed. In addition, the blood pump 4 starts rotating at a flow rate of, for example, 40 ml/min, external air is sucked in from the blood outlet H1 , and the remaining blood in the blood circulation channel is returned to the human body from the blood inlet H2 . . This state is the first
This is step K2 in the flowchart of FIG. 2, and this state is shown in FIG. If the state of step K2 continues, the blood in the plasma separator 3 runs out, and then the blood level in the venous chamber 18 decreases, and the detector 18D installed in the chamber detects air, leading to the next step K3. Proceed to. Venous chamber 1
8, since air is mixed in at the end of step K2 , a safety measure is taken to prevent the process from proceeding to the next step if air is detected for a short period of time (for example, within 1 second).
血液導出部H1は外部開放せず、生理食塩水貯
留器に接続しても、ステツプK2の処理時間が長
くなるが、血漿分離器３内の残血液がより完全に
下流に追い出され、血液回収効率が上昇し、生理
食塩水が無くなると空気がとり込まれるので、同
様なフローで適応出来る。 Even if the blood outlet H1 is not opened to the outside and is connected to a physiological saline reservoir, the processing time of step K2 will be longer, but the remaining blood in the plasma separator 3 will be more completely expelled downstream, Blood collection efficiency increases and air is taken in when saline runs out, so a similar flow can be applied.
ステツプK3ではバルブ２５，２０が開放し、
バルブ１７，１１，３８が閉止して、血液ポンプ
４を停止させ、血漿ポンプ７１を、例えば40ml／
分の流量で回転させて、血漿分離器３の残血漿を
バルブ２５から空気を入れることにより血漿成分
分離器６へ送出し始める。この状態を第８図に示
す。この時２次膜圧が静脈圧以上になるまで血漿
成分分離器６の分離膜での血漿の逆流を防止する
為、バルブ１１は閉じておく。 In step K3 , valves 25 and 20 are opened,
The valves 17, 11, 38 are closed to stop the blood pump 4 and pump the plasma pump 71 to, for example, 40ml/
The remaining plasma in the plasma separator 3 is started to be sent to the plasma component separator 6 by introducing air from the valve 25. This state is shown in FIG. At this time, the valve 11 is kept closed to prevent backflow of plasma across the separation membrane of the plasma component separator 6 until the secondary membrane pressure becomes equal to or higher than the venous pressure.
２次膜圧が静脈圧より大の条件が成立するとス
テツプK4に進みバルブ１１を開き血漿ポンプ７
１で血漿成分分離器に送り込まれた血漿は、過
され低分子量成分のみが血漿流路下流側回路を通
り、静脈チヤンバー１８を経由して血液導入部
H2より人体に戻される。この状態を第９図に示
す。一方、血漿分離器３の残血漿が無くなり、バ
ルブ２５からは空気が入つてきているのでしばら
くすると、２次膜チヤンバー３２の血漿レベルは
低下し、２次膜チヤンバー３２に設けられた検出
器３９で空気が検出され、同時に血漿ポンプ７１
の累積流量が算出される。この流量が例えば100
mlに達するまで血漿成分分離器６には血漿と空気
が送り込まれる。この100mlの値は血漿成分分離
器６の分離膜内容量に相当し、血漿成分分離器６
では空気は過されないので、大量に空気を血漿
成分分離器６に送り込むことは、２次膜圧が上昇
するのみで好ましくない。血漿成分分離器６内の
分離膜内が血漿から空気に置換されると次のステ
ツプK5に進む。 When the condition that the secondary membrane pressure is greater than the venous pressure is established, the process proceeds to step K4 , where the valve 11 is opened and the plasma pump 7 is activated.
The plasma sent to the plasma component separator in step 1 is filtered, and only low molecular weight components pass through the downstream circuit of the plasma flow path and are sent to the blood introduction section via the venous chamber 18.
Returned to the human body by H2 . This state is shown in FIG. On the other hand, since the remaining plasma in the plasma separator 3 is gone and air is coming in from the valve 25, the plasma level in the secondary membrane chamber 32 will decrease after a while, and the detector installed in the secondary membrane chamber 32 will Air is detected at 39 and at the same time plasma pump 71
The cumulative flow rate is calculated. For example, if this flow rate is 100
Plasma and air are fed into the plasma component separator 6 until the amount reaches ml. This value of 100ml corresponds to the content of the separation membrane in the plasma component separator 6.
Since the air is not passed through, it is not preferable to send a large amount of air to the plasma component separator 6 because this only increases the secondary membrane pressure. When the separation membrane in the plasma component separator 6 is replaced with air from plasma, the process proceeds to the next step K5 .
ステツプK5ではドレンポンプが例えば40ml／
分の流量で回転し残補液及び血漿成分分離器６で
過された血漿が血漿流路の下流側を通り、静脈
チヤンバーを経由して血液導入部H2より人体に
返却されるこの状態を第１０図に示す。 In step K 5 , the drain pump is e.g. 40ml/
The remaining replacement fluid and plasma passed through the plasma component separator 6 pass through the downstream side of the plasma flow path and are returned to the human body from the blood introduction part H2 via the venous chamber. It is shown in Figure 10.
また、この状態では血漿成分分離器６内の空気
がドレンポンプより外部に排出されるので、分離
器内の圧力が低下して、補液が分離器内に逆流す
るのを防止するため、２次膜圧が設定値例えば
400mmHgになる様、血漿ポンプ７１を作動させ
る。 In addition, in this state, the air inside the plasma component separator 6 is discharged to the outside from the drain pump, so the pressure inside the separator decreases, and in order to prevent replacement fluid from flowing back into the separator, a secondary For example, if the membrane pressure is the set value
The plasma pump 71 is operated so that the blood pressure becomes 400 mmHg.
補液がなくなると、空気が入り、血漿成分分離
器６からバルブ１１を通り、静脈圧チヤンバー１
８を経由して検出器１９を通過する。検知器１９
が空気を検出するとバルブ２０を閉じて、ドレン
ポンプを一旦停止し、次に第１１図に示すステツ
プK6に移る。 When the replacement fluid runs out, air enters and passes from the plasma component separator 6 through the valve 11 and into the venous pressure chamber 1.
8 and passes through a detector 19. Detector 19
When air is detected, the valve 20 is closed, the drain pump is temporarily stopped, and then the process moves to step K6 shown in FIG.
この状態では血漿は血液循環流路１の検出器１
９と血液導出部H2の間に残つており、ステツプ
K7，K8に示す。スタートスイツチで血漿を血液
導入部H2の近くまで追い込んでストツプスイツ
チで止めることにより、血漿も完全に回収出来
る。 In this state, plasma is transferred to the detector 1 of the blood circulation flow path 1.
9 and the blood outlet H2 , and the step
Shown in K 7 and K 8 . Plasma can be completely collected by driving the plasma close to the blood introduction part H2 with the start switch and stopping it with the stop switch.
以上説明したように、この発明によれば、臨床
処理終了後、血液導出部を人体から取り外し回収
スタートスイツチを押すだけで、血液循環流路中
の残血液と血漿流路中の残血漿を完全に回収でき
る。
As explained above, according to the present invention, after the clinical treatment is completed, the remaining blood in the blood circulation channel and the remaining plasma in the plasma channel can be completely removed by simply removing the blood outlet part from the human body and pressing the collection start switch. can be recovered.
上記操作は全て自動で行われるため、操作が簡
単で習熱したテクニツクを必要とせず、きわめて
安全に回収が出来る。 All of the above operations are performed automatically, so they are easy to operate, do not require any trained techniques, and can be collected extremely safely.
第１図はこの発明の構成を示す回路図、第２図
はこの発明に係る二重過型血液処理装置の血液
処理時の状態を示す回路図、第３図はこの発明の
装置が取り付けられる取付台を示す側面図、第４
図は同正面図、第５図から第１１図までは同実施
例の動作を示す簡略化した回路図、第１２図と第
３図は同実施例の制御方法を示すフローチヤート
である。
１……血液循環流路、２……血漿流路、３……
血漿分離器、４……血液ポンプ、１８Ｄ……第１
の検知器、６……血漿成分分離器、８……第５の
検知器、９……補液供給源、１１……第３のバル
ブ、１３……血液回収手段、１４……第３のポン
プ制御手段、１５……血漿回収手段、１６……回
収終了手段、１７……第２のバルブ、１９……第
１の検知器、２０……第１のバルブ、２５……第
４のバルブ、３７……第３の検知器、３９……第
４の検知器。
FIG. 1 is a circuit diagram showing the configuration of the present invention, FIG. 2 is a circuit diagram showing the state of the double-pass type blood processing device according to the present invention during blood processing, and FIG. 3 is a circuit diagram showing the state in which the device of the present invention is installed. Side view showing the mounting base, No. 4
5 to 11 are simplified circuit diagrams showing the operation of the same embodiment, and FIGS. 12 and 3 are flowcharts showing the control method of the same embodiment. 1... Blood circulation channel, 2... Plasma channel, 3...
Plasma separator, 4...Blood pump, 18D...1st
Detector, 6...Plasma component separator, 8...Fifth detector, 9...Replacement fluid supply source, 11...Third valve, 13...Blood collection means, 14...Third pump Control means, 15... Plasma collection means, 16... Collection termination means, 17... Second valve, 19... First detector, 20... First valve, 25... Fourth valve, 37...Third detector, 39...Fourth detector.
Claims (1)
液を血球成分と血漿成分とに分離し、血球成分を
人体に返還する血液循環流路１と、 上記血漿分離器３で分離された血漿成分を血漿
ポンプ７１で血漿成分分離器６に供給して、高分
子量成分と低分子量成分とに分離し、分離された
低分子量成分に、補液ポンプ７２で、廃棄される
高分子量成分と等量の補液を加えて混合した後、
血漿分離器よりも下流の血液循環流路１を経て人
体へ返還する血漿流路２と、 上記血漿分離器３の下流の血液循環流路１内の
流体を識別する第１の検知器１８Ｄと、 上記第１の検知器１８Ｄの下流の血液循環流路
内の流体を識別する第２の検知器１９と、 上記血漿ポンプ７１の下流の血漿流路２内の流
体を識別する第４の検知器３９と、 上記第２の検知器１９の下流の血液循環流路１
を開閉する第１のバルブ２０と、 上記血漿分離器３の下流で、かつ第１の検知器
１８Ｄの上流の血液循環流路１を開閉する第２の
バルブ１７と、 上記血漿流路２と、血漿分離器３よりも下流の
血液循環流路１との連通および遮断を行う第３の
バルブ１１と、 上記血漿分離器３の液室の丈夫に設けられた
空気導入口を開閉する第４のバルブ２５と、 外部からのスタート信号を受けて、血液ポンプ
４に駆動信号を送り、この血液ポンプを駆動させ
る第１のポンプ制御手段１３１と、上記スタート
信号を受けて、第３のバルブ１１を閉止し、第１
のバルブ２０と第２のバルブ１７を開放させる第
１のバルブ制御手段１３２と、 上記第１の検知器１８Ｄからの気体検知信号を
受けて、第２のバルブ１７を閉止し、第３のバル
ブ１１と第４のバルブ２５を開放させる第２のバ
ルブ制御手段１４１と、上記気体検知信号を受け
て血液ポンプ４に停止信号を送つて、このポンプ
を停止させ、血漿ポンプ７１に駆動信号を送つ
て、このポンプを駆動させる第２のポンプ制御手
段１４２と、 上記第４の検知器３９からの気体検知信号を受
けて補液ポンプ７２に駆動信号を送つて、このポ
ンプを駆動させる第３のポンプ制御手段１５と、 上記第２の検知器１９からの気体検知信号を受
けて、第１のバルブ２０を閉止させる第３のバル
ブ制御手段１６１と、上記気体検知信号を受け
て、血漿ポンプ７１に停止信号を送つて、このポ
ンプの駆動を停止させる第４のポンプ制御手段１
[Scope of Claims] 1. A blood circulation channel 1 that separates blood supplied to the plasma separator 3 by a blood pump 4 into blood cell components and plasma components, and returns the blood cell components to the human body; and the plasma separator 3. A plasma pump 71 supplies the separated plasma components to the plasma component separator 6 to separate them into high molecular weight components and low molecular weight components. After adding and mixing the same amount of replacement fluid as the molecular weight components,
a plasma flow path 2 that returns to the human body via the blood circulation flow path 1 downstream of the plasma separator; a first detector 18D that identifies fluid in the blood circulation flow path 1 downstream of the plasma separator 3; , a second detector 19 for identifying fluid in the blood circulation channel downstream of the first detector 18D; and a fourth detector for identifying fluid in the plasma channel 2 downstream of the plasma pump 71. blood circulation channel 1 downstream of the second detector 19
A first valve 20 that opens and closes; a second valve 17 that opens and closes the blood circulation channel 1 downstream of the plasma separator 3 and upstream of the first detector 18D; and the plasma channel 2. , a third valve 11 that communicates with and shuts off the blood circulation channel 1 downstream of the plasma separator 3, and a fourth valve that opens and closes an air inlet that is firmly provided in the liquid chamber of the plasma separator 3. a first pump control means 131 that receives a start signal from the outside and sends a drive signal to the blood pump 4 to drive the blood pump; and a third valve 11 that receives the start signal. Close the first
a first valve control means 132 that opens the valve 20 and the second valve 17; and upon receiving the gas detection signal from the first detector 18D, closes the second valve 17 and opens the third valve 17. 11 and a second valve control means 141 that opens the fourth valve 25; and upon receiving the gas detection signal, sends a stop signal to the blood pump 4 to stop this pump, and sends a drive signal to the plasma pump 71. a second pump control means 142 that drives this pump; and a third pump that receives a gas detection signal from the fourth detector 39 and sends a drive signal to the replacement fluid pump 72 to drive this pump. a control means 15; a third valve control means 161 which receives the gas detection signal from the second detector 19 and closes the first valve 20; and a third valve control means 161 which receives the gas detection signal and closes the first valve 20; Fourth pump control means 1 that sends a stop signal to stop the drive of this pump
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60284797A JPS62142567A (en) | 1985-12-17 | 1985-12-17 | Double filtering type blood treatment apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60284797A JPS62142567A (en) | 1985-12-17 | 1985-12-17 | Double filtering type blood treatment apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62142567A JPS62142567A (en) | 1987-06-25 |
| JPH0117704B2 true JPH0117704B2 (en) | 1989-03-31 |
Family
ID=17683139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60284797A Granted JPS62142567A (en) | 1985-12-17 | 1985-12-17 | Double filtering type blood treatment apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62142567A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010058583A1 (en) | 2008-11-19 | 2010-05-27 | 旭化成クラレメディカル株式会社 | Plasma purifying device and method for controlling blood purifying device |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS645563A (en) * | 1987-06-30 | 1989-01-10 | Terumo Corp | Apparatus for removing unnecessary substance in blood |
| JPS649652U (en) * | 1987-07-03 | 1989-01-19 | ||
| JP5952601B2 (en) * | 2012-03-15 | 2016-07-13 | 旭化成メディカル株式会社 | Ascites treatment apparatus and ascites treatment method |
| JP5914106B2 (en) * | 2012-03-30 | 2016-05-11 | 日機装株式会社 | Blood purification equipment |
| JP6017712B2 (en) * | 2016-01-08 | 2016-11-02 | 日機装株式会社 | Blood purification equipment |
| JP6017713B2 (en) * | 2016-01-08 | 2016-11-02 | 日機装株式会社 | Blood purification equipment |
| JP6017711B2 (en) * | 2016-01-08 | 2016-11-02 | 日機装株式会社 | Blood purification equipment |
| JP6775056B2 (en) * | 2019-04-01 | 2020-10-28 | 日機装株式会社 | Blood purification device |
-
1985
- 1985-12-17 JP JP60284797A patent/JPS62142567A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010058583A1 (en) | 2008-11-19 | 2010-05-27 | 旭化成クラレメディカル株式会社 | Plasma purifying device and method for controlling blood purifying device |
| JP5385917B2 (en) * | 2008-11-19 | 2014-01-08 | 旭化成メディカル株式会社 | Plasma purification apparatus and blood purification apparatus control method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62142567A (en) | 1987-06-25 |
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